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Bcl-2-related protein A1 (A1-A) (Hemopoietic-specific early response protein) (Protein BFL-1)

 B2LA1_MOUSE             Reviewed;         172 AA.
Q07440;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1995, sequence version 1.
12-SEP-2018, entry version 139.
RecName: Full=Bcl-2-related protein A1;
AltName: Full=A1-A;
AltName: Full=Hemopoietic-specific early response protein;
AltName: Full=Protein BFL-1;
Name=Bcl2a1; Synonyms=A1, Bcl2a1a, Bfl1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=CBA/J; TISSUE=Bone marrow;
PubMed=8345191;
Lin E.Y., Orlofsky A., Berger M.S., Prystowsky M.B.;
"Characterization of A1, a novel hemopoietic-specific early-response
gene with sequence similarity to bcl-2.";
J. Immunol. 151:1979-1988(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv; TISSUE=Liver;
PubMed=9645611; DOI=10.1093/intimm/10.5.631;
Hatakeyama S., Hamasaki A., Negishi I., Loh D.Y., Sendo F.,
Nakayama K., Nakayama K.;
"Multiple gene duplication and expression of mouse bcl-2-related
genes, A1.";
Int. Immunol. 10:631-637(1998).
[3]
FUNCTION, AND INTERACTION WITH ING4.
PubMed=11888890;
Ha S., Lee S., Chung M., Choi Y.;
"Mouse ING1 homologue, a protein interacting with A1, enhances cell
death and is inhibited by A1 in mammary epithelial cells.";
Cancer Res. 62:1275-1278(2002).
[4]
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1-152 IN COMPLEXES WITH BAK1;
BID; BMF AND BBC3.
PubMed=18462686; DOI=10.1016/j.str.2008.02.009;
Smits C., Czabotar P.E., Hinds M.G., Day C.L.;
"Structural plasticity underpins promiscuous binding of the
prosurvival protein A1.";
Structure 16:818-829(2008).
-!- FUNCTION: Retards apoptosis induced by IL-3 deprivation. May
function in the response of hemopoietic cells to external signals
and in maintaining endothelial survival during infection. Can
inhibit apoptosis induced by serum starvation in the mammary
epithelial cell line HC11 (PubMed:11888890).
{ECO:0000269|PubMed:11888890}.
-!- SUBUNIT: Interacts directly with BCL2L11/BIM and PMAIP1 (By
similarity). Interacts directly with BAK1, BID, BMF and BBC3.
Interacts with BOP (By similarity). Interacts with isoform 3,
isoform 4 and isoform 5 of ING4. {ECO:0000250|UniProtKB:Q16548,
ECO:0000269|PubMed:11888890}.
-!- INTERACTION:
O08734:Bak1; NbExp=2; IntAct=EBI-707754, EBI-822441;
Q99ML1:Bbc3; NbExp=2; IntAct=EBI-707754, EBI-727801;
O43521:BCL2L11 (xeno); NbExp=2; IntAct=EBI-707754, EBI-526406;
P55957:BID (xeno); NbExp=3; IntAct=EBI-707754, EBI-519672;
P70444:Bid; NbExp=2; IntAct=EBI-707754, EBI-783400;
Q91ZE9:Bmf; NbExp=2; IntAct=EBI-707754, EBI-708032;
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- TISSUE SPECIFICITY: Expressed in hemopoietic tissues, including
bone marrow, spleen and thymus.
-!- INDUCTION: By granulocyte-macrophage colony-stimulating factor and
LPS in macrophages.
-!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
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EMBL; L16462; AAA16886.1; -; mRNA.
EMBL; U23774; AAB97953.1; -; Genomic_DNA.
EMBL; U23773; AAB97953.1; JOINED; Genomic_DNA.
CCDS; CCDS23391.1; -.
PIR; I49449; I49449.
RefSeq; NP_033872.1; NM_009742.3.
UniGene; Mm.425593; -.
UniGene; Mm.479217; -.
PDB; 2VOF; X-ray; 1.80 A; A/C=1-152.
PDB; 2VOG; X-ray; 1.90 A; A=1-152.
PDB; 2VOH; X-ray; 1.90 A; A=1-152.
PDB; 2VOI; X-ray; 2.10 A; A=1-152.
PDBsum; 2VOF; -.
PDBsum; 2VOG; -.
PDBsum; 2VOH; -.
PDBsum; 2VOI; -.
ProteinModelPortal; Q07440; -.
SMR; Q07440; -.
BioGrid; 198319; 1.
DIP; DIP-29804N; -.
ELM; Q07440; -.
IntAct; Q07440; 11.
STRING; 10090.ENSMUSP00000096086; -.
BindingDB; Q07440; -.
ChEMBL; CHEMBL1293239; -.
PhosphoSitePlus; Q07440; -.
PaxDb; Q07440; -.
PRIDE; Q07440; -.
DNASU; 12044; -.
Ensembl; ENSMUST00000098485; ENSMUSP00000096086; ENSMUSG00000102037.
GeneID; 12044; -.
KEGG; mmu:12044; -.
UCSC; uc009qzh.1; mouse.
CTD; 12044; -.
MGI; MGI:102687; Bcl2a1a.
eggNOG; KOG4728; Eukaryota.
eggNOG; ENOG41123S0; LUCA.
GeneTree; ENSGT00510000048456; -.
HOGENOM; HOG000059278; -.
HOVERGEN; HBG004840; -.
InParanoid; Q07440; -.
KO; K02162; -.
OMA; LRIRCEI; -.
OrthoDB; EOG091G0N5N; -.
PhylomeDB; Q07440; -.
TreeFam; TF315834; -.
ChiTaRS; Tcf3; mouse.
EvolutionaryTrace; Q07440; -.
PRO; PR:Q07440; -.
Proteomes; UP000000589; Chromosome 9.
Bgee; ENSMUSG00000102037; Expressed in 28 organ(s), highest expression level in mandible.
CleanEx; MM_BCL2A1A; -.
Genevisible; Q07440; MM.
GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
GO; GO:0051400; F:BH domain binding; ISO:MGI.
GO; GO:0015267; F:channel activity; IBA:GO_Central.
GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
GO; GO:0001782; P:B cell homeostasis; IDA:MGI.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
GO; GO:0008053; P:mitochondrial fusion; IBA:GO_Central.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO; GO:0002903; P:negative regulation of B cell apoptotic process; IDA:MGI.
GO; GO:0043065; P:positive regulation of apoptotic process; IBA:GO_Central.
GO; GO:0001836; P:release of cytochrome c from mitochondria; IBA:GO_Central.
Gene3D; 1.10.437.10; -; 1.
InterPro; IPR002475; Bcl2-like.
InterPro; IPR020717; Bcl2_BH1_motif_CS.
InterPro; IPR020726; Bcl2_BH2_motif_CS.
InterPro; IPR013282; Bcl2A1.
InterPro; IPR036834; Blc2-like_sf.
InterPro; IPR026298; Blc2_fam.
PANTHER; PTHR11256; PTHR11256; 1.
PANTHER; PTHR11256:SF10; PTHR11256:SF10; 1.
Pfam; PF00452; Bcl-2; 1.
PRINTS; PR01862; BCL2FAMILY.
PRINTS; PR01867; BCL2RLATEDA1.
SUPFAM; SSF56854; SSF56854; 1.
PROSITE; PS50062; BCL2_FAMILY; 1.
PROSITE; PS01080; BH1; 1.
PROSITE; PS01258; BH2; 1.
1: Evidence at protein level;
3D-structure; Apoptosis; Complete proteome; Cytoplasm;
Reference proteome.
CHAIN 1 172 Bcl-2-related protein A1.
/FTId=PRO_0000143095.
MOTIF 77 97 BH1.
MOTIF 132 147 BH2.
COMPBIAS 24 33 Ala/Pro-rich.
HELIX 1 21 {ECO:0000244|PDB:2VOF}.
HELIX 32 51 {ECO:0000244|PDB:2VOF}.
HELIX 53 56 {ECO:0000244|PDB:2VOF}.
HELIX 64 79 {ECO:0000244|PDB:2VOF}.
HELIX 86 105 {ECO:0000244|PDB:2VOF}.
HELIX 114 136 {ECO:0000244|PDB:2VOF}.
TURN 137 142 {ECO:0000244|PDB:2VOF}.
HELIX 143 147 {ECO:0000244|PDB:2VOF}.
SEQUENCE 172 AA; 19914 MW; 37AD35818E756488 CRC64;
MAESELMHIH SLAEHYLQYV LQVPAFESAP SQACRVLQRV AFSVQKEVEK NLKSYLDDFH
VESIDTARII FNQVMEKEFE DGIINWGRIV TIFAFGGVLL KKLPQEQIAL DVCAYKQVSS
FVAEFIMNNT GEWIRQNGGW EDGFIKKFEP KSGWLTFLQM TGQIWEMLFL LK


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