Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Bifunctional polymyxin resistance protein ArnA [Includes: UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating (EC 1.1.1.305) (UDP-glucuronic acid dehydrogenase) (UDP-GlcUA decarboxylase) (ArnADH); UDP-4-amino-4-deoxy-L-arabinose formyltransferase (EC 2.1.2.13) (UDP-L-Ara4N formyltransferase) (ArnAFT)]

 K1J0X5_9GAMM            Unreviewed;       663 AA.
K1J0X5;
28-NOV-2012, integrated into UniProtKB/TrEMBL.
28-NOV-2012, sequence version 1.
07-JUN-2017, entry version 33.
RecName: Full=Bifunctional polymyxin resistance protein ArnA {ECO:0000256|HAMAP-Rule:MF_01166};
Includes:
RecName: Full=UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating {ECO:0000256|HAMAP-Rule:MF_01166};
EC=1.1.1.305 {ECO:0000256|HAMAP-Rule:MF_01166};
AltName: Full=UDP-glucuronic acid dehydrogenase {ECO:0000256|HAMAP-Rule:MF_01166};
AltName: Full=UDP-GlcUA decarboxylase {ECO:0000256|HAMAP-Rule:MF_01166};
AltName: Full=ArnADH {ECO:0000256|HAMAP-Rule:MF_01166};
Includes:
RecName: Full=UDP-4-amino-4-deoxy-L-arabinose formyltransferase {ECO:0000256|HAMAP-Rule:MF_01166};
EC=2.1.2.13 {ECO:0000256|HAMAP-Rule:MF_01166};
AltName: Full=UDP-L-Ara4N formyltransferase {ECO:0000256|HAMAP-Rule:MF_01166};
AltName: Full=ArnAFT {ECO:0000256|HAMAP-Rule:MF_01166};
Name=arnA {ECO:0000256|HAMAP-Rule:MF_01166};
ORFNames=HMPREF1168_00577 {ECO:0000313|EMBL:EKB24056.1};
Aeromonas veronii AMC34.
Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
Aeromonadaceae; Aeromonas.
NCBI_TaxID=1073383 {ECO:0000313|EMBL:EKB24056.1, ECO:0000313|Proteomes:UP000006087};
[1] {ECO:0000313|EMBL:EKB24056.1, ECO:0000313|Proteomes:UP000006087}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AMC34 {ECO:0000313|EMBL:EKB24056.1,
ECO:0000313|Proteomes:UP000006087};
The Broad Institute Genome Sequencing Platform;
Earl A., Ward D., Feldgarden M., Gevers D., Graf J., Tomasi A.,
Horneman A., Walker B., Young S.K., Zeng Q., Gargeya S.,
Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
Nusbaum C., Birren B.;
"The Genome Sequence of Aeromonas veronii AMC34.";
Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Bifunctional enzyme that catalyzes the oxidative
decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-
arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-
amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-
arabinose (UDP-L-Ara4FN). The modified arabinose is attached to
lipid A and is required for resistance to polymyxin and cationic
antimicrobial peptides. {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00657529}.
-!- CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + UDP-4-amino-4-
deoxy-beta-L-arabinose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-
formamido-beta-L-arabinose. {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00657531}.
-!- CATALYTIC ACTIVITY: UDP-alpha-D-glucuronate + NAD(+) = UDP-beta-L-
threo-pentapyranos-4-ulose + CO(2) + NADH. {ECO:0000256|HAMAP-
Rule:MF_01166, ECO:0000256|SAAS:SAAS00657567}.
-!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
biosynthesis. {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00657623}.
-!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido-
beta-L-arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L-
arabinose from UDP-alpha-D-glucuronate: step 1/3.
{ECO:0000256|HAMAP-Rule:MF_01166, ECO:0000256|SAAS:SAAS00657609}.
-!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido-
beta-L-arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L-
arabinose from UDP-alpha-D-glucuronate: step 3/3.
{ECO:0000256|HAMAP-Rule:MF_01166, ECO:0000256|SAAS:SAAS00657621}.
-!- SUBUNIT: Homohexamer, formed by a dimer of trimers.
{ECO:0000256|HAMAP-Rule:MF_01166, ECO:0000256|SAAS:SAAS00657620}.
-!- SIMILARITY: In the C-terminal section; belongs to the NAD(P)-
dependent epimerase/dehydratase family. UDP-glucuronic acid
decarboxylase subfamily. {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00657606}.
-!- SIMILARITY: In the N-terminal section; belongs to the Fmt family.
UDP-L-Ara4N formyltransferase subfamily. {ECO:0000256|HAMAP-
Rule:MF_01166, ECO:0000256|SAAS:SAAS00657608}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_01166}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:EKB24056.1}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AGWU01000006; EKB24056.1; -; Genomic_DNA.
RefSeq; WP_005341908.1; NZ_JH823256.1.
EnsemblBacteria; EKB24056; EKB24056; HMPREF1168_00577.
PATRIC; fig|1073383.3.peg.584; -.
UniPathway; UPA00030; -.
UniPathway; UPA00032; UER00492.
UniPathway; UPA00032; UER00494.
Proteomes; UP000006087; Unassembled WGS sequence.
GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
GO; GO:0099619; F:UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity; IEA:UniProtKB-EC.
GO; GO:0099618; F:UDP-glucuronic acid dehydrogenase activity; IEA:UniProtKB-EC.
GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
Gene3D; 3.10.25.10; -; 1.
Gene3D; 3.40.50.170; -; 1.
HAMAP; MF_01166; ArnA; 1.
InterPro; IPR021168; Bifun_polymyxin_resist_ArnA.
InterPro; IPR001509; Epimerase_deHydtase.
InterPro; IPR005793; Formyl_trans_C.
InterPro; IPR002376; Formyl_transf_N.
InterPro; IPR011034; Formyl_transferase_C-like.
InterPro; IPR016040; NAD(P)-bd_dom.
Pfam; PF01370; Epimerase; 1.
Pfam; PF02911; Formyl_trans_C; 1.
Pfam; PF00551; Formyl_trans_N; 1.
PIRSF; PIRSF036506; Bifun_polymyxin_resist_ArnA; 1.
SUPFAM; SSF50486; SSF50486; 1.
SUPFAM; SSF51735; SSF51735; 1.
SUPFAM; SSF53328; SSF53328; 1.
3: Inferred from homology;
Antibiotic resistance {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00657527};
Complete proteome {ECO:0000313|Proteomes:UP000006087};
Lipid A biosynthesis {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00657624};
Lipid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00657624};
Lipid metabolism {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00657624};
Lipopolysaccharide biosynthesis {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00657587};
Multifunctional enzyme {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00657604};
NAD {ECO:0000256|HAMAP-Rule:MF_01166, ECO:0000256|SAAS:SAAS00657548};
Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00657599};
Transferase {ECO:0000256|HAMAP-Rule:MF_01166,
ECO:0000256|SAAS:SAAS00657534}.
DOMAIN 26 172 Formyl_trans_N.
{ECO:0000259|Pfam:PF00551}.
DOMAIN 202 294 Formyl_trans_C.
{ECO:0000259|Pfam:PF02911}.
DOMAIN 320 568 Epimerase. {ECO:0000259|Pfam:PF01370}.
NP_BIND 370 371 NAD binding. {ECO:0000256|HAMAP-
Rule:MF_01166}.
REGION 1 304 Formyltransferase ArnAFT.
{ECO:0000256|HAMAP-Rule:MF_01166}.
REGION 136 140 10-formyltetrahydrofolate binding.
{ECO:0000256|HAMAP-Rule:MF_01166}.
REGION 316 663 Dehydrogenase ArnADH. {ECO:0000256|HAMAP-
Rule:MF_01166}.
REGION 434 435 UDP-glucuronate binding.
{ECO:0000256|HAMAP-Rule:MF_01166}.
REGION 528 537 UDP-glucuronate binding.
{ECO:0000256|HAMAP-Rule:MF_01166}.
ACT_SITE 104 104 Proton donor; for formyltransferase
activity. {ECO:0000256|HAMAP-
Rule:MF_01166}.
ACT_SITE 436 436 Proton acceptor; for decarboxylase
activity. {ECO:0000256|HAMAP-
Rule:MF_01166}.
ACT_SITE 621 621 Proton donor; for decarboxylase activity.
{ECO:0000256|HAMAP-Rule:MF_01166}.
BINDING 114 114 10-formyltetrahydrofolate.
{ECO:0000256|HAMAP-Rule:MF_01166}.
BINDING 349 349 NAD. {ECO:0000256|HAMAP-Rule:MF_01166}.
BINDING 395 395 UDP-glucuronate; via carbonyl oxygen.
{ECO:0000256|HAMAP-Rule:MF_01166}.
BINDING 400 400 UDP-glucuronate. {ECO:0000256|HAMAP-
Rule:MF_01166}.
BINDING 462 462 UDP-glucuronate. {ECO:0000256|HAMAP-
Rule:MF_01166}.
BINDING 494 494 UDP-glucuronate. {ECO:0000256|HAMAP-
Rule:MF_01166}.
BINDING 615 615 UDP-glucuronate. {ECO:0000256|HAMAP-
Rule:MF_01166}.
SITE 102 102 Transition state stabilizer.
{ECO:0000256|HAMAP-Rule:MF_01166}.
SITE 140 140 Raises pKa of active site His.
{ECO:0000256|HAMAP-Rule:MF_01166}.
SEQUENCE 663 AA; 74322 MW; E53A3F6A086D6557 CRC64;
MNVVVFAYHD IGCTGIESLL QAGYQIQAVF THADDPGENR FFDSVAQLCA EHDLPVFSPE
DVNHPLWIER IRELAPEAIF SFYYRNMLKQ EILDIPTVGA FNLHGSLLPA YRGRAPINWC
LVNGERETGM TLHQMTARAD AGDILARQAV TIAHDDTALT LHGKMRQAAR ALLEGELVKL
KRGDATFTPQ DESKASYYGR RTPADGELRW DKPASDLYNL VRAVTQPYPG AFSFAGDRKL
TVWQAKPLAI QSDLQPGTIL SHDPLRVACG EGVLEILTGQ AEGGLYVRGA QLARELGLVE
GMKIGAKASN ALRKARLTRV LILGVNGFIG NHLTERLLKD GGYEVYGLDI GSSAVDRFIG
HPNFHFVEGD ISIHTEWIEY HIKKCDVILP LVAIATPIEY TRNPLRVFEL DFEENLKIVR
YCVKYNKRII FPSTSEVYGM CDDHSFDEDS SRLIVGPINK QRWIYSVSKQ LLDRVIWAYG
KKEGLNFTLF RPFNWMGPRL DSLDSARIGS SRAITQLILN LVDGTPIQLV DGGAQKRCFT
DIEDGIEALF RIVENKSDRC NGQIINIGNP DNEASIREMA EVLLAKFDAH PLRDHFPPFA
GFKLVESKSF YGDGYQDVSH RRPSIRNARK LIDWEPTIEM EETIGKTLDF FLQGAVTTGV
EHD


Related products :

Catalog number Product name Quantity
30-461 CSGlcA-T belongs to the chondroitin N-acetylgalactosaminyltransferase family. It transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elong 0.05 mg
26-230 ChGn transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). This protein is required for addition of the first GalNAc to the core tetrasacchar 0.05 mg
EIAAB45515 Rat,Rattus norvegicus,UDP-glucuronate decarboxylase 1,UDP-glucuronic acid decarboxylase 1,UGD,Uxs1,UXS-1
EIAAB45517 Mouse,Mus musculus,UDP-glucuronate decarboxylase 1,UDP-glucuronic acid decarboxylase 1,UGD,Uxs1,UXS-1
E1749h Rat ELISA Kit FOR UDP-glucuronic acid decarboxylase 1 96T
EIAAB45516 Homo sapiens,Human,UDP-glucuronate decarboxylase 1,UDP-glucuronic acid decarboxylase 1,UGD,UNQ2538_PRO6079,UXS1,UXS-1
I0551 UDP-glucuronic acid decarboxylase 1 (UXS1), Rat, ELISA Kit 96T
E1895m Human ELISA Kit FOR UDP-glucuronic acid decarboxylase 1 96T
CSB-EL025777RA Rat UDP-glucuronic acid decarboxylase 1(UXS1) ELISA kit 96T
CSB-EL025777RA Rat UDP-glucuronic acid decarboxylase 1(UXS1) ELISA kit SpeciesRat 96T
CSB-EL025777MO Mouse UDP-glucuronic acid decarboxylase 1(UXS1) ELISA kit 96T
I0549 UDP-glucuronic acid decarboxylase 1 (UXS1), Human, ELISA Kit 96T
CSB-EL025777HU Human UDP-glucuronic acid decarboxylase 1(UXS1) ELISA kit 96T
I0550 UDP-glucuronic acid decarboxylase 1 (UXS1), Mouse, ELISA Kit 96T
UXS1_RAT ELISA Kit FOR UDP-glucuronic acid decarboxylase 1; organism: Rat; gene name: Uxs1 96T
CSB-EL025777MO Mouse UDP-glucuronic acid decarboxylase 1(UXS1) ELISA kit SpeciesMouse 96T
CSB-EL025777HU Human UDP-glucuronic acid decarboxylase 1(UXS1) ELISA kit SpeciesHuman 96T
30-284 CSGALNACT1 is a transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). It is required for addition of the first GalNAc to the core tetrasaccha 0.05 mg
18968-14-4 D_(+)Glucuronic acid Glucuronic acid, D_(+) 1g
CSB-EL002299HU Human Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit 96T
CSB-EL002299BO Bovine Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit 96T
CSB-EL002299CH Chicken Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit 96T
CSB-EL002299MO Mouse Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit 96T
CSB-EL002299CH Chicken Bifunctional purine biosynthesis protein PURH [Includes Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit SpeciesChicken 96T
CSB-EL002299BO Bovine Bifunctional purine biosynthesis protein PURH [Includes Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit SpeciesBovine 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur