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Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase); Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase)]

 GAL10_KLULA             Reviewed;         688 AA.
P09609; Q6CKS7;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
27-SEP-2004, sequence version 2.
23-MAY-2018, entry version 135.
RecName: Full=Bifunctional protein GAL10;
Includes:
RecName: Full=UDP-glucose 4-epimerase;
EC=5.1.3.2;
AltName: Full=Galactowaldenase;
Includes:
RecName: Full=Aldose 1-epimerase;
EC=5.1.3.3;
AltName: Full=Galactose mutarotase;
Name=GAL10; OrderedLocusNames=KLLA0F08415g;
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC
1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
NCBI_TaxID=284590;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
WM37;
PubMed=3419917; DOI=10.1093/nar/16.16.8192;
Webster T.D., Dickson R.C.;
"Nucleotide sequence of the galactose gene cluster of Kluyveromyces
lactis.";
Nucleic Acids Res. 16:8192-8194(1988).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
WM37;
PubMed=15229592; DOI=10.1038/nature02579;
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
-!- FUNCTION: Mutarotase converts alpha-aldose to the beta-anomer. It
is active on D-glucose, L-arabinose, D-xylose, D-galactose,
maltose and lactose (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: UDP-alpha-D-glucose = UDP-alpha-D-galactose.
-!- CATALYTIC ACTIVITY: Alpha-D-glucose = beta-D-glucose.
{ECO:0000255|PROSITE-ProRule:PRU10126}.
-!- COFACTOR:
Name=NAD(+); Xref=ChEBI:CHEBI:57540;
-!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
-!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
-!- INDUCTION: By galactose.
-!- SIMILARITY: In the N-terminal section; belongs to the NAD(P)-
dependent epimerase/dehydratase family. {ECO:0000305}.
-!- SIMILARITY: In the C-terminal section; belongs to the aldose
epimerase family. {ECO:0000305}.
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EMBL; X07039; CAA30090.1; -; Genomic_DNA.
EMBL; CR382126; CAG98170.1; -; Genomic_DNA.
PIR; S01407; XUVKG.
RefSeq; XP_455462.1; XM_455462.1.
ProteinModelPortal; P09609; -.
SMR; P09609; -.
STRING; 284590.XP_455462.1; -.
EnsemblFungi; CAG98170; CAG98170; KLLA0_F08415g.
GeneID; 2894953; -.
KEGG; kla:KLLA0F08415g; -.
eggNOG; KOG1371; Eukaryota.
eggNOG; COG1087; LUCA.
eggNOG; COG2017; LUCA.
HOGENOM; HOG000247896; -.
InParanoid; P09609; -.
KO; K01784; -.
KO; K01785; -.
OMA; YREWNLG; -.
OrthoDB; EOG092C4CZ3; -.
UniPathway; UPA00214; -.
UniPathway; UPA00242; -.
Proteomes; UP000000598; Chromosome F.
GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
GO; GO:0033499; P:galactose catabolic process via UDP-galactose; IEA:EnsemblFungi.
CDD; cd05247; UDP_G4E_1_SDR_e; 1.
Gene3D; 2.70.98.10; -; 1.
InterPro; IPR018052; Ald1_epimerase_CS.
InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
InterPro; IPR001509; Epimerase_deHydtase.
InterPro; IPR011013; Gal_mutarotase_sf_dom.
InterPro; IPR014718; GH-type_carb-bd.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR005886; UDP_G4E.
Pfam; PF01263; Aldose_epim; 1.
Pfam; PF01370; Epimerase; 1.
SUPFAM; SSF51735; SSF51735; 1.
SUPFAM; SSF74650; SSF74650; 1.
TIGRFAMs; TIGR01179; galE; 1.
PROSITE; PS00545; ALDOSE_1_EPIMERASE; 1.
2: Evidence at transcript level;
Carbohydrate metabolism; Complete proteome; Galactose metabolism;
Isomerase; Multifunctional enzyme; NAD; Reference proteome.
CHAIN 1 688 Bifunctional protein GAL10.
/FTId=PRO_0000197439.
NP_BIND 6 37 NAD. {ECO:0000255}.
REGION 1 346 Galactowaldenase.
REGION 347 688 Mutarotase.
ACT_SITE 525 525 For mutarotase activity. {ECO:0000255}.
CONFLICT 199 201 DPL -> AF (in Ref. 1; CAA30090).
{ECO:0000305}.
SEQUENCE 688 AA; 76359 MW; 1BB0087A2D6C574A CRC64;
MSEDKYCLVT GGAGYIGSHT VVELCEAGYK CIVVDNLSNS SYESVARMEL LTGQEIKFAK
IDLCELEPLN KLFDDYKIDS VLHFAGLKAV GESTQIPLTY YFNNIVGTIN LLECMKSHDV
KKLVFSSSAT VYGDATRFEN MIPIPETCPT GPTNPYGKTK LTIEDMMRDL HFSDKSFSFA
ILRYFNPIGA HPSGVIGEDP LGIPNNLLPF MAQVAIGRRP KLYVFGDDYD SVDGTPIRDY
IHVVDLAKGH LAALKYLEKY AGTCREWNLG TGHGTTVLQM YRAFCDAIGF NFEYVVTARR
DGDVLNLTAK CDRATNELEW KTELDVNKAC VDLWKWTQDN PFGYQIKGVD SKFFGDKGDF
SSRVVSLGKG TSFEVKLANL GATIVDIVVN GCSVVASLDN ETEYKDQSNP FFGATVGPYA
NRIANGTFEI NGKRIQLTVS KEDGNVVHSG INSYHSKKFL GPIVKNPEAH IWTADFKYVD
EETEFPARLS TLVRYKVDSE KKTLTVEYES KVAGQGSTGA NITNHTYFNL NKFNEATIKG
SKVQLIDNTG LEVNNKLLPT GNLKKYTQVA TFNDSPTEIT EKEPVLDFCF VSGLPAKLDT
RSSPLTPVFK LSNEDAKLEV EVATTEPTFQ VYTGDYVDVK DKYENRAGIC CEPGRYIDAV
NNPEWKSSVV LPAGETYGHK LSYTFRTL


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