Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)

 BMP4_MOUSE              Reviewed;         408 AA.
P21275;
01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
01-FEB-1994, sequence version 2.
27-SEP-2017, entry version 181.
RecName: Full=Bone morphogenetic protein 4;
Short=BMP-4;
AltName: Full=Bone morphogenetic protein 2B;
Short=BMP-2B;
Flags: Precursor;
Name=Bmp4; Synonyms=Bmp-4, Dvr-4;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Dickinson M.E., van der Meer-De Jong R., Hogan B.L.M.;
"Nucleotide sequence of the mouse bone morphogenetic protein-4 (BMP-4)
cDNA.";
Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8507180; DOI=10.1006/bbrc.1993.1523;
Kurihara T., Kitamura K., Takaoka K., Nakazato H.;
"Murine bone morphogenetic protein-4 gene: existence of multiple
promoters and exons for the 5'-untranslated region.";
Biochem. Biophys. Res. Commun. 192:1049-1056(1993).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8358941;
Takaoka K., Yoshikawa H., Hasimoto J., Masuhara K., Miyamoto S.,
Suzuki S., Ono K., Matsui M., Oikawa S., Tsuruoka N.;
"Gene cloning and expression of a bone morphogenetic protein derived
from a murine osteosarcoma.";
Clin. Orthop. Relat. Res. 294:344-352(1993).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv; TISSUE=Liver;
PubMed=7499338; DOI=10.1074/jbc.270.47.28364;
Feng J.Q., Chen D., Cooney A.J., Tsai M., Harris M.A., Tsai S.Y.,
Feng M., Mundy G.R., Harris S.E.;
"The mouse bone morphogenetic protein-4 gene. Analysis of promoter
utilization in fetal rat calvarial osteoblasts and regulation by COUP-
TFI orphan receptor.";
J. Biol. Chem. 270:28364-28373(1995).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C3H/He, and FVB/N;
TISSUE=Colon, Osteoblast, and Salivary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE OF 241-408.
PubMed=1970330; DOI=10.1016/0888-7543(90)90480-I;
Dickinson M.E., Kobrin M.S., Silan C.M., Kingsley D.M., Justice M.J.,
Miller D.A., Ceci J.D., Lock L.F., Lee A., Buchberg A.M.,
Siracusa L.D., Lyons K.M., Derynck R., Hogan B.L.M., Copeland N.G.,
Jenkins N.A.;
"Chromosomal localization of seven members of the murine TGF-beta
superfamily suggests close linkage to several morphogenetic mutant
loci.";
Genomics 6:505-520(1990).
[7]
INTERACTION WITH TWSG1 AND CHRD.
PubMed=11260715; DOI=10.1038/35068572;
Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y.,
Greenspan D.S.;
"Homologues of Twisted gastrulation are extracellular cofactors in
antagonism of BMP signalling.";
Nature 410:475-478(2001).
[8]
INTERACTION WITH SOSTDC1.
PubMed=14623234; DOI=10.1016/j.ydbio.2003.08.011;
Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N.;
"Identification of a secreted BMP antagonist, ectodin, integrating
BMP, FGF, and SHH signals from the tooth enamel knot.";
Dev. Biol. 264:91-105(2003).
[9]
INTERACTION WITH HTRA3, AND FUNCTION.
PubMed=15206957; DOI=10.1111/j.1440-169X.2004.00743.x;
Tocharus J., Tsuchiya A., Kajikawa M., Ueta Y., Oka C., Kawaichi M.;
"Developmentally regulated expression of mouse HtrA3 and its role as
an inhibitor of TGF-beta signaling.";
Dev. Growth Differ. 46:257-274(2004).
[10]
INTERACTION WITH HTRA1, AND FUNCTION.
PubMed=14973287; DOI=10.1242/dev.00999;
Oka C., Tsujimoto R., Kajikawa M., Koshiba-Takeuchi K., Ina J.,
Yano M., Tsuchiya A., Ueta Y., Soma A., Kanda H., Matsumoto M.,
Kawaichi M.;
"HtrA1 serine protease inhibits signaling mediated by Tgfbeta family
proteins.";
Development 131:1041-1053(2004).
[11]
INTERACTION WITH GREM2.
PubMed=15039429; DOI=10.1074/jbc.M402376200;
Sudo S., Avsian-Kretchmer O., Wang L.S., Hsueh A.J.;
"Protein related to DAN and cerberus is a bone morphogenetic protein
antagonist that participates in ovarian paracrine regulation.";
J. Biol. Chem. 279:23134-23141(2004).
[12]
INTERACTION WITH RGMB.
PubMed=15671031; DOI=10.1074/jbc.M410034200;
Samad T.A., Rebbapragada A., Bell E., Zhang Y., Sidis Y., Jeong S.-J.,
Campagna J.A., Perusini S., Fabrizio D.A., Schneyer A.L., Lin H.Y.,
Brivanlou A.H., Attisano L., Woolf C.J.;
"DRAGON, a bone morphogenetic protein co-receptor.";
J. Biol. Chem. 280:14122-14129(2005).
[13]
INTERACTION WITH RGMA.
PubMed=15975920; DOI=10.1074/jbc.M503511200;
Babitt J.L., Zhang Y., Samad T.A., Xia Y., Tang J., Campagna J.A.,
Schneyer A.L., Woolf C.J., Lin H.Y.;
"Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone
morphogenetic protein co-receptor.";
J. Biol. Chem. 280:29820-29827(2005).
[14]
INTERACTION WITH RGMC.
PubMed=16604073; DOI=10.1038/ng1777;
Babitt J.L., Huang F.W., Wrighting D.M., Xia Y., Sidis Y., Samad T.A.,
Campagna J.A., Chung R.T., Schneyer A.L., Woolf C.J., Andrews N.C.,
Lin H.Y.;
"Bone morphogenetic protein signaling by hemojuvelin regulates
hepcidin expression.";
Nat. Genet. 38:531-539(2006).
[15]
FUNCTION.
PubMed=17301089; DOI=10.1242/dev.000182;
Hens J.R., Dann P., Zhang J.P., Harris S., Robinson G.W.,
Wysolmerski J.;
"BMP4 and PTHrP interact to stimulate ductal outgrowth during
embryonic mammary development and to inhibit hair follicle
induction.";
Development 134:1221-1230(2007).
[16]
INTERACTION WITH RGMA.
PubMed=17472960; DOI=10.1074/jbc.M701679200;
Xia Y., Yu P.B., Sidis Y., Beppu H., Bloch K.D., Schneyer A.L.,
Lin H.Y.;
"Repulsive guidance molecule RGMa alters utilization of bone
morphogenetic protein (BMP) type II receptors by BMP2 and BMP4.";
J. Biol. Chem. 282:18129-18140(2007).
-!- FUNCTION: Induces cartilage and bone formation. Acts in concert
with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic
mammary development and to inhibit hair follicle induction.
{ECO:0000269|PubMed:14973287, ECO:0000269|PubMed:15206957,
ECO:0000269|PubMed:17301089}.
-!- SUBUNIT: Homodimer; disulfide-linked (By similarity). Interacts
with SOSTDC1, GREM2, RGMA, RGMB and RGMC. Part of a complex
consisting of TWSG1 and CHRD. Interacts with the serine proteases,
HTRA1 and HTRA3; the interaction with either inhibits BMP4-
mediated signaling. The HTRA protease activity is required for
this inhibition. Interacts with FBN1 (via N-terminal domain) and
FBN2 (By similarity). {ECO:0000250|UniProtKB:P12644,
ECO:0000269|PubMed:11260715, ECO:0000269|PubMed:14623234,
ECO:0000269|PubMed:14973287, ECO:0000269|PubMed:15039429,
ECO:0000269|PubMed:15206957, ECO:0000269|PubMed:15671031,
ECO:0000269|PubMed:15975920, ECO:0000269|PubMed:16604073,
ECO:0000269|PubMed:17472960}.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAC37698.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X56848; CAA40179.1; -; mRNA.
EMBL; D14814; BAA03555.1; -; Genomic_DNA.
EMBL; S65032; AAB28021.1; -; mRNA.
EMBL; L47480; AAC37698.1; ALT_INIT; Genomic_DNA.
EMBL; BC013459; AAH13459.1; -; mRNA.
EMBL; BC034053; AAH34053.1; -; mRNA.
EMBL; BC052846; AAH52846.1; -; mRNA.
CCDS; CCDS36897.1; -.
PIR; I49541; I49541.
PIR; JH0801; JH0801.
RefSeq; NP_001303289.1; NM_001316360.1.
RefSeq; NP_031580.2; NM_007554.3.
RefSeq; XP_006518530.1; XM_006518467.3.
RefSeq; XP_006518531.1; XM_006518468.3.
RefSeq; XP_011243236.1; XM_011244934.2.
RefSeq; XP_011243237.1; XM_011244935.2.
UniGene; Mm.6813; -.
ProteinModelPortal; P21275; -.
BioGrid; 198364; 3.
STRING; 10090.ENSMUSP00000073720; -.
BindingDB; P21275; -.
ChEMBL; CHEMBL2384894; -.
iPTMnet; P21275; -.
PhosphoSitePlus; P21275; -.
PaxDb; P21275; -.
PRIDE; P21275; -.
Ensembl; ENSMUST00000074077; ENSMUSP00000073720; ENSMUSG00000021835.
Ensembl; ENSMUST00000100676; ENSMUSP00000098242; ENSMUSG00000021835.
GeneID; 12159; -.
KEGG; mmu:12159; -.
UCSC; uc007thd.2; mouse.
CTD; 652; -.
MGI; MGI:88180; Bmp4.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
GeneTree; ENSGT00760000118883; -.
HOGENOM; HOG000249478; -.
HOVERGEN; HBG004860; -.
InParanoid; P21275; -.
KO; K04662; -.
OMA; QGFHRIN; -.
OrthoDB; EOG091G0K7Z; -.
PhylomeDB; P21275; -.
TreeFam; TF351789; -.
Reactome; R-MMU-2129379; Molecules associated with elastic fibres.
Reactome; R-MMU-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-MMU-8957275; Post-translational protein phosphorylation.
PRO; PR:P21275; -.
Proteomes; UP000000589; Chromosome 14.
Bgee; ENSMUSG00000021835; -.
CleanEx; MM_BMP4; -.
ExpressionAtlas; P21275; baseline and differential.
Genevisible; P21275; MM.
GO; GO:0005576; C:extracellular region; IDA:MGI.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
GO; GO:0070700; F:BMP receptor binding; ISS:UniProtKB.
GO; GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
GO; GO:0039706; F:co-receptor binding; ISO:MGI.
GO; GO:0005125; F:cytokine activity; ISO:MGI.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0008201; F:heparin binding; IDA:MGI.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IBA:GO_Central.
GO; GO:0000186; P:activation of MAPKK activity; ISS:UniProtKB.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IGI:MGI.
GO; GO:0001525; P:angiogenesis; IMP:MGI.
GO; GO:0009948; P:anterior/posterior axis specification; IGI:MGI.
GO; GO:0003180; P:aortic valve morphogenesis; IMP:BHF-UCL.
GO; GO:0001568; P:blood vessel development; IDA:MGI.
GO; GO:0002043; P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis; ISS:UniProtKB.
GO; GO:0030509; P:BMP signaling pathway; IDA:MGI.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IMP:BHF-UCL.
GO; GO:0003130; P:BMP signaling pathway involved in heart induction; ISS:UniProtKB.
GO; GO:0071893; P:BMP signaling pathway involved in nephric duct formation; ISS:UniProtKB.
GO; GO:0061151; P:BMP signaling pathway involved in renal system segmentation; IMP:UniProtKB.
GO; GO:0061149; P:BMP signaling pathway involved in ureter morphogenesis; IDA:UniProtKB.
GO; GO:0060348; P:bone development; IDA:MGI.
GO; GO:0060442; P:branching involved in prostate gland morphogenesis; IMP:MGI.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IGI:MGI.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; ISS:UniProtKB.
GO; GO:0060433; P:bronchus development; ISO:MGI.
GO; GO:0060503; P:bud dilation involved in lung branching; ISO:MGI.
GO; GO:0060449; P:bud elongation involved in lung branching; IDA:MGI.
GO; GO:0043010; P:camera-type eye development; IMP:MGI.
GO; GO:0048593; P:camera-type eye morphogenesis; IMP:MGI.
GO; GO:0055007; P:cardiac muscle cell differentiation; IGI:BHF-UCL.
GO; GO:0045165; P:cell fate commitment; IDA:MGI.
GO; GO:0071773; P:cellular response to BMP stimulus; ISO:MGI.
GO; GO:0071363; P:cellular response to growth factor stimulus; IDA:MGI.
GO; GO:0002062; P:chondrocyte differentiation; IMP:UniProtKB.
GO; GO:0060197; P:cloacal septation; IEP:UniProtKB.
GO; GO:0007182; P:common-partner SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:0060976; P:coronary vasculature development; IMP:BHF-UCL.
GO; GO:0060363; P:cranial suture morphogenesis; IDA:MGI.
GO; GO:0035993; P:deltoid tuberosity development; IMP:UniProtKB.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; IDA:MGI.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:MGI.
GO; GO:0042733; P:embryonic digit morphogenesis; IGI:MGI.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IGI:MGI.
GO; GO:0030326; P:embryonic limb morphogenesis; IMP:MGI.
GO; GO:0048598; P:embryonic morphogenesis; IMP:MGI.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IMP:MGI.
GO; GO:0048706; P:embryonic skeletal system development; IMP:MGI.
GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
GO; GO:0003197; P:endocardial cushion development; IMP:BHF-UCL.
GO; GO:0001958; P:endochondral ossification; IMP:UniProtKB.
GO; GO:0007492; P:endoderm development; IDA:MGI.
GO; GO:0060502; P:epithelial cell proliferation involved in lung morphogenesis; ISO:MGI.
GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; ISO:MGI.
GO; GO:0060684; P:epithelial-mesenchymal cell signaling; IDA:MGI.
GO; GO:0060429; P:epithelium development; IDA:MGI.
GO; GO:0030218; P:erythrocyte differentiation; IDA:MGI.
GO; GO:0030900; P:forebrain development; IMP:MGI.
GO; GO:0007281; P:germ cell development; IMP:MGI.
GO; GO:0072104; P:glomerular capillary formation; IMP:UniProtKB.
GO; GO:0072015; P:glomerular visceral epithelial cell development; IEP:UniProtKB.
GO; GO:0007507; P:heart development; IMP:MGI.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IDA:MGI.
GO; GO:0060113; P:inner ear receptor cell differentiation; IGI:MGI.
GO; GO:0048392; P:intermediate mesodermal cell differentiation; ISS:UniProtKB.
GO; GO:0001822; P:kidney development; IMP:MGI.
GO; GO:0060235; P:lens induction in camera-type eye; IMP:MGI.
GO; GO:0048286; P:lung alveolus development; ISO:MGI.
GO; GO:0030324; P:lung development; IMP:MGI.
GO; GO:0060425; P:lung morphogenesis; ISO:MGI.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; ISS:UniProtKB.
GO; GO:0030225; P:macrophage differentiation; ISO:MGI.
GO; GO:0060592; P:mammary gland formation; IMP:MGI.
GO; GO:0003149; P:membranous septum morphogenesis; IMP:BHF-UCL.
GO; GO:0072161; P:mesenchymal cell differentiation involved in kidney development; IMP:UniProtKB.
GO; GO:2001012; P:mesenchymal cell differentiation involved in renal system development; IMP:UniProtKB.
GO; GO:0072198; P:mesenchymal cell proliferation involved in ureter development; IEP:UniProtKB.
GO; GO:0072138; P:mesenchymal cell proliferation involved in ureteric bud development; IEP:UniProtKB.
GO; GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; ISS:UniProtKB.
GO; GO:0001707; P:mesoderm formation; IDA:MGI.
GO; GO:0048333; P:mesodermal cell differentiation; IDA:MGI.
GO; GO:0007500; P:mesodermal cell fate determination; IMP:MGI.
GO; GO:0001823; P:mesonephros development; ISS:UniProtKB.
GO; GO:0072205; P:metanephric collecting duct development; IMP:UniProtKB.
GO; GO:0001656; P:metanephros development; IDA:MGI.
GO; GO:0030224; P:monocyte differentiation; ISO:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO; GO:0072097; P:negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway; ISS:UniProtKB.
GO; GO:0090191; P:negative regulation of branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
GO; GO:0060548; P:negative regulation of cell death; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.
GO; GO:2000137; P:negative regulation of cell proliferation involved in heart morphogenesis; ISS:UniProtKB.
GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IDA:MGI.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:BHF-UCL.
GO; GO:0010629; P:negative regulation of gene expression; IDA:MGI.
GO; GO:0072125; P:negative regulation of glomerular mesangial cell proliferation; ISS:UniProtKB.
GO; GO:0090194; P:negative regulation of glomerulus development; ISS:UniProtKB.
GO; GO:0033088; P:negative regulation of immature T cell proliferation in thymus; ISS:UniProtKB.
GO; GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.
GO; GO:0072200; P:negative regulation of mesenchymal cell proliferation involved in ureter development; ISS:UniProtKB.
GO; GO:2000007; P:negative regulation of metanephric comma-shaped body morphogenesis; ISS:UniProtKB.
GO; GO:2000005; P:negative regulation of metanephric S-shaped body morphogenesis; ISS:UniProtKB.
GO; GO:0045839; P:negative regulation of mitotic nuclear division; ISS:UniProtKB.
GO; GO:0045662; P:negative regulation of myoblast differentiation; ISO:MGI.
GO; GO:0042326; P:negative regulation of phosphorylation; ISS:UniProtKB.
GO; GO:0060686; P:negative regulation of prostatic bud formation; IDA:MGI.
GO; GO:0045843; P:negative regulation of striated muscle tissue development; ISO:MGI.
GO; GO:0033085; P:negative regulation of T cell differentiation in thymus; ISO:MGI.
GO; GO:0070244; P:negative regulation of thymocyte apoptotic process; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0001843; P:neural tube closure; IDA:MGI.
GO; GO:0048663; P:neuron fate commitment; IDA:MGI.
GO; GO:0042476; P:odontogenesis; ISS:UniProtKB.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IDA:MGI.
GO; GO:0001759; P:organ induction; IMP:MGI.
GO; GO:0001649; P:osteoblast differentiation; IDA:MGI.
GO; GO:0003151; P:outflow tract morphogenesis; IGI:BHF-UCL.
GO; GO:0003148; P:outflow tract septum morphogenesis; IMP:BHF-UCL.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IMP:BHF-UCL.
GO; GO:0021983; P:pituitary gland development; IMP:MGI.
GO; GO:0050918; P:positive chemotaxis; ISS:UniProtKB.
GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IDA:UniProtKB.
GO; GO:0030501; P:positive regulation of bone mineralization; ISS:UniProtKB.
GO; GO:0061047; P:positive regulation of branching involved in lung morphogenesis; IMP:UniProtKB.
GO; GO:0055020; P:positive regulation of cardiac muscle fiber development; ISS:UniProtKB.
GO; GO:1905312; P:positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; IGI:BHF-UCL.
GO; GO:0061036; P:positive regulation of cartilage development; ISO:MGI.
GO; GO:0010942; P:positive regulation of cell death; ISO:MGI.
GO; GO:0045597; P:positive regulation of cell differentiation; IDA:MGI.
GO; GO:0030335; P:positive regulation of cell migration; IMP:CACAO.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
GO; GO:1901964; P:positive regulation of cell proliferation involved in outflow tract morphogenesis; IMP:BHF-UCL.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISS:UniProtKB.
GO; GO:2000105; P:positive regulation of DNA-dependent DNA replication; ISS:UniProtKB.
GO; GO:0045603; P:positive regulation of endothelial cell differentiation; IDA:DFLAT.
GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:DFLAT.
GO; GO:0045606; P:positive regulation of epidermal cell differentiation; ISS:UniProtKB.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:BHF-UCL.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IGI:BHF-UCL.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:MGI.
GO; GO:0010628; P:positive regulation of gene expression; IDA:CACAO.
GO; GO:0090184; P:positive regulation of kidney development; ISS:UniProtKB.
GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:MGI.
GO; GO:0045778; P:positive regulation of ossification; IDA:MGI.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISS:UniProtKB.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription from RNA polymerase II promoter; IGI:BHF-UCL.
GO; GO:1903800; P:positive regulation of production of miRNAs involved in gene silencing by miRNA; ISO:MGI.
GO; GO:0032092; P:positive regulation of protein binding; ISO:MGI.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IMP:MGI.
GO; GO:0060391; P:positive regulation of SMAD protein import into nucleus; ISS:UniProtKB.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; TAS:DFLAT.
GO; GO:0009791; P:post-embryonic development; IMP:MGI.
GO; GO:0060512; P:prostate gland morphogenesis; IMP:MGI.
GO; GO:0034504; P:protein localization to nucleus; ISS:UniProtKB.
GO; GO:0061155; P:pulmonary artery endothelial tube morphogenesis; ISS:UniProtKB.
GO; GO:0003184; P:pulmonary valve morphogenesis; IMP:BHF-UCL.
GO; GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IMP:MGI.
GO; GO:0061035; P:regulation of cartilage development; IDA:MGI.
GO; GO:0045595; P:regulation of cell differentiation; IGI:MGI.
GO; GO:0010453; P:regulation of cell fate commitment; ISS:UniProtKB.
GO; GO:0001936; P:regulation of endothelial cell proliferation; TAS:DFLAT.
GO; GO:0010468; P:regulation of gene expression; IDA:MGI.
GO; GO:0060688; P:regulation of morphogenesis of a branching structure; IMP:MGI.
GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IGI:MGI.
GO; GO:0060393; P:regulation of pathway-restricted SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:0042306; P:regulation of protein import into nucleus; ISO:MGI.
GO; GO:0051150; P:regulation of smooth muscle cell differentiation; IDA:MGI.
GO; GO:0048660; P:regulation of smooth muscle cell proliferation; IDA:MGI.
GO; GO:0072001; P:renal system development; IGI:MGI.
GO; GO:0003014; P:renal system process; IMP:MGI.
GO; GO:0003139; P:secondary heart field specification; ISS:UniProtKB.
GO; GO:0001501; P:skeletal system development; IDA:MGI.
GO; GO:0060395; P:SMAD protein signal transduction; IDA:MGI.
GO; GO:0051145; P:smooth muscle cell differentiation; IDA:MGI.
GO; GO:0048745; P:smooth muscle tissue development; IMP:UniProtKB.
GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
GO; GO:0010159; P:specification of animal organ position; IMP:MGI.
GO; GO:0072101; P:specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway; ISS:UniProtKB.
GO; GO:0043401; P:steroid hormone mediated signaling pathway; ISS:UniProtKB.
GO; GO:0021537; P:telencephalon development; ISO:MGI.
GO; GO:0021978; P:telencephalon regionalization; IDA:MGI.
GO; GO:0035990; P:tendon cell differentiation; IMP:UniProtKB.
GO; GO:0009888; P:tissue development; IGI:MGI.
GO; GO:0060438; P:trachea development; ISO:MGI.
GO; GO:0060440; P:trachea formation; IMP:MGI.
GO; GO:0003323; P:type B pancreatic cell development; ISS:UniProtKB.
GO; GO:0072192; P:ureter epithelial cell differentiation; IMP:UniProtKB.
GO; GO:0072193; P:ureter smooth muscle cell differentiation; IMP:UniProtKB.
GO; GO:0001657; P:ureteric bud development; IDA:MGI.
GO; GO:0001944; P:vasculature development; IMP:MGI.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
1: Evidence at protein level;
Chondrogenesis; Cleavage on pair of basic residues; Complete proteome;
Cytokine; Developmental protein; Differentiation; Disulfide bond;
Extracellular matrix; Glycoprotein; Growth factor; Osteogenesis;
Phosphoprotein; Reference proteome; Secreted; Signal.
SIGNAL 1 19 {ECO:0000255}.
PROPEP 20 292
/FTId=PRO_0000033858.
CHAIN 293 408 Bone morphogenetic protein 4.
/FTId=PRO_0000033859.
MOD_RES 91 91 Phosphoserine.
{ECO:0000250|UniProtKB:P12644}.
CARBOHYD 144 144 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 209 209 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 350 350 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 365 365 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 308 373 {ECO:0000250}.
DISULFID 337 405 {ECO:0000250}.
DISULFID 341 407 {ECO:0000250}.
DISULFID 372 372 Interchain. {ECO:0000250}.
CONFLICT 407 407 C -> S (in Ref. 2; BAA03555).
{ECO:0000305}.
SEQUENCE 408 AA; 46497 MW; 35053D844624EF9D CRC64;
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS QGTGLEYPER PASRANTVRS
FHHEEHLENI PGTSESSAFR FLFNLSSIPE NEVISSAELR LFREQVDQGP DWEQGFHRIN
IYEVMKPPAE MVPGHLITRL LDTRLVHHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT
HLHQTRTHQG QHVRISRSLP QGSGDWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR
SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR


Related products :

Catalog number Product name Quantity
200-001 BMP-2 Human Host: E. coli bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 5
200-002 BMP-2 Human Host: E. coli bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 25
102-PA106S BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
102-PA106 BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 200
101-M233 BMP-2 Anti-Human Host: Mouse bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
102-P03A BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
U0014h CLIA BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0014h ELISA kit BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0014h ELISA BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0013h ELISA BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
U0013h CLIA BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
E0013h ELISA kit BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
E0013m ELISA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0014m ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
U0013r CLIA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
U0014r CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
E0014m ELISA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
U0014m CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
E0014r ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
E0013m ELISA kit Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0014r ELISA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
U0013m CLIA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0013r ELISA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
E0013r ELISA kit Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
024-15071 Bone Morphogenetic Protein 13 (BMP 13), Human, recombinant Source Human bone morphogenetic protein 13 cDNA expressed in E.coli Appearance Lyophilized form with no additives (Sterile_filtered) Molecul 10ìg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur