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Bestrophin

 Q6AYG9_RAT              Unreviewed;       550 AA.
Q6AYG9;
13-SEP-2004, integrated into UniProtKB/TrEMBL.
13-SEP-2004, sequence version 1.
25-OCT-2017, entry version 93.
RecName: Full=Bestrophin {ECO:0000256|RuleBase:RU363126};
Name=Best1 {ECO:0000313|EMBL:AAH79048.1,
ECO:0000313|Ensembl:ENSRNOP00000007320, ECO:0000313|RGD:1311656};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:AAH79048.1};
[1] {ECO:0000313|EMBL:AAH79048.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis {ECO:0000313|EMBL:AAH79048.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
Makowski K.A., Bosak S., Malek J.;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2] {ECO:0000313|Ensembl:ENSRNOP00000007320, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007320,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[3] {ECO:0000313|Ensembl:ENSRNOP00000007320}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007320};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
-!- FUNCTION: Forms calcium-sensitive chloride channels. Permeable to
bicarbonate. {ECO:0000256|RuleBase:RU363126}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000256|RuleBase:RU363126}; Multi-pass membrane protein
{ECO:0000256|RuleBase:RU363126}.
-!- SIMILARITY: Belongs to the bestrophin family.
{ECO:0000256|RuleBase:RU363126}.
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EMBL; AABR07006255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC079048; AAH79048.1; -; mRNA.
RefSeq; NP_001011940.1; NM_001011940.1.
UniGene; Rn.136565; -.
STRING; 10116.ENSRNOP00000007320; -.
Ensembl; ENSRNOT00000007320; ENSRNOP00000007320; ENSRNOG00000020346.
GeneID; 293735; -.
KEGG; rno:293735; -.
CTD; 7439; -.
RGD; 1311656; Best1.
eggNOG; KOG3547; Eukaryota.
eggNOG; ENOG410XS3J; LUCA.
GeneTree; ENSGT00390000002997; -.
HOGENOM; HOG000115678; -.
HOVERGEN; HBG044928; -.
KO; K13878; -.
OMA; FIDNIAC; -.
OrthoDB; EOG091G06XO; -.
TreeFam; TF315803; -.
Reactome; R-RNO-2672351; Stimuli-sensing channels.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000020346; -.
GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0050908; P:detection of light stimulus involved in visual perception; IEA:Ensembl.
GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
GO; GO:0030321; P:transepithelial chloride transport; IEA:Ensembl.
InterPro; IPR033041; Best1.
InterPro; IPR000615; Bestrophin.
InterPro; IPR021134; Bestrophin/UPF0187.
PANTHER; PTHR10736; PTHR10736; 1.
PANTHER; PTHR10736:SF4; PTHR10736:SF4; 1.
Pfam; PF01062; Bestrophin; 1.
2: Evidence at transcript level;
Cell membrane {ECO:0000256|RuleBase:RU363126};
Chloride {ECO:0000256|RuleBase:RU363126};
Chloride channel {ECO:0000256|RuleBase:RU363126};
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Ion channel {ECO:0000256|RuleBase:RU363126};
Ion transport {ECO:0000256|RuleBase:RU363126};
Membrane {ECO:0000256|RuleBase:RU363126};
Reference proteome {ECO:0000313|Proteomes:UP000002494};
Transmembrane {ECO:0000256|RuleBase:RU363126};
Transmembrane helix {ECO:0000256|RuleBase:RU363126};
Transport {ECO:0000256|RuleBase:RU363126}.
TRANSMEM 31 50 Helical. {ECO:0000256|RuleBase:RU363126}.
TRANSMEM 71 94 Helical. {ECO:0000256|RuleBase:RU363126}.
TRANSMEM 234 257 Helical. {ECO:0000256|RuleBase:RU363126}.
TRANSMEM 269 288 Helical. {ECO:0000256|RuleBase:RU363126}.
SEQUENCE 550 AA; 63940 MW; C1790B0D9AD4C2D5 CRC64;
MTITYTNEVA NARLGSFSCL LLRWRGSIYK LLYGEFLVFI FLYYCIRGLY RMVLSNHQQQ
QFEKLALYCN SYIQFIPISF VLGFYVTLVV SRWWNQYENL PWPDRLMMQV SSFVEGKDEQ
GRLLRRTLIR YAILGQVLIL RSISTSVYKR FPSLQHLMQA GFMTPGEYKQ LQRLGLPHNT
FWVPWVWFAN LSMKAYLGGR IRDTVLLQSL MNEVCTLRTQ CGHLYAYDWI NIPLVYTQVV
TVAVYSFFLA CLIGRQFLNP LKNYPGHEMD LVVPVFTILQ FLFYMGWLKV AEQLINPFGE
DDDDFETNWI IDRNLQVSLL SVDGMHHDVP PLERDLYWNE AAPQPPYTAA SAGSHRQSFM
GSTFNMSLKK KDSEEESDTY DKKENDYGST IGRFLGLQSN DYHPPKTDLK TKLLWSKKDP
FLEDQSKNDK QKDQKNDVWK PKDLFRAIPK FKRPSYRQAP QPLGSHLPMV FPPQQSAPSV
RYSDTGGGPS AQYQEACHMK KKTVEFNLNI PECPTEHEQP HLDQMHTILK EPGESYPVSD
KADTNPVSYK


Related products :

Catalog number Product name Quantity
orb2889 Bestrophin antibody 100 ug
YF-PA15287 anti-Bestrophin 50 ug
orb1261 Bestrophin 4 antibody 100 ug
orb1261 Bestrophin 4 antibody 200 ug
PC-Best4 Bestrophin 4, WB control 100-150ul
PC-Best2 Bestrophin 2, WB control 100-150ul
orb1275 Bestrophin 3 antibody 100 ug
orb1275 Bestrophin 3 antibody 200 ug
YF-MA16062 anti-Bestrophin (1C2) 100 ug
'H00007439-P01-10 Bestrophin-1 antigen 10
PC-Best3 Bestrophin 3, WB control 100-150ul
'H00007439-P01-25 Bestrophin-1 antigen 25
'H00007439-Q01-10 Bestrophin-1 antigen 10
'H00007439-Q01-25 Bestrophin-1 antigen 25
orb2889 Bestrophin antibody 200 ug
orb2916 Bestrophin 2 antibody 100 ug
orb2916 Bestrophin 2 antibody 200 ug
orb7784 Bestrophin antibody (FITC) 100 ug
orb7825 Bestrophin 2 antibody (FITC) 100 ug
BEST1_HUMAN Human ELISA Kit FOR Bestrophin-1 96T
BEST3 BEST1 Gene bestrophin 1
PC-Best1 Bestrophin 1 C terminus, WB control 100-150ul
PC-Best1 Bestrophin 1 mid region, WB control 100-150ul
PC-Best1 Bestrophin 1 N- terminus, WB control 100-150ul
BEST4 BEST2 Gene bestrophin 2


 

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