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Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)

 G7PMY2_MACFA            Unreviewed;       198 AA.
G7PMY2;
25-JAN-2012, integrated into UniProtKB/TrEMBL.
25-JAN-2012, sequence version 1.
07-NOV-2018, entry version 18.
RecName: Full=Bcl-2-like protein 11 {ECO:0000256|PIRNR:PIRNR037827};
Short=Bcl2-L-11 {ECO:0000256|PIRNR:PIRNR037827};
AltName: Full=Bcl2-interacting mediator of cell death {ECO:0000256|PIRNR:PIRNR037827};
Name=BCL2L11 {ECO:0000313|Ensembl:ENSMFAP00000043450};
ORFNames=EGM_05108 {ECO:0000313|EMBL:EHH55827.1};
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
[1] {ECO:0000313|EMBL:EHH55827.1, ECO:0000313|Proteomes:UP000009130}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CE-4 {ECO:0000313|EMBL:EHH55827.1};
PubMed=22002653; DOI=10.1038/nbt.1992;
Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
Wang X., Wang J.;
"Genome sequencing and comparison of two nonhuman primate animal
models, the cynomolgus and Chinese rhesus macaques.";
Nat. Biotechnol. 29:1019-1023(2011).
[2] {ECO:0000313|Ensembl:ENSMFAP00000043450}
NUCLEOTIDE SEQUENCE.
Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSMFAP00000043450}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2018) to UniProtKB.
-!- FUNCTION: Induces apoptosis and anoikis.
{ECO:0000256|PIRNR:PIRNR037827}.
-!- SUBUNIT: Forms heterodimers with a number of antiapoptotic Bcl-2
proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L),
BCL2A1/BFL-1. {ECO:0000256|PIRNR:PIRNR037827}.
-!- SIMILARITY: Belongs to the Bcl-2 family.
{ECO:0000256|PIRNR:PIRNR037827}.
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EMBL; AQIA01017020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CM001288; EHH55827.1; -; Genomic_DNA.
Ensembl; ENSMFAT00000017740; ENSMFAP00000043450; ENSMFAG00000039143.
GeneTree; ENSGT00390000003178; -.
Proteomes; UP000009130; Chromosome 13.
GO; GO:0097136; C:Bcl-2 family protein complex; IEA:Ensembl.
GO; GO:0019898; C:extrinsic component of membrane; IEA:Ensembl.
GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-UniRule.
GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:1902263; P:apoptotic process involved in embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0001783; P:B cell apoptotic process; IEA:UniProtKB-UniRule.
GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
GO; GO:0007160; P:cell-matrix adhesion; IEA:UniProtKB-UniRule.
GO; GO:0060154; P:cellular process regulating host cell cycle in response to virus; IEA:Ensembl.
GO; GO:0048066; P:developmental pigmentation; IEA:Ensembl.
GO; GO:0043583; P:ear development; IEA:Ensembl.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
GO; GO:0002262; P:myeloid cell homeostasis; IEA:Ensembl.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0060139; P:positive regulation of apoptotic process by virus; IEA:Ensembl.
GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:2000271; P:positive regulation of fibroblast apoptotic process; IEA:Ensembl.
GO; GO:1902110; P:positive regulation of mitochondrial membrane permeability involved in apoptotic process; IEA:Ensembl.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0032464; P:positive regulation of protein homooligomerization; IEA:Ensembl.
GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
GO; GO:0048563; P:post-embryonic animal organ morphogenesis; IEA:Ensembl.
GO; GO:0048070; P:regulation of developmental pigmentation; IEA:Ensembl.
GO; GO:0046620; P:regulation of organ growth; IEA:Ensembl.
GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0048536; P:spleen development; IEA:Ensembl.
GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
GO; GO:0070242; P:thymocyte apoptotic process; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0035148; P:tube formation; IEA:Ensembl.
InterPro; IPR014771; Apoptosis_Bim_N.
InterPro; IPR017288; Bcl-2-like_11.
InterPro; IPR015040; Bcl-x_interacting_BH3_dom.
Pfam; PF08945; Bclx_interact; 1.
Pfam; PF06773; Bim_N; 1.
PIRSF; PIRSF037827; Bcl-2-like_p11; 1.
3: Inferred from homology;
Apoptosis {ECO:0000256|PIRNR:PIRNR037827};
Complete proteome {ECO:0000313|Proteomes:UP000009130};
Membrane {ECO:0000256|PIRNR:PIRNR037827};
Mitochondrion {ECO:0000256|PIRNR:PIRNR037827};
Reference proteome {ECO:0000313|Proteomes:UP000009130}.
DOMAIN 4 40 Bim_N. {ECO:0000259|Pfam:PF06773}.
DOMAIN 133 166 Bclx_interact.
{ECO:0000259|Pfam:PF08945}.
SEQUENCE 198 AA; 22138 MW; C5D5A79DA6ECB427 CRC64;
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
CQAFNHYLSA MASRRQAEPA DMRPEIRIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPQ
MVILRLLRYI VRLVWRMH


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