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Betacellulin

 Q9JJM4_RAT              Unreviewed;       177 AA.
Q9JJM4; F1LPG4;
01-OCT-2000, integrated into UniProtKB/TrEMBL.
01-OCT-2000, sequence version 1.
12-SEP-2018, entry version 134.
SubName: Full=Betacellulin {ECO:0000313|EMBL:BAA96731.1, ECO:0000313|Ensembl:ENSRNOP00000003686};
Name=Btc {ECO:0000313|Ensembl:ENSRNOP00000003686,
ECO:0000313|RGD:620275}; Synonyms=BTC {ECO:0000313|EMBL:BAA96731.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:BAA96731.1};
[1] {ECO:0000313|EMBL:BAA96731.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Kidney {ECO:0000313|EMBL:BAA96731.1};
PubMed=11004502; DOI=10.1016/S0167-4781(00)00106-8;
Tada H., Seno M., Yamada H., Sasada R., Igarashi K.;
"Molecular cloning and expression of rat betacellulin cDNA.";
Biochim. Biophys. Acta 1492:285-288(2000).
[2] {ECO:0000313|Ensembl:ENSRNOP00000003686, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003686,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[3] {ECO:0000313|Ensembl:ENSRNOP00000003686}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003686};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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EMBL; AABR07014503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AABR07014504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AB028862; BAA96731.1; -; mRNA.
RefSeq; NP_071592.1; NM_022256.2.
UniGene; Rn.53987; -.
STRING; 10116.ENSRNOP00000003686; -.
Ensembl; ENSRNOT00000003686; ENSRNOP00000003686; ENSRNOG00000002728.
GeneID; 64022; -.
KEGG; rno:64022; -.
UCSC; RGD:620275; rat.
CTD; 685; -.
RGD; 620275; Btc.
eggNOG; ENOG410IWUI; Eukaryota.
eggNOG; ENOG41126JP; LUCA.
GeneTree; ENSGT00730000110951; -.
HOGENOM; HOG000237352; -.
HOVERGEN; HBG004905; -.
KO; K09783; -.
OMA; ILHCVVA; -.
OrthoDB; EOG091G0RK4; -.
TreeFam; TF332938; -.
Reactome; R-RNO-1227986; Signaling by ERBB2.
Reactome; R-RNO-1236394; Signaling by ERBB4.
Reactome; R-RNO-1250196; SHC1 events in ERBB2 signaling.
Reactome; R-RNO-1250342; PI3K events in ERBB4 signaling.
Reactome; R-RNO-1250347; SHC1 events in ERBB4 signaling.
Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
Reactome; R-RNO-1963640; GRB2 events in ERBB2 signaling.
Reactome; R-RNO-1963642; PI3K events in ERBB2 signaling.
Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
Reactome; R-RNO-6785631; ERBB2 Regulates Cell Motility.
Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-RNO-8847993; ERBB2 Activates PTK6 Signaling.
Reactome; R-RNO-8863795; Downregulation of ERBB2 signaling.
Proteomes; UP000002494; Chromosome 14.
Bgee; ENSRNOG00000002728; Expressed in 8 organ(s), highest expression level in adult mammalian kidney.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005154; F:epidermal growth factor receptor binding; IDA:RGD.
GO; GO:0008083; F:growth factor activity; IDA:RGD.
GO; GO:0030154; P:cell differentiation; TAS:RGD.
GO; GO:0006260; P:DNA replication; TAS:RGD.
GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IDA:RGD.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0045597; P:positive regulation of cell differentiation; IMP:RGD.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; IDA:RGD.
GO; GO:0045840; P:positive regulation of mitotic nuclear division; IDA:RGD.
GO; GO:0035810; P:positive regulation of urine volume; IDA:RGD.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR015497; EGF_rcpt_ligand.
PANTHER; PTHR10740; PTHR10740; 1.
Pfam; PF00008; EGF; 1.
PROSITE; PS00022; EGF_1; 1.
PROSITE; PS01186; EGF_2; 1.
PROSITE; PS50026; EGF_3; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000002494};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 31 {ECO:0000256|SAM:SignalP}.
CHAIN 32 177 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5015299808.
TRANSMEM 119 143 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 65 105 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DISULFID 95 104 {ECO:0000256|PROSITE-ProRule:PRU00076}.
SEQUENCE 177 AA; 19579 MW; FAB2AF1F844E114D CRC64;
MDSTAPGSGV SSLPLLLALV LGLVILQCVV ADGNTTRTPE TNGSLCGAPG ENCTGTTPRQ
KSKTHFSRCP KQYKHYCIHG RCRFVMDEQT PSCICEKGYF GARCEQVDLF YLQQDRGQIL
VVCLIGVMVL FIILVIGVCT CCHPLRKHRK KKKEEKMETL SKDKTPISED IQETNIA


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