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Beta-cardiotoxin CTX21

 3SDC1_OPHHA             Reviewed;          84 AA.
Q2VBN5;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
10-JAN-2006, sequence version 1.
27-SEP-2017, entry version 52.
RecName: Full=Beta-cardiotoxin CTX21;
Flags: Precursor;
Ophiophagus hannah (King cobra) (Naja hannah).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
NCBI_TaxID=8665;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Venom gland;
PubMed=16689684; DOI=10.1042/BJ20060004;
Li J., Zhang H., Liu J., Xu K.;
"Novel genes encoding six kinds of three-finger toxins in Ophiophagus
hannah (king cobra) and function characterization of two recombinant
long-chain neurotoxins.";
Biochem. J. 398:233-242(2006).
-!- FUNCTION: Acts as a beta-blocker by binding to beta-1 and beta-2
adrenergic receptors (ADRB1 and ADRB2). It dose-dependently
decreases the heart rate (bradycardia), whereas conventional
cardiotoxins increases it. At 100 mg/kg, intraperitoneal injection
into mice provokes labored breathing, impaired locomotion, lack of
response to external stimuli, and death (after 30 min).
{ECO:0000250|UniProtKB:Q69CK0}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q69CK0}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
-!- MISCELLANEOUS: Does not affect blood coagulation and does not show
significant hemolytic activity. {ECO:0000250|UniProtKB:Q69CK0}.
-!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-
chain subfamily. Beta-cardiotoxin sub-subfamily. {ECO:0000305}.
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EMBL; DQ273580; ABB83634.1; -; mRNA.
ProteinModelPortal; Q2VBN5; -.
SMR; Q2VBN5; -.
HOVERGEN; HBG006553; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0090729; F:toxin activity; IEA:InterPro.
CDD; cd00206; snake_toxin; 1.
InterPro; IPR003572; Cytotoxin.
InterPro; IPR003571; Snake_3FTx.
InterPro; IPR018354; Snake_toxin_con_site.
InterPro; IPR035076; Toxin/TOLIP.
Pfam; PF00087; Toxin_TOLIP; 1.
PRINTS; PR00282; CYTOTOXIN.
PROSITE; PS00272; SNAKE_TOXIN; 1.
3: Inferred from homology;
Cardiotoxin; Disulfide bond;
G-protein coupled receptor impairing toxin; Secreted; Signal; Toxin.
SIGNAL 1 21 {ECO:0000250|UniProtKB:Q69CK0}.
CHAIN 22 84 Beta-cardiotoxin CTX21.
/FTId=PRO_5000006490.
DISULFID 24 43 {ECO:0000250|UniProtKB:Q69CK0}.
DISULFID 36 61 {ECO:0000250|UniProtKB:Q69CK0}.
DISULFID 65 76 {ECO:0000250|UniProtKB:Q69CK0}.
DISULFID 77 82 {ECO:0000250|UniProtKB:Q69CK0}.
SEQUENCE 84 AA; 9255 MW; 8A59407FCDDD655F CRC64;
MKTLLLTLVV VTIVCLDLGY TRKCLNTPLP LIYTTCPIGQ DKCVKMTIKK LPSKYDVIRG
CTDICPKSSA DVVVVCCDTN KCNK


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