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Bladder cancer-associated protein (Bladder cancer 10 kDa protein) (Bc10)

 BLCAP_HUMAN             Reviewed;          87 AA.
P62952; A2A2K7; O60629; Q9D3B5;
31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
31-AUG-2004, sequence version 1.
27-SEP-2017, entry version 103.
RecName: Full=Bladder cancer-associated protein;
AltName: Full=Bladder cancer 10 kDa protein;
Short=Bc10;
Name=BLCAP; Synonyms=BC10;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Urinary bladder;
PubMed=10197429;
DOI=10.1002/(SICI)1522-2683(19990201)20:2<241::AID-ELPS241>3.3.CO;2-1;
Gromova I., Gromov P., Celis J.E.;
"Identification of true differentially expressed mRNAs in a pair of
human bladder transitional cell carcinomas using an improved
differential display procedure.";
Electrophoresis 20:241-248(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11780052; DOI=10.1038/414865a;
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon, and Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
TISSUE SPECIFICITY.
PubMed=16675915; DOI=10.1159/000093057;
Zuo Z., Zhao M., Liu J., Gao G., Wu X.;
"Functional analysis of bladder cancer-related protein gene: a
putative cervical cancer tumor suppressor gene in cervical
carcinoma.";
Tumor Biol. 27:221-226(2006).
[5]
FUNCTION.
PubMed=17031575; DOI=10.1007/s11010-006-9332-2;
Yao J., Duan L., Fan M., Yuan J., Wu X.;
"Overexpression of BLCAP induces S phase arrest and apoptosis
independent of p53 and NF-kappaB in human tongue carcinoma: BLCAP
overexpression induces S phase arrest and apoptosis.";
Mol. Cell. Biochem. 297:81-92(2007).
[6]
RNA EDITING OF POSITIONS 2; 5 AND 15, AND TISSUE SPECIFICITY.
PubMed=19908260; DOI=10.1002/ijc.25022;
Galeano F., Leroy A., Rossetti C., Gromova I., Gautier P.,
Keegan L.P., Massimi L., Di Rocco C., O'Connell M.A., Gallo A.;
"Human BLCAP transcript: new editing events in normal and cancerous
tissues.";
Int. J. Cancer 127:127-137(2010).
-!- FUNCTION: May regulate cell proliferation and coordinate apoptosis
and cell cycle progression via a novel mechanism independent of
both p53/TP53 and NF-kappa-B. {ECO:0000269|PubMed:17031575}.
-!- INTERACTION:
P03372:ESR1; NbExp=2; IntAct=EBI-3895726, EBI-78473;
Q7Z3S9:NOTCH2NL; NbExp=3; IntAct=EBI-3895726, EBI-945833;
Q86WV1:SKAP1; NbExp=3; IntAct=EBI-3895726, EBI-2477305;
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}.
-!- TISSUE SPECIFICITY: Ubiquitous. Expressed in cervical tissues.
Down-regulated in bladder invasive carcinoma, renal cell carcinoma
and in primary cervical carcinoma. {ECO:0000269|PubMed:10197429,
ECO:0000269|PubMed:16675915, ECO:0000269|PubMed:19908260}.
-!- RNA EDITING: Modified_positions=2 {ECO:0000269|PubMed:19908260}, 5
{ECO:0000269|PubMed:19908260}, 15 {ECO:0000269|PubMed:19908260};
Note=Partially edited. Decreased editing levels seen in
astrocytomas, bladder cancer and colorectal cancer as compared to
the related normal tissues.;
-!- SIMILARITY: Belongs to the BLCAP family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
and Haematology;
URL="http://atlasgeneticsoncology.org/Genes/BLCAPID801ch20q11.html";
-----------------------------------------------------------------------
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EMBL; AF053470; AAC06370.1; -; mRNA.
EMBL; AL109614; CAC00475.1; -; Genomic_DNA.
EMBL; AL109614; CAM19261.1; -; Genomic_DNA.
EMBL; BC047692; AAH47692.1; -; mRNA.
EMBL; BC071704; AAH71704.1; -; mRNA.
CCDS; CCDS13295.1; -.
RefSeq; NP_001161292.1; NM_001167820.1.
RefSeq; NP_001161293.1; NM_001167821.1.
RefSeq; NP_001161294.1; NM_001167822.2.
RefSeq; NP_001161295.1; NM_001167823.1.
RefSeq; NP_001304003.1; NM_001317074.1.
RefSeq; NP_001304004.1; NM_001317075.1.
RefSeq; NP_006689.1; NM_006698.3.
RefSeq; XP_016883088.1; XM_017027599.1.
UniGene; Hs.472651; -.
ProteinModelPortal; P62952; -.
BioGrid; 116110; 3.
IntAct; P62952; 7.
STRING; 9606.ENSP00000362637; -.
BioMuta; BLCAP; -.
DMDM; 51702217; -.
PaxDb; P62952; -.
PeptideAtlas; P62952; -.
PRIDE; P62952; -.
Ensembl; ENST00000373537; ENSP00000362637; ENSG00000166619.
Ensembl; ENST00000397131; ENSP00000380320; ENSG00000166619.
Ensembl; ENST00000397134; ENSP00000380323; ENSG00000166619.
Ensembl; ENST00000397135; ENSP00000380324; ENSG00000166619.
Ensembl; ENST00000397137; ENSP00000380326; ENSG00000166619.
Ensembl; ENST00000414542; ENSP00000397172; ENSG00000166619.
Ensembl; ENST00000432507; ENSP00000414973; ENSG00000166619.
GeneID; 10904; -.
KEGG; hsa:10904; -.
UCSC; uc002xha.4; human.
CTD; 10904; -.
DisGeNET; 10904; -.
EuPathDB; HostDB:ENSG00000166619.12; -.
GeneCards; BLCAP; -.
HGNC; HGNC:1055; BLCAP.
HPA; HPA047390; -.
MIM; 613110; gene.
neXtProt; NX_P62952; -.
OpenTargets; ENSG00000166619; -.
PharmGKB; PA25367; -.
eggNOG; KOG4489; Eukaryota.
eggNOG; ENOG4111WJP; LUCA.
GeneTree; ENSGT00390000014105; -.
HOVERGEN; HBG105413; -.
InParanoid; P62952; -.
OMA; THVMFMV; -.
OrthoDB; EOG091G18IM; -.
PhylomeDB; P62952; -.
TreeFam; TF313306; -.
ChiTaRS; BLCAP; human.
GeneWiki; BLCAP; -.
GenomeRNAi; 10904; -.
PRO; PR:P62952; -.
Proteomes; UP000005640; Chromosome 20.
Bgee; ENSG00000166619; -.
CleanEx; HS_BLCAP; -.
ExpressionAtlas; P62952; baseline and differential.
Genevisible; P62952; HS.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0030262; P:apoptotic nuclear changes; IDA:UniProtKB.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
InterPro; IPR009598; BC10.
PANTHER; PTHR13259; PTHR13259; 1.
ProDom; PD062192; BC10-like; 1.
SMART; SM01396; BC10; 1.
1: Evidence at protein level;
Apoptosis; Cell cycle; Complete proteome; Membrane;
Reference proteome; RNA editing; Transmembrane; Transmembrane helix.
CHAIN 1 87 Bladder cancer-associated protein.
/FTId=PRO_0000064850.
TRANSMEM 19 39 Helical. {ECO:0000255}.
TRANSMEM 43 63 Helical. {ECO:0000255}.
VARIANT 2 2 Y -> C (in RNA edited version;
dbSNP:rs11557677).
/FTId=VAR_068908.
VARIANT 5 5 Q -> R (in RNA edited version).
/FTId=VAR_068909.
VARIANT 15 15 K -> R (in RNA edited version;
dbSNP:rs11557676).
/FTId=VAR_068910.
SEQUENCE 87 AA; 9876 MW; 06A45C03E27D3E87 CRC64;
MYCLQWLLPV LLIPKPLNPA LWFSHSMFMG FYLLSFLLER KPCTICALVF LAALFLICYS
CWGNCFLYHC SDSPLPESAH DPGVVGT


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