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Blood group Rh(CE) polypeptide (Rh polypeptide 1) (RhPI) (Rh30A) (RhIXB) (Rhesus C/E antigens) (CD antigen CD240CE)

 RHCE_HUMAN              Reviewed;         417 AA.
P18577; A7DW68; B7UDF3; B7UDF4; B7UDF5; B7UDF6; B7UDF7; B7UDF8;
B7UDF9; B7UDG0; B7UDG1; B7UDG2; B7UDG3; Q02163; Q02164; Q02165;
Q16160; Q2MJW0; Q2VC86; Q3LTM6; Q6AZX5; Q6J2U3; Q7RU06; Q8IZT2;
Q8IZT3; Q8IZT4; Q8IZT5; Q9UD13; Q9UD14; Q9UD15; Q9UD16; Q9UD73;
Q9UD74; Q9UEC2; Q9UEC3; Q9UPN0;
01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
27-SEP-2017, entry version 157.
RecName: Full=Blood group Rh(CE) polypeptide;
AltName: Full=Rh polypeptide 1;
Short=RhPI;
AltName: Full=Rh30A;
AltName: Full=RhIXB;
AltName: Full=Rhesus C/E antigens;
AltName: CD_antigen=CD240CE;
Name=RHCE; Synonyms=RHC, RHE;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RHI).
TISSUE=Bone marrow;
PubMed=2123099; DOI=10.1042/bj2710821;
Avent N.D., Ridgwell K., Tanner M.J.A., Anstee D.J.;
"cDNA cloning of a 30 kDa erythrocyte membrane protein associated with
Rh (Rhesus)-blood-group-antigen expression.";
Biochem. J. 271:821-825(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RHI), AND PARTIAL PROTEIN
SEQUENCE.
TISSUE=Bone marrow;
PubMed=1696722; DOI=10.1073/pnas.87.16.6243;
Cherif-Zahar B., Bloy C., le van Kim C., Blanchard D., Bailly P.,
Hermand P., Salmon C., Cartron J.-P., Colin Y.;
"Molecular cloning and protein structure of a human blood group Rh
polypeptide.";
Proc. Natl. Acad. Sci. U.S.A. 87:6243-6247(1990).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS RHIV; RHVI AND RHVIII).
TISSUE=Bone marrow;
PubMed=1379850;
le van Kim C., Cherif-Zahar B., Raynal V., Mouro I., Lopez M.,
Cartron J.-P., Colin Y.;
"Multiple Rh messenger RNA isoforms are produced by alternative
splicing.";
Blood 80:1074-1078(1992).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RHI).
PubMed=7916743; DOI=10.1007/BF00222717;
Kajii E., Umenishi F., Iwamoto S., Ikemoto S.;
"Isolation of a new cDNA clone encoding an Rh polypeptide associated
with the Rh blood group system.";
Hum. Genet. 91:157-162(1993).
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RHI), VARIANT CYS-16, AND VARIANT
E/RH5 ANTIGEN ALA-226.
PubMed=11380456; DOI=10.1046/j.1365-2141.2001.02803.x;
Westhoff C.M., Silberstein L.E., Wylie D.E., Skavdahl M., Reid M.E.;
"16Cys encoded by the RHce gene is associated with altered expression
of the e antigen and is frequent in the R0 haplotype.";
Br. J. Haematol. 113:666-671(2001).
[6]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RHI), AND VARIANTS ILE-60; SER-68;
SER-103; VAL-127; ASP-128; RHEKH THR-154; RHEFM GLU-233 AND RHEFM
VAL-238.
PubMed=11724987; DOI=10.1046/j.1537-2995.2001.41111408.x;
Kashiwase K., Ishikawa Y., Hyodo H., Watanabe Y., Ogawa A.,
Tsuneyama H., Toyoda C., Uchikawa M., Akaza T., Omine M., Juji T.;
"E variants found in Japanese and c antigenicity alteration without
substitution in the second extracellular loop.";
Transfusion 41:1408-1412(2001).
[7]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RHI), AND VARIANTS CYS-16;
ALA-226; VAL-238; VAL-245; GLY-263 AND LYS-267.
PubMed=12393640; DOI=10.1182/blood-2002-01-0229;
Noizat-Pirenne F., Lee K., Le Pennec P.-Y., Simon P., Kazup P.,
Bachir D., Rouzaud A.M., Roussel M., Juszczak G., Menanteau C.,
Rouger P., Kotb R., Cartron J.-P., Ansart-Pirenne H.;
"Rare RHCE phenotypes in black individuals of Afro-Caribbean origin:
identification and transfusion safety.";
Blood 100:4223-4231(2002).
[8]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RHI), AND VARIANTS CYS-16; ILE-60;
SER-68; SER-103 AND ALA-226.
Yan L., Xu X., Zhu F.;
"A new RhCe allele in Chinese Han population.";
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RHI), AND VARIANTS CYS-16;
ALA-226; GLU-233 AND VAL-245.
Westhoff C.M., Vege S.;
"Molecular basis for Crawford antigen expression.";
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RHI), AND VARIANTS CYS-16; ILE-60;
SER-68 AND SER-103.
Vege S., Westhoff C.M.;
"RHCE gene, allele CE, antigen CE.";
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
[11]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RHI), AND VARIANT ALA-226.
Westhoff C.M., Vege S.;
"RHCE gene, allele RHce, ce antigen.";
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
[12]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS CYS-16; ILE-60;
SER-68; SER-103; ALA-226 AND GLU-398.
Wei Q., Flegel W.A.;
"RHD allele and RH haplotype distribution in Tibetans.";
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
[13]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS CYS-16; ILE-60;
SER-68; SER-103; ALA-226 AND LYS-267.
Bugert P., Scharberg E.A., Geisen C., von Zabern I., Flegel W.A.;
Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
[14]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS CYS-16 AND
ALA-226.
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[15]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM RHI), AND VARIANTS
CYS-16; ILE-60; SER-68; SER-103 AND ALA-226.
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[16]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
PubMed=8188244; DOI=10.1006/geno.1994.1014;
Cherif-Zahar B., le van Kim C., Rouillac C., Raynal V., Cartron J.-P.,
Colin Y.;
"Organization of the gene (RHCE) encoding the human blood group RhCcEe
antigens and characterization of the promoter region.";
Genomics 19:68-74(1994).
[17]
PROTEIN SEQUENCE OF 2-33.
PubMed=3146980; DOI=10.1042/bj2561043;
Avent N.D., Ridgwell K., Mawby W.J., Tanner M.J.A., Anstee D.J.,
Kumpel B.;
"Protein-sequence studies on Rh-related polypeptides suggest the
presence of at least two groups of proteins which associate in the
human red-cell membrane.";
Biochem. J. 256:1043-1046(1988).
[18]
PROTEIN SEQUENCE OF 2-17.
PubMed=3135863;
Bloy C., Blanchard D., Dahr W., Beyreuther K., Salmon C.,
Cartron J.-P.;
"Determination of the N-terminal sequence of human red cell Rh(D)
polypeptide and demonstration that the Rh(D), (c), and (E) antigens
are carried by distinct polypeptide chains.";
Blood 72:661-666(1988).
[19]
NUCLEOTIDE SEQUENCE [MRNA] OF 141-417 (ISOFORMS 1C; 1D; 1H; 2E; 4G;
7A; 8A; 8E; 8H; RHIV AND RHVI), AND ALTERNATIVE SPLICING.
TISSUE=Blood;
PubMed=7789951; DOI=10.1007/BF00209483;
Kajii E., Umenishi F., Omi T., Ikemoto S.;
"Intricate combinatorial patterns of exon splicing generate multiple
Rh-related isoforms in human erythroid cells.";
Hum. Genet. 95:657-665(1995).
[20]
NUCLEOTIDE SEQUENCE [MRNA] OF 201-417 (ISOFORMS 4G AND RHPI-ALPHA),
AND TISSUE SPECIFICITY.
TISSUE=Erythroblast;
PubMed=8117271; DOI=10.1006/bbrc.1994.1161;
Umenishi F., Kajii E., Ikemoto S.;
"Identification of two Rh mRNA isoforms expressed in immature
erythroblasts.";
Biochem. Biophys. Res. Commun. 198:1135-1142(1994).
[21]
PROTEIN SEQUENCE OF 402-409.
PubMed=1898705;
Suyama K., Goldstein J., Aebersold R., Kent S.;
"Regarding the size of Rh proteins.";
Blood 77:411-411(1991).
[22]
IDENTIFICATION, AND VARIANTS CYS-16 AND ALA-226.
PubMed=11902138; DOI=10.1182/blood-2001-12-0153;
Wagner F.F., Flegel W.A.;
"RHCE represents the ancestral RH position, while RHD is the
duplicated gene.";
Blood 99:2272-2273(2002).
[23]
VARIANTS BLOOD GROUP C AND E.
PubMed=8220426; DOI=10.1038/ng0993-62;
Mouro I., Colin Y., Cherif-Zahar B., Cartron J.-P., le van Kim C.;
"Molecular genetic basis of the human Rhesus blood group system.";
Nat. Genet. 5:62-65(1993).
-!- FUNCTION: May be part of an oligomeric complex which is likely to
have a transport or channel function in the erythrocyte membrane.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=14;
Name=RHI;
IsoId=P18577-1; Sequence=Displayed;
Name=RHIV; Synonyms=1e;
IsoId=P18577-2; Sequence=VSP_005703, VSP_005704;
Name=RHVI; Synonyms=7c;
IsoId=P18577-3; Sequence=VSP_005702, VSP_005705;
Name=RHVIII;
IsoId=P18577-4; Sequence=VSP_005701;
Name=1c;
IsoId=P18577-5; Sequence=VSP_005705;
Name=1d;
IsoId=P18577-6; Sequence=VSP_037514;
Name=1h;
IsoId=P18577-7; Sequence=VSP_037513;
Name=2e;
IsoId=P18577-8; Sequence=VSP_037510, VSP_037512;
Name=4g; Synonyms=RhPI-Beta;
IsoId=P18577-9; Sequence=VSP_037509;
Name=7a;
IsoId=P18577-10; Sequence=VSP_005702;
Name=8a;
IsoId=P18577-11; Sequence=VSP_037506, VSP_037511;
Name=8e;
IsoId=P18577-12; Sequence=VSP_037507, VSP_037508;
Name=8h;
IsoId=P18577-13; Sequence=VSP_037505;
Name=RhPI-Alpha;
IsoId=P18577-14; Sequence=VSP_038405, VSP_038406;
-!- TISSUE SPECIFICITY: Restricted to tissues or cell lines expressing
erythroid characters. Isoform 4g and isoform RhPI-Alpha are
expressed in immature erythroblasts but not in mature
erythroblasts. {ECO:0000269|PubMed:8117271}.
-!- POLYMORPHISM: RhCE and RhD are responsible for the RH blood group
system. The molecular basis of the E=Rh3/e=Rh5 blood group
antigens is a single variation in position 226; Pro-226
corresponds to Rh3 and Ala-226 to Rh5. The molecular basis of the
C=Rh2/c=Rh4 blood group antigens is a single variation in position
102; Ser-103 corresponds to Rh2 and Pro-103 to Rh4.
-!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49)
family. Rh subfamily. {ECO:0000305}.
-!- WEB RESOURCE: Name=dbRBC/BGMUT; Note=Blood group antigen gene
mutation database;
URL="https://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=rh";
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EMBL; X54534; CAA38401.1; -; mRNA.
EMBL; M34015; AAA36567.1; -; mRNA.
EMBL; X63095; CAA44809.1; -; mRNA.
EMBL; X63096; CAA44810.1; -; mRNA.
EMBL; X63098; CAA44812.1; -; mRNA.
EMBL; S57967; AAB26080.1; -; mRNA.
EMBL; DQ266400; ABB69097.1; -; mRNA.
EMBL; AB018644; BAA33927.1; -; mRNA.
EMBL; AB018645; BAA33928.1; -; mRNA.
EMBL; AB030388; BAA82627.1; -; mRNA.
EMBL; AB049753; BAB16597.1; -; mRNA.
EMBL; AF510065; AAN75121.1; -; mRNA.
EMBL; AF510066; AAN75122.1; -; mRNA.
EMBL; AF510067; AAN75123.1; -; mRNA.
EMBL; AF510068; AAN75124.1; -; mRNA.
EMBL; AY603478; AAT35811.1; -; mRNA.
EMBL; DQ178642; ABA25912.1; -; mRNA.
EMBL; DQ266353; ABB97471.1; -; mRNA.
EMBL; DQ322275; ABC55358.1; -; mRNA.
EMBL; AM398146; CAL44958.1; -; Genomic_DNA.
EMBL; FJ486155; ACK75562.1; -; Genomic_DNA.
EMBL; FJ486156; ACK75563.1; -; Genomic_DNA.
EMBL; FJ486157; ACK75564.1; -; Genomic_DNA.
EMBL; FJ486158; ACK75565.1; -; Genomic_DNA.
EMBL; FJ486159; ACK75566.1; -; Genomic_DNA.
EMBL; FJ486160; ACK75567.1; -; Genomic_DNA.
EMBL; FJ486161; ACK75568.1; -; Genomic_DNA.
EMBL; FJ486162; ACK75569.1; -; Genomic_DNA.
EMBL; FJ486163; ACK75570.1; -; Genomic_DNA.
EMBL; FJ486164; ACK75571.1; -; Genomic_DNA.
EMBL; FJ486165; ACK75572.1; -; Genomic_DNA.
EMBL; AL031284; CAM12858.1; -; Genomic_DNA.
EMBL; AL928711; CAM12858.1; JOINED; Genomic_DNA.
EMBL; AL928711; CAH72605.1; -; Genomic_DNA.
EMBL; AL031284; CAH72605.1; JOINED; Genomic_DNA.
EMBL; BC075081; AAH75081.1; -; mRNA.
EMBL; BC139905; AAI39906.1; -; mRNA.
EMBL; S70456; AAD14061.1; -; Genomic_DNA.
EMBL; BN000065; CAD29850.1; -; Genomic_DNA.
CCDS; CCDS30634.1; -. [P18577-4]
CCDS; CCDS30635.1; -. [P18577-1]
CCDS; CCDS30636.1; -. [P18577-3]
CCDS; CCDS30637.1; -. [P18577-2]
CCDS; CCDS81283.1; -. [P18577-5]
PIR; A30405; A30405.
PIR; I54193; I54193.
PIR; PC2032; PC2032.
PIR; PC2033; PC2033.
PIR; S78478; S78478.
PIR; S78479; S78479.
PIR; S78480; S78480.
RefSeq; NP_001317359.1; NM_001330430.1.
RefSeq; NP_065231.3; NM_020485.4.
RefSeq; NP_619522.3; NM_138616.3. [P18577-4]
RefSeq; NP_619523.3; NM_138617.3. [P18577-3]
RefSeq; NP_619524.3; NM_138618.3.
UniGene; Hs.449968; -.
UniGene; Hs.523054; -.
ProteinModelPortal; P18577; -.
STRING; 9606.ENSP00000294413; -.
TCDB; 1.A.11.4.3; the ammonium transporter channel (amt) family.
iPTMnet; P18577; -.
PhosphoSitePlus; P18577; -.
BioMuta; RHCE; -.
DMDM; 132558; -.
PaxDb; P18577; -.
PeptideAtlas; P18577; -.
PRIDE; P18577; -.
Ensembl; ENST00000294413; ENSP00000294413; ENSG00000188672.
GeneID; 6006; -.
KEGG; hsa:6006; -.
UCSC; uc001bkf.4; human. [P18577-1]
CTD; 6006; -.
DisGeNET; 6006; -.
EuPathDB; HostDB:ENSG00000188672.16; -.
GeneCards; RHCE; -.
H-InvDB; HIX0023511; -.
HGNC; HGNC:10008; RHCE.
MalaCards; RHCE; -.
MIM; 111690; phenotype.
MIM; 111700; gene+phenotype.
neXtProt; NX_P18577; -.
Orphanet; 71275; Rh deficiency syndrome.
PharmGKB; PA34386; -.
eggNOG; KOG3796; Eukaryota.
eggNOG; ENOG410XTF8; LUCA.
HOVERGEN; HBG004374; -.
InParanoid; P18577; -.
KO; K06579; -.
OrthoDB; EOG091G06KX; -.
PhylomeDB; P18577; -.
TreeFam; TF314450; -.
GeneWiki; RHCE_(gene); -.
GenomeRNAi; 6006; -.
PRO; PR:P18577; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000188672; -.
CleanEx; HS_RHCE; -.
ExpressionAtlas; P18577; baseline and differential.
Genevisible; P18577; HS.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
GO; GO:0072488; P:ammonium transmembrane transport; IBA:GO_Central.
GO; GO:0015695; P:organic cation transport; IBA:GO_Central.
InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
InterPro; IPR002229; RhesusRHD.
Pfam; PF00909; Ammonium_transp; 1.
PRINTS; PR00342; RHESUSRHD.
SUPFAM; SSF111352; SSF111352; 1.
1: Evidence at protein level;
Alternative splicing; Blood group antigen; Complete proteome;
Direct protein sequencing; Membrane; Polymorphism; Reference proteome;
Transmembrane; Transmembrane helix.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:3135863,
ECO:0000269|PubMed:3146980}.
CHAIN 2 417 Blood group Rh(CE) polypeptide.
/FTId=PRO_0000168189.
TRANSMEM 12 32 Helical. {ECO:0000255}.
TRANSMEM 44 64 Helical. {ECO:0000255}.
TRANSMEM 77 97 Helical. {ECO:0000255}.
TRANSMEM 125 145 Helical. {ECO:0000255}.
TRANSMEM 172 192 Helical. {ECO:0000255}.
TRANSMEM 203 223 Helical. {ECO:0000255}.
TRANSMEM 238 258 Helical. {ECO:0000255}.
TRANSMEM 265 285 Helical. {ECO:0000255}.
TRANSMEM 287 307 Helical. {ECO:0000255}.
TRANSMEM 331 351 Helical. {ECO:0000255}.
TRANSMEM 358 378 Helical. {ECO:0000255}.
VAR_SEQ 163 409 Missing (in isoform 8h).
{ECO:0000303|PubMed:7789951}.
/FTId=VSP_037505.
VAR_SEQ 163 313 Missing (in isoform RHVIII).
{ECO:0000303|PubMed:1379850}.
/FTId=VSP_005701.
VAR_SEQ 163 220 Missing (in isoform 8a).
{ECO:0000303|PubMed:7789951}.
/FTId=VSP_037506.
VAR_SEQ 163 203 TDYHMNLRHFYVFAAYFGLTVAWCLPKPLPKGTEDNDQRAT
-> DWLPGPPQHWGTQLGHRDSSHVWSPDRFAPKSQNMEST
SCG (in isoform 8e).
{ECO:0000303|PubMed:7789951}.
/FTId=VSP_037507.
VAR_SEQ 164 268 Missing (in isoform RHVI and isoform 7a).
{ECO:0000303|PubMed:1379850,
ECO:0000303|PubMed:7789951}.
/FTId=VSP_005702.
VAR_SEQ 204 417 Missing (in isoform 8e).
{ECO:0000303|PubMed:7789951}.
/FTId=VSP_037508.
VAR_SEQ 212 384 Missing (in isoform 4g).
{ECO:0000303|PubMed:7789951,
ECO:0000303|PubMed:8117271}.
/FTId=VSP_037509.
VAR_SEQ 227 242 LLRSPIQRKNAMFNTY -> DRFAPKSQNMESTSCG (in
isoform RhPI-Alpha).
{ECO:0000303|PubMed:8117271}.
/FTId=VSP_038405.
VAR_SEQ 243 417 Missing (in isoform RhPI-Alpha).
{ECO:0000303|PubMed:8117271}.
/FTId=VSP_038406.
VAR_SEQ 268 308 TYVHSAVLAGGVAVGTSCHLIPSPWLAMVLGLVAGLISIGG
-> DWLPGPPQHWGTQLGHRDSSHVWSPDRFAPKSQNMEST
SCG (in isoform 2e).
{ECO:0000303|PubMed:7789951}.
/FTId=VSP_037510.
VAR_SEQ 301 313 Missing (in isoform 8a).
{ECO:0000303|PubMed:7789951}.
/FTId=VSP_037511.
VAR_SEQ 309 417 Missing (in isoform 2e).
{ECO:0000303|PubMed:7789951}.
/FTId=VSP_037512.
VAR_SEQ 314 409 Missing (in isoform 1h).
{ECO:0000303|PubMed:7789951}.
/FTId=VSP_037513.
VAR_SEQ 314 354 VCCNRVLGIHHISVMHSIFSLLGLLGEITYIVLLVLHTVWN
-> DWLPGPPQHWGTQLGHRDSSHVWSPDRFAPKSQNMEST
SCG (in isoform RHIV).
{ECO:0000303|PubMed:1379850,
ECO:0000303|PubMed:7789951}.
/FTId=VSP_005703.
VAR_SEQ 355 417 Missing (in isoform RHIV).
{ECO:0000303|PubMed:1379850,
ECO:0000303|PubMed:7789951}.
/FTId=VSP_005704.
VAR_SEQ 358 417 MIGFQVLLSIGELSLAIVIALTSGLLTGLLLNLKIWKAPHV
AKYFDDQVFWKFPHLAVGF -> IFLIWLLDFKQKHPRKTR
PVQKQDNFLSLLPAVREKRS (in isoform 1d).
{ECO:0000303|PubMed:7789951}.
/FTId=VSP_037514.
VAR_SEQ 359 417 IGFQVLLSIGELSLAIVIALTSGLLTGLLLNLKIWKAPHVA
KYFDDQVFWKFPHLAVGF -> FAPKSQNMESTSCG (in
isoform RHVI and isoform 1c).
{ECO:0000303|PubMed:1379850,
ECO:0000303|PubMed:7789951}.
/FTId=VSP_005705.
VARIANT 16 16 W -> C (associated with altered
expression of E antigen).
{ECO:0000269|PubMed:11380456,
ECO:0000269|PubMed:11902138,
ECO:0000269|PubMed:12393640,
ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:16710414,
ECO:0000269|Ref.10, ECO:0000269|Ref.12,
ECO:0000269|Ref.13, ECO:0000269|Ref.8,
ECO:0000269|Ref.9}.
/FTId=VAR_006911.
VARIANT 36 36 A -> T (in C(X)/Rh9 antigen).
/FTId=VAR_006912.
VARIANT 41 41 Q -> R (in C(W)/Rh8 antigen;
dbSNP:rs138268848).
/FTId=VAR_006913.
VARIANT 60 60 L -> I (in dbSNP:rs181860403).
{ECO:0000269|PubMed:11724987,
ECO:0000269|PubMed:15489334,
ECO:0000269|Ref.10, ECO:0000269|Ref.12,
ECO:0000269|Ref.13, ECO:0000269|Ref.8}.
/FTId=VAR_006914.
VARIANT 68 68 N -> S (in dbSNP:rs1053344).
{ECO:0000269|PubMed:11724987,
ECO:0000269|PubMed:15489334,
ECO:0000269|Ref.10, ECO:0000269|Ref.12,
ECO:0000269|Ref.13, ECO:0000269|Ref.8}.
/FTId=VAR_006915.
VARIANT 103 103 P -> S (in C/Rh2 antigen;
dbSNP:rs676785).
{ECO:0000269|PubMed:11724987,
ECO:0000269|PubMed:15489334,
ECO:0000269|Ref.10, ECO:0000269|Ref.12,
ECO:0000269|Ref.13, ECO:0000269|Ref.8}.
/FTId=VAR_006916.
VARIANT 127 127 A -> V (in dbSNP:rs1053346).
{ECO:0000269|PubMed:11724987}.
/FTId=VAR_055260.
VARIANT 128 128 G -> D (in dbSNP:rs1053347).
{ECO:0000269|PubMed:11724987}.
/FTId=VAR_055261.
VARIANT 154 154 R -> T (found in antigen RhEKH).
{ECO:0000269|PubMed:11724987}.
/FTId=VAR_013301.
VARIANT 182 182 T -> S (in dbSNP:rs1053350).
/FTId=VAR_055262.
VARIANT 198 198 N -> K (in dbSNP:rs1053354).
/FTId=VAR_055263.
VARIANT 226 226 P -> A (in E/Rh5 antigen;
dbSNP:rs609320).
{ECO:0000269|PubMed:11380456,
ECO:0000269|PubMed:11902138,
ECO:0000269|PubMed:12393640,
ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:16710414,
ECO:0000269|Ref.11, ECO:0000269|Ref.12,
ECO:0000269|Ref.13, ECO:0000269|Ref.8,
ECO:0000269|Ref.9}.
/FTId=VAR_006917.
VARIANT 233 233 Q -> E (found in antigen RhEFM).
{ECO:0000269|PubMed:11724987,
ECO:0000269|Ref.9}.
/FTId=VAR_013302.
VARIANT 238 238 M -> V (found in antigen RhEFM;
dbSNP:rs144163296).
{ECO:0000269|PubMed:11724987,
ECO:0000269|PubMed:12393640}.
/FTId=VAR_013303.
VARIANT 245 245 L -> V (in VS antigen; dbSNP:rs1053361).
{ECO:0000269|PubMed:12393640,
ECO:0000269|Ref.9}.
/FTId=VAR_006918.
VARIANT 263 263 R -> G (in dbSNP:rs1132763).
{ECO:0000269|PubMed:12393640}.
/FTId=VAR_057987.
VARIANT 267 267 M -> K (in dbSNP:rs1132764).
{ECO:0000269|PubMed:12393640,
ECO:0000269|Ref.13}.
/FTId=VAR_057988.
VARIANT 323 323 H -> P (in dbSNP:rs1053366).
/FTId=VAR_055264.
VARIANT 325 325 I -> S (in dbSNP:rs1053367).
/FTId=VAR_055265.
VARIANT 329 329 H -> D (in dbSNP:rs1053370).
/FTId=VAR_055266.
VARIANT 329 329 H -> R (in dbSNP:rs1053371).
/FTId=VAR_055267.
VARIANT 330 330 S -> Y (in dbSNP:rs1053372).
/FTId=VAR_055268.
VARIANT 331 331 I -> N (in dbSNP:rs1053373).
/FTId=VAR_055269.
VARIANT 398 398 V -> E (in dbSNP:rs630612).
{ECO:0000269|Ref.12}.
/FTId=VAR_057989.
CONFLICT 10 10 R -> W (in Ref. 13; ACK75562).
{ECO:0000305}.
CONFLICT 12 12 C -> L (in Ref. 18; AA sequence).
{ECO:0000305}.
CONFLICT 53 53 D -> G (in Ref. 3; CAA44812).
{ECO:0000305}.
CONFLICT 61 61 G -> C (in Ref. 3; CAA44812).
{ECO:0000305}.
CONFLICT 114 114 R -> W (in Ref. 7; AAN75123).
{ECO:0000305}.
CONFLICT 115 115 L -> P (in Ref. 13; ACK75563/ACK75565).
{ECO:0000305}.
CONFLICT 121 121 M -> L (in Ref. 6; BAB16597/BAA82627).
{ECO:0000305}.
CONFLICT 122 122 S -> P (in Ref. 13; ACK75564).
{ECO:0000305}.
CONFLICT 125 125 I -> N (in Ref. 13; ACK75565).
{ECO:0000305}.
CONFLICT 152 152 T -> N (in Ref. 6; BAB16597/BAA82627).
{ECO:0000305}.
CONFLICT 155 155 M -> V (in Ref. 8; AAT35811).
{ECO:0000305}.
CONFLICT 166 166 H -> L (in Ref. 13; ACK75566).
{ECO:0000305}.
CONFLICT 169 169 L -> Q (in Ref. 13; ACK75567).
{ECO:0000305}.
CONFLICT 201 201 R -> T (in Ref. 13; ACK75568).
{ECO:0000305}.
CONFLICT 217 217 W -> R (in Ref. 13; ACK75569).
{ECO:0000305}.
CONFLICT 241 241 T -> I (in Ref. 13; ACK75570).
{ECO:0000305}.
CONFLICT 250 250 V -> M (in Ref. 7; AAN75124).
{ECO:0000305}.
CONFLICT 273 273 A -> V (in Ref. 7; AAN75122).
{ECO:0000305}.
CONFLICT 303 303 L -> Q (in Ref. 13; ACK75572).
{ECO:0000305}.
CONFLICT 378 378 L -> V (in Ref. 7; AAN75122).
{ECO:0000305}.
CONFLICT 408 409 WK -> DI (in Ref. 21; AA sequence).
{ECO:0000305}.
SEQUENCE 417 AA; 45560 MW; 29D33E778D9053DF CRC64;
MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV GQDLTVMAAL
GLGFLTSNFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ FPPGKVVITL FSIRLATMSA
MSVLISAGAV LGKVNLAQLV VMVLVEVTAL GTLRMVISNI FNTDYHMNLR HFYVFAAYFG
LTVAWCLPKP LPKGTEDNDQ RATIPSLSAM LGALFLWMFW PSVNSPLLRS PIQRKNAMFN
TYYALAVSVV TAISGSSLAH PQRKISMTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV
AGLISIGGAK CLPVCCNRVL GIHHISVMHS IFSLLGLLGE ITYIVLLVLH TVWNGNGMIG
FQVLLSIGEL SLAIVIALTS GLLTGLLLNL KIWKAPHVAK YFDDQVFWKF PHLAVGF


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