Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Bifunctional polymyxin resistance protein ArnA [Includes: UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating (EC 1.1.1.305) (UDP-GlcUA decarboxylase) (UDP-glucuronic acid dehydrogenase) (ArnADH); UDP-4-amino-4-deoxy-L-arabinose formyltransferase (EC 2.1.2.13) (UDP-L-Ara4N formyltransferase) (ArnAFT)]

 A0A1B4WYT6_9PSED        Unreviewed;       663 AA.
A0A1B4WYT6;
02-NOV-2016, integrated into UniProtKB/TrEMBL.
02-NOV-2016, sequence version 1.
22-NOV-2017, entry version 9.
RecName: Full=Bifunctional polymyxin resistance protein ArnA {ECO:0000256|HAMAP-Rule:MF_01166};
Includes:
RecName: Full=UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating {ECO:0000256|HAMAP-Rule:MF_01166};
EC=1.1.1.305 {ECO:0000256|HAMAP-Rule:MF_01166};
AltName: Full=UDP-GlcUA decarboxylase {ECO:0000256|HAMAP-Rule:MF_01166};
AltName: Full=UDP-glucuronic acid dehydrogenase {ECO:0000256|HAMAP-Rule:MF_01166};
AltName: Full=ArnADH {ECO:0000256|HAMAP-Rule:MF_01166};
Includes:
RecName: Full=UDP-4-amino-4-deoxy-L-arabinose formyltransferase {ECO:0000256|HAMAP-Rule:MF_01166};
EC=2.1.2.13 {ECO:0000256|HAMAP-Rule:MF_01166};
AltName: Full=UDP-L-Ara4N formyltransferase {ECO:0000256|HAMAP-Rule:MF_01166};
AltName: Full=ArnAFT {ECO:0000256|HAMAP-Rule:MF_01166};
Name=arnA {ECO:0000256|HAMAP-Rule:MF_01166};
ORFNames=LAB08_2443 {ECO:0000313|EMBL:BAV27713.1};
Pseudomonas sp. LAB-08.
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
Pseudomonadaceae; Pseudomonas.
NCBI_TaxID=143813 {ECO:0000313|EMBL:BAV27713.1};
[1] {ECO:0000313|EMBL:BAV27713.1}
NUCLEOTIDE SEQUENCE.
Suzuki K., Fatma A., Inuzuka Y., Tashiro Y., Futamata H.;
"Draft genome sequence of Pseudomonassp. LAB-08 isolated from TCE
contaminated aquifer soil.";
Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Bifunctional enzyme that catalyzes the oxidative
decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-
arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-
amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-
arabinose (UDP-L-Ara4FN). The modified arabinose is attached to
lipid A and is required for resistance to polymyxin and cationic
antimicrobial peptides. {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00930012}.
-!- CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + UDP-4-amino-4-
deoxy-beta-L-arabinose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-
formamido-beta-L-arabinose. {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00930196}.
-!- CATALYTIC ACTIVITY: UDP-alpha-D-glucuronate + NAD(+) = UDP-beta-L-
threo-pentapyranos-4-ulose + CO(2) + NADH. {ECO:0000256|HAMAP-
Rule:MF_01166, ECO:0000256|SAAS:SAAS00930065}.
-!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
biosynthesis. {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00930195}.
-!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido-
beta-L-arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L-
arabinose from UDP-alpha-D-glucuronate: step 1/3.
{ECO:0000256|HAMAP-Rule:MF_01166, ECO:0000256|SAAS:SAAS00930158}.
-!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido-
beta-L-arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L-
arabinose from UDP-alpha-D-glucuronate: step 3/3.
{ECO:0000256|HAMAP-Rule:MF_01166, ECO:0000256|SAAS:SAAS00930003}.
-!- SUBUNIT: Homohexamer, formed by a dimer of trimers.
{ECO:0000256|HAMAP-Rule:MF_01166, ECO:0000256|SAAS:SAAS00930146}.
-!- SIMILARITY: In the C-terminal section; belongs to the NAD(P)-
dependent epimerase/dehydratase family. UDP-glucuronic acid
decarboxylase subfamily. {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00930110}.
-!- SIMILARITY: In the N-terminal section; belongs to the Fmt family.
UDP-L-Ara4N formyltransferase subfamily. {ECO:0000256|HAMAP-
Rule:MF_01166, ECO:0000256|SAAS:SAAS00930013}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_01166}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AP017423; BAV27713.1; -; Genomic_DNA.
UniPathway; UPA00030; -.
UniPathway; UPA00032; UER00492.
UniPathway; UPA00032; UER00494.
GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
GO; GO:0099619; F:UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity; IEA:UniProtKB-EC.
GO; GO:0099618; F:UDP-glucuronic acid dehydrogenase activity; IEA:UniProtKB-EC.
GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
Gene3D; 3.10.25.10; -; 1.
Gene3D; 3.40.50.170; -; 1.
HAMAP; MF_01166; ArnA; 1.
InterPro; IPR021168; Bifun_polymyxin_resist_ArnA.
InterPro; IPR001509; Epimerase_deHydtase.
InterPro; IPR005793; Formyl_trans_C.
InterPro; IPR037022; Formyl_trans_C_sf.
InterPro; IPR002376; Formyl_transf_N.
InterPro; IPR036477; Formyl_transf_N_sf.
InterPro; IPR011034; Formyl_transferase-like_C_sf.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
Pfam; PF01370; Epimerase; 1.
Pfam; PF02911; Formyl_trans_C; 1.
Pfam; PF00551; Formyl_trans_N; 1.
PIRSF; PIRSF036506; Bifun_polymyxin_resist_ArnA; 1.
SUPFAM; SSF50486; SSF50486; 1.
SUPFAM; SSF51735; SSF51735; 1.
SUPFAM; SSF53328; SSF53328; 1.
3: Inferred from homology;
Antibiotic resistance {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00930186};
Lipid A biosynthesis {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00930035};
Lipid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00930035};
Lipid metabolism {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00930035};
Lipopolysaccharide biosynthesis {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00930194};
Multifunctional enzyme {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00930103};
NAD {ECO:0000256|HAMAP-Rule:MF_01166, ECO:0000256|SAAS:SAAS00930009};
Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00930032};
Transferase {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00930026}.
DOMAIN 27 176 Formyl_trans_N.
{ECO:0000259|Pfam:PF00551}.
DOMAIN 204 284 Formyl_trans_C.
{ECO:0000259|Pfam:PF02911}.
DOMAIN 321 568 Epimerase. {ECO:0000259|Pfam:PF01370}.
NP_BIND 371 372 NAD binding. {ECO:0000256|HAMAP-
Rule:MF_01166}.
REGION 1 307 Formyltransferase ArnAFT.
{ECO:0000256|HAMAP-Rule:MF_01166}.
REGION 138 142 10-formyltetrahydrofolate binding.
{ECO:0000256|HAMAP-Rule:MF_01166}.
REGION 317 663 Dehydrogenase ArnADH. {ECO:0000256|HAMAP-
Rule:MF_01166}.
REGION 435 436 UDP-glucuronate binding.
{ECO:0000256|HAMAP-Rule:MF_01166}.
REGION 528 537 UDP-glucuronate binding.
{ECO:0000256|HAMAP-Rule:MF_01166}.
ACT_SITE 106 106 Proton donor; for formyltransferase
activity. {ECO:0000256|HAMAP-
Rule:MF_01166}.
ACT_SITE 437 437 Proton acceptor; for decarboxylase
activity. {ECO:0000256|HAMAP-
Rule:MF_01166}.
ACT_SITE 621 621 Proton donor; for decarboxylase activity.
{ECO:0000256|HAMAP-Rule:MF_01166}.
BINDING 116 116 10-formyltetrahydrofolate.
{ECO:0000256|HAMAP-Rule:MF_01166}.
BINDING 350 350 NAD. {ECO:0000256|HAMAP-Rule:MF_01166}.
BINDING 396 396 UDP-glucuronate; via carbonyl oxygen.
{ECO:0000256|HAMAP-Rule:MF_01166}.
BINDING 401 401 UDP-glucuronate. {ECO:0000256|HAMAP-
Rule:MF_01166}.
BINDING 463 463 UDP-glucuronate. {ECO:0000256|HAMAP-
Rule:MF_01166}.
BINDING 494 494 UDP-glucuronate. {ECO:0000256|HAMAP-
Rule:MF_01166}.
BINDING 615 615 UDP-glucuronate. {ECO:0000256|HAMAP-
Rule:MF_01166}.
SITE 104 104 Transition state stabilizer.
{ECO:0000256|HAMAP-Rule:MF_01166}.
SITE 142 142 Raises pKa of active site His.
{ECO:0000256|HAMAP-Rule:MF_01166}.
SEQUENCE 663 AA; 73710 MW; 4FC32B1BF347ACA2 CRC64;
MSAKAVVFAY HDIGCAGIES LLSSGFEIAA VFTHADDPKE NAFYGSVAQL CARHGIAVHA
PEDANHPLWI ERIAKLDPDY IFSFYYRNLL SESLLATARK GAFNLHGSLL PRYRGRAPAN
WVLVNGETET GVTLHRMVKR ADAGAIVAQQ KVAIERSDTA LSLHGKLRSA ASDLLRDTLP
ALLQGKASET PQDESKATVF GRRTPADGKL VWAKPAEELF NLVRAVTQPY PGAFCAVGEH
KLIVWSAEVA KGNEGLAPGR VISVDPLRIA CGEDSLVINA GQRNDNGLYL SGPQLANELG
LVDGSVLRGA ESGRAPRRTR VLILGVNGFI GNHLSERLLR DDRYEVYGLD IGSDAIERLR
SHPNFHFVEG DISIHSEWIE YHIKKCDVVL PLVAIATPIE YTRNPLRVFE LDFEENLKLV
RYCVKYNKRV IFPSTSEVYG MCQDPNFDED NSNLVVGPIN KQRWIYSVSK QLLDRVIWAY
GQKGLNFTLF RPFNWMGPRL DRLDSARIGS SRAITQLILN LVEGTPIRLF DGGEQKRCFT
DIADGVEALA RIIDNDNDVC NGQIINIGNP ENEASIRQLG EELLRQFEAH PLRANFPPFA
GFRDIESKAF YGGGYQDVSH RKPSIANAKR LLDWTPTVEM SETIGNTLDF FLREAMLEIA
DKR


Related products :

Catalog number Product name Quantity
30-461 CSGlcA-T belongs to the chondroitin N-acetylgalactosaminyltransferase family. It transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elong 0.05 mg
26-230 ChGn transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). This protein is required for addition of the first GalNAc to the core tetrasacchar 0.05 mg
EIAAB45515 Rat,Rattus norvegicus,UDP-glucuronate decarboxylase 1,UDP-glucuronic acid decarboxylase 1,UGD,Uxs1,UXS-1
EIAAB45517 Mouse,Mus musculus,UDP-glucuronate decarboxylase 1,UDP-glucuronic acid decarboxylase 1,UGD,Uxs1,UXS-1
E1749h Rat ELISA Kit FOR UDP-glucuronic acid decarboxylase 1 96T
EIAAB45516 Homo sapiens,Human,UDP-glucuronate decarboxylase 1,UDP-glucuronic acid decarboxylase 1,UGD,UNQ2538_PRO6079,UXS1,UXS-1
I0551 UDP-glucuronic acid decarboxylase 1 (UXS1), Rat, ELISA Kit 96T
E1895m Human ELISA Kit FOR UDP-glucuronic acid decarboxylase 1 96T
CSB-EL025777RA Rat UDP-glucuronic acid decarboxylase 1(UXS1) ELISA kit 96T
CSB-EL025777RA Rat UDP-glucuronic acid decarboxylase 1(UXS1) ELISA kit SpeciesRat 96T
CSB-EL025777MO Mouse UDP-glucuronic acid decarboxylase 1(UXS1) ELISA kit 96T
I0549 UDP-glucuronic acid decarboxylase 1 (UXS1), Human, ELISA Kit 96T
CSB-EL025777HU Human UDP-glucuronic acid decarboxylase 1(UXS1) ELISA kit 96T
I0550 UDP-glucuronic acid decarboxylase 1 (UXS1), Mouse, ELISA Kit 96T
UXS1_RAT ELISA Kit FOR UDP-glucuronic acid decarboxylase 1; organism: Rat; gene name: Uxs1 96T
CSB-EL025777MO Mouse UDP-glucuronic acid decarboxylase 1(UXS1) ELISA kit SpeciesMouse 96T
CSB-EL025777HU Human UDP-glucuronic acid decarboxylase 1(UXS1) ELISA kit SpeciesHuman 96T
30-284 CSGALNACT1 is a transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). It is required for addition of the first GalNAc to the core tetrasaccha 0.05 mg
18968-14-4 D_(+)Glucuronic acid Glucuronic acid, D_(+) 1g
CSB-EL002299HU Human Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit 96T
CSB-EL002299BO Bovine Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit 96T
CSB-EL002299CH Chicken Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit 96T
CSB-EL002299MO Mouse Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit 96T
CSB-EL002299CH Chicken Bifunctional purine biosynthesis protein PURH [Includes Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit SpeciesChicken 96T
CSB-EL002299BO Bovine Bifunctional purine biosynthesis protein PURH [Includes Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit SpeciesBovine 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur