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Bcr/CflA family drug resistance efflux transporter (Drug resistance transporter, Bcr/CflA subfamily) (TcaB) (Teicoplanin resistance associated membrane protein TcaB)

 Q9F4G1_STAAU            Unreviewed;       402 AA.
Q9F4G1;
01-MAR-2001, integrated into UniProtKB/TrEMBL.
01-MAR-2001, sequence version 1.
22-NOV-2017, entry version 114.
SubName: Full=Bcr/CflA family drug resistance efflux transporter {ECO:0000313|EMBL:OWU44688.1};
SubName: Full=Drug resistance transporter, Bcr/CflA subfamily {ECO:0000313|EMBL:KXA33655.1};
SubName: Full=TcaB {ECO:0000313|EMBL:AAG23889.1};
SubName: Full=Teicoplanin resistance associated membrane protein TcaB {ECO:0000313|EMBL:CXE34614.1};
Name=tcaB {ECO:0000313|EMBL:AAG23889.1};
Synonyms=bcr {ECO:0000313|EMBL:CXE34614.1};
ORFNames=CEJ93_13815 {ECO:0000313|EMBL:OWU44688.1},
ERS072738_00602 {ECO:0000313|EMBL:CXL71383.1},
ERS074020_00602 {ECO:0000313|EMBL:CXE34614.1},
HMPREF3211_02144 {ECO:0000313|EMBL:KXA33655.1};
Staphylococcus aureus.
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
Staphylococcus.
NCBI_TaxID=1280 {ECO:0000313|EMBL:AAG23889.1};
[1] {ECO:0000313|EMBL:AAG23889.1}
NUCLEOTIDE SEQUENCE.
STRAIN=COL {ECO:0000313|EMBL:AAG23889.1};
PubMed=11042376; DOI=10.1016/S0304-4165(00)00133-1;
Brandenberger M., Tschierske M., Giachino P., Wada A.,
Berger-Baechi B.;
"Inactivation of a novel three-cistronic operon tcaR-tcaA-tcaB
increases teicoplanin resistance in Staphylococcus aureus.";
Biochim. Biophys. Acta 1523:135-139(2000).
[2] {ECO:0000313|EMBL:AAG23889.1}
NUCLEOTIDE SEQUENCE.
STRAIN=COL {ECO:0000313|EMBL:AAG23889.1};
Burger S.;
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:KXA33655.1, ECO:0000313|Proteomes:UP000070177}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PSS7673 {ECO:0000313|EMBL:KXA33655.1,
ECO:0000313|Proteomes:UP000070177};
Oliw E.H.;
Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:CXE34614.1, ECO:0000313|Proteomes:UP000071995, ECO:0000313|Proteomes:UP000072664}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=St3021 {ECO:0000313|EMBL:CXE34614.1},
st3021 {ECO:0000313|Proteomes:UP000072664},
St697 {ECO:0000313|EMBL:CXL71383.1}, and
st697 {ECO:0000313|Proteomes:UP000071995};
Pathogen Informatics;
Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:OWU44688.1, ECO:0000313|Proteomes:UP000197690}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=H5 {ECO:0000313|EMBL:OWU44688.1,
ECO:0000313|Proteomes:UP000197690};
Lepuschitz S., Huhulescu S., Monschein S., Springer B., Mach R.,
Allerberger F., Ruppitsch W.;
"Isolation and characterization of an MRSA USA300 isolate from a river
sample and whole-genome based comparison to clinical USA300 isolates
in Austria, 2016.";
Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
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EMBL; AY008833; AAG23889.1; -; Genomic_DNA.
EMBL; FFPZ01000002; CXE34614.1; -; Genomic_DNA.
EMBL; FGBR01000002; CXL71383.1; -; Genomic_DNA.
EMBL; LRQH01000159; KXA33655.1; -; Genomic_DNA.
EMBL; NKCS01000018; OWU44688.1; -; Genomic_DNA.
PIR; F90035; F90035.
RefSeq; WP_000999131.1; NZ_NMZG01000132.1.
TCDB; 2.A.1.2.100; the major facilitator superfamily (mfs).
EnsemblBacteria; AOO99657; AOO99657; FORC27_2419.
EnsemblBacteria; CFG04811; CFG04811; ERS093009_01624.
EnsemblBacteria; CXE34614; CXE34614; ERS074020_00602.
EnsemblBacteria; CXL71383; CXL71383; ERS072738_00602.
EnsemblBacteria; CZQ28220; CZQ28220; ERS1058648_01201.
EnsemblBacteria; KXA33655; KXA33655; HMPREF3211_02144.
EnsemblBacteria; OAP78284; OAP78284; A4U86_02685.
EnsemblBacteria; SCQ98453; SCQ98453; SAMEA2298760_00430.
KEGG; saud:CH52_07200; -.
KEGG; sauf:X998_2339; -.
PATRIC; fig|1280.10341.peg.2419; -.
eggNOG; ENOG4105C2C; Bacteria.
eggNOG; ENOG410XNNX; LUCA.
KO; K07552; -.
Proteomes; UP000070177; Unassembled WGS sequence.
Proteomes; UP000071995; Unassembled WGS sequence.
Proteomes; UP000072664; Unassembled WGS sequence.
Proteomes; UP000197690; Unassembled WGS sequence.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005215; F:transporter activity; IEA:InterPro.
GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
CDD; cd06174; MFS; 1.
InterPro; IPR004812; Efflux_drug-R_Bcr/CmlA.
InterPro; IPR011701; MFS.
InterPro; IPR020846; MFS_dom.
InterPro; IPR036259; MFS_trans_sf.
Pfam; PF07690; MFS_1; 1.
SUPFAM; SSF103473; SSF103473; 1.
TIGRFAMs; TIGR00710; efflux_Bcr_CflA; 1.
PROSITE; PS50850; MFS; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000070177,
ECO:0000313|Proteomes:UP000071995, ECO:0000313|Proteomes:UP000072664,
ECO:0000313|Proteomes:UP000197690};
Membrane {ECO:0000256|SAM:Phobius};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 12 32 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 52 69 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 81 103 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 138 160 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 166 186 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 219 244 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 256 277 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 289 305 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 311 336 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 348 367 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 373 393 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 14 402 MFS. {ECO:0000259|PROSITE:PS50850}.
SEQUENCE 402 AA; 43823 MW; 105705E34C4F5D3B CRC64;
MNDLTHFNKR SPIFIIILGS LTAIGALSID MFLPGLPDIR HDFQTTTSNA QLTLSMFMIG
LAFGNLFAGP ISDSTGRRKP LIIAMIIFTL ASLGIVFVHN IWLMVALRFL QGVTGGAAAV
ISRAIASDMY SGNELTKFMA LLMLVNGIAP VVAPTIGGII LNYSVWRMVF VILTIFGFVM
VIGSLLKVPE SLTVTNRESS SGLKTMFKNF KILLKTPRFV LPMLIQGMTF VILFTYISAS
PFIIQKIYGM TAIQFSWMFA GIGITLIISS QLTGYLVDFI DSQKLMRGMT MIQIIGVILV
TIVLLNHWNF WILAIGFIIL IAPVTGVATL GFTIAMDESS SGRGSSSSLL GLVQFLFGGV
ASPLVGVKGE DNPIPYIIII IATAVILIIL QIYNMKVFKT NR


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