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Beta-porphyranase A (EC 3.2.1.178) (Glycosyl hydrolase 86 family protein A) (GH86A)

 PORA_BACPM              Reviewed;         728 AA.
B5CY96;
03-APR-2013, integrated into UniProtKB/Swiss-Prot.
14-OCT-2008, sequence version 1.
22-NOV-2017, entry version 36.
RecName: Full=Beta-porphyranase A;
EC=3.2.1.178;
AltName: Full=Glycosyl hydrolase 86 family protein A;
Short=GH86A;
Flags: Precursor;
ORFNames=BACPLE_01693;
Bacteroides plebeius (strain DSM 17135 / JCM 12973 / M2).
Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
Bacteroides.
NCBI_TaxID=484018;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=DSM 17135 / JCM 12973 / M2;
Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M.,
Liep D., Gordon J.;
"Draft genome sequence of Bacteroides plebeius (DSM 17135).";
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
[2]
X-RAY CRYSTALLOGRAPHY (1.33 ANGSTROMS) OF 30-598 IN COMPLEX WITH
PORPHYRAN-AGAROSE-OLIGOSACCHARIDE, FUNCTION, AND CATALYTIC ACTIVITY.
STRAIN=DSM 17135 / JCM 12973 / M2;
PubMed=23150581; DOI=10.1073/pnas.1211002109;
Hehemann J.H., Kelly A.G., Pudlo N.A., Martens E.C., Boraston A.B.;
"Bacteria of the human gut microbiome catabolize red seaweed glycans
with carbohydrate-active enzyme updates from extrinsic microbes.";
Proc. Natl. Acad. Sci. U.S.A. 109:19786-19791(2012).
-!- FUNCTION: Cleaves the sulfated polysaccharide porphyran at the
(1->4) linkages between beta-D-galactopyranose and alpha-L-
galactopyranose-6-sulfate, forming mostly the disaccharide alpha-
L-galactopyranose-6-sulfate-(1->3)-beta-D-galactose. Some longer
oligosaccharides of even number of residues are also observed.
Inactive on the non-sulfated agarose portion of the porphyran
backbone. {ECO:0000269|PubMed:23150581}.
-!- CATALYTIC ACTIVITY: Hydrolysis of beta-D-galactopyranose-(1->4)-
alpha-L-galactopyranose-6-sulfate linkages in porphyran.
{ECO:0000269|PubMed:23150581}.
-!- MISCELLANEOUS: Gut bacteria supply the human body with energy from
dietary polysaccharides through glycosidases that are absent in
the human genome. Beta-porphyranases, which are active on sulfated
polysaccharides from marine red algae of the genus Porphyra, are
present in marine bacteria. They are absent from metagenome data
of gut bacteria, except from the genome of the gut bacterium
B.plebeius isolated from Japanese individuals. Seaweeds make an
important contribution to the diet in Japan and Porphyra (nori) is
the most important nutritional seaweed used to prepare sushi,
suggesting that seaweeds with associated marine bacteria have been
the route by which genes coding for beta-porphyranases have been
transferred in human gut B.plebeius genome (PubMed:23150581).
{ECO:0000305|PubMed:23150581}.
-!- SIMILARITY: Belongs to the glycosyl hydrolase 86 family.
{ECO:0000305}.
-!- WEB RESOURCE: Name=Protein Spotlight; Note=A gut's tale - Issue
158 of March 2014;
URL="https://web.expasy.org/spotlight/back_issues/158/";
-----------------------------------------------------------------------
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EMBL; ABQC02000019; EDY95427.1; -; Genomic_DNA.
RefSeq; WP_007560960.1; NZ_DS990130.1.
PDB; 4AW7; X-ray; 1.33 A; A=30-598.
PDBsum; 4AW7; -.
ProteinModelPortal; B5CY96; -.
SMR; B5CY96; -.
STRING; 484018.BACPLE_01693; -.
CAZy; GH86; Glycoside Hydrolase Family 86.
EnsemblBacteria; EDY95427; EDY95427; BACPLE_01693.
eggNOG; ENOG4108KBQ; Bacteria.
eggNOG; ENOG410XSB9; LUCA.
OrthoDB; POG091H0A4S; -.
Proteomes; UP000003452; Unassembled WGS sequence.
GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
Gene3D; 2.60.120.260; -; 2.
InterPro; IPR003305; CenC_carb-bd.
InterPro; IPR008979; Galactose-bd-like_sf.
InterPro; IPR017853; Glycoside_hydrolase_SF.
Pfam; PF02018; CBM_4_9; 1.
SUPFAM; SSF49785; SSF49785; 1.
SUPFAM; SSF51445; SSF51445; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Glycosidase; Hydrolase; Signal.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 728 Beta-porphyranase A.
/FTId=PRO_0000422034.
DOMAIN 599 701 CBM-cenC.
REGION 77 78 Substrate binding.
REGION 151 152 Substrate binding.
BINDING 53 53 Substrate.
BINDING 87 87 Substrate.
BINDING 114 114 Substrate.
BINDING 156 156 Substrate.
BINDING 237 237 Substrate.
BINDING 324 324 Substrate.
BINDING 331 331 Substrate.
BINDING 342 342 Substrate.
STRAND 30 38 {ECO:0000244|PDB:4AW7}.
HELIX 46 48 {ECO:0000244|PDB:4AW7}.
STRAND 50 53 {ECO:0000244|PDB:4AW7}.
HELIX 60 69 {ECO:0000244|PDB:4AW7}.
STRAND 75 77 {ECO:0000244|PDB:4AW7}.
HELIX 80 88 {ECO:0000244|PDB:4AW7}.
STRAND 105 112 {ECO:0000244|PDB:4AW7}.
TURN 117 119 {ECO:0000244|PDB:4AW7}.
HELIX 126 138 {ECO:0000244|PDB:4AW7}.
STRAND 141 148 {ECO:0000244|PDB:4AW7}.
STRAND 150 152 {ECO:0000244|PDB:4AW7}.
HELIX 154 156 {ECO:0000244|PDB:4AW7}.
HELIX 166 185 {ECO:0000244|PDB:4AW7}.
TURN 188 193 {ECO:0000244|PDB:4AW7}.
STRAND 195 202 {ECO:0000244|PDB:4AW7}.
TURN 206 211 {ECO:0000244|PDB:4AW7}.
HELIX 212 216 {ECO:0000244|PDB:4AW7}.
HELIX 218 225 {ECO:0000244|PDB:4AW7}.
HELIX 226 228 {ECO:0000244|PDB:4AW7}.
STRAND 230 240 {ECO:0000244|PDB:4AW7}.
HELIX 252 269 {ECO:0000244|PDB:4AW7}.
STRAND 275 284 {ECO:0000244|PDB:4AW7}.
TURN 294 299 {ECO:0000244|PDB:4AW7}.
HELIX 300 312 {ECO:0000244|PDB:4AW7}.
HELIX 313 317 {ECO:0000244|PDB:4AW7}.
STRAND 318 324 {ECO:0000244|PDB:4AW7}.
HELIX 330 332 {ECO:0000244|PDB:4AW7}.
HELIX 335 337 {ECO:0000244|PDB:4AW7}.
STRAND 346 350 {ECO:0000244|PDB:4AW7}.
TURN 355 357 {ECO:0000244|PDB:4AW7}.
STRAND 360 362 {ECO:0000244|PDB:4AW7}.
HELIX 366 372 {ECO:0000244|PDB:4AW7}.
STRAND 377 386 {ECO:0000244|PDB:4AW7}.
STRAND 389 396 {ECO:0000244|PDB:4AW7}.
STRAND 399 406 {ECO:0000244|PDB:4AW7}.
STRAND 408 410 {ECO:0000244|PDB:4AW7}.
STRAND 412 417 {ECO:0000244|PDB:4AW7}.
TURN 419 424 {ECO:0000244|PDB:4AW7}.
STRAND 425 436 {ECO:0000244|PDB:4AW7}.
TURN 437 439 {ECO:0000244|PDB:4AW7}.
STRAND 440 450 {ECO:0000244|PDB:4AW7}.
STRAND 453 457 {ECO:0000244|PDB:4AW7}.
STRAND 461 469 {ECO:0000244|PDB:4AW7}.
STRAND 476 484 {ECO:0000244|PDB:4AW7}.
STRAND 489 491 {ECO:0000244|PDB:4AW7}.
STRAND 498 505 {ECO:0000244|PDB:4AW7}.
STRAND 509 521 {ECO:0000244|PDB:4AW7}.
STRAND 529 532 {ECO:0000244|PDB:4AW7}.
STRAND 535 537 {ECO:0000244|PDB:4AW7}.
STRAND 551 562 {ECO:0000244|PDB:4AW7}.
HELIX 564 566 {ECO:0000244|PDB:4AW7}.
STRAND 569 577 {ECO:0000244|PDB:4AW7}.
STRAND 583 596 {ECO:0000244|PDB:4AW7}.
SEQUENCE 728 AA; 81281 MW; 192BD9484B946F0E CRC64;
MSYKYIFLLS AFTLGVPPGI YCQGRNEVVV DYNTRRFLSG VSELDRSKYF NIHSTSDDDK
DVGKFLADYQ VGLGRKFWGP YSYAYNKTHE VGKYPQMKPY SGNISVKRYI ATEHPYVQHI
QGGIDVQAAG AWSAEYYSNS ELVPEFFEPL NEPFVHANDA GFTVQGQAMR ELMVDFYASI
GKHIHNNPRL NGKMKVIGYA AAYPAWEDGN FNYWNTRMKM FIDRAGAYMD GFSVHLYDGI
NVTGTDTKRS GSNSEAVLDM VEAYSYIKFG HVKPLAISEF GGIDNSKPDD SYDDISSVRS
VSSFNHFLFN LMERQDNLFI SIPFVSDKAE WHITAANNYT SYSAALFIPD NPQNLKNTTW
RLNDKKYFFE LWKNVKGERV DITSSNPDIQ VQAFKDGGRL YIALDNLDDN PQTVYLNNKN
SWKDVSNVTK RSLYVNYNAG IEYTEQNVPS MPESISIVPN QTIVLVADVS SSAFTNSIIR
NKYYSSEYLK PISAGSSLSF PFTGIESGSG RASLRMSIGR PVSASKKPVV KINGTAVSVP
DNWKGYGQSN RNIFFGMIEV PFDIQLLKNG DNNVDITFSD GGGHVSSMIL QVEKYTVSTL
QNGTFSEGLS AWQPLGNYGT VCVQTDNAGN NVACISGHAG LMQRVDMESG RTYRFSADVK
TEGACKLKVM LQDMSTGTVY TEEFSSPGNY KAVSFDFNST VKKVVCAIVC ERQNDAAWID
NIVLLPQN


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