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Beta sliding clamp (Beta clamp) (Sliding clamp) (Beta-clamp processivity factor) (DNA polymerase III beta sliding clamp subunit) (DNA polymerase III subunit beta)

 DPO3B_AQUAE             Reviewed;         363 AA.
O67725;
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
25-OCT-2017, entry version 95.
RecName: Full=Beta sliding clamp;
Short=Beta clamp;
Short=Sliding clamp;
AltName: Full=Beta-clamp processivity factor;
AltName: Full=DNA polymerase III beta sliding clamp subunit;
AltName: Full=DNA polymerase III subunit beta;
Name=dnaN; OrderedLocusNames=aq_1882;
Aquifex aeolicus (strain VF5).
Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
NCBI_TaxID=224324;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=VF5;
PubMed=9537320; DOI=10.1038/32831;
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
"The complete genome of the hyperthermophilic bacterium Aquifex
aeolicus.";
Nature 392:353-358(1998).
-!- FUNCTION: Confers DNA tethering and processivity to DNA
polymerases and other proteins. Acts as a clamp, forming a ring
around DNA (a reaction catalyzed by the clamp-loading complex)
which diffuses in an ATP-independent manner freely and
bidirectionally along dsDNA. Initially characterized for its
ability to contact the catalytic subunit of DNA polymerase III
(Pol III), a complex, multichain enzyme responsible for most of
the replicative synthesis in bacteria; Pol III exhibits 3'-5'
exonuclease proofreading activity. The beta chain is required for
initiation of replication as well as for processivity of DNA
replication. {ECO:0000250|UniProtKB:P0A988}.
-!- SUBUNIT: Forms a ring-shaped head-to-tail homodimer around DNA
which binds and tethers DNA polymerases and other proteins to the
DNA. The DNA replisome complex has a single clamp-loading complex
(3 tau and 1 each of delta, delta', psi and chi subunits) which
binds 3 Pol III cores (1 core on the leading strand and 2 on the
lagging strand) each with a beta sliding clamp dimer. Additional
proteins in the replisome are other copies of gamma, psi and chi,
Ssb, DNA helicase and RNA primase. {ECO:0000250|UniProtKB:P0A988}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P0A988}.
-!- SIMILARITY: Belongs to the beta sliding clamp family.
{ECO:0000305}.
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EMBL; AE000657; AAC07688.1; -; Genomic_DNA.
PIR; C70462; C70462.
RefSeq; NP_214293.1; NC_000918.1.
RefSeq; WP_010881229.1; NC_000918.1.
ProteinModelPortal; O67725; -.
SMR; O67725; -.
STRING; 224324.aq_1882; -.
PRIDE; O67725; -.
EnsemblBacteria; AAC07688; AAC07688; aq_1882.
GeneID; 1193532; -.
KEGG; aae:aq_1882; -.
PATRIC; fig|224324.8.peg.1458; -.
eggNOG; ENOG4105CZ8; Bacteria.
eggNOG; COG0592; LUCA.
HOGENOM; HOG000071791; -.
InParanoid; O67725; -.
KO; K02338; -.
OMA; NYEAVIP; -.
OrthoDB; POG091H02B3; -.
Proteomes; UP000000798; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
CDD; cd00140; beta_clamp; 1.
InterPro; IPR001001; DNA_polIII_beta.
InterPro; IPR022635; DNA_polIII_beta_C.
InterPro; IPR022637; DNA_polIII_beta_cen.
InterPro; IPR022634; DNA_polIII_beta_N.
PANTHER; PTHR30478; PTHR30478; 1.
Pfam; PF00712; DNA_pol3_beta; 1.
Pfam; PF02767; DNA_pol3_beta_2; 1.
Pfam; PF02768; DNA_pol3_beta_3; 1.
PIRSF; PIRSF000804; DNA_pol_III_b; 1.
SMART; SM00480; POL3Bc; 1.
TIGRFAMs; TIGR00663; dnan; 1.
3: Inferred from homology;
Complete proteome; Cytoplasm; DNA replication; DNA-binding;
DNA-directed DNA polymerase; Nucleotidyltransferase;
Reference proteome; Transferase.
CHAIN 1 363 Beta sliding clamp.
/FTId=PRO_0000105422.
SEQUENCE 363 AA; 41300 MW; DD077039BE4E5A5A CRC64;
MRVKVDREEL EEVLKKARES TEKKAALPIL ANFLLSAKEE NLIVRATDLE NYLVVSVKGE
VEEEGEVCVH SQKLYDIVKN LNSAYVYLHT EGEKLVITGG KSTYKLPTAP AEDFPEFPEI
VEGGETLSGN LLVNGIEKVE YAIAKEEANI ALQGMYLRGY EDRIHFVGSD GHRLALYEPL
GEFSKELLIP RKSLKVLKKL ITGIEDVNIE KSEDESFAYF STPEWKLAVR LLEGEFPDYM
SVIPEEFSAE VLFETEEVLK VLKRLKALSE GKVFPVKITL SENLAIFEFA DPEFGEAREE
IEVEYTGEPF EIGFNGKYLM EALDAYDSER VWFKFTTPDT ATLLEAEDYE KEPYKCIIMP
MRV


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