Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)

 BMP4_HUMAN              Reviewed;         408 AA.
P12644; Q9UM80;
01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
01-OCT-1989, sequence version 1.
25-OCT-2017, entry version 198.
RecName: Full=Bone morphogenetic protein 4;
Short=BMP-4;
AltName: Full=Bone morphogenetic protein 2B;
Short=BMP-2B;
Flags: Precursor;
Name=BMP4; Synonyms=BMP2B, DVR4;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3201241; DOI=10.1126/science.3201241;
Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J.,
Kriz R.W., Hewick R.M., Wang E.A.;
"Novel regulators of bone formation: molecular clones and
activities.";
Science 242:1528-1534(1988).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALA-152.
PubMed=9701626; DOI=10.1007/s002239900518;
Shore E.M., Xu M., Shah P.B., Janoff H.B., Hahn G.V., Deardorff M.A.,
Sovinsky L., Spinner N.B., Zasloff M.A., Wozney J.M., Kaplan F.S.;
"The human bone morphogenetic protein 4 (BMP-4) gene: molecular
structure and transcriptional regulation.";
Calcif. Tissue Int. 63:221-229(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-152.
TISSUE=Duodenum;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 7-408.
TISSUE=Placenta;
PubMed=7579580; DOI=10.3109/10425179509030980;
Oida S., Iimura T., Maruoka Y., Takeda K., Sasaki S.;
"Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a
human placental cDNA library.";
DNA Seq. 5:273-275(1995).
[5]
INTERACTION WITH SOSTDC1.
PubMed=15020244; DOI=10.1016/j.bbrc.2004.02.075;
Yanagita M., Oka M., Watabe T., Iguchi H., Niida A., Takahashi S.,
Akiyama T., Miyazono K., Yanagisawa M., Sakurai T.;
"USAG-1: a bone morphogenetic protein antagonist abundantly expressed
in the kidney.";
Biochem. Biophys. Res. Commun. 316:490-500(2004).
[6]
INTERACTION WITH FBN1 AND FBN2.
PubMed=18339631; DOI=10.1074/jbc.M707820200;
Sengle G., Charbonneau N.L., Ono R.N., Sasaki T., Alvarez J.,
Keene D.R., Baechinger H.P., Sakai L.Y.;
"Targeting of bone morphogenetic protein growth factor complexes to
fibrillin.";
J. Biol. Chem. 283:13874-13888(2008).
[7]
PHOSPHORYLATION AT SER-91.
PubMed=26091039; DOI=10.1016/j.cell.2015.05.028;
Tagliabracci V.S., Wiley S.E., Guo X., Kinch L.N., Durrant E., Wen J.,
Xiao J., Cui J., Nguyen K.B., Engel J.L., Coon J.J., Grishin N.,
Pinna L.A., Pagliarini D.J., Dixon J.E.;
"A single kinase generates the majority of the secreted
phosphoproteome.";
Cell 161:1619-1632(2015).
[8]
VARIANTS CYS-91; ALA-152; ALA-225; TRP-226 AND THR-367.
PubMed=12404109; DOI=10.1038/sj.ejhg.5200875;
Felder B., Stegmann K., Schultealbert A., Geller F., Strehl E.,
Ermert A., Koch M.C.;
"Evaluation of BMP4 and its specific inhibitor NOG as candidates in
human neural tube defects (NTDs).";
Eur. J. Hum. Genet. 10:753-756(2002).
[9]
VARIANT MCOPS6 GLY-93.
PubMed=18252212; DOI=10.1016/j.ajhg.2007.09.023;
Bakrania P., Efthymiou M., Klein J.C., Salt A., Bunyan D.J., Wyatt A.,
Ponting C.P., Martin A., Williams S., Lindley V., Gilmore J.,
Restori M., Robson A.G., Neveu M.M., Holder G.E., Collin J.R.O.,
Robinson D.O., Farndon P., Johansen-Berg H., Gerrelli D., Ragge N.K.;
"Mutations in BMP4 cause eye, brain, and digit developmental
anomalies: overlap between the BMP4 and hedgehog signaling pathways.";
Am. J. Hum. Genet. 82d:304-319(2008).
[10]
VARIANTS CYS-91; SER-116 AND LYS-150.
PubMed=18305125; DOI=10.1681/ASN.2006111282;
Weber S., Taylor J.C., Winyard P., Baker K.F., Sullivan-Brown J.,
Schild R., Knueppel T., Zurowska A.M., Caldas-Alfonso A., Litwin M.,
Emre S., Ghiggeri G.M., Bakkaloglu A., Mehls O., Antignac C.,
Schaefer F., Burdine R.D.;
"SIX2 and BMP4 mutations associate with anomalous kidney
development.";
J. Am. Soc. Nephrol. 19:891-903(2008).
[11]
VARIANTS OFC11 CYS-91; GLN-162; HIS-287 AND VAL-346, AND VARIANTS
ALA-102; ALA-152 AND ALA-168.
PubMed=19249007; DOI=10.1016/j.ajhg.2009.02.002;
Suzuki S., Marazita M.L., Cooper M.E., Miwa N., Hing A., Jugessur A.,
Natsume N., Shimozato K., Ohbayashi N., Suzuki Y., Niimi T.,
Minami K., Yamamoto M., Altannamar T.J., Erkhembaatar T., Furukawa H.,
Daack-Hirsch S., L'heureux J., Brandon C.A., Weinberg S.M.,
Neiswanger K., Deleyiannis F.W., de Salamanca J.E., Vieira A.R.,
Lidral A.C., Martin J.F., Murray J.C.;
"Mutations in BMP4 are associated with subepithelial, microform, and
overt cleft lip.";
Am. J. Hum. Genet. 84:406-411(2009).
-!- FUNCTION: Induces cartilage and bone formation. Also act in
mesoderm induction, tooth development, limb formation and fracture
repair. Acts in concert with PTHLH/PTHRP to stimulate ductal
outgrowth during embryonic mammary development and to inhibit hair
follicle induction (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer; disulfide-linked (By similarity). Interacts
with GREM2. Part of a complex consisting of TWSG1 and CHRD.
Interacts with the serine proteases, HTRA1 and HTRA3; the
interaction with either inhibits BMP4-mediated signaling. The HTRA
protease activity is required for this inhibition (By similarity).
Interacts with SOSTDC1. Interacts with FBN1 (via N-terminal
domain) and FBN2 (PubMed:18339631). {ECO:0000250|UniProtKB:P21275,
ECO:0000269|PubMed:15020244, ECO:0000269|PubMed:18339631}.
-!- INTERACTION:
P36894:BMPR1A; NbExp=2; IntAct=EBI-1998134, EBI-1029237;
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix.
-!- TISSUE SPECIFICITY: Expressed in the lung and lower levels seen in
the kidney. Present also in normal and neoplastic prostate
tissues, and prostate cancer cell lines.
-!- DISEASE: Microphthalmia, syndromic, 6 (MCOPS6) [MIM:607932]: A
disease characterized by microphthalmia/anophthalmia associated
with facial, genital, skeletal, neurologic and endocrine
anomalies. Microphthalmia is a disorder of eye formation, ranging
from small size of a single eye to complete bilateral absence of
ocular tissues (anophthalmia). In many cases,
microphthalmia/anophthalmia occurs in association with syndromes
that include non-ocular abnormalities.
{ECO:0000269|PubMed:18252212}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- DISEASE: Non-syndromic orofacial cleft 11 (OFC11) [MIM:600625]: A
birth defect consisting of cleft lips with or without cleft
palate. Cleft lips are associated with cleft palate in two-third
of cases. A cleft lip can occur on one or both sides and range in
severity from a simple notch in the upper lip to a complete
opening in the lip extending into the floor of the nostril and
involving the upper gum. {ECO:0000269|PubMed:19249007}. Note=The
disease is caused by mutations affecting the gene represented in
this entry.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Wikipedia; Note=Bone morphogenetic protein 4
entry;
URL="https://en.wikipedia.org/wiki/Bone_morphogenetic_protein_4";
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
and Haematology;
URL="http://atlasgeneticsoncology.org/Genes/BMP4ID811ch14q22.html";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M22490; AAA51835.1; -; mRNA.
EMBL; U43842; AAC72278.1; -; Genomic_DNA.
EMBL; BC020546; AAH20546.1; -; mRNA.
EMBL; D30751; BAA06410.1; -; mRNA.
CCDS; CCDS9715.1; -.
PIR; C37278; BMHU4.
RefSeq; NP_001193.2; NM_001202.5.
RefSeq; NP_001334843.1; NM_001347914.1.
RefSeq; NP_001334845.1; NM_001347916.1.
RefSeq; NP_570911.2; NM_130850.4.
RefSeq; NP_570912.2; NM_130851.3.
UniGene; Hs.68879; -.
ProteinModelPortal; P12644; -.
BioGrid; 107120; 13.
CORUM; P12644; -.
DIP; DIP-5795N; -.
ELM; P12644; -.
IntAct; P12644; 10.
MINT; MINT-1184353; -.
STRING; 9606.ENSP00000245451; -.
BindingDB; P12644; -.
ChEMBL; CHEMBL5350; -.
iPTMnet; P12644; -.
PhosphoSitePlus; P12644; -.
BioMuta; BMP4; -.
DMDM; 115073; -.
PaxDb; P12644; -.
PeptideAtlas; P12644; -.
PRIDE; P12644; -.
DNASU; 652; -.
Ensembl; ENST00000245451; ENSP00000245451; ENSG00000125378.
Ensembl; ENST00000417573; ENSP00000394165; ENSG00000125378.
Ensembl; ENST00000558984; ENSP00000454134; ENSG00000125378.
Ensembl; ENST00000559087; ENSP00000453485; ENSG00000125378.
GeneID; 652; -.
KEGG; hsa:652; -.
CTD; 652; -.
DisGeNET; 652; -.
EuPathDB; HostDB:ENSG00000125378.15; -.
GeneCards; BMP4; -.
GeneReviews; BMP4; -.
HGNC; HGNC:1071; BMP4.
HPA; CAB006863; -.
HPA; HPA066235; -.
MalaCards; BMP4; -.
MIM; 112262; gene.
MIM; 600625; phenotype.
MIM; 607932; phenotype.
neXtProt; NX_P12644; -.
OpenTargets; ENSG00000125378; -.
Orphanet; 264200; 14q22q23 microdeletion syndrome.
Orphanet; 1991; Cleft lip with or without cleft palate.
Orphanet; 139471; Microphthalmia with brain and digit anomalies.
Orphanet; 93100; Unilateral renal agenesis.
PharmGKB; PA25381; -.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
GeneTree; ENSGT00760000118883; -.
HOGENOM; HOG000249478; -.
HOVERGEN; HBG004860; -.
InParanoid; P12644; -.
KO; K04662; -.
OMA; QGFHRIN; -.
OrthoDB; EOG091G0K7Z; -.
PhylomeDB; P12644; -.
TreeFam; TF351789; -.
Reactome; R-HSA-2129379; Molecules associated with elastic fibres.
Reactome; R-HSA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-HSA-8957275; Post-translational protein phosphorylation.
SignaLink; P12644; -.
SIGNOR; P12644; -.
GeneWiki; Bone_morphogenetic_protein_4; -.
GenomeRNAi; 652; -.
PRO; PR:P12644; -.
Proteomes; UP000005640; Chromosome 14.
Bgee; ENSG00000125378; -.
CleanEx; HS_BMP4; -.
ExpressionAtlas; P12644; baseline and differential.
Genevisible; P12644; HS.
GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
GO; GO:0070700; F:BMP receptor binding; IDA:MGI.
GO; GO:0042056; F:chemoattractant activity; IDA:UniProtKB.
GO; GO:0039706; F:co-receptor binding; IPI:BHF-UCL.
GO; GO:0005125; F:cytokine activity; IDA:MGI.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0008201; F:heparin binding; IEA:Ensembl.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IBA:GO_Central.
GO; GO:0000186; P:activation of MAPKK activity; IDA:UniProtKB.
GO; GO:0009948; P:anterior/posterior axis specification; IEA:Ensembl.
GO; GO:0003180; P:aortic valve morphogenesis; ISS:BHF-UCL.
GO; GO:0002043; P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IDA:BHF-UCL.
GO; GO:0030509; P:BMP signaling pathway; IDA:BHF-UCL.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; ISS:BHF-UCL.
GO; GO:0003130; P:BMP signaling pathway involved in heart induction; IMP:BHF-UCL.
GO; GO:0071893; P:BMP signaling pathway involved in nephric duct formation; IDA:UniProtKB.
GO; GO:0061151; P:BMP signaling pathway involved in renal system segmentation; ISS:UniProtKB.
GO; GO:0061149; P:BMP signaling pathway involved in ureter morphogenesis; ISS:UniProtKB.
GO; GO:0060442; P:branching involved in prostate gland morphogenesis; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IDA:UniProtKB.
GO; GO:0060433; P:bronchus development; IDA:MGI.
GO; GO:0060503; P:bud dilation involved in lung branching; IDA:MGI.
GO; GO:0060449; P:bud elongation involved in lung branching; IEA:Ensembl.
GO; GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl.
GO; GO:0003279; P:cardiac septum development; TAS:BHF-UCL.
GO; GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO; GO:0071773; P:cellular response to BMP stimulus; IMP:BHF-UCL.
GO; GO:0002062; P:chondrocyte differentiation; ISS:UniProtKB.
GO; GO:0060197; P:cloacal septation; IEA:Ensembl.
GO; GO:0007182; P:common-partner SMAD protein phosphorylation; IDA:UniProtKB.
GO; GO:0060976; P:coronary vasculature development; ISS:BHF-UCL.
GO; GO:0060363; P:cranial suture morphogenesis; IEA:Ensembl.
GO; GO:0035993; P:deltoid tuberosity development; ISS:UniProtKB.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
GO; GO:0003197; P:endocardial cushion development; ISS:BHF-UCL.
GO; GO:0001958; P:endochondral ossification; ISS:UniProtKB.
GO; GO:0007492; P:endoderm development; IEA:Ensembl.
GO; GO:0060502; P:epithelial cell proliferation involved in lung morphogenesis; IDA:MGI.
GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IDA:MGI.
GO; GO:0060684; P:epithelial-mesenchymal cell signaling; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:0007281; P:germ cell development; IEA:Ensembl.
GO; GO:0072104; P:glomerular capillary formation; ISS:UniProtKB.
GO; GO:0072015; P:glomerular visceral epithelial cell development; IEA:Ensembl.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IDA:UniProtKB.
GO; GO:0060113; P:inner ear receptor cell differentiation; IEA:Ensembl.
GO; GO:0048392; P:intermediate mesodermal cell differentiation; IDA:UniProtKB.
GO; GO:0001822; P:kidney development; IMP:UniProtKB.
GO; GO:0060235; P:lens induction in camera-type eye; IEA:Ensembl.
GO; GO:0048286; P:lung alveolus development; IDA:MGI.
GO; GO:0060425; P:lung morphogenesis; IDA:MGI.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; IMP:BHF-UCL.
GO; GO:0030225; P:macrophage differentiation; IDA:DFLAT.
GO; GO:0060592; P:mammary gland formation; IEA:Ensembl.
GO; GO:0003149; P:membranous septum morphogenesis; ISS:BHF-UCL.
GO; GO:0072161; P:mesenchymal cell differentiation involved in kidney development; IEA:Ensembl.
GO; GO:0072198; P:mesenchymal cell proliferation involved in ureter development; IEA:Ensembl.
GO; GO:0072138; P:mesenchymal cell proliferation involved in ureteric bud development; IEA:Ensembl.
GO; GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IDA:UniProtKB.
GO; GO:0007500; P:mesodermal cell fate determination; IEA:Ensembl.
GO; GO:0001823; P:mesonephros development; IEP:UniProtKB.
GO; GO:0072205; P:metanephric collecting duct development; ISS:UniProtKB.
GO; GO:0030224; P:monocyte differentiation; IDA:DFLAT.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO; GO:0072097; P:negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway; IDA:UniProtKB.
GO; GO:0090191; P:negative regulation of branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
GO; GO:0045786; P:negative regulation of cell cycle; IDA:HGNC.
GO; GO:0060548; P:negative regulation of cell death; IDA:UniProtKB.
GO; GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.
GO; GO:2000137; P:negative regulation of cell proliferation involved in heart morphogenesis; IMP:BHF-UCL.
GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; ISS:BHF-UCL.
GO; GO:0072125; P:negative regulation of glomerular mesangial cell proliferation; IDA:UniProtKB.
GO; GO:0090194; P:negative regulation of glomerulus development; IDA:UniProtKB.
GO; GO:0033088; P:negative regulation of immature T cell proliferation in thymus; IMP:BHF-UCL.
GO; GO:0043407; P:negative regulation of MAP kinase activity; IDA:UniProtKB.
GO; GO:0072200; P:negative regulation of mesenchymal cell proliferation involved in ureter development; IDA:UniProtKB.
GO; GO:2000007; P:negative regulation of metanephric comma-shaped body morphogenesis; IDA:UniProtKB.
GO; GO:2000005; P:negative regulation of metanephric S-shaped body morphogenesis; IDA:UniProtKB.
GO; GO:0045839; P:negative regulation of mitotic nuclear division; IDA:UniProtKB.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IDA:MGI.
GO; GO:0042326; P:negative regulation of phosphorylation; IDA:UniProtKB.
GO; GO:0060686; P:negative regulation of prostatic bud formation; IEA:Ensembl.
GO; GO:0045843; P:negative regulation of striated muscle tissue development; IDA:MGI.
GO; GO:0033085; P:negative regulation of T cell differentiation in thymus; IMP:BHF-UCL.
GO; GO:0070244; P:negative regulation of thymocyte apoptotic process; IMP:BHF-UCL.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
GO; GO:0042476; P:odontogenesis; IGI:UniProtKB.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IDA:BHF-UCL.
GO; GO:0003148; P:outflow tract septum morphogenesis; ISS:BHF-UCL.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; ISS:BHF-UCL.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.
GO; GO:0030501; P:positive regulation of bone mineralization; IDA:UniProtKB.
GO; GO:0061047; P:positive regulation of branching involved in lung morphogenesis; ISS:UniProtKB.
GO; GO:0055020; P:positive regulation of cardiac muscle fiber development; IMP:BHF-UCL.
GO; GO:1905312; P:positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0061036; P:positive regulation of cartilage development; IDA:MGI.
GO; GO:0010942; P:positive regulation of cell death; IDA:MGI.
GO; GO:1901964; P:positive regulation of cell proliferation involved in outflow tract morphogenesis; ISS:BHF-UCL.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IDA:BHF-UCL.
GO; GO:2000105; P:positive regulation of DNA-dependent DNA replication; IDA:BHF-UCL.
GO; GO:0045603; P:positive regulation of endothelial cell differentiation; IEA:Ensembl.
GO; GO:0010595; P:positive regulation of endothelial cell migration; IDA:UniProtKB.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:UniProtKB.
GO; GO:0045606; P:positive regulation of epidermal cell differentiation; IDA:UniProtKB.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:BHF-UCL.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IDA:BHF-UCL.
GO; GO:0090184; P:positive regulation of kidney development; IDA:UniProtKB.
GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
GO; GO:0045778; P:positive regulation of ossification; IDA:MGI.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IDA:BHF-UCL.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IDA:UniProtKB.
GO; GO:1903800; P:positive regulation of production of miRNAs involved in gene silencing by miRNA; IDA:BHF-UCL.
GO; GO:0032092; P:positive regulation of protein binding; IDA:MGI.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:MGI.
GO; GO:0060391; P:positive regulation of SMAD protein import into nucleus; IDA:BHF-UCL.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0009791; P:post-embryonic development; IDA:MGI.
GO; GO:0043687; P:post-translational protein modification; TAS:Reactome.
GO; GO:0034504; P:protein localization to nucleus; IDA:UniProtKB.
GO; GO:0061155; P:pulmonary artery endothelial tube morphogenesis; IDA:UniProtKB.
GO; GO:0003184; P:pulmonary valve morphogenesis; ISS:BHF-UCL.
GO; GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IEA:Ensembl.
GO; GO:0010453; P:regulation of cell fate commitment; IDA:UniProtKB.
GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0060393; P:regulation of pathway-restricted SMAD protein phosphorylation; IDA:BHF-UCL.
GO; GO:0042306; P:regulation of protein import into nucleus; IDA:MGI.
GO; GO:0051150; P:regulation of smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0072001; P:renal system development; IEP:UniProtKB.
GO; GO:0003014; P:renal system process; IEA:Ensembl.
GO; GO:0003139; P:secondary heart field specification; IMP:BHF-UCL.
GO; GO:0060395; P:SMAD protein signal transduction; IDA:UniProtKB.
GO; GO:0048745; P:smooth muscle tissue development; ISS:UniProtKB.
GO; GO:0007224; P:smoothened signaling pathway; IEP:UniProtKB.
GO; GO:0010159; P:specification of animal organ position; IEA:Ensembl.
GO; GO:0072101; P:specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway; IDA:UniProtKB.
GO; GO:0043401; P:steroid hormone mediated signaling pathway; IMP:UniProtKB.
GO; GO:0021537; P:telencephalon development; IDA:MGI.
GO; GO:0021978; P:telencephalon regionalization; IEA:Ensembl.
GO; GO:0035990; P:tendon cell differentiation; ISS:UniProtKB.
GO; GO:0060438; P:trachea development; IDA:MGI.
GO; GO:0060440; P:trachea formation; IEA:Ensembl.
GO; GO:0003323; P:type B pancreatic cell development; IDA:BHF-UCL.
GO; GO:0072192; P:ureter epithelial cell differentiation; ISS:UniProtKB.
GO; GO:0072193; P:ureter smooth muscle cell differentiation; ISS:UniProtKB.
GO; GO:0001657; P:ureteric bud development; IDA:MGI.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
1: Evidence at protein level;
Chondrogenesis; Cleavage on pair of basic residues; Complete proteome;
Cytokine; Developmental protein; Differentiation; Disease mutation;
Disulfide bond; Extracellular matrix; Glycoprotein; Growth factor;
Microphthalmia; Osteogenesis; Phosphoprotein; Polymorphism;
Reference proteome; Secreted; Signal.
SIGNAL 1 19 {ECO:0000255}.
PROPEP 20 292
/FTId=PRO_0000033856.
CHAIN 293 408 Bone morphogenetic protein 4.
/FTId=PRO_0000033857.
MOD_RES 91 91 Phosphoserine; by FAM20C.
{ECO:0000269|PubMed:26091039}.
CARBOHYD 143 143 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 208 208 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 350 350 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 365 365 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 308 373 {ECO:0000250}.
DISULFID 337 405 {ECO:0000250}.
DISULFID 341 407 {ECO:0000250}.
DISULFID 372 372 Interchain. {ECO:0000250}.
VARIANT 91 91 S -> C (in OFC11; also found in renal
hypodysplasia patients;
dbSNP:rs121912767).
{ECO:0000269|PubMed:12404109,
ECO:0000269|PubMed:18305125,
ECO:0000269|PubMed:19249007}.
/FTId=VAR_043531.
VARIANT 93 93 E -> G (in MCOPS6; dbSNP:rs121912765).
{ECO:0000269|PubMed:18252212}.
/FTId=VAR_043532.
VARIANT 102 102 T -> A (in dbSNP:rs202159001).
{ECO:0000269|PubMed:19249007}.
/FTId=VAR_058314.
VARIANT 116 116 T -> S (in a renal hypodysplasia patient;
dbSNP:rs750427266).
{ECO:0000269|PubMed:18305125}.
/FTId=VAR_043533.
VARIANT 150 150 N -> K (in a renal hypodysplasia patient;
dbSNP:rs767216159).
{ECO:0000269|PubMed:18305125}.
/FTId=VAR_043534.
VARIANT 152 152 V -> A (in dbSNP:rs17563).
{ECO:0000269|PubMed:12404109,
ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:19249007,
ECO:0000269|PubMed:9701626}.
/FTId=VAR_016174.
VARIANT 162 162 R -> Q (in OFC11; dbSNP:rs770493925).
{ECO:0000269|PubMed:19249007}.
/FTId=VAR_058315.
VARIANT 168 168 G -> A. {ECO:0000269|PubMed:19249007}.
/FTId=VAR_058316.
VARIANT 225 225 T -> A (in dbSNP:rs144556455).
{ECO:0000269|PubMed:12404109}.
/FTId=VAR_043535.
VARIANT 226 226 R -> W (in dbSNP:rs140590144).
{ECO:0000269|PubMed:12404109}.
/FTId=VAR_043536.
VARIANT 287 287 R -> H (in OFC11; dbSNP:rs121912768).
{ECO:0000269|PubMed:19249007}.
/FTId=VAR_058317.
VARIANT 346 346 A -> V (in OFC11; dbSNP:rs121912766).
{ECO:0000269|PubMed:19249007}.
/FTId=VAR_058318.
VARIANT 367 367 S -> T. {ECO:0000269|PubMed:12404109}.
/FTId=VAR_043537.
SEQUENCE 408 AA; 46555 MW; 79B01179DBB98204 CRC64;
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH STGLEYPERP ASRANTVRSF
HHEEHLENIP GTSENSAFRF LFNLSSIPEN EVISSAELRL FREQVDQGPD WERGFHRINI
YEVMKPPAEV VPGHLITRLL DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH
LHQTRTHQGQ HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR
ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR


Related products :

Catalog number Product name Quantity
200-001 BMP-2 Human Host: E. coli bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 5
200-002 BMP-2 Human Host: E. coli bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 25
102-PA106S BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
102-PA106 BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 200
101-M233 BMP-2 Anti-Human Host: Mouse bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
102-P03A BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
U0014h CLIA BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0014h ELISA kit BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0014h ELISA BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0013h ELISA BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
U0013h CLIA BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
E0013h ELISA kit BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
E0013m ELISA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0014m ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
U0013r CLIA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
U0014r CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
E0014m ELISA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
U0014m CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
E0014r ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
E0013m ELISA kit Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0014r ELISA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
U0013m CLIA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0013r ELISA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
E0013r ELISA kit Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
024-15071 Bone Morphogenetic Protein 13 (BMP 13), Human, recombinant Source Human bone morphogenetic protein 13 cDNA expressed in E.coli Appearance Lyophilized form with no additives (Sterile_filtered) Molecul 10ìg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur