GENTAUR Molecular Products.

 E1C0T2_CHICK            Unreviewed;       404 AA.
 E1C0T2;
 02-NOV-2010, integrated into UniProtKB/TrEMBL.
 26-JUN-2013, sequence version 2.
 16-JAN-2019, entry version 67.
 SubName: Full=Bone morphogenetic protein 4 {ECO:0000313|Ensembl:ENSGALP00000020289};
 Name=BMP4 {ECO:0000313|Ensembl:ENSGALP00000020289};
 Gallus gallus (Chicken).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
 Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
 Phasianidae; Phasianinae; Gallus.
 NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000020289, ECO:0000313|Proteomes:UP000000539};
 [1] {ECO:0000313|Ensembl:ENSGALP00000020289, ECO:0000313|Proteomes:UP000000539}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000020289,
 ECO:0000313|Proteomes:UP000000539};
 PubMed=15592404; DOI=10.1038/nature03154;
 International Chicken Genome Sequencing Consortium;
 Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
 Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
 Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
 Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
 Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
 Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
 Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
 Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
 Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
 Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
 van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
 Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
 Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
 Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
 Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
 Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
 Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
 Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
 Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
 Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
 Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
 King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
 Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
 Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
 Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
 Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
 Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
 Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
 Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
 Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
 Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
 Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
 Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
 Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
 Mardis E.R., Wilson R.K.;
 "Sequence and comparative analysis of the chicken genome provide
 unique perspectives on vertebrate evolution.";
 Nature 432:695-716(2004).
 [2] {ECO:0000313|Ensembl:ENSGALP00000020289}
 IDENTIFICATION.
 STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000020289};
 Ensembl;
 Submitted (JUL-2011) to UniProtKB.
 -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00581915}.
 -!- SIMILARITY: Belongs to the TGF-beta family.
     {ECO:0000256|RuleBase:RU000354, ECO:0000256|SAAS:SAAS00581927}.
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 EMBL; AC172371; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 RefSeq; NP_990568.3; NM_205237.3.
 UniGene; Gga.686; -.
 Ensembl; ENSGALT00000020316; ENSGALP00000020289; ENSGALG00000012429.
 GeneID; 396165; -.
 KEGG; gga:396165; -.
 CTD; 652; -.
 eggNOG; KOG3900; Eukaryota.
 eggNOG; ENOG410XT8Z; LUCA.
 GeneTree; ENSGT00940000159502; -.
 KO; K04662; -.
 OMA; QGFHRIN; -.
 OrthoDB; 962484at2759; -.
 Reactome; R-GGA-2129379; Molecules associated with elastic fibres.
 Reactome; R-GGA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
 Reactome; R-GGA-8957275; Post-translational protein phosphorylation.
 Proteomes; UP000000539; Chromosome 5.
 Bgee; ENSGALG00000012429; Expressed in 9 organ(s), highest expression level in cerebellum.
 ExpressionAtlas; E1C0T2; baseline and differential.
 GO; GO:0005615; C:extracellular space; IEA:Ensembl.
 GO; GO:0070700; F:BMP receptor binding; IEA:Ensembl.
 GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
 GO; GO:0039706; F:co-receptor binding; IEA:Ensembl.
 GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
 GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
 GO; GO:0008201; F:heparin binding; IEA:Ensembl.
 GO; GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
 GO; GO:0009948; P:anterior/posterior axis specification; IEA:Ensembl.
 GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
 GO; GO:0002043; P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IEA:Ensembl.
 GO; GO:0061312; P:BMP signaling pathway involved in heart development; IEA:Ensembl.
 GO; GO:0003130; P:BMP signaling pathway involved in heart induction; IEA:Ensembl.
 GO; GO:0071893; P:BMP signaling pathway involved in nephric duct formation; IEA:Ensembl.
 GO; GO:0061151; P:BMP signaling pathway involved in renal system segmentation; IEA:Ensembl.
 GO; GO:0061149; P:BMP signaling pathway involved in ureter morphogenesis; IEA:Ensembl.
 GO; GO:0060442; P:branching involved in prostate gland morphogenesis; IEA:Ensembl.
 GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
 GO; GO:0060433; P:bronchus development; IEA:Ensembl.
 GO; GO:0060503; P:bud dilation involved in lung branching; IEA:Ensembl.
 GO; GO:0060449; P:bud elongation involved in lung branching; IEA:Ensembl.
 GO; GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl.
 GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
 GO; GO:0060197; P:cloacal septation; IEA:Ensembl.
 GO; GO:0007182; P:common-partner SMAD protein phosphorylation; IEA:Ensembl.
 GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
 GO; GO:0060363; P:cranial suture morphogenesis; IEA:Ensembl.
 GO; GO:0035993; P:deltoid tuberosity development; IEA:Ensembl.
 GO; GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
 GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
 GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
 GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
 GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
 GO; GO:0003197; P:endocardial cushion development; IEA:Ensembl.
 GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
 GO; GO:0007492; P:endoderm development; IEA:Ensembl.
 GO; GO:0060502; P:epithelial cell proliferation involved in lung morphogenesis; IEA:Ensembl.
 GO; GO:0060684; P:epithelial-mesenchymal cell signaling; IEA:Ensembl.
 GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
 GO; GO:0007281; P:germ cell development; IEA:Ensembl.
 GO; GO:0072104; P:glomerular capillary formation; IEA:Ensembl.
 GO; GO:0072015; P:glomerular visceral epithelial cell development; IEA:Ensembl.
 GO; GO:0060113; P:inner ear receptor cell differentiation; IEA:Ensembl.
 GO; GO:0048392; P:intermediate mesodermal cell differentiation; IEA:Ensembl.
 GO; GO:0060235; P:lens induction in camera-type eye; IEA:Ensembl.
 GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
 GO; GO:0002320; P:lymphoid progenitor cell differentiation; IEA:Ensembl.
 GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
 GO; GO:0003149; P:membranous septum morphogenesis; IEA:Ensembl.
 GO; GO:0072161; P:mesenchymal cell differentiation involved in kidney development; IEA:Ensembl.
 GO; GO:0072198; P:mesenchymal cell proliferation involved in ureter development; IEA:Ensembl.
 GO; GO:0072138; P:mesenchymal cell proliferation involved in ureteric bud development; IEA:Ensembl.
 GO; GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Ensembl.
 GO; GO:0007500; P:mesodermal cell fate determination; IEA:Ensembl.
 GO; GO:0072205; P:metanephric collecting duct development; IEA:Ensembl.
 GO; GO:0030224; P:monocyte differentiation; IEA:Ensembl.
 GO; GO:0072097; P:negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway; IEA:Ensembl.
 GO; GO:2000137; P:negative regulation of cell proliferation involved in heart morphogenesis; IEA:Ensembl.
 GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl.
 GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
 GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
 GO; GO:0072125; P:negative regulation of glomerular mesangial cell proliferation; IEA:Ensembl.
 GO; GO:0033088; P:negative regulation of immature T cell proliferation in thymus; IEA:Ensembl.
 GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
 GO; GO:0072200; P:negative regulation of mesenchymal cell proliferation involved in ureter development; IEA:Ensembl.
 GO; GO:2000007; P:negative regulation of metanephric comma-shaped body morphogenesis; IEA:Ensembl.
 GO; GO:2000005; P:negative regulation of metanephric S-shaped body morphogenesis; IEA:Ensembl.
 GO; GO:0045839; P:negative regulation of mitotic nuclear division; IEA:Ensembl.
 GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
 GO; GO:1902894; P:negative regulation of pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
 GO; GO:0060686; P:negative regulation of prostatic bud formation; IEA:Ensembl.
 GO; GO:0045843; P:negative regulation of striated muscle tissue development; IEA:Ensembl.
 GO; GO:0070244; P:negative regulation of thymocyte apoptotic process; IEA:Ensembl.
 GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
 GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
 GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
 GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
 GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
 GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
 GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
 GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
 GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
 GO; GO:0061047; P:positive regulation of branching involved in lung morphogenesis; IEA:Ensembl.
 GO; GO:0055020; P:positive regulation of cardiac muscle fiber development; IEA:Ensembl.
 GO; GO:1905312; P:positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; IEA:Ensembl.
 GO; GO:0061036; P:positive regulation of cartilage development; IEA:Ensembl.
 GO; GO:1901964; P:positive regulation of cell proliferation involved in outflow tract morphogenesis; IEA:Ensembl.
 GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
 GO; GO:0045603; P:positive regulation of endothelial cell differentiation; IEA:Ensembl.
 GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
 GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
 GO; GO:0045606; P:positive regulation of epidermal cell differentiation; IEA:Ensembl.
 GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
 GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
 GO; GO:0090184; P:positive regulation of kidney development; IEA:Ensembl.
 GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
 GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
 GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
 GO; GO:1902895; P:positive regulation of pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
 GO; GO:1903800; P:positive regulation of production of miRNAs involved in gene silencing by miRNA; IEA:Ensembl.
 GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
 GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; IEA:Ensembl.
 GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
 GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
 GO; GO:0034504; P:protein localization to nucleus; IEA:Ensembl.
 GO; GO:0061155; P:pulmonary artery endothelial tube morphogenesis; IEA:Ensembl.
 GO; GO:0003184; P:pulmonary valve morphogenesis; IEA:Ensembl.
 GO; GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IEA:Ensembl.
 GO; GO:0010453; P:regulation of cell fate commitment; IEA:Ensembl.
 GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
 GO; GO:0042306; P:regulation of protein import into nucleus; IEA:Ensembl.
 GO; GO:0051150; P:regulation of smooth muscle cell differentiation; IEA:Ensembl.
 GO; GO:0003014; P:renal system process; IEA:Ensembl.
 GO; GO:0003139; P:secondary heart field specification; IEA:Ensembl.
 GO; GO:0060395; P:SMAD protein signal transduction; IEA:Ensembl.
 GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
 GO; GO:0010159; P:specification of animal organ position; IEA:Ensembl.
 GO; GO:0072101; P:specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway; IEA:Ensembl.
 GO; GO:0043401; P:steroid hormone mediated signaling pathway; IEA:Ensembl.
 GO; GO:0021978; P:telencephalon regionalization; IEA:Ensembl.
 GO; GO:0035990; P:tendon cell differentiation; IEA:Ensembl.
 GO; GO:0060440; P:trachea formation; IEA:Ensembl.
 GO; GO:0003323; P:type B pancreatic cell development; IEA:Ensembl.
 GO; GO:0072192; P:ureter epithelial cell differentiation; IEA:Ensembl.
 GO; GO:0072193; P:ureter smooth muscle cell differentiation; IEA:Ensembl.
 Gene3D; 2.10.90.10; -; 1.
 InterPro; IPR029034; Cystine-knot_cytokine.
 InterPro; IPR001839; TGF-b_C.
 InterPro; IPR001111; TGF-b_propeptide.
 InterPro; IPR015615; TGF-beta-rel.
 InterPro; IPR017948; TGFb_CS.
 PANTHER; PTHR11848; PTHR11848; 1.
 Pfam; PF00019; TGF_beta; 1.
 Pfam; PF00688; TGFb_propeptide; 1.
 SMART; SM00204; TGFB; 1.
 SUPFAM; SSF57501; SSF57501; 1.
 PROSITE; PS00250; TGF_BETA_1; 1.
 PROSITE; PS51362; TGF_BETA_2; 1.
 3: Inferred from homology;
 Complete proteome {ECO:0000313|Proteomes:UP000000539};
 Disulfide bond {ECO:0000256|SAAS:SAAS00516088};
 Growth factor {ECO:0000256|RuleBase:RU000354,
 ECO:0000256|SAAS:SAAS00516085};
 Reference proteome {ECO:0000313|Proteomes:UP000000539};
 Secreted {ECO:0000256|SAAS:SAAS00516087};
 Signal {ECO:0000256|SAM:SignalP}.
 SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
 CHAIN        24    404       {ECO:0000256|SAM:SignalP}.
                              /FTId=PRO_5003144452.
 DOMAIN      287    404       TGF_BETA_2.
                              {ECO:0000259|PROSITE:PS51362}.
 SEQUENCE   404 AA;  46017 MW;  7081CE433B342582 CRC64;
 MIPGNRMLMV ILLCQVLLGG TNHASLIPET GRKKVAELQG QAGSGRRSAQ SHELLRGFET
 TLLQMFGLRR RPQPSKSAVI PSYMLDLYRL QSGEEEESLQ EISLQYPERS TSRANTVRSF
 HHEEHLESVP GPSEVPRIRF VFNLSSVPDN EVISSAELRL YREQVEEPSA AWERGFHRIN
 IYEVMKPLSE RSQAITRLLD TRLVHHNVTR WETFDVSPAV IRWTKDKQPN HGLVIEVTHL
 HQAQTHQGKH VRISRSLPQG YGGDWAQLRP LLVTFGHDGR GHALTRRARR SPKHQRSRKN
 KKNCRRHALY VDFSDVGWND WIVAPPGYQA FYCHGDCPFP LADHLNSTNH AIVQTLVNSV
 NSSIPKACCV PTELSAISML YLDEYDKVVL KNYQEMVVEG CGCR

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