Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Bifunctional ribulose 5-phosphate reductase/CDP-ribitol pyrophosphorylase Acs1 [Includes: Ribitol-5-phosphate cytidylyltransferase (EC 2.7.7.40); Ribulose-5-phosphate reductase (Ribulose-5-P reductase) (EC 1.1.1.405) (Ribitol-5-phosphate dehydrogenase)]

 ACS1_HAEIF              Reviewed;         474 AA.
Q48154;
05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
25-OCT-2017, entry version 86.
RecName: Full=Bifunctional ribulose 5-phosphate reductase/CDP-ribitol pyrophosphorylase Acs1 {ECO:0000303|PubMed:10094675};
Includes:
RecName: Full=Ribitol-5-phosphate cytidylyltransferase {ECO:0000303|PubMed:10094675};
EC=2.7.7.40 {ECO:0000269|PubMed:10094675};
Includes:
RecName: Full=Ribulose-5-phosphate reductase {ECO:0000303|PubMed:10094675};
Short=Ribulose-5-P reductase {ECO:0000305};
EC=1.1.1.405 {ECO:0000269|PubMed:10094675};
AltName: Full=Ribitol-5-phosphate dehydrogenase {ECO:0000305};
Name=acs1 {ECO:0000303|PubMed:10094675};
Haemophilus influenzae.
Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
Pasteurellaceae; Haemophilus.
NCBI_TaxID=727 {ECO:0000312|EMBL:CAA85750.1};
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, AND
BIOPHYSICOCHEMICAL PROPERTIES.
STRAIN=ATCC 9006 / Serotype A {ECO:0000312|EMBL:CAA85750.1};
PubMed=10094675;
Follens A., Veiga-da-Cunha M., Merckx R., an Schaftingen E.,
van Eldere J.;
"acs1 of Haemophilus influenzae type a capsulation locus region II
encodes a bifunctional ribulose 5-phosphate reductase- CDP-ribitol
pyrophosphorylase.";
J. Bacteriol. 181:2001-2007(1999).
-!- FUNCTION: Catalyzes the NADPH-dependent reduction of D-ribulose 5-
phosphate to D-ribitol 5-phosphate and the further reaction of D-
ribitol 5-phosphate with CTP to form CDP-ribitol.
{ECO:0000269|PubMed:10094675}.
-!- CATALYTIC ACTIVITY: CTP + D-ribitol 5-phosphate = diphosphate +
CDP-ribitol. {ECO:0000269|PubMed:10094675}.
-!- CATALYTIC ACTIVITY: D-ribitol 5-phosphate + NADP(+) = D-ribulose
5-phosphate + NADPH. {ECO:0000269|PubMed:10094675}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=50 uM for D-ribulose 5-phosphate (in the presence of 50 uM
CTP) {ECO:0000269|PubMed:10094675};
KM=400 uM for D-ribulose 5-phosphate (in the absence of CTP)
{ECO:0000269|PubMed:10094675};
KM=10 uM for NADPH {ECO:0000269|PubMed:10094675};
KM=37 uM for D-ribitol 5-phosphate (for the cytidylyltransferase
reaction) {ECO:0000269|PubMed:10094675};
KM=150 uM for CTP {ECO:0000269|PubMed:10094675};
Vmax=9.55 umol/min/mg enzyme (for the reductase reaction in the
absence of CTP) {ECO:0000269|PubMed:10094675};
Vmax=27.9 umol/min/mg enzyme (for the reductase reaction in the
presence of 50 uM CTP) {ECO:0000269|PubMed:10094675};
Vmax=15.7 umol/min/mg enzyme (for the cytidylyltransferase
reaction) {ECO:0000269|PubMed:10094675};
pH dependence:
Optimum pH is 7-8.4 for D-ribulose 5-phosphate reductase
activity. {ECO:0000269|PubMed:10094675};
-!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
{ECO:0000305}.
-!- SIMILARITY: In the N-terminal section; belongs to the IspD/TarI
cytidylyltransferase family. {ECO:0000305}.
-!- SIMILARITY: In the C-terminal section; belongs to the short-chain
dehydrogenases/reductases (SDR) family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; Z37516; CAA85750.1; -; Genomic_DNA.
ProteinModelPortal; Q48154; -.
SMR; Q48154; -.
UniPathway; UPA00934; -.
GO; GO:0050518; F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity; IEA:InterPro.
GO; GO:0047349; F:D-ribitol-5-phosphate cytidylyltransferase activity; IEA:UniProtKB-EC.
GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
CDD; cd02516; CDP-ME_synthetase; 1.
Gene3D; 3.90.550.10; -; 1.
HAMAP; MF_00108; IspD; 1.
InterPro; IPR012115; CDP-ribitol_syn.
InterPro; IPR001228; IspD.
InterPro; IPR034683; IspD/TarI.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR029044; Nucleotide-diphossugar_trans.
InterPro; IPR020904; Sc_DH/Rdtase_CS.
InterPro; IPR002347; SDR_fam.
Pfam; PF01128; IspD; 1.
PIRSF; PIRSF036586; CDP-ribitol_syn; 1.
PRINTS; PR00081; GDHRDH.
SUPFAM; SSF51735; SSF51735; 1.
SUPFAM; SSF53448; SSF53448; 1.
PROSITE; PS00061; ADH_SHORT; 1.
1: Evidence at protein level;
Capsule biogenesis/degradation; NADP; Nucleotidyltransferase;
Oxidoreductase; Transferase.
CHAIN 1 474 Bifunctional ribulose 5-phosphate
reductase/CDP-ribitol pyrophosphorylase
Acs1.
/FTId=PRO_0000437505.
REGION 1 238 Ribitol-5-phosphate cytidylyltransferase.
REGION 250 474 Ribulose-5-phosphate reductase.
SEQUENCE 474 AA; 52438 MW; A8FEBE0FF6452BF7 CRC64;
MLKNKNIGII LAGGIGSRMG LGYPKQFSKI AGKTALEHTI FIFQEHKEID EIIIVSERTS
YRRIEDIVSK AGFSKVNRII FGGKERSDST LSAITALQDE PRNTKLIIHD AVRPLLATEI
ISECIAKLDK YNAVDVAIPA VDTIVHVNND TQEIIKIPKR AEYYQGQTPQ AFKLGTLKKA
YDIYTQGGIE GTCDCSIVLK TLPEERVGIV SGFETNIKLT RPVDLFIADK LFQSRSHFSL
RNITSIDRLY DMKDQVLVVI GGSYGIGAHI IDVAKKFGIK TYSLSRSNGV DVGDVKSIEK
AFAGIYGKEH KIDHIVNTAA VLNHKTLASM SYEEIVTSIN VNYTGMINAV ITAYPYLKQT
HGSFLGFTSS SYTRGRPFYA IYSSAKAAVV NLTQAISEEW LPDNIKINCV NPERTKTPMR
TKAFGIEPEG TLLDPKTVAF ASLTVLASRE TGNIIDVVLK DEEYISHILA DLYK


Related products :

Catalog number Product name Quantity
EIAAB35839 Homo sapiens,Human,HUSSY-17,Ribulose-5-phosphate-3-epimerase,Ribulose-phosphate 3-epimerase,RPE
EIAAB35838 Mouse,Mus musculus,Ribulose-5-phosphate-epimerase,Ribulose-phosphate 3-epimerase,Rpe
CF37 Ribulose-Phosphate 3-Epimerase RPE 500
RPE RPE Gene ribulose-5-phosphate-3-epimerase
CF37 Ribulose-Phosphate 3-Epimerase RPE lmg
201-20-4964 RPE{ribulose-5-phosphate-3-epimerase}rabbit.pAb 0.2ml
enz-584 Recombinant Human Ribulose-5-Phosphate-3-Epimerase 20
C532 Human Ribulose-Phosphate 3-Epimerase RPE l0
REN-584 Recombinant Human Ribulose-5-Phosphate-3-Epimerase 5
enz-584 Recombinant Human Ribulose-5-Phosphate-3-Epimerase 5
enz-584 Recombinant Human Ribulose-5-Phosphate-3-Epimerase 1mg
C034 Human Ribulose-Phosphate 3-Epimerase RPE 50
enz-584 Recombinant Human Ribulose-5-Phosphate-3-Epimerase ENZYMES 20
CF37 Recombinant Human Ribulose-Phosphate 3-Epimerase_RPE 500 ug
enz-584 Recombinant Human Ribulose-5-Phosphate-3-Epimerase ENZYMES 5
CF37 Recombinant Human Ribulose-Phosphate 3-Epimerase_RPE 50 ug
CF37 Recombinant Human Ribulose-Phosphate 3-Epimerase_RPE 10 ug
G8040 Ribulose-phosphate 3-epimerase (RPE), Human, ELISA Kit 96T
CSB-EL020097HU Human Ribulose-phosphate 3-epimerase(RPE) ELISA kit 96T
enz-584 Recombinant Human Ribulose-5-Phosphate-3-Epimerase ENZYMES 1mg
G8041 Ribulose-phosphate 3-epimerase (RPE), Mouse, ELISA Kit 96T
CSB-EL020097MO Mouse Ribulose-phosphate 3-epimerase(RPE) ELISA kit 96T
CF37 Recombinant Human Ribulose-Phosphate 3-Epimerase_RPE 1 mg
CF37 Recombinant Human Ribulose-Phosphate 3-Epimerase per RPE (C-6His) 10ug
CSB-EL020097HU Human Ribulose-phosphate 3-epimerase(RPE) ELISA kit SpeciesHuman 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur