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Bifunctional methyltransferase-like/endonuclease [Includes: Probable methylated-DNA--protein-cysteine methyltransferase-like; Endonuclease V (EC 3.1.21.7) (Deoxyinosine 3'endonuclease) (Deoxyribonuclease V) (DNase V)]

 NFI_NANEQ               Reviewed;         299 AA.
Q74NK2;
07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
25-OCT-2017, entry version 72.
RecName: Full=Bifunctional methyltransferase-like/endonuclease;
Includes:
RecName: Full=Probable methylated-DNA--protein-cysteine methyltransferase-like;
Includes:
RecName: Full=Endonuclease V;
EC=3.1.21.7;
AltName: Full=Deoxyinosine 3'endonuclease;
AltName: Full=Deoxyribonuclease V;
Short=DNase V;
OrderedLocusNames=NEQ345.1; ORFNames=NEQ345a;
Nanoarchaeum equitans (strain Kin4-M).
Archaea; Nanoarchaeota; Nanoarchaeales; Nanoarchaeaceae; Nanoarchaeum.
NCBI_TaxID=228908;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Kin4-M;
PubMed=14566062; DOI=10.1073/pnas.1735403100;
Waters E., Hohn M.J., Ahel I., Graham D.E., Adams M.D., Barnstead M.,
Beeson K.Y., Bibbs L., Bolanos R., Keller M., Kretz K., Lin X.,
Mathur E., Ni J., Podar M., Richardson T., Sutton G.G., Simon M.,
Soell D., Stetter K.O., Short J.M., Noorderwier M.;
"The genome of Nanoarchaeum equitans: insights into early archaeal
evolution and derived parasitism.";
Proc. Natl. Acad. Sci. U.S.A. 100:12984-12988(2003).
-!- FUNCTION: DNA repair enzyme involved in the repair of deaminated
bases. Selectively cleaves double-stranded DNA at the second
phosphodiester bond 3' to a deoxyinosine leaving behind the intact
lesion on the nicked DNA (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: Endonucleolytic cleavage at apurinic or
apyrimidinic sites to products with a 5'-phosphate.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- SIMILARITY: In the N-terminal section; belongs to the MGMT family.
{ECO:0000305}.
-!- SIMILARITY: In the C-terminal section; belongs to the endonuclease
V family. {ECO:0000305}.
-!- CAUTION: Lacks the potential active site region of the MGMT family
and therefore has probably lost the methyltransferase activity.
{ECO:0000305}.
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EMBL; AE017199; AAR39194.1; -; Genomic_DNA.
ProteinModelPortal; Q74NK2; -.
SMR; Q74NK2; -.
EnsemblBacteria; AAR39194; AAR39194; NEQ345a.
KEGG; neq:NEQ345a; -.
KO; K05982; -.
OMA; PRIPCHR; -.
Proteomes; UP000000578; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0043737; F:deoxyribonuclease V activity; IEA:UniProtKB-EC.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
CDD; cd06445; ATase; 1.
CDD; cd06559; Endonuclease_V; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR007581; Endonuclease-V.
InterPro; IPR014048; MethylDNA_cys_MeTrfase_DNA-bd.
InterPro; IPR036217; MethylDNA_cys_MeTrfase_DNAb.
InterPro; IPR036388; WH-like_DNA-bd_sf.
PANTHER; PTHR28511; PTHR28511; 2.
Pfam; PF01035; DNA_binding_1; 1.
Pfam; PF04493; Endonuclease_5; 1.
SUPFAM; SSF46767; SSF46767; 1.
3: Inferred from homology;
Complete proteome; Cytoplasm; DNA damage; DNA repair; Endonuclease;
Hydrolase; Magnesium; Metal-binding; Nuclease; Reference proteome.
CHAIN 1 299 Bifunctional methyltransferase-
like/endonuclease.
/FTId=PRO_0000159697.
REGION 1 80 Probable methylated-DNA--protein-cysteine
methyltransferase-like.
REGION 81 299 Endonuclease V.
METAL 135 135 Magnesium. {ECO:0000250}.
METAL 197 197 Magnesium. {ECO:0000255}.
SITE 168 168 Interaction with target DNA.
{ECO:0000250}.
SEQUENCE 299 AA; 34366 MW; A4513D0BDFFC50D4 CRC64;
MLSSKLLDIN YWNKFGKRLI NELINLIEQI PKGYVTTFKE LAKALGDPIA TKFVAMYYKK
APHWYRVVSS NLIVSPMQKA LLEKEVKIIG NKVYAPIFKD FKSSKPLLEL QKIQEYLVNK
IKFDYPEYDY VIGIDIGYKN NIIALAIFDK NKKLIETKTC KHNIEFPYIP TYLSFREGIP
IVNILKDLDY TALYIINGHG LSHPRKMGLA TFVGTVLDLP TIGDAKKLLY GKIKNNIIYA
HNMPVGYFVG HYVTIGNRTN LEFLKEFIKE WNSKKYLLPI EVADKITKCG RGDSNPGRD


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