Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Bifunctional enzyme LpxC/FabZ [Includes: UDP-3-O-acyl-N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase) (EC 3.5.1.108) (UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ (EC 4.2.1.59) ((3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase) ((3R)-hydroxymyristoyl-ACP dehydrase) (Beta-hydroxyacyl-ACP dehydratase)]

 LPXZ_CHLTE              Reviewed;         467 AA.
Q8KBX0;
24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
22-NOV-2017, entry version 92.
RecName: Full=Bifunctional enzyme LpxC/FabZ;
Includes:
RecName: Full=UDP-3-O-acyl-N-acetylglucosamine deacetylase;
Short=UDP-3-O-acyl-GlcNAc deacetylase;
EC=3.5.1.108;
AltName: Full=UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase;
Includes:
RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ;
EC=4.2.1.59;
AltName: Full=(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase;
Short=(3R)-hydroxymyristoyl-ACP dehydrase;
AltName: Full=Beta-hydroxyacyl-ACP dehydratase;
Name=lpxC/fabZ; OrderedLocusNames=CT1662;
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 /
TLS).
Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
Chlorobaculum.
NCBI_TaxID=194439;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49652 / DSM 12025 / NBRC 103806 / TLS;
PubMed=12093901; DOI=10.1073/pnas.132181499;
Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M.,
Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H.,
Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F.,
Holt I.E., Umayam L.A., Mason T.M., Brenner M., Shea T.P.,
Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B.,
Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M.,
Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M.;
"The complete genome sequence of Chlorobium tepidum TLS, a
photosynthetic, anaerobic, green-sulfur bacterium.";
Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
-!- FUNCTION: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-
acetylglucosamine to form UDP-3-O-myristoylglucosamine and
acetate, the committed step in lipid A biosynthesis.
-!- FUNCTION: Involved in unsaturated fatty acids biosynthesis.
Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and
long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
{ECO:0000250}.
-!- CATALYTIC ACTIVITY: UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N-
acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-
hydroxytetradecanoyl)-alpha-D-glucosamine + acetate.
-!- CATALYTIC ACTIVITY: A (3R)-3-hydroxyacyl-[acyl-carrier protein] =
a trans-2-enoyl-[acyl-carrier protein] + H(2)O.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
-!- PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid
IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and
UDP-N-acetyl-alpha-D-glucosamine: step 2/6.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- SIMILARITY: In the N-terminal section; belongs to the LpxC family.
{ECO:0000305}.
-!- SIMILARITY: In the C-terminal section; belongs to the thioester
dehydratase family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AE006470; AAM72887.1; -; Genomic_DNA.
RefSeq; NP_662545.1; NC_002932.3.
RefSeq; WP_010933326.1; NC_002932.3.
ProteinModelPortal; Q8KBX0; -.
STRING; 194439.CT1662; -.
PRIDE; Q8KBX0; -.
EnsemblBacteria; AAM72887; AAM72887; CT1662.
GeneID; 1006145; -.
KEGG; cte:CT1662; -.
PATRIC; fig|194439.7.peg.1500; -.
eggNOG; ENOG4105C7C; Bacteria.
eggNOG; COG0764; LUCA.
eggNOG; COG0774; LUCA.
HOGENOM; HOG000029820; -.
KO; K16363; -.
OMA; MVDFGTK; -.
OrthoDB; POG091H0292; -.
UniPathway; UPA00359; UER00478.
Proteomes; UP000001007; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0047451; F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0008759; F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity; IEA:InterPro.
GO; GO:0103117; F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity; IEA:UniProtKB-EC.
GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW.
Gene3D; 3.30.1700.10; -; 1.
Gene3D; 3.30.230.20; -; 1.
HAMAP; MF_00406; FabZ; 1.
HAMAP; MF_00388; LpxC; 1.
InterPro; IPR013114; FabA_FabZ.
InterPro; IPR010084; FabZ.
InterPro; IPR029069; HotDog_dom_sf.
InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
InterPro; IPR004463; UDP-acyl_GlcNac_deAcase.
InterPro; IPR011334; UDP-acyl_GlcNac_deAcase_C.
InterPro; IPR015870; UDP-acyl_N-AcGlcN_deAcase_N.
PANTHER; PTHR33694; PTHR33694; 2.
Pfam; PF07977; FabA; 1.
Pfam; PF03331; LpxC; 1.
SUPFAM; SSF54211; SSF54211; 3.
SUPFAM; SSF54637; SSF54637; 1.
TIGRFAMs; TIGR01750; fabZ; 1.
TIGRFAMs; TIGR00325; lpxC; 1.
3: Inferred from homology;
Complete proteome; Cytoplasm; Hydrolase; Lipid A biosynthesis;
Lipid biosynthesis; Lipid metabolism; Lyase; Metal-binding;
Multifunctional enzyme; Reference proteome; Zinc.
CHAIN 1 467 Bifunctional enzyme LpxC/FabZ.
/FTId=PRO_0000191974.
REGION 1 306 UDP-3-O-acyl-N-acetylglucosamine
deacetylase.
REGION 307 467 3-hydroxyacyl-[acyl-carrier-protein]
dehydratase.
ACT_SITE 291 291 Proton donor. {ECO:0000250}.
ACT_SITE 370 370 {ECO:0000250}.
METAL 79 79 Zinc; via tele nitrogen. {ECO:0000250}.
METAL 264 264 Zinc; via tele nitrogen. {ECO:0000250}.
METAL 268 268 Zinc. {ECO:0000250}.
SEQUENCE 467 AA; 51844 MW; 355120C7D2B654E7 CRC64;
MLIHQRTLQN EISLTGIGLH TGHECTITFK PAPVNTGYIF VRTDINDCPE IPALIDHVVD
VLRGTTIGIG DVKVHTTEHV LAALYGLQID NCRIELSGPE PPVLDGSSNP FAEALLSAGI
AEQDEPKNYL VIDETIEFHN PEKSVDIVAL PLDGFRMTVM VDYKNPALGS QHSGLFDLDK
EFLREFSPCR TFCFLSEVEA MANQGIIKGA DIDNAIVIVD KQLDETEVQT LADKVGVDAS
HLVLGQNGIL NNRELRFSNE PARHKLLDLL GDLALLGMPV KAQILAXRPG HASNVEFVKQ
LKKYADRNKL ARQYQHEKKA GVIFDINAIQ NILPHRYPFL LIDKIVEFKL DEKIVSIKNV
TMNEPFFQGH FPGNPIMPGV LIIEAMAQTG GIMMLNGKEN IKESVVFFMG IDKARFRKPV
LPGDTLVIEA VMTNMRRTVC QFDAKAYVRG ELVCEASLMA TVMEKKN


Related products :

Catalog number Product name Quantity
EIAAB26277 Amdhd2,Amidohydrolase domain-containing protein 2,GlcNAc 6-P deacetylase,Mouse,Mus musculus,Putative N-acetylglucosamine-6-phosphate deacetylase
EIAAB26278 AMDHD2,Amidohydrolase domain-containing protein 2,Bos taurus,Bovine,GlcNAc 6-P deacetylase,Putative N-acetylglucosamine-6-phosphate deacetylase
EIAAB26279 Amdhd2,Amidohydrolase domain-containing protein 2,GlcNAc 6-P deacetylase,Putative N-acetylglucosamine-6-phosphate deacetylase,Rat,Rattus norvegicus
20-783-73539 MOUSE ANTI BOVINE NEUROFILAMENT 145kDa - EC 3.5.1.-; UDP-3-O-acyl-GlcNAc deacetylase; Protein envA Monoclonal 0.1 ml
20-783-73537 MOUSE ANTI BOVINE NEUROFILAMENT 68kDa - EC 3.5.1.-; UDP-3-O-acyl-GlcNAc deacetylase; Protein envA Monoclonal 0.1 ml
EIAAB26280 AMDHD2,Amidohydrolase domain-containing protein 2,CGI-14,GlcNAc 6-P deacetylase,Homo sapiens,Human,Putative N-acetylglucosamine-6-phosphate deacetylase
EIAAB14290 [Acyl-carrier-protein] malonyltransferase,Homo sapiens,Human,Malonyl-CoA-acyl carrier protein transacylase, mitochondrial,MCAT,MCT,Mitochondrial malonyltransferase,MT
EIAAB14289 [Acyl-carrier-protein] malonyltransferase,Malonyl-CoA-acyl carrier protein transacylase, mitochondrial,Mcat,MCT,Mitochondrial malonyltransferase,Mouse,Mt,Mus musculus
orb70387 Acyl Carrier Protein (65-74) peptide This is Acyl Carrier Protein (65-74) peptide. For research use only. 1 mg
orb70386 Acyl Carrier Protein (65-74) peptide This is Acyl Carrier Protein (65-74) peptide. For research use only. 1 mg
26-896 Short_branched chain acyl-CoA dehydrogenase (ACADSB) is a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty ac 0.05 mg
25-757 Acyl-CoA thioesterases, such as ACOT2, are a group of enzymes that hydrolyze CoA esters, such as acyl-CoAs, bile CoAs, and CoA esters of prostaglandins, to the corresponding free acid and CoA.Acyl-CoA 0.05 mg
26-455 ACBD4 is a member of the acyl-coenzyme A binding domain containing protein family. All family members contain the conserved acyl-Coenzyme A binding domain, which binds acyl-CoA thiol esters. They are 0.05 mg
EIAAB36953 Acyl-malonyl-condensing enzyme 1-like protein 1,AMAC1L1,Homo sapiens,Human,SLC35G4,Solute carrier family 35 member G4
EIAAB36955 Acyl-malonyl-condensing enzyme 1-like protein 3,AMAC1L3,Homo sapiens,Human,SLC35G6,Solute carrier family 35 member G6,TMEM21B,Transmembrane protein 21B
EIAAB36954 Acyl-malonyl-condensing enzyme 1-like protein 2,AMAC,AMAC1L2,Homo sapiens,Human,SLC35G5,Solute carrier family 35 member G5
30-881 Carnitine acetyltransferase (CRAT) is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-C 0.05 mg
EIAAB36951 Acyl-malonyl-condensing enzyme 1,AMAC1,Homo sapiens,Human,SLC35G3,Solute carrier family 35 member G3,TMEM21A,Transmembrane protein 21A
26-336 The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-Co 0.05 mg
SP-86553-5 Acyl Carrier Protein (65-74) (acid) [Val-Gln-Ala-Ala-Ile-Asp-Tyr-Ile-Asn-Gly (MW: 1063.18)] 5 mg
SP-86554-5 Acyl Carrier Protein (65-74) (amide) (AA: Val-Gln-Ala-Ala-Ile-Asp-Tyr-Ile-Asn-Gly-NH2) (MW: 1062.20) 5 mg
SP-86553-5 Acyl Carrier Protein (65_74) (acid) 5 mg
A-0501-2 Acyl Carrier Protein (ACP) (65-74) (amide) 98 percent C47H75N13O15 CAS: 5mg
E2890h Human Malonyl CoA Acyl Carrier Protein Transacylas 96T
E1408m Human ELISA Kit FOR Acyl carrier protein, mitochondrial 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur