Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Biofilm regulator 1

 BRG1_CANAL              Reviewed;         422 AA.
Q59LY1; A0A1D8PDH2;
26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
15-MAR-2017, sequence version 2.
28-MAR-2018, entry version 81.
RecName: Full=Biofilm regulator 1;
Name=BRG1; Synonyms=GAT2; OrderedLocusNames=CAALFM_C105140WA;
ORFNames=CaO19.11538, CaO19.4056;
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
Candida/Lodderomyces clade; Candida.
NCBI_TaxID=237561;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=15123810; DOI=10.1073/pnas.0401648101;
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
Davis R.W., Scherer S.;
"The diploid genome sequence of Candida albicans.";
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
[2]
GENOME REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
Chibana H., Nantel A., Magee P.T.;
"Assembly of the Candida albicans genome into sixteen supercontigs
aligned on the eight chromosomes.";
Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME
REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
"Assembly of a phased diploid Candida albicans genome facilitates
allele-specific measurements and provides a simple model for repeat
and indel structure.";
Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
[4]
FUNCTION.
PubMed=12773383; DOI=10.1093/emboj/cdg256;
Uhl M.A., Biery M., Craig N., Johnson A.D.;
"Haploinsufficiency-based large-scale forward genetic analysis of
filamentous growth in the diploid human fungal pathogen C.albicans.";
EMBO J. 22:2668-2678(2003).
[5]
INDUCTION.
PubMed=18321992; DOI=10.1091/mbc.E07-09-0960;
Goyard S., Knechtle P., Chauvel M., Mallet A., Prevost M.C., Proux C.,
Coppee J.Y., Schwartz P., Dromer F., Park H., Filler S.G., Janbon G.,
d'Enfert C.;
"The Yak1 kinase is involved in the initiation and maintenance of
hyphal growth in Candida albicans.";
Mol. Biol. Cell 19:2251-2266(2008).
[6]
FUNCTION.
PubMed=20041210; DOI=10.1371/journal.pgen.1000783;
Homann O.R., Dea J., Noble S.M., Johnson A.D.;
"A phenotypic profile of the Candida albicans regulatory network.";
PLoS Genet. 5:E1000783-E1000783(2009).
[7]
INDUCTION.
PubMed=21414038; DOI=10.1111/j.1365-2958.2011.07626.x;
Bonhomme J., Chauvel M., Goyard S., Roux P., Rossignol T.,
d'Enfert C.;
"Contribution of the glycolytic flux and hypoxia adaptation to
efficient biofilm formation by Candida albicans.";
Mol. Microbiol. 80:995-1013(2011).
[8]
FUNCTION.
PubMed=22757963; DOI=10.1111/j.1365-2958.2012.08127.x;
Cleary I.A., Lazzell A.L., Monteagudo C., Thomas D.P., Saville S.P.;
"BRG1 and NRG1 form a novel feedback circuit regulating Candida
albicans hypha formation and virulence.";
Mol. Microbiol. 85:557-573(2012).
[9]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=22276126; DOI=10.1371/journal.pone.0029707;
Du H., Guan G., Xie J., Sun Y., Tong Y., Zhang L., Huang G.;
"Roles of Candida albicans Gat2, a GATA-type zinc finger transcription
factor, in biofilm formation, filamentous growth and virulence.";
PLoS ONE 7:E29707-E29707(2012).
[10]
FUNCTION.
PubMed=23049891; DOI=10.1371/journal.pone.0045912;
Chauvel M., Nesseir A., Cabral V., Znaidi S., Goyard S.,
Bachellier-Bassi S., Firon A., Legrand M., Diogo D., Naulleau C.,
Rossignol T., d'Enfert C.;
"A versatile overexpression strategy in the pathogenic yeast Candida
albicans: identification of regulators of morphogenesis and fitness.";
PLoS ONE 7:E45912-E45912(2012).
[11]
FUNCTION, INTERACTION WITH HDA1, SUBCELLULAR LOCATION, AND
DNA-BINDING.
PubMed=22536157; DOI=10.1371/journal.ppat.1002663;
Lu Y., Su C., Liu H.;
"A GATA transcription factor recruits Hda1 in response to reduced Tor1
signaling to establish a hyphal chromatin state in Candida albicans.";
PLoS Pathog. 8:E1002663-E1002663(2012).
[12]
FUNCTION, AND INDUCTION.
PubMed=23171549; DOI=10.1091/mbc.E12-06-0477;
Su C., Lu Y., Liu H.;
"Reduced TOR signaling sustains hyphal development in Candida albicans
by lowering Hog1 basal activity.";
Mol. Biol. Cell 24:385-397(2013).
[13]
FUNCTION IN WHITE-OPAQUE SWITCHING.
PubMed=23555196; DOI=10.1371/journal.pbio.1001525;
Xie J., Tao L., Nobile C.J., Tong Y., Guan G., Sun Y., Cao C.,
Hernday A.D., Johnson A.D., Zhang L., Bai F.Y., Huang G.;
"White-opaque switching in natural MTLa/alpha isolates of Candida
albicans: evolutionary implications for roles in host adaptation,
pathogenesis, and sex.";
PLoS Biol. 11:E1001525-E1001525(2013).
[14]
FUNCTION.
PubMed=23637598; DOI=10.1371/journal.ppat.1003305;
Lin C.H., Kabrawala S., Fox E.P., Nobile C.J., Johnson A.D.,
Bennett R.J.;
"Genetic control of conventional and pheromone-stimulated biofilm
formation in Candida albicans.";
PLoS Pathog. 9:E1003305-E1003305(2013).
-!- FUNCTION: Transcription factor required for hyphal growth, biofilm
formation, and virulence. Promotes formation of both conventional
and pheromone-stimulated biofilms. Binds and recruits HDA1 to
promoters of hypha-specific genes in a rapamycin-dependent manner.
Involved in the switch between two heritable states, the white and
opaque states. These two cell types differ in many
characteristics, including cell structure, mating competence, and
virulence. Each state is heritable for many generations, and
switching between states occurs stochastically at low frequency.
{ECO:0000269|PubMed:12773383, ECO:0000269|PubMed:20041210,
ECO:0000269|PubMed:22276126, ECO:0000269|PubMed:22536157,
ECO:0000269|PubMed:22757963, ECO:0000269|PubMed:23049891,
ECO:0000269|PubMed:23171549, ECO:0000269|PubMed:23555196,
ECO:0000269|PubMed:23637598}.
-!- SUBUNIT: Interacts with HDA1. {ECO:0000269|PubMed:22536157}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22536157}.
-!- INDUCTION: Up-regulation during the yeast-to-hypha transition is
dependent upon the function of YAK1. HOG1 represses the expression
of BRG1 via the transcriptional repressor SKO1. Regulated by TYE7
during late-stage biofilm formation. {ECO:0000269|PubMed:18321992,
ECO:0000269|PubMed:21414038, ECO:0000269|PubMed:23171549}.
-!- DISRUPTION PHENOTYPE: Attenuates virulence in a mouse model of
systemic infection. {ECO:0000269|PubMed:22276126}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; CP017623; AOW26184.1; -; Genomic_DNA.
RefSeq; XP_710725.2; XM_705633.2.
ProteinModelPortal; Q59LY1; -.
SMR; Q59LY1; -.
PRIDE; Q59LY1; -.
EnsemblFungi; AOW26184; AOW26184; CAALFM_C105140WA.
GeneID; 3647664; -.
KEGG; cal:CAALFM_C105140WA; -.
CGD; CAL0000196982; BRG1.
InParanoid; Q59LY1; -.
OrthoDB; EOG092C1ZL9; -.
PRO; PR:Q59LY1; -.
Proteomes; UP000000559; Chromosome 1.
GO; GO:0000790; C:nuclear chromatin; IDA:CGD.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005667; C:transcription factor complex; IBA:GO_Central.
GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0001085; F:RNA polymerase II transcription factor binding; IBA:GO_Central.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:CGD.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
GO; GO:0030447; P:filamentous growth; IMP:CGD.
GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
GO; GO:0009405; P:pathogenesis; IMP:CGD.
GO; GO:1900430; P:positive regulation of filamentous growth of a population of unicellular organisms; IMP:CGD.
GO; GO:1900233; P:positive regulation of single-species biofilm formation on inanimate substrate; IMP:CGD.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:CGD.
GO; GO:0044011; P:single-species biofilm formation on inanimate substrate; IMP:CGD.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR000679; Znf_GATA.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00320; GATA; 1.
SMART; SM00401; ZnF_GATA; 1.
PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
1: Evidence at protein level;
Cell adhesion; Complete proteome; Metal-binding; Nucleus;
Reference proteome; Transcription; Transcription regulation;
Virulence; Zinc; Zinc-finger.
CHAIN 1 422 Biofilm regulator 1.
/FTId=PRO_0000422799.
ZN_FING 282 307 GATA-type. {ECO:0000255|PROSITE-
ProRule:PRU00094}.
COMPBIAS 2 79 Ser-rich. {ECO:0000255|PROSITE-
ProRule:PRU00016}.
COMPBIAS 115 235 Pro-rich. {ECO:0000255|PROSITE-
ProRule:PRU00015}.
COMPBIAS 127 225 Gln-rich. {ECO:0000255|PROSITE-
ProRule:PRU00006}.
COMPBIAS 354 417 Gln-rich. {ECO:0000255|PROSITE-
ProRule:PRU00006}.
SEQUENCE 422 AA; 45513 MW; 41BA1B04FEBC4F7A CRC64;
MSSSSSLSSS TTTATTTSAR IRLPSISELT SRSTISGGSN NGNGSALKSQ ISPRLSDTSR
ILPSILKNTS GSSTPTSSST PFKCPPIKST VGGTLSSGNT QSNYVLGNTK INSLPRLSSP
TLPVKVQPQQ QPQLPPASSL SPVTRVINTP PQQPQSVSAS TSPNTQYQYY QYQQQSSPIQ
QQQQQQQATP AATPTVMQMA QNQPSHPAPL QYATQQYYPQ PVYYQSPAGV PPPPPSVTHQ
GHIIAVHQHP GHLPQVGVNG MPPNVGYTIV QPEIVNKSTN RCHRCGTTET PEWRRGPKGV
RTLCNACGLF HAKLVKRKGA ALAAEEVLNN KVTKGKNGRR ISMKKHLLNE SLKQQQQING
VGIPINGFNH QILPPSFKPQ QGGIATLPPL MHGQYPNNVN NLVIHQPPPQ QQQQQQQHNN
IC


Related products :

Catalog number Product name Quantity
K226 Detecting of Biofilm producing bacteria 100
K226 Detecting of Biofilm producing bacteria 100 reactions
K226 Detecting of Biofilm producing bacteria conventional PCR 100 REACTIONS
K226 Detecting of Biofilm producing bacteria, BACTERIA & PARASITES, conventional PCR 100 REACTIONS
EIAAB47168 AFP regulator 1,Afr1,Alpha-fetoprotein regulator 1,Raf,Rat,Rattus norvegicus,Regulator of AFP,Zhx2,Zinc finger and homeodomain protein 2,Zinc fingers and homeoboxes protein 2
EIAAB47170 AFP regulator 1,Afr1,Alpha-fetoprotein regulator 1,Mouse,Mus musculus,Raf,Regulator of AFP,Zhx2,Zinc finger and homeodomain protein 2,Zinc fingers and homeoboxes protein 2
EIAAB47169 AFP regulator 1,AFR1,Alpha-fetoprotein regulator 1,Homo sapiens,Human,KIAA0854,RAF,Regulator of AFP,ZHX2,Zinc finger and homeodomain protein 2,Zinc fingers and homeoboxes protein 2
18-003-43259 Zinc fingers and homeoboxes protein 2 - Zinc finger and homeodomain protein 2; Alpha-fetoprotein regulator 1; AFP regulator 1; Regulator of AFP Polyclonal 0.1 mg Protein A
26-298 The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. PSMD8 is a non-ATPase subunit of the 19S regulator. T 0.05 mg
EIAAB34563 G(z)GAP,Gz-GAP,Gz-selective GTPase-activating protein,Homo sapiens,Human,Regulator of G-protein signaling 20,Regulator of G-protein signaling Z1,Regulator of Gz-selective protein signaling 1,RGS20,RGS
28-816 The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 19S regulator is composed of a base, which contai 0.1 mg
28-956 Leucine-zipper-like transcriptional regulator 1 (LZTR1) is belived to be a DNA-binding protein and transcriptional regulator based on its predicted structural characteristics. The transcript is presen 0.1 mg
26-109 DLG7 is a potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. It is a mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. DLG7 is the key regulator 0.05 mg
15-288-21321 Regulator of G-protein signaling 16 - RGS16; Retinally abundant regulator of G-protein signaling; RGS-R; A28-RGS14P Polyclonal 0.1 mg
15-288-21321 Regulator of G-protein signaling 16 - RGS16; Retinally abundant regulator of G-protein signaling; RGS-R; A28-RGS14P Polyclonal 0.05 mg
18-003-42464 Regulator of G-protein signaling 16 - RGS16; Retinally abundant regulator of G-protein signaling; RGS-R; A28-RGS14P Polyclonal 0.1 mg Protein A
15-288-22454A Transcriptional regulatory protein UME6 - Unscheduled meiotic gene expression protein 6; Negative transcriptional regulator of IME2; Regulator of inducer of meiosis protein 16 Polyclonal 0.1 mg
15-288-22454A Transcriptional regulatory protein UME6 - Unscheduled meiotic gene expression protein 6; Negative transcriptional regulator of IME2; Regulator of inducer of meiosis protein 16 Polyclonal 0.05 mg
EIAAB12512 Calcium release-activated calcium channel regulator 2B,CRAC channel regulator 2B,CRACR2B,EFCAB4A,EF-hand calcium-binding domain-containing protein 4A,Homo sapiens,Human
EIAAB12514 Calcium release-activated calcium channel regulator 2A,CRAC channel regulator 2A,CRACR2A,EFCAB4B,EF-hand calcium-binding domain-containing protein 4B,Homo sapiens,Human
29-804 RGS8 is a member of the regulator of G protein signaling (RGS) family and is a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural component 0.1 mg
orb81128 E.coli Ferric Uptake Regulator protein Ferric Uptake Regulator Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 148 amino acids and having a molecular mass of 5
EIAAB34546 A28-RGS14P,Homo sapiens,hRGS-r,Human,Regulator of G-protein signaling 16,Retinally abundant regulator of G-protein signaling,Retinal-specific RGS,RGS16,RGS16,RGSR,RGS-r
EIAAB34545 A28-RGS14P,Mouse,Mus musculus,Regulator of G-protein signaling 16,Retinally abundant regulator of G-protein signaling,Retinal-specific RGS,RGS16,Rgs16,Rgsr,RGS-r
EIAAB34543 Rat,Rattus norvegicus,Regulator of G-protein signaling 16,Retinally abundant regulator of G-protein signaling,Retinal-specific RGS,RGS16,Rgs16,Rgsr,RGS-r


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur