Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (N-acetyl-beta-glucosaminidase subunit beta)

 HEXB_FELCA              Reviewed;         531 AA.
P49614;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
10-MAY-2005, sequence version 2.
22-NOV-2017, entry version 103.
RecName: Full=Beta-hexosaminidase subunit beta;
EC=3.2.1.52;
AltName: Full=Beta-N-acetylhexosaminidase subunit beta;
Short=Hexosaminidase subunit B;
AltName: Full=N-acetyl-beta-glucosaminidase subunit beta;
Flags: Precursor;
Name=HEXB;
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND DISEASE.
STRAIN=Korat; TISSUE=Liver;
PubMed=8178934;
Muldoon L.L., Neuwelt E.A., Pagel M.A., Weiss D.L.;
"Characterization of the molecular defect in a feline model for type
II GM2-gangliosidosis (Sandhoff disease).";
Am. J. Pathol. 144:1109-1118(1994).
-!- FUNCTION: Responsible for the degradation of GM2 gangliosides, and
a variety of other molecules containing terminal N-acetyl
hexosamines, in the brain and other tissues.
-!- CATALYTIC ACTIVITY: Hydrolysis of terminal non-reducing N-acetyl-
D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
-!- SUBCELLULAR LOCATION: Lysosome.
-!- DISEASE: Note=Defects in HEXB are responsible for Sandhoff disease
(GM2-gangliosidosis type-II). This disorder is found in Korat cats
(initially imported from Thailand). {ECO:0000269|PubMed:8178934}.
-!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAB30707.2; Type=Frameshift; Positions=27; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; S70340; AAB30707.2; ALT_FRAME; mRNA.
RefSeq; NP_001009333.2; NM_001009333.2.
ProteinModelPortal; P49614; -.
SMR; P49614; -.
STRING; 9685.ENSFCAP00000016100; -.
CAZy; GH20; Glycoside Hydrolase Family 20.
PRIDE; P49614; -.
GeneID; 493928; -.
KEGG; fca:493928; -.
CTD; 3074; -.
eggNOG; KOG2499; Eukaryota.
eggNOG; COG3525; LUCA.
HOVERGEN; HBG005961; -.
InParanoid; P49614; -.
KO; K12373; -.
BRENDA; 3.2.1.52; 2235.
Proteomes; UP000011712; Unplaced.
GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
Gene3D; 3.30.379.10; -; 1.
InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
InterPro; IPR029018; Chitobiase/Hex-like_dom2.
InterPro; IPR015883; Glyco_hydro_20_cat.
InterPro; IPR017853; Glycoside_hydrolase_SF.
InterPro; IPR029019; HEX_eukaryotic_N.
Pfam; PF00728; Glyco_hydro_20; 1.
Pfam; PF14845; Glycohydro_20b2; 1.
PIRSF; PIRSF001093; B-hxosamndse_ab_euk_; 1.
PRINTS; PR00738; GLHYDRLASE20.
SUPFAM; SSF51445; SSF51445; 1.
SUPFAM; SSF55545; SSF55545; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Glycosidase;
Hydrolase; Lysosome; Reference proteome; Signal.
SIGNAL 1 24 {ECO:0000255}.
CHAIN 25 531 Beta-hexosaminidase subunit beta.
/FTId=PRO_0000012001.
ACT_SITE 329 329 Proton donor. {ECO:0000250}.
CARBOHYD 50 50 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 116 116 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 164 164 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 301 301 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 65 111 {ECO:0000250}.
DISULFID 283 334 {ECO:0000250}.
DISULFID 508 525 {ECO:0000250}.
SEQUENCE 531 AA; 60427 MW; AC6E0C8C6509509B CRC64;
MRHRGLGLAA LLALLAAVAP RSSAAAGAAL WPMPLSVKTS PRLLHLSRDN FSIGYGPSST
AGPTCSLLQE AFRRYHEYIF GFDKRQRRPA KPNSAIELQQ LLVTVVLDSE CDLFPNITSD
ESYTLLVKEP VAFLKANRVW GVLRGLETFS QLIYQDSYGT FTVNESDIID SPRFPHRGIL
IDTARHFLPV KSILKTLDAM AFNKFNVLHW HIVDDQSFPY QSVTFPELSN KGSYSLSHVY
TPNDVHTVIE YARLRGIRVI PEFDSPGHTQ SWGKGQKDLL TPCYNEHKQS GTFGPINPIL
NSTYNFLSQF FKEVSMVFPD HFVHLGGDEV EFQCWESNPE IQGFMKQKGF GKDFRRLESF
YLQKLLGIVS TVKKGSIVWQ EVFDDHVKLL PGTIVQVWKN QVYTEELREV TAAGFPVILS
APWYLDWISY GQDWRNYYKV DPLHFDGSQE QKKLVIGGEA CLWGEFVDAT NLTPRLWPRA
SAVGERLWSP EDITSVGNAY NRLTVHRCRM VRRGISAEPL FTGYCDYEYK T


Related products :

Catalog number Product name Quantity
E0195h ELISA Beta-hexosaminidase subunit alpha,Beta-N-acetylhexosaminidase subunit alpha,HEXA,Hexosaminidase subunit A,Homo sapiens,Human,N-acetyl-beta-glucosaminidase subunit alpha 96T
U0195h CLIA Beta-hexosaminidase subunit alpha,Beta-N-acetylhexosaminidase subunit alpha,HEXA,Hexosaminidase subunit A,Homo sapiens,Human,N-acetyl-beta-glucosaminidase subunit alpha 96T
E0195h ELISA kit Beta-hexosaminidase subunit alpha,Beta-N-acetylhexosaminidase subunit alpha,HEXA,Hexosaminidase subunit A,Homo sapiens,Human,N-acetyl-beta-glucosaminidase subunit alpha 96T
E0195b ELISA kit Beta-hexosaminidase subunit alpha,Beta-N-acetylhexosaminidase subunit alpha,Bos taurus,Bovine,HEXA,Hexosaminidase subunit A,N-acetyl-beta-glucosaminidase subunit alpha 96T
E0195r ELISA kit Beta-hexosaminidase subunit alpha,Beta-N-acetylhexosaminidase subunit alpha,Hexa,Hexosaminidase subunit A,N-acetyl-beta-glucosaminidase subunit alpha,Rat,Rattus norvegicus 96T
E0195b ELISA Beta-hexosaminidase subunit alpha,Beta-N-acetylhexosaminidase subunit alpha,Bos taurus,Bovine,HEXA,Hexosaminidase subunit A,N-acetyl-beta-glucosaminidase subunit alpha 96T
E0195m ELISA kit Beta-hexosaminidase subunit alpha,Beta-N-acetylhexosaminidase subunit alpha,Hexa,Hexosaminidase subunit A,Mouse,Mus musculus,N-acetyl-beta-glucosaminidase subunit alpha 96T
E0195m ELISA Beta-hexosaminidase subunit alpha,Beta-N-acetylhexosaminidase subunit alpha,Hexa,Hexosaminidase subunit A,Mouse,Mus musculus,N-acetyl-beta-glucosaminidase subunit alpha 96T
E0195r ELISA Beta-hexosaminidase subunit alpha,Beta-N-acetylhexosaminidase subunit alpha,Hexa,Hexosaminidase subunit A,N-acetyl-beta-glucosaminidase subunit alpha,Rat,Rattus norvegicus 96T
U0195m CLIA Beta-hexosaminidase subunit alpha,Beta-N-acetylhexosaminidase subunit alpha,Hexa,Hexosaminidase subunit A,Mouse,Mus musculus,N-acetyl-beta-glucosaminidase subunit alpha 96T
U0195r CLIA Beta-hexosaminidase subunit alpha,Beta-N-acetylhexosaminidase subunit alpha,Hexa,Hexosaminidase subunit A,N-acetyl-beta-glucosaminidase subunit alpha,Rat,Rattus norvegicus 96T
U0195b CLIA Beta-hexosaminidase subunit alpha,Beta-N-acetylhexosaminidase subunit alpha,Bos taurus,Bovine,HEXA,Hexosaminidase subunit A,N-acetyl-beta-glucosaminidase subunit alpha 96T
E1761h ELISA Homo sapiens,Human,IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,OSMR,OSMRB 96T
E1761h ELISA kit Homo sapiens,Human,IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,OSMR,OSMRB 96T
U1761h CLIA Homo sapiens,Human,IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,OSMR,OSMRB 96T
E1761r ELISA IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb,Rat,Rattus norvegicus 96T
U1761r CLIA IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb,Rat,Rattus norvegicus 96T
U1761m CLIA IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Mouse,Mus musculus,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb 96T
E1761r ELISA kit IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb,Rat,Rattus norvegicus 96T
E1761m ELISA IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Mouse,Mus musculus,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb 96T
E1761m ELISA kit IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Mouse,Mus musculus,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb 96T
U2224r CLIA Beta OL,Beta oligodendroglia,Fibronectin receptor subunit beta,Integrin beta-1,Itgb1,Rat,Rattus norvegicus,VLA-4 subunit beta 96T
E2224r ELISA Beta OL,Beta oligodendroglia,Fibronectin receptor subunit beta,Integrin beta-1,Itgb1,Rat,Rattus norvegicus,VLA-4 subunit beta 96T
E2224r ELISA kit Beta OL,Beta oligodendroglia,Fibronectin receptor subunit beta,Integrin beta-1,Itgb1,Rat,Rattus norvegicus,VLA-4 subunit beta 96T
U2224r CLIA kit Beta OL,Beta oligodendroglia,Fibronectin receptor subunit beta,Integrin beta-1,Itgb1,Rat,Rattus norvegicus,VLA-4 subunit beta 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur