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Bestrophin

 A5H7G8_CANLF            Unreviewed;       580 AA.
A5H7G8; F1Q123;
12-JUN-2007, integrated into UniProtKB/TrEMBL.
12-JUN-2007, sequence version 1.
25-OCT-2017, entry version 60.
RecName: Full=Bestrophin {ECO:0000256|RuleBase:RU363126};
Name=VMD2 {ECO:0000313|EMBL:ABO34020.1};
Synonyms=BEST1 {ECO:0000313|Ensembl:ENSCAFP00000023408};
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615 {ECO:0000313|EMBL:ABO34020.1};
[1] {ECO:0000313|Ensembl:ENSCAFP00000023408, ECO:0000313|Proteomes:UP000002254}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000023408,
ECO:0000313|Proteomes:UP000002254};
PubMed=16341006; DOI=10.1038/nature04338;
Broad Sequencing Platform;
Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
"Genome sequence, comparative analysis and haplotype structure of the
domestic dog.";
Nature 438:803-819(2005).
[2] {ECO:0000313|EMBL:ABO34020.1}
NUCLEOTIDE SEQUENCE.
PubMed=17460247; DOI=10.1167/iovs.06-1374;
Guziewicz K.E., Zangerl B., Lindauer S.J., Mullins R.F.,
Sandmeyer L.S., Grahn B.H., Stone E.M., Acland G.M., Aguirre G.D.;
"Bestrophin gene mutations cause canine multifocal retinopathy: a
novel animal model for best disease.";
Invest. Ophthalmol. Vis. Sci. 48:1959-1967(2007).
[3] {ECO:0000313|Ensembl:ENSCAFP00000023408}
IDENTIFICATION.
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000023408};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- FUNCTION: Forms calcium-sensitive chloride channels. Permeable to
bicarbonate. {ECO:0000256|RuleBase:RU363126}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000256|RuleBase:RU363126}; Multi-pass membrane protein
{ECO:0000256|RuleBase:RU363126}.
-!- SIMILARITY: Belongs to the bestrophin family.
{ECO:0000256|RuleBase:RU363126}.
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EMBL; AAEX03011667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; EF110978; ABO34020.1; -; mRNA.
RefSeq; NP_001091014.1; NM_001097545.1.
UniGene; Cfa.46597; -.
STRING; 9615.ENSCAFP00000023408; -.
Ensembl; ENSCAFT00000025216; ENSCAFP00000023408; ENSCAFG00000015909.
GeneID; 483791; -.
KEGG; cfa:483791; -.
CTD; 7439; -.
eggNOG; KOG3547; Eukaryota.
eggNOG; ENOG410XS3J; LUCA.
GeneTree; ENSGT00390000002997; -.
HOGENOM; HOG000115678; -.
HOVERGEN; HBG044928; -.
KO; K13878; -.
OMA; RSGYHSA; -.
OrthoDB; EOG091G06XO; -.
TreeFam; TF315803; -.
Reactome; R-CFA-2672351; Stimuli-sensing channels.
Proteomes; UP000002254; Chromosome 18.
Bgee; ENSCAFG00000015909; -.
GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0050908; P:detection of light stimulus involved in visual perception; IEA:Ensembl.
GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
GO; GO:0030321; P:transepithelial chloride transport; IEA:Ensembl.
InterPro; IPR033041; Best1.
InterPro; IPR000615; Bestrophin.
InterPro; IPR021134; Bestrophin/UPF0187.
PANTHER; PTHR10736; PTHR10736; 1.
PANTHER; PTHR10736:SF4; PTHR10736:SF4; 1.
Pfam; PF01062; Bestrophin; 1.
2: Evidence at transcript level;
Cell membrane {ECO:0000256|RuleBase:RU363126};
Chloride {ECO:0000256|RuleBase:RU363126};
Chloride channel {ECO:0000256|RuleBase:RU363126};
Complete proteome {ECO:0000313|Proteomes:UP000002254};
Ion channel {ECO:0000256|RuleBase:RU363126};
Ion transport {ECO:0000256|RuleBase:RU363126};
Membrane {ECO:0000256|RuleBase:RU363126};
Reference proteome {ECO:0000313|Proteomes:UP000002254};
Transmembrane {ECO:0000256|RuleBase:RU363126};
Transmembrane helix {ECO:0000256|RuleBase:RU363126};
Transport {ECO:0000256|RuleBase:RU363126}.
TRANSMEM 31 50 Helical. {ECO:0000256|RuleBase:RU363126}.
TRANSMEM 71 94 Helical. {ECO:0000256|RuleBase:RU363126}.
TRANSMEM 235 257 Helical. {ECO:0000256|RuleBase:RU363126}.
TRANSMEM 269 287 Helical. {ECO:0000256|RuleBase:RU363126}.
SEQUENCE 580 AA; 66298 MW; D6CB18CE0ECF9567 CRC64;
MTVTYSSQVA NARLGSFSRL LLCWRGSIYK LLYGEFLIFL LSYYTIRFIY RMALTEEQQV
MFEKLTLYCD SYIQLIPISF VLGFYVTLVV TRWWNQYENL PWPDRLMNLV SGLVEGRDEQ
GRLLRRTLIR YANLGNVLIL RSVSAAVYKR FPSSQHLVKA GFMTPAECKH LEKLSLPHNT
FWVPWVWFAN LSMKAWIGGR IRDPVLLQSL LDEMNILRTQ CGHLFAYDWI SIPLVYTQVV
TVAVYSFFLA CLVGRQFLNP AKAYPGHELD LVVPVFTFLQ FFFYAGWLKV AEQLINPFGE
DDDDFETNWI VDRSLQVSLL AVDEMHQDLP PMERDMYWNE PEPQPPYTAA SAQYRRASFL
GSTFNINLHK EDMEEEEEGT HAGIIGRFLG LQSHDHQPPR TNSKTKLLWP KKEGFLQDGQ
PKKLGGARQT SRDKEDSKAW EIKEEGAFET AAFYGRSGYH SAPQTPLSHT PMVFPSGQSA
PSSLRRVSGI DGAVKDQSLQ PGIKTSSEAL PENVGFSLEN PESGHVKRKT VEFNLTDMSG
TPEHHLRDSD LSQSTSNLHT ILKGHGDPYW ALENRDEAHS


Related products :

Catalog number Product name Quantity
orb2889 Bestrophin antibody 100 ug
YF-PA15287 anti-Bestrophin 50 ug
orb1261 Bestrophin 4 antibody 100 ug
orb1261 Bestrophin 4 antibody 200 ug
PC-Best4 Bestrophin 4, WB control 100-150ul
PC-Best2 Bestrophin 2, WB control 100-150ul
orb1275 Bestrophin 3 antibody 100 ug
orb1275 Bestrophin 3 antibody 200 ug
YF-MA16062 anti-Bestrophin (1C2) 100 ug
'H00007439-P01-10 Bestrophin-1 antigen 10
PC-Best3 Bestrophin 3, WB control 100-150ul
'H00007439-P01-25 Bestrophin-1 antigen 25
'H00007439-Q01-10 Bestrophin-1 antigen 10
'H00007439-Q01-25 Bestrophin-1 antigen 25
orb2889 Bestrophin antibody 200 ug
orb2916 Bestrophin 2 antibody 100 ug
orb2916 Bestrophin 2 antibody 200 ug
orb7784 Bestrophin antibody (FITC) 100 ug
orb7825 Bestrophin 2 antibody (FITC) 100 ug
BEST1_HUMAN Human ELISA Kit FOR Bestrophin-1 96T
BEST3 BEST1 Gene bestrophin 1
PC-Best1 Bestrophin 1 C terminus, WB control 100-150ul
PC-Best1 Bestrophin 1 mid region, WB control 100-150ul
PC-Best1 Bestrophin 1 N- terminus, WB control 100-150ul
BEST4 BEST2 Gene bestrophin 2


 

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