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BmK-YA precursor [Cleaved into: BmK-YA 1 (Enkephalin-like peptide 1); BmK-YA 2 (Enkephalin-like peptide 2); BmK-YA 3 (Enkephalin-like peptide 3); BmK-YA 4 (Enkephalin-like peptide 4)]

 YA_MESMA                Reviewed;         200 AA.
Q9Y0X6;
16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
16-OCT-2013, sequence version 2.
29-APR-2015, entry version 23.
RecName: Full=BmK-YA precursor {ECO:0000303|PubMed:22792309};
Contains:
RecName: Full=BmK-YA 1 {ECO:0000303|PubMed:22792309};
AltName: Full=Enkephalin-like peptide 1 {ECO:0000303|PubMed:22792309};
Contains:
RecName: Full=BmK-YA 2 {ECO:0000303|PubMed:22792309};
AltName: Full=Enkephalin-like peptide 2 {ECO:0000303|PubMed:22792309};
Contains:
RecName: Full=BmK-YA 3 {ECO:0000303|PubMed:22792309};
AltName: Full=Enkephalin-like peptide 3 {ECO:0000303|PubMed:22792309};
Contains:
RecName: Full=BmK-YA 4 {ECO:0000303|PubMed:22792309};
AltName: Full=Enkephalin-like peptide 4 {ECO:0000303|PubMed:22792309};
Flags: Precursor;
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
NCBI_TaxID=34649;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 35-42; 101-108;
145-152 AND 189-196, SYNTHESIS, FUNCTION, SUBCELLULAR LOCATION, MASS
SPECTROMETRY, AMIDATION AT ALA-42; ALA-108; ALA-152 AND ALA-196, AND
MUTAGENESIS OF TYR-38; TYR-104; TYR-148 AND TYR-192.
TISSUE=Venom;
PubMed=22792309; DOI=10.1371/journal.pone.0040417;
Zhang Y., Xu J., Wang Z., Zhang X., Liang X., Civelli O.;
"BmK-YA, an enkephalin-like peptide in scorpion venom.";
PLoS ONE 7:E40417-E40417(2012).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 106-200.
TISSUE=Venom gland;
Wenxin L., Shunyi Z.;
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Synthetic BmK-YA activates human opioid receptors in
vitro, with highest activity on the delta-type/OPRD1 receptor
(EC(50)=2.5 uM) and lower activity on mu-type/OPRM1 and kappa-
type/OPRK1 receptors (EC(50)=17 uM and 30 uM, respectively).
{ECO:0000269|PubMed:22792309}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22792309}.
-!- TISSUE SPECIFICITY: Venom gland. {ECO:0000305|PubMed:22792309}.
-!- MASS SPECTROMETRY: Mass=871.3; Method=Electrospray; Range=35-42,
101-108, 145-152, 189-196; Evidence={ECO:0000269|PubMed:22792309};
-!- MISCELLANEOUS: Four additional, similar peptides (containing a
substitution of Tyr-4 to His-4) are predicted from this sequence:
however, there is no evidence that they exist in vivo and the
synthetic peptide has no known function.
{ECO:0000269|PubMed:22792309, ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAD39510.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AF146742; AAD39510.1; ALT_INIT; mRNA.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0001515; F:opioid peptide activity; IDA:CACAO.
1: Evidence at protein level;
Amidation; Direct protein sequencing;
G-protein coupled receptor impairing toxin; Secreted; Signal; Toxin.
SIGNAL 1 23 {ECO:0000255}.
PROPEP 24 34 {ECO:0000269|PubMed:22792309}.
/FTId=PRO_0000423811.
PEPTIDE 35 42 BmK-YA 1. {ECO:0000269|PubMed:22792309}.
/FTId=PRO_0000423812.
PROPEP 45 100 {ECO:0000269|PubMed:22792309}.
/FTId=PRO_0000423813.
PEPTIDE 101 108 BmK-YA 2. {ECO:0000269|PubMed:22792309}.
/FTId=PRO_0000423814.
PROPEP 111 144 {ECO:0000269|PubMed:22792309}.
/FTId=PRO_0000423815.
PEPTIDE 145 152 BmK-YA 3. {ECO:0000269|PubMed:22792309}.
/FTId=PRO_0000423816.
PROPEP 155 188 {ECO:0000269|PubMed:22792309}.
/FTId=PRO_0000423817.
PEPTIDE 189 196 BmK-YA 4. {ECO:0000269|PubMed:22792309}.
/FTId=PRO_0000423818.
PROPEP 199 200 {ECO:0000269|PubMed:22792309}.
/FTId=PRO_0000423819.
MOD_RES 42 42 Alanine amide.
{ECO:0000269|PubMed:22792309}.
MOD_RES 108 108 Alanine amide.
{ECO:0000269|PubMed:22792309}.
MOD_RES 152 152 Alanine amide.
{ECO:0000269|PubMed:22792309}.
MOD_RES 196 196 Alanine amide.
{ECO:0000269|PubMed:22792309}.
MUTAGEN 38 38 Y->F: Increased potency on delta-type,
mu-type and kappa-type opioid receptors.
{ECO:0000269|PubMed:22792309}.
MUTAGEN 104 104 Y->F: Increased potency on delta-type,
mu-type and kappa-type opioid receptors.
{ECO:0000269|PubMed:22792309}.
MUTAGEN 148 148 Y->F: Increased potency on delta-type,
mu-type and kappa-type opioid receptors.
{ECO:0000269|PubMed:22792309}.
MUTAGEN 192 192 Y->F: Increased potency on delta-type,
mu-type and kappa-type opioid receptors.
{ECO:0000269|PubMed:22792309}.
SEQUENCE 200 AA; 22968 MW; 19E74AF01166CF5E CRC64;
MIFHQFYSIL ILCLIFPNQV VQSDKERQDW IPSDYGGYMN PAGRSDEERQ DWIPSDYGGH
MNPAGRSDEE RQDWIPSDYG GHMNPAGRSN EERQDWIPSD YGGYMNPAGR SDEERQDWIP
SDYGGHMNPA GRSNEERQDW IPSDYGGYMN PAGRSDEERQ DWIPSDYGGH MNPAGRSDEE
RQDWIPSDYG GYMNPAGRSD


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