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Battenin (Protein CLN3)

 CLN3_MACFA              Reviewed;         438 AA.
Q60HH0;
12-APR-2005, integrated into UniProtKB/Swiss-Prot.
23-NOV-2004, sequence version 1.
25-OCT-2017, entry version 56.
RecName: Full=Battenin;
AltName: Full=Protein CLN3;
Flags: Precursor;
Name=CLN3; ORFNames=QccE-16380;
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain cortex;
Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.;
"Isolation and characterization of cDNA for macaque neurological
disease genes.";
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Involved in microtubule-dependent, anterograde transport
of late endosomes and lysosomes. {ECO:0000250|UniProtKB:Q13286}.
-!- SUBUNIT: Interacts with DCTN1, KIF3A, RAB7A and RILP. Interacts
with CLN5. {ECO:0000250|UniProtKB:Q13286}.
-!- SUBCELLULAR LOCATION: Lysosome membrane
{ECO:0000250|UniProtKB:Q13286}; Multi-pass membrane protein
{ECO:0000255}. Late endosome {ECO:0000250|UniProtKB:Q13286}.
Lysosome {ECO:0000250|UniProtKB:Q13286}.
-!- PTM: Highly glycosylated. {ECO:0000250|UniProtKB:Q13286}.
-!- PTM: Farnesylation is important for trafficking to lysosomes.
{ECO:0000250|UniProtKB:Q13286}.
-!- SIMILARITY: Belongs to the battenin family. {ECO:0000305}.
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EMBL; AB125157; BAD51945.1; -; mRNA.
UniGene; Mfa.13031; -.
UniGene; Mfa.8746; -.
HOVERGEN; HBG017297; -.
GO; GO:0005901; C:caveola; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005769; C:early endosome; ISS:UniProtKB.
GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
GO; GO:0005795; C:Golgi stack; ISS:UniProtKB.
GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
GO; GO:0005770; C:late endosome; ISS:UniProtKB.
GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
GO; GO:0005764; C:lysosome; ISS:UniProtKB.
GO; GO:0045121; C:membrane raft; ISS:UniProtKB.
GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
GO; GO:0042987; P:amyloid precursor protein catabolic process; ISS:UniProtKB.
GO; GO:0015809; P:arginine transport; ISS:UniProtKB.
GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
GO; GO:0006681; P:galactosylceramide metabolic process; ISS:UniProtKB.
GO; GO:0001575; P:globoside metabolic process; ISS:UniProtKB.
GO; GO:0006678; P:glucosylceramide metabolic process; ISS:UniProtKB.
GO; GO:0007042; P:lysosomal lumen acidification; ISS:UniProtKB.
GO; GO:0035752; P:lysosomal lumen pH elevation; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0006898; P:receptor-mediated endocytosis; ISS:UniProtKB.
GO; GO:0006684; P:sphingomyelin metabolic process; ISS:UniProtKB.
GO; GO:0047496; P:vesicle transport along microtubule; ISS:UniProtKB.
InterPro; IPR003492; Battenin_disease_Cln3.
InterPro; IPR018460; Battenin_disease_Cln3_subgr.
InterPro; IPR036259; MFS_trans_sf.
PANTHER; PTHR10981; PTHR10981; 1.
Pfam; PF02487; CLN3; 1.
PIRSF; PIRSF015974; CLN3_BTN1; 1.
PRINTS; PR01315; BATTENIN.
SUPFAM; SSF103473; SSF103473; 1.
2: Evidence at transcript level;
Endosome; Glycoprotein; Lipoprotein; Lysosome; Membrane; Methylation;
Phosphoprotein; Prenylation; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 435 Battenin.
/FTId=PRO_0000089858.
PROPEP 436 438 Removed in mature form.
{ECO:0000250|UniProtKB:Q13286}.
/FTId=PRO_0000422291.
TOPO_DOM 1 37 Cytoplasmic. {ECO:0000255}.
TRANSMEM 38 58 Helical. {ECO:0000255}.
TOPO_DOM 59 127 Lumenal. {ECO:0000255}.
TRANSMEM 128 148 Helical. {ECO:0000255}.
TOPO_DOM 149 151 Cytoplasmic. {ECO:0000255}.
TRANSMEM 152 172 Helical. {ECO:0000255}.
TOPO_DOM 173 182 Lumenal. {ECO:0000255}.
TRANSMEM 183 203 Helical. {ECO:0000255}.
TOPO_DOM 204 277 Cytoplasmic. {ECO:0000255}.
TRANSMEM 278 298 Helical. {ECO:0000255}.
TOPO_DOM 299 346 Lumenal. {ECO:0000255}.
TRANSMEM 347 367 Helical. {ECO:0000255}.
TOPO_DOM 368 438 Cytoplasmic. {ECO:0000255}.
MOD_RES 12 12 Phosphoserine.
{ECO:0000250|UniProtKB:Q13286}.
MOD_RES 14 14 Phosphoserine.
{ECO:0000250|UniProtKB:Q13286}.
MOD_RES 435 435 Cysteine methyl ester.
{ECO:0000250|UniProtKB:Q13286}.
LIPID 435 435 S-farnesyl cysteine.
{ECO:0000250|UniProtKB:Q13286}.
CARBOHYD 71 71 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 85 85 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 310 310 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 438 AA; 47545 MW; D502E87BD24CDA19 CRC64;
MGGCAGSRRR LSDSEGEETV PEPRLPLLDH QGAHWKNAVG FWLLGLCNNF SYVVMLSAAH
DILSHERTSG NQSHVDPGPA PIPHNSSSRF DCNSVSTAAV LLADILPTLV IKLLAPLGLH
LLPYSPRVLV SGICAAGSFV LVAFSHSVGT SLCGVVLASI SSGLGEVTFL SLTAFYPRAV
ISWWSSGTGG AGLLGALSYL GLTQAGLSPQ QTLLSMLGIP ALLLASYFLL LTSPEAQDPG
GEEEAESSAR QPLIRTEAPE SKPGSSSSLS LRERWTVFKG LLWYIVPLVV VYFAEYFINQ
GLFELLFFRN TSLSHAQQYR WYQMLYQAGV FASRSSLRCC HIRFTWALAL LQCLNLAFLL
ADVWFGFLLS IYFVFLIILY EGLLGGAAYV NTFHNIALET SDEHREFAMA TTCISDTLGI
SLSGLLALPL HDFLCQLS


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