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Beta-catenin-interacting protein 1 (Inhibitor of beta-catenin and Tcf-4)

 CNBP1_MOUSE             Reviewed;          81 AA.
Q9JJN6;
28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
18-JUL-2018, entry version 137.
RecName: Full=Beta-catenin-interacting protein 1;
AltName: Full=Inhibitor of beta-catenin and Tcf-4;
Name=Ctnnbip1; Synonyms=Catnbip1, Icat;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, AND MUTAGENESIS OF
37-GLU--GLU-39.
TISSUE=Embryo;
PubMed=10898789;
Tago K., Nakamura T., Nishita M., Hyodo J., Nagai S., Murata Y.,
Adachi S., Ohwada S., Morishita Y., Shibuya H., Akiyama T.;
"Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting
protein.";
Genes Dev. 14:1741-1749(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Cerebellum, Embryo, Head, and Tongue;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Prevents the interaction between CTNNB1 and TCF family
members, and acts as negative regulator of the Wnt signaling
pathway.
-!- SUBUNIT: Binds CTNNB1.
-!- INTERACTION:
Q02248:Ctnnb1; NbExp=5; IntAct=EBI-7338912, EBI-397872;
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
-!- TISSUE SPECIFICITY: Highly expressed in heart, brain, liver and
skeletal muscle. Detected at low levels in kidney, testis and
lung.
-!- SIMILARITY: Belongs to the CTNNBIP1 family. {ECO:0000305}.
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EMBL; AB021261; BAB03457.1; -; mRNA.
EMBL; AK003595; BAB22883.1; -; mRNA.
EMBL; AK009066; BAB26052.1; -; mRNA.
EMBL; AK036181; BAC29336.1; -; mRNA.
EMBL; AK048258; BAC33287.1; -; mRNA.
EMBL; BC038253; AAH38253.1; -; mRNA.
CCDS; CCDS38975.1; -.
RefSeq; NP_001135402.1; NM_001141930.1.
RefSeq; NP_075954.1; NM_023465.4.
UniGene; Mm.299735; -.
UniGene; Mm.474667; -.
ProteinModelPortal; Q9JJN6; -.
SMR; Q9JJN6; -.
BioGrid; 211930; 3.
ComplexPortal; CPX-86; Beta-catenin-ICAT complex.
IntAct; Q9JJN6; 1.
MINT; Q9JJN6; -.
STRING; 10090.ENSMUSP00000030839; -.
iPTMnet; Q9JJN6; -.
PhosphoSitePlus; Q9JJN6; -.
MaxQB; Q9JJN6; -.
PaxDb; Q9JJN6; -.
PeptideAtlas; Q9JJN6; -.
PRIDE; Q9JJN6; -.
Ensembl; ENSMUST00000030839; ENSMUSP00000030839; ENSMUSG00000028988.
Ensembl; ENSMUST00000105692; ENSMUSP00000101317; ENSMUSG00000028988.
GeneID; 67087; -.
KEGG; mmu:67087; -.
UCSC; uc008vwm.2; mouse.
CTD; 56998; -.
MGI; MGI:1915756; Ctnnbip1.
eggNOG; ENOG410IYM5; Eukaryota.
eggNOG; ENOG4111UJF; LUCA.
GeneTree; ENSGT00860000133817; -.
HOGENOM; HOG000037432; -.
HOVERGEN; HBG051037; -.
InParanoid; Q9JJN6; -.
KO; K04493; -.
OMA; HPIDQGA; -.
OrthoDB; EOG091G0RZ1; -.
PhylomeDB; Q9JJN6; -.
Reactome; R-MMU-3769402; Deactivation of the beta-catenin transactivating complex.
ChiTaRS; Ctnnbip1; mouse.
PRO; PR:Q9JJN6; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000028988; -.
CleanEx; MM_CTNNBIP1; -.
Genevisible; Q9JJN6; MM.
GO; GO:0030877; C:beta-catenin destruction complex; ISO:MGI.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0070016; F:armadillo repeat domain binding; ISO:MGI.
GO; GO:0008013; F:beta-catenin binding; IPI:MGI.
GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IMP:MGI.
GO; GO:0043392; P:negative regulation of DNA binding; IDA:BHF-UCL.
GO; GO:0043433; P:negative regulation of DNA binding transcription factor activity; IDA:BHF-UCL.
GO; GO:0072201; P:negative regulation of mesenchymal cell proliferation; ISO:MGI.
GO; GO:0032091; P:negative regulation of protein binding; ISO:MGI.
GO; GO:0031333; P:negative regulation of protein complex assembly; IDA:BHF-UCL.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IMP:BHF-UCL.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
GO; GO:0060633; P:negative regulation of transcription initiation from RNA polymerase II promoter; IDA:BHF-UCL.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IDA:MGI.
GO; GO:0045657; P:positive regulation of monocyte differentiation; ISO:MGI.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISO:MGI.
GO; GO:0002528; P:regulation of vascular permeability involved in acute inflammatory response; ISO:MGI.
GO; GO:0016055; P:Wnt signaling pathway; IPI:MGI.
Gene3D; 1.10.10.490; -; 1.
InterPro; IPR009428; ICAT.
InterPro; IPR036911; ICAT_sf.
Pfam; PF06384; ICAT; 1.
SUPFAM; SSF81730; SSF81730; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Nucleus; Phosphoprotein;
Reference proteome; Wnt signaling pathway.
CHAIN 1 81 Beta-catenin-interacting protein 1.
/FTId=PRO_0000152883.
MOD_RES 59 59 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MUTAGEN 37 39 EEE->AAA: Abolishes CTNNB1 binding.
{ECO:0000269|PubMed:10898789}.
SEQUENCE 81 AA; 9174 MW; 2C58D060B50CE942 CRC64;
MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVSS QLSQLPQHSI
DQGAEDVVMA FSRSETEDRR Q


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