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Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP)]

 PRG2_MOUSE              Reviewed;         223 AA.
Q61878;
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
25-OCT-2017, entry version 126.
RecName: Full=Bone marrow proteoglycan;
Short=BMPG;
AltName: Full=Proteoglycan 2;
Contains:
RecName: Full=Eosinophil granule major basic protein;
Short=EMBP;
Short=MBP;
Flags: Precursor;
Name=Prg2; Synonyms=Mbp-1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
STRAIN=CBA/J; TISSUE=Liver;
PubMed=7673718;
Larson K.A., Horton M.A., Madden B.J., Gleich G.J., Lee N.A.,
Lee J.J.;
"The identification and cloning of a murine major basic protein gene
expressed in eosinophils.";
J. Immunol. 155:3002-3012(1995).
[2]
NITRATION.
PubMed=18694936; DOI=10.1074/jbc.M801196200;
Ulrich M., Petre A., Youhnovski N., Proemm F., Schirle M., Schumm M.,
Pero R.S., Doyle A., Checkel J., Kita H., Thiyagarajan N.,
Acharya K.R., Schmid-Grendelmeier P., Simon H.-U., Schwarz H.,
Tsutsui M., Shimokawa H., Bellon G., Lee J.J., Przybylski M.,
Doering G.;
"Post-translational tyrosine nitration of eosinophil granule toxins
mediated by eosinophil peroxidase.";
J. Biol. Chem. 283:28629-28640(2008).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Cytotoxin and helminthotoxin. MBP also induces non-
cytolytic histamine release from basophils. It is involved in
antiparasitic defense mechanisms and immune hypersensitivity
reactions (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000250}.
Note=Matrix of eosinophil's large specific granule (crystalloid
core). {ECO:0000250}.
-!- PTM: Nitrated. {ECO:0000269|PubMed:18694936}.
-!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
Note=Eosinophil major basic protein;
URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_151";
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EMBL; L46768; AAA83027.1; -; Genomic_DNA.
CCDS; CCDS16198.1; -.
RefSeq; NP_032946.1; NM_008920.4.
UniGene; Mm.142727; -.
ProteinModelPortal; Q61878; -.
SMR; Q61878; -.
STRING; 10090.ENSMUSP00000028467; -.
MEROPS; I63.001; -.
PhosphoSitePlus; Q61878; -.
MaxQB; Q61878; -.
PaxDb; Q61878; -.
PRIDE; Q61878; -.
DNASU; 19074; -.
Ensembl; ENSMUST00000028467; ENSMUSP00000028467; ENSMUSG00000027073.
GeneID; 19074; -.
KEGG; mmu:19074; -.
UCSC; uc008kjp.1; mouse.
CTD; 5553; -.
MGI; MGI:103294; Prg2.
eggNOG; KOG4297; Eukaryota.
eggNOG; ENOG410XPJ1; LUCA.
GeneTree; ENSGT00440000039859; -.
HOGENOM; HOG000261603; -.
HOVERGEN; HBG005583; -.
InParanoid; Q61878; -.
KO; K10786; -.
OMA; GHWRRAH; -.
OrthoDB; EOG091G0LK4; -.
PhylomeDB; Q61878; -.
TreeFam; TF336281; -.
Reactome; R-MMU-6798695; Neutrophil degranulation.
PRO; PR:Q61878; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000027073; -.
CleanEx; MM_PRG2; -.
ExpressionAtlas; Q61878; baseline and differential.
Genevisible; Q61878; MM.
GO; GO:0070062; C:extracellular exosome; ISO:MGI.
GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
GO; GO:0002215; P:defense response to nematode; IMP:MGI.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0032693; P:negative regulation of interleukin-10 production; IMP:MGI.
GO; GO:0032753; P:positive regulation of interleukin-4 production; IMP:MGI.
GO; GO:0042035; P:regulation of cytokine biosynthetic process; IBA:GO_Central.
CDD; cd03598; CLECT_EMBP_like; 1.
Gene3D; 3.10.100.10; -; 1.
InterPro; IPR001304; C-type_lectin-like.
InterPro; IPR016186; C-type_lectin-like/link.
InterPro; IPR016187; CTDL_fold.
InterPro; IPR033816; EMBP_CTLD.
InterPro; IPR002352; Eosinophil_major_basic.
Pfam; PF00059; Lectin_C; 1.
PRINTS; PR00770; EMAJORBASICP.
SMART; SM00034; CLECT; 1.
SUPFAM; SSF56436; SSF56436; 1.
PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
1: Evidence at protein level;
Antibiotic; Antimicrobial; Complete proteome;
Direct protein sequencing; Disulfide bond; Immunity; Lectin;
Nitration; Reference proteome; Signal.
SIGNAL 1 16 {ECO:0000255}.
CHAIN 17 223 Bone marrow proteoglycan.
/FTId=PRO_0000259924.
PROPEP 17 106 Acidic.
/FTId=PRO_0000017387.
CHAIN 107 223 Eosinophil granule major basic protein.
/FTId=PRO_0000017388.
DOMAIN 124 223 C-type lectin. {ECO:0000255|PROSITE-
ProRule:PRU00040}.
DISULFID 126 221 {ECO:0000255|PROSITE-ProRule:PRU00040}.
DISULFID 198 213 {ECO:0000255|PROSITE-ProRule:PRU00040}.
SEQUENCE 223 AA; 24255 MW; 7D66D946DCEADA00 CRC64;
MKFPLLLALL VGGASALHLS SETSDSKSPL MDENLPRDAE ISGPEGEECP PGEELMPLEG
EKEEGSGSEG VPGDEGAVSG QDVTDVDLQC PKEEDTTSLM GDSGCKTCRY LLVRRAECFD
KAQSVCRRCY RGTLASIHSF SVNFGIQSAV RGINQGQVWI GGRIKGWGRC KRFRWVDGSS
WNFAYWAAGQ PCPGGGRCVT LCTQGGHWRL SHCVKRRPFI CSY


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