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Beta-1,4-mannosyltransferase egh (EC 2.4.1.-) (Protein egghead) (Protein zeste-white 4)

 EGH_DROME               Reviewed;         457 AA.
O01346; O01347; Q9V3B0;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
12-SEP-2018, entry version 140.
RecName: Full=Beta-1,4-mannosyltransferase egh;
EC=2.4.1.-;
AltName: Full=Protein egghead;
AltName: Full=Protein zeste-white 4;
Name=egh; Synonyms=l(1)3Ae, zw4; ORFNames=CG9659;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=9012507;
Goode S., Melnick M., Chou T.-B., Perrimon N.;
"The neurogenic genes egghead and brainiac define a novel signaling
pathway essential for epithelial morphogenesis during Drosophila
oogenesis.";
Development 122:3863-3879(1996).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Oregon-R;
Simmerl E., Hollmann M., Lammermann U., Ruebsam R., Schaefer U.,
Buening J., Schaefer M.A.;
"Characterization of a viable egh allele.";
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[4]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Oregon-R;
PubMed=10731137; DOI=10.1126/science.287.5461.2220;
Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D.,
Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E.,
Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D.,
Minana B., Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S.,
Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B.,
Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F.,
Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A.,
Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
Glover D.M.;
"From sequence to chromosome: the tip of the X chromosome of D.
melanogaster.";
Science 287:2220-2222(2000).
[6]
FUNCTION.
PubMed=12454022; DOI=10.1074/jbc.C200619200;
Wandall H.H., Pedersen J.W., Park C., Levery S.B., Pizette S.,
Cohen S.M., Schwientek T., Clausen H.;
"Drosophila egghead encodes a beta 1,4-mannosyltransferase predicted
to form the immediate precursor glycosphingolipid substrate for
brainiac.";
J. Biol. Chem. 278:1411-1414(2003).
-!- FUNCTION: Glycosyltransferase with a proposed role in
glycosphingolipid biosynthesis. Neurogenic protein implicated in
epithelial development. Critical component of a differential
oocyte-follicle cell adhesive system.
{ECO:0000269|PubMed:12454022}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}.
-!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; U15602; AAB49734.1; -; mRNA.
EMBL; U21218; AAB49735.1; -; Genomic_DNA.
EMBL; AF233288; AAF43419.1; -; Genomic_DNA.
EMBL; AE014298; AAF45792.1; -; Genomic_DNA.
EMBL; AL138972; CAB72293.1; -; Genomic_DNA.
RefSeq; NP_001284829.1; NM_001297900.1.
RefSeq; NP_525052.1; NM_080313.3.
RefSeq; NP_726818.1; NM_166946.2.
UniGene; Dm.8115; -.
ProteinModelPortal; O01346; -.
BioGrid; 57772; 6.
DIP; DIP-24087N; -.
IntAct; O01346; 1.
STRING; 7227.FBpp0070423; -.
CAZy; GT2; Glycosyltransferase Family 2.
PaxDb; O01346; -.
PRIDE; O01346; -.
EnsemblMetazoa; FBtr0070439; FBpp0070423; FBgn0001404.
EnsemblMetazoa; FBtr0070440; FBpp0070424; FBgn0001404.
EnsemblMetazoa; FBtr0340091; FBpp0309090; FBgn0001404.
GeneID; 31239; -.
KEGG; dme:Dmel_CG9659; -.
CTD; 31239; -.
FlyBase; FBgn0001404; egh.
eggNOG; ENOG410IG70; Eukaryota.
eggNOG; ENOG410XRNS; LUCA.
GeneTree; ENSGT00520000061918; -.
InParanoid; O01346; -.
KO; K02359; -.
OMA; FICIRVV; -.
OrthoDB; EOG091G0B93; -.
PhylomeDB; O01346; -.
GenomeRNAi; 31239; -.
PRO; PR:O01346; -.
Proteomes; UP000000803; Chromosome X.
Bgee; FBgn0001404; Expressed in 31 organ(s), highest expression level in second segment of antenna (Drosophila).
ExpressionAtlas; O01346; baseline and differential.
Genevisible; O01346; DM.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO; GO:0019187; F:beta-1,4-mannosyltransferase activity; IDA:UniProtKB.
GO; GO:0007411; P:axon guidance; IMP:FlyBase.
GO; GO:0007298; P:border follicle cell migration; IMP:FlyBase.
GO; GO:0045165; P:cell fate commitment; IMP:UniProtKB.
GO; GO:0033227; P:dsRNA transport; IMP:FlyBase.
GO; GO:0007281; P:germ cell development; IMP:FlyBase.
GO; GO:0007293; P:germarium-derived egg chamber formation; IMP:FlyBase.
GO; GO:0006688; P:glycosphingolipid biosynthetic process; IDA:UniProtKB.
GO; GO:0042248; P:maintenance of polarity of follicular epithelium; IMP:FlyBase.
GO; GO:0008049; P:male courtship behavior; IMP:FlyBase.
GO; GO:0016333; P:morphogenesis of follicular epithelium; IMP:FlyBase.
GO; GO:0045434; P:negative regulation of female receptivity, post-mating; IMP:FlyBase.
GO; GO:0030720; P:oocyte localization involved in germarium-derived egg chamber formation; IMP:FlyBase.
GO; GO:0016325; P:oocyte microtubule cytoskeleton organization; IMP:FlyBase.
GO; GO:0001744; P:optic lobe placode formation; IMP:FlyBase.
GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase.
GO; GO:0007299; P:ovarian follicle cell-cell adhesion; IMP:UniProtKB.
GO; GO:0048935; P:peripheral nervous system neuron development; IMP:FlyBase.
GO; GO:0046662; P:regulation of oviposition; IMP:FlyBase.
Gene3D; 3.90.550.10; -; 1.
InterPro; IPR027389; B_mannosylTrfase_Bre-3/Egh.
InterPro; IPR001173; Glyco_trans_2-like.
InterPro; IPR029044; Nucleotide-diphossugar_trans.
PANTHER; PTHR16779; PTHR16779; 2.
Pfam; PF13632; Glyco_trans_2_3; 1.
SUPFAM; SSF53448; SSF53448; 1.
2: Evidence at transcript level;
Complete proteome; Developmental protein; Glycosyltransferase;
Membrane; Reference proteome; Transferase; Transmembrane;
Transmembrane helix.
CHAIN 1 457 Beta-1,4-mannosyltransferase egh.
/FTId=PRO_0000059274.
TRANSMEM 8 28 Helical. {ECO:0000255}.
TRANSMEM 35 55 Helical. {ECO:0000255}.
TRANSMEM 57 77 Helical. {ECO:0000255}.
TRANSMEM 346 366 Helical. {ECO:0000255}.
TRANSMEM 378 398 Helical. {ECO:0000255}.
TRANSMEM 415 435 Helical. {ECO:0000255}.
CONFLICT 262 262 S -> R (in Ref. 1; AAB49735).
{ECO:0000305}.
SEQUENCE 457 AA; 51984 MW; F5781C27FAF4A4B5 CRC64;
MNSTTKHLLH CTLLITVIVT FEVFSGGIKI DENSFTLVDP WTEYGQLATV LLYLLRFLTL
LTLPQVLFNF CGLVFYNAFP EKVVLKGSPL LAPFICIRVV TRGDFPDLVK TNVLRNMNTC
LDTGLENFLI EVVTDKAVNL SQHRRIREIV VPKEYKTRTG ALFKSRALQY CLEDNVNVLN
DSDWIVHLDE ETLLTENSVR GIINFVLDGK HPFGQGLITY ANENVVNWLT TLADSFRVSD
DMGKLRLQFK LFHKPLFSWK GSYVVTQVSA ERSVSFDNGI DGSVAEDCFF AMRAFSQGYT
FNFIEGEMYE KSPFTLLDFL QQRKRWLQGI LLVVHSKMIP FKHKLLLGIS VYSWVTMPLS
TSNIIFAALY PIPCPNLVDF VCAFIAAINI YMYVFGVIKS FSLYRFGLFR FLACVLGAVC
TIPVNVVIEN VAVIWGLVGK KHKFYVVQKD VRVLETV


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