Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Bifunctional purine synthesis protein purC/E [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)]

 PURCE_DICDI             Reviewed;         997 AA.
Q54QE4;
03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
24-MAY-2005, sequence version 1.
22-NOV-2017, entry version 86.
RecName: Full=Bifunctional purine synthesis protein purC/E;
Includes:
RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase;
EC=6.3.2.6;
AltName: Full=SAICAR synthetase;
Includes:
RecName: Full=Phosphoribosylaminoimidazole carboxylase;
EC=4.1.1.21;
AltName: Full=AIR carboxylase;
Short=AIRC;
Name=purC/E; Synonyms=purC, purE; ORFNames=DDB_G0283987;
Dictyostelium discoideum (Slime mold).
Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
NCBI_TaxID=44689;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
PubMed=15875012; DOI=10.1038/nature03481;
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
[2]
PROTEIN SEQUENCE OF 76-98; 161-169; 643-654; 676-689; 712-720; 761-768
AND 823-837, AND IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=AX2;
Bienvenut W.V., Sumpton D., Ura S., Insall R.H.;
Submitted (OCT-2008) to UniProtKB.
-!- FUNCTION: Bifunctional enzyme involved in de novo IMP synthesis,
an essential step for de nove purine synthesis. {ECO:0000250}.
-!- CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-
ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate +
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
carboxamido)succinate.
-!- CATALYTIC ACTIVITY: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
-!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-
amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step
1/1.
-!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-
amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
-!- SIMILARITY: In the N-terminal section; belongs to the SAICAR
synthetase family. {ECO:0000305}.
-!- SIMILARITY: In the C-terminal section; belongs to the AIR
carboxylase family. Class I subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AAFI02000058; EAL65481.1; -; Genomic_DNA.
RefSeq; XP_638800.1; XM_633708.1.
ProteinModelPortal; Q54QE4; -.
SMR; Q54QE4; -.
STRING; 44689.DDB0230088; -.
PaxDb; Q54QE4; -.
PRIDE; Q54QE4; -.
EnsemblProtists; EAL65481; EAL65481; DDB_G0283987.
GeneID; 8624324; -.
KEGG; ddi:DDB_G0283987; -.
dictyBase; DDB_G0283987; purC/E.
eggNOG; ENOG410IMSB; Eukaryota.
eggNOG; ENOG410IMSC; Eukaryota.
eggNOG; KOG2835; Eukaryota.
eggNOG; COG0026; LUCA.
eggNOG; COG0041; LUCA.
eggNOG; COG0152; LUCA.
InParanoid; Q54QE4; -.
OMA; FENIMVE; -.
UniPathway; UPA00074; UER00130.
UniPathway; UPA00074; UER00131.
PRO; PR:Q54QE4; -.
Proteomes; UP000002195; Chromosome 4.
Proteomes; UP000002195; Unassembled WGS sequence.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity; ISS:dictyBase.
GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; ISS:dictyBase.
GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0006144; P:purine nucleobase metabolic process; ISS:dictyBase.
Gene3D; 3.30.1490.20; -; 1.
Gene3D; 3.40.50.7700; -; 1.
HAMAP; MF_01929; PurE_classI; 1.
HAMAP; MF_01928; PurK; 1.
HAMAP; MF_00137; SAICAR_synth; 1.
InterPro; IPR011761; ATP-grasp.
InterPro; IPR003135; ATP-grasp_carboxylate-amine.
InterPro; IPR013815; ATP_grasp_subdomain_1.
InterPro; IPR016185; PreATP-grasp_dom_sf.
InterPro; IPR033747; PurE_ClassI.
InterPro; IPR000031; PurE_dom.
InterPro; IPR035893; PurE_sf.
InterPro; IPR005875; PurK.
InterPro; IPR011054; Rudment_hybrid_motif.
InterPro; IPR028923; SAICAR_synt/ADE2_N.
InterPro; IPR018236; SAICAR_synthetase_CS.
Pfam; PF00731; AIRC; 1.
Pfam; PF02222; ATP-grasp; 1.
Pfam; PF01259; SAICAR_synt; 1.
SMART; SM01001; AIRC; 1.
SUPFAM; SSF51246; SSF51246; 1.
SUPFAM; SSF52255; SSF52255; 1.
SUPFAM; SSF52440; SSF52440; 1.
TIGRFAMs; TIGR01162; purE; 1.
TIGRFAMs; TIGR01161; purK; 1.
PROSITE; PS50975; ATP_GRASP; 1.
PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
1: Evidence at protein level;
ATP-binding; Complete proteome; Decarboxylase;
Direct protein sequencing; Ligase; Lyase; Magnesium; Manganese;
Metal-binding; Multifunctional enzyme; Nucleotide-binding;
Purine biosynthesis; Reference proteome.
CHAIN 1 997 Bifunctional purine synthesis protein
purC/E.
/FTId=PRO_0000388376.
DOMAIN 732 927 ATP-grasp.
NP_BIND 807 810 ATP. {ECO:0000250}.
NP_BIND 897 898 ATP. {ECO:0000250}.
REGION 1 ?305 SAICAR synthetase.
REGION ?305 997 AIR carboxylase.
COMPBIAS 67 70 Poly-Thr.
COMPBIAS 293 311 Poly-Asn.
COMPBIAS 334 340 His-rich.
COMPBIAS 341 344 Poly-Gln.
COMPBIAS 349 354 Poly-Asn.
COMPBIAS 524 535 Poly-Thr.
COMPBIAS 561 568 Poly-Gln.
METAL 880 880 Magnesium or manganese. {ECO:0000250}.
METAL 898 898 Magnesium or manganese. {ECO:0000250}.
BINDING 728 728 ATP. {ECO:0000250}.
BINDING 768 768 ATP. {ECO:0000250}.
BINDING 779 779 ATP. {ECO:0000250}.
BINDING 815 815 ATP. {ECO:0000250}.
SEQUENCE 997 AA; 108939 MW; 09B1DA8B64E07D00 CRC64;
MTTAINNNIV NKEFDLKDKT FLASGKTKTI YQLNKEDQYV LIESNSAITA GDGAKKDILP
NKDIYSTTTT VNNFKVLQLS GINTHFVKQV EPNAFIAKKC SMIPLEVIVR RLATGSYLKR
NTHVTEGTKF NPPLIEFTFK DDVQHDPLVT EQDILEMNLK IGGVPITSKL LSQTRHIATL
SFEALERAWQ SLDVTLVDFK VEFGITSQGE LILADVIDND SWRIWPKGDK TLMKDKQVYR
NLPSALNTPG ATPTTQSGPL LNTLSDQQLK MIEDNYAWVA TSTEKLVEFT AANLNNNNNN
NNNNSNNNNN NTSSTSRSNS LPNVPSITTT PTLHHHHHHH QQQQSGVGNN NNVNSGFQVQ
LNQPLVGIIM GSQSDWETMK LAANTLTTLG VPFETRIVSA HRTPDRLFEY AKTAKSRGLK
IVIAGAGGAA HLPGMVAALT PLPVFGVPVQ SKALSGVDSL LSIVQMPAGI PVGTVAIGAA
GATNAALLSA AVLAPYYPSI ELSLDLYRKK QTDAVAEIPV DNPTSTSTTT TTTTTSNATS
ILSAIHTSTI NSNTSSHNNN QQQQQQQQTI LPTQPTIINT PTPVRSSVSR SQSPLPSGNG
SSIISQEKTP LSTFVLSTCR PSALVLPPGS TIGILGGGQL ARMMAIAAAQ LGYKTHIFCP
ENDPSASHVA TYTTKSNYNN YSALDIFARQ VDVVTYEFEN IMVEPVEYLT KQVAVFPDPK
ILRTCQDRVL EKTFIQSLDI PTAQFQSVES FNDLKSAIEK IGYPAILKSN TMGYDGKGQV
KLTDQVDLEQ AWKKVTSETC ATKAILEQYI EFESEASVIV ARALDGTELT FPLVTNKHRN
HILRQTIAPA QLPEYIHKQA NEIGLKIARS NGLVGIIAVE LFVVKNNETG QYSLMVNELA
PRPHNSGHWT IEGCVTSQFE QLIRCVCGLP LGSVDFTKRI SEAEFIQQQI PPIVMTNLLG
QEVNGWEKIL QTKGSHLHIY AKGDAKEGRK MGHVTQQ


Related products :

Catalog number Product name Quantity
26-098 PAICS is a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal re 0.05 mg
PAIP2 PAICS Gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
201-20-4016 PAICS{phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase}rabbit.pAb 0.2ml
GS-1543a phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase primary antibody, Host: Rabbit 200ul
CSB-EL017397RA Rat phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL017397HU Human phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL017397MO Mouse phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-PA017397GA01HU Rabbit anti-human phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase polyclonal Antibody Primary antibody Host:Rabbit IgG 50ul
CSB-PA017397GA01HU Rabbit anti-human phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase polyclonal Antibody Primary antibody Host:Rabbit IgG 150ul
CSB-EL017397RA Rat Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase(PAICS) ELISA kit 96T
CSB-EL017397MO Mouse Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase(PAICS) ELISA kit 96T
CSB-EL017397RA Rat Multifunctional protein ADE2 [Includes Phosphoribosylaminoimidazole-succinocarboxamide synthase(PAICS) ELISA kit SpeciesRat 96T
CSB-EL017397HU Human Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase(PAICS) ELISA kit 96T
CSB-EL017397MO Mouse Multifunctional protein ADE2 [Includes Phosphoribosylaminoimidazole-succinocarboxamide synthase(PAICS) ELISA kit SpeciesMouse 96T
CSB-EL017397HU Human Multifunctional protein ADE2 [Includes Phosphoribosylaminoimidazole-succinocarboxamide synthase(PAICS) ELISA kit SpeciesHuman 96T
ARP46049_P050 PAICS(phosphoribosylaminoimidazole succinocarboxamide synthetase) 50 µg
201-20-2189 GART{Homo sapiens phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase, mRNA (cDNA clone IMAGE 5789599), complete cds}rabbit.pAb 0.2ml
GAS2 GART Gene phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
CSB-EL009263HU Human phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (GART) ELISA kit, Species Human, Sample Type serum, plasma 96T
EIAAB45818 Gamma-glutamyl carboxylase,GC,GGCX,Homo sapiens,Human,Peptidyl-glutamate 4-carboxylase,Vitamin K gamma glutamyl carboxylase,Vitamin K-dependent gamma-carboxylase
EIAAB45817 Bos taurus,Bovine,Gamma-glutamyl carboxylase,GC,GGCX,Peptidyl-glutamate 4-carboxylase,Vitamin K gamma glutamyl carboxylase,Vitamin K-dependent gamma-carboxylase
EIAAB45819 Gamma-glutamyl carboxylase,Ggcx,Peptidyl-glutamate 4-carboxylase,Rat,Rattus norvegicus,Vitamin K gamma glutamyl carboxylase,Vitamin K-dependent gamma-carboxylase
EIAAB45820 Gamma-glutamyl carboxylase,Ggcx,Mouse,Mus musculus,Peptidyl-glutamate 4-carboxylase,Vitamin K gamma glutamyl carboxylase,Vitamin K-dependent gamma-carboxylase
CSB-EL002299BO Bovine Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit 96T
CSB-EL002299CH Chicken Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase(ATIC) ELISA kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur