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Betacellulin

 H2PDL8_PONAB            Unreviewed;       178 AA.
H2PDL8; A0A2J8UU15;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
09-JAN-2013, sequence version 2.
23-MAY-2018, entry version 35.
SubName: Full=BTC isoform 1 {ECO:0000313|EMBL:PNJ48754.1};
SubName: Full=Betacellulin {ECO:0000313|Ensembl:ENSPPYP00000016569};
Name=BTC {ECO:0000313|Ensembl:ENSPPYP00000016569};
ORFNames=CR201_G0024855 {ECO:0000313|EMBL:PNJ48754.1};
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000016569, ECO:0000313|Proteomes:UP000001595};
[1] {ECO:0000313|Ensembl:ENSPPYP00000016569, ECO:0000313|Proteomes:UP000001595}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Wilson R.K., Mardis E.;
"A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSPPYP00000016569}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[3] {ECO:0000313|EMBL:PNJ48754.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Susie {ECO:0000313|EMBL:PNJ48754.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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EMBL; ABGA01246705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01246706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; NDHI03003443; PNJ48754.1; -; Genomic_DNA.
RefSeq; XP_002814922.1; XM_002814876.2.
STRING; 9601.ENSPPYP00000016569; -.
Ensembl; ENSPPYT00000017244; ENSPPYP00000016569; ENSPPYG00000014839.
KEGG; pon:100445807; -.
CTD; 685; -.
eggNOG; ENOG410IWUI; Eukaryota.
eggNOG; ENOG41126JP; LUCA.
GeneTree; ENSGT00730000110951; -.
InParanoid; H2PDL8; -.
KO; K09783; -.
OMA; ILHCVVA; -.
OrthoDB; EOG091G0RK4; -.
TreeFam; TF332938; -.
Proteomes; UP000001595; Chromosome 4.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR015497; EGF_rcpt_ligand.
PANTHER; PTHR10740; PTHR10740; 1.
PROSITE; PS00022; EGF_1; 1.
PROSITE; PS01186; EGF_2; 1.
PROSITE; PS50026; EGF_3; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000001595};
Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000001595};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 31 {ECO:0000256|SAM:SignalP}.
CHAIN 32 178 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5014575046.
TRANSMEM 119 145 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 65 105 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DISULFID 95 104 {ECO:0000256|PROSITE-ProRule:PRU00076}.
SEQUENCE 178 AA; 19757 MW; A8B2670B6C4CA47A CRC64;
MDRAARGSGA SSLPLLLALA LGLVILHCVV ADGNSTRSPE TNGLLCGYPE ENCAATTTQS
KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYI GARCERVDLF YLRGDRGQIL
VICLIAVMVV FIILVIGVCT CCHPLRKHRK RKKKEEEMET LGKDITPINE DIEETNIV


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