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Bcl-xL-like protein 1 (Bcl2-like 1) (Bcl2l protein)

 Q90Z98_DANRE            Unreviewed;       238 AA.
Q90Z98;
01-DEC-2001, integrated into UniProtKB/TrEMBL.
01-DEC-2001, sequence version 1.
12-SEP-2018, entry version 135.
SubName: Full=Bcl-XL-like protein 1 {ECO:0000313|EMBL:AAK81706.1, ECO:0000313|EMBL:AAY43152.1};
SubName: Full=Bcl2-like 1 {ECO:0000313|Ensembl:ENSDARP00000027919};
SubName: Full=Bcl2l protein {ECO:0000313|EMBL:AAH44130.1};
Name=bcl2l1 {ECO:0000313|Ensembl:ENSDARP00000027919,
ECO:0000313|ZFIN:ZDB-GENE-010730-1};
Synonyms=bcl2l {ECO:0000313|EMBL:AAH71291.1,
ECO:0000313|ZFIN:ZDB-GENE-010730-1},
blp1 {ECO:0000313|EMBL:AAK81706.1};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|EMBL:AAK81706.1};
[1] {ECO:0000313|EMBL:AAK81706.1}
NUCLEOTIDE SEQUENCE.
PubMed=11406282; DOI=10.1016/S0167-4781(01)00209-3;
Chen M.C., Gong H.Y., Cheng C.Y., Wang J.P., Hong J.R., Wu J.L.;
"Cloning and characterization of zfBLP1, a Bcl-XL homologue from the
zebrafish, Danio rerio.";
Biochim. Biophys. Acta 1519:127-133(2001).
[2] {ECO:0000313|EMBL:AAH44130.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=AB {ECO:0000313|EMBL:AAH44130.1};
TISSUE=Whole body {ECO:0000313|EMBL:AAH44130.1};
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:AAH71291.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo {ECO:0000313|EMBL:AAH71291.1};
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:AAY43152.1}
NUCLEOTIDE SEQUENCE.
STRAIN=AB {ECO:0000313|EMBL:AAY43152.1};
Takahashi N., Dawid I.B.;
"Splicing isoform of Bcl-XL-like protein 1.";
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:AAI65156.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=PCR rescue {ECO:0000313|EMBL:AAI65156.1};
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
[6] {ECO:0000313|Ensembl:ENSDARP00000027919}
IDENTIFICATION.
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000027919};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[7] {ECO:0000313|Ensembl:ENSDARP00000027919, ECO:0000313|Proteomes:UP000000437}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000027919,
ECO:0000313|Proteomes:UP000000437};
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
Saunders D., Wallis J., Babbage A., Hammond S.,
Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
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EMBL; CR788311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC044130; AAH44130.1; -; mRNA.
EMBL; BC071291; AAH71291.1; -; mRNA.
EMBL; BC165156; AAI65156.1; -; mRNA.
EMBL; AF317837; AAK81706.1; -; mRNA.
EMBL; DQ022560; AAY43152.1; -; mRNA.
RefSeq; NP_571882.1; NM_131807.1.
RefSeq; XP_005162083.1; XM_005162026.3.
UniGene; Dr.79623; -.
STRING; 7955.ENSDARP00000119990; -.
Ensembl; ENSDART00000012507; ENSDARP00000027919; ENSDARG00000008434.
Ensembl; ENSDART00000147617; ENSDARP00000119990; ENSDARG00000008434.
GeneID; 114401; -.
KEGG; dre:114401; -.
CTD; 598; -.
ZFIN; ZDB-GENE-010730-1; bcl2l1.
eggNOG; KOG4728; Eukaryota.
eggNOG; ENOG41123S0; LUCA.
GeneTree; ENSGT00530000062935; -.
HOGENOM; HOG000056452; -.
HOVERGEN; HBG004472; -.
KO; K04570; -.
OMA; NGSPSWH; -.
OrthoDB; EOG091G0OCU; -.
TreeFam; TF315834; -.
Reactome; R-DRE-111453; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
Reactome; R-DRE-844455; The NLRP1 inflammasome.
Proteomes; UP000000437; Chromosome 23.
Bgee; ENSDARG00000008434; Expressed in 47 organ(s), highest expression level in testis.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:ZFIN.
GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central.
GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:ZFIN.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:ZFIN.
GO; GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IDA:ZFIN.
GO; GO:0030878; P:thyroid gland development; IMP:ZFIN.
GO; GO:0001894; P:tissue homeostasis; IMP:ZFIN.
InterPro; IPR013279; Apop_reg_BclX.
InterPro; IPR002475; Bcl2-like.
InterPro; IPR020717; Bcl2_BH1_motif_CS.
InterPro; IPR003093; Bcl2_BH4.
InterPro; IPR036834; Blc2-like_sf.
InterPro; IPR026298; Blc2_fam.
PANTHER; PTHR11256; PTHR11256; 1.
PANTHER; PTHR11256:SF12; PTHR11256:SF12; 1.
Pfam; PF00452; Bcl-2; 1.
Pfam; PF02180; BH4; 1.
PRINTS; PR01864; APOPREGBCLX.
PRINTS; PR01862; BCL2FAMILY.
SMART; SM00265; BH4; 1.
SUPFAM; SSF56854; SSF56854; 1.
PROSITE; PS50062; BCL2_FAMILY; 1.
PROSITE; PS01080; BH1; 1.
PROSITE; PS50063; BH4_2; 1.
1: Evidence at protein level;
Apoptosis {ECO:0000256|PROSITE-ProRule:PRU00025};
Complete proteome {ECO:0000313|Proteomes:UP000000437};
Membrane {ECO:0000256|SAM:Phobius};
Proteomics identification {ECO:0000213|PeptideAtlas:Q90Z98};
Reference proteome {ECO:0000313|Proteomes:UP000000437};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 216 234 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 5 22 BH4_2. {ECO:0000259|PROSITE:PS50063}.
MOTIF 5 22 BH4. {ECO:0000256|PROSITE-
ProRule:PRU00025}.
SEQUENCE 238 AA; 26253 MW; 6E58394933EEFDDB CRC64;
MSYYNRELVV FFIKYKLSQR NYPCNHIGLT EDTNRTDGAE ENGEGAAGAT TLVNGTMNRT
NASSTGTPPQ SPASSPQRQT NGSGGLDAVK EALRDSANEF ELRYSRAFND LSSQLHITPA
TAYQSFESVM DEVFRDGVNW GRIVGLFAFG GALCVECVEK EMSPLVGRIA EWMTVYLDNH
IQPWIQSQGG WERFAEIFGK DAAAESRKSQ ESFKKWLFAG MTLLTGVVVG GLIAQKRL


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