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Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1)

 BMP7_MOUSE              Reviewed;         430 AA.
P23359; Q91XF7;
01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
23-JAN-2002, sequence version 2.
20-DEC-2017, entry version 164.
RecName: Full=Bone morphogenetic protein 7;
Short=BMP-7;
AltName: Full=Osteogenic protein 1;
Short=OP-1;
Flags: Precursor;
Name=Bmp7; Synonyms=Bmp-7, Op1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1715687; DOI=10.1016/0006-291X(91)91342-A;
Oezkaynak E., Schnegelsberg P.N.J., Oppermann H.;
"Murine osteogenic protein (OP-1): high levels of mRNA in kidney.";
Biochem. Biophys. Res. Commun. 179:116-123(1991).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
INTERACTION WITH TWSG1.
PubMed=15843411; DOI=10.1242/dev.01822;
Zakin L., Reversade B., Kuroda H., Lyons K.M., De Robertis E.M.;
"Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp
signaling in the development of ventral posterior mesoderm.";
Development 132:2489-2499(2005).
[4]
INTERACTION WITH SOSTDC1.
PubMed=14623234; DOI=10.1016/j.ydbio.2003.08.011;
Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N.;
"Identification of a secreted BMP antagonist, ectodin, integrating
BMP, FGF, and SHH signals from the tooth enamel knot.";
Dev. Biol. 264:91-105(2003).
-!- FUNCTION: Induces cartilage and bone formation. May be the
osteoinductive factor responsible for the phenomenon of epithelial
osteogenesis. Plays a role in calcium regulation and bone
homeostasis.
-!- SUBUNIT: Homodimer; disulfide-linked. Interacts with SOSTDC1
(PubMed:14623234). Interacts with TWSG1 (PubMed:15843411).
Interacts with FBN1 (via N-terminal domain) and FBN2 (By
similarity). {ECO:0000250|UniProtKB:P18075,
ECO:0000269|PubMed:14623234, ECO:0000269|PubMed:15843411}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; X56906; CAA40222.1; -; mRNA.
EMBL; BC010771; AAH10771.1; -; mRNA.
CCDS; CCDS17136.1; -.
PIR; JQ1184; JQ1184.
RefSeq; NP_031583.2; NM_007557.3.
UniGene; Mm.392150; -.
UniGene; Mm.595; -.
ProteinModelPortal; P23359; -.
SMR; P23359; -.
BioGrid; 198367; 3.
STRING; 10090.ENSMUSP00000009143; -.
iPTMnet; P23359; -.
PhosphoSitePlus; P23359; -.
PaxDb; P23359; -.
PRIDE; P23359; -.
Ensembl; ENSMUST00000009143; ENSMUSP00000009143; ENSMUSG00000008999.
GeneID; 12162; -.
KEGG; mmu:12162; -.
UCSC; uc008odb.3; mouse.
CTD; 655; -.
MGI; MGI:103302; Bmp7.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
GeneTree; ENSGT00760000118883; -.
HOGENOM; HOG000249476; -.
HOVERGEN; HBG004860; -.
InParanoid; P23359; -.
KO; K16621; -.
OMA; ETFQISV; -.
OrthoDB; EOG091G0C2J; -.
PhylomeDB; P23359; -.
TreeFam; TF316134; -.
Reactome; R-MMU-2129379; Molecules associated with elastic fibres.
PRO; PR:P23359; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000008999; -.
CleanEx; MM_BMP7; -.
Genevisible; P23359; MM.
GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0031982; C:vesicle; IEA:Ensembl.
GO; GO:0070700; F:BMP receptor binding; ISO:MGI.
GO; GO:0005125; F:cytokine activity; TAS:MGI.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0008201; F:heparin binding; IEA:Ensembl.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IBA:GO_Central.
GO; GO:1905069; P:allantois development; IGI:BHF-UCL.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IMP:MGI.
GO; GO:0009887; P:animal organ morphogenesis; IMP:MGI.
GO; GO:0007411; P:axon guidance; IDA:MGI.
GO; GO:0030509; P:BMP signaling pathway; IDA:MGI.
GO; GO:0060445; P:branching involved in salivary gland morphogenesis; IMP:MGI.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IDA:MGI.
GO; GO:0048593; P:camera-type eye morphogenesis; IMP:MGI.
GO; GO:0048738; P:cardiac muscle tissue development; IGI:BHF-UCL.
GO; GO:0060411; P:cardiac septum morphogenesis; IGI:BHF-UCL.
GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
GO; GO:0048468; P:cell development; IDA:MGI.
GO; GO:0071773; P:cellular response to BMP stimulus; ISO:MGI.
GO; GO:0060710; P:chorio-allantoic fusion; IGI:BHF-UCL.
GO; GO:0048596; P:embryonic camera-type eye morphogenesis; IMP:MGI.
GO; GO:0030326; P:embryonic limb morphogenesis; IMP:MGI.
GO; GO:0009880; P:embryonic pattern specification; IMP:MGI.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IMP:MGI.
GO; GO:0003272; P:endocardial cushion formation; IGI:BHF-UCL.
GO; GO:0030855; P:epithelial cell differentiation; IMP:MGI.
GO; GO:0001654; P:eye development; IMP:UniProtKB.
GO; GO:0061384; P:heart trabecula morphogenesis; IGI:BHF-UCL.
GO; GO:0030902; P:hindbrain development; IGI:BHF-UCL.
GO; GO:0001822; P:kidney development; IMP:UniProtKB.
GO; GO:0048762; P:mesenchymal cell differentiation; ISS:UniProtKB.
GO; GO:0060485; P:mesenchyme development; IMP:UniProtKB.
GO; GO:0001707; P:mesoderm formation; IGI:MGI.
GO; GO:0072136; P:metanephric mesenchymal cell proliferation involved in metanephros development; IGI:UniProtKB.
GO; GO:0072133; P:metanephric mesenchyme morphogenesis; IGI:UniProtKB.
GO; GO:0070487; P:monocyte aggregation; ISO:MGI.
GO; GO:0045786; P:negative regulation of cell cycle; ISO:MGI.
GO; GO:0060548; P:negative regulation of cell death; ISO:MGI.
GO; GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
GO; GO:0072125; P:negative regulation of glomerular mesangial cell proliferation; ISS:UniProtKB.
GO; GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.
GO; GO:0072040; P:negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis; IMP:MGI.
GO; GO:0045839; P:negative regulation of mitotic nuclear division; ISS:UniProtKB.
GO; GO:0050768; P:negative regulation of neurogenesis; IDA:MGI.
GO; GO:0045665; P:negative regulation of neuron differentiation; IMP:MGI.
GO; GO:0045746; P:negative regulation of Notch signaling pathway; IGI:MGI.
GO; GO:0042326; P:negative regulation of phosphorylation; ISS:UniProtKB.
GO; GO:0060686; P:negative regulation of prostatic bud formation; IDA:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0072134; P:nephrogenic mesenchyme morphogenesis; IGI:UniProtKB.
GO; GO:0021502; P:neural fold elevation formation; IGI:BHF-UCL.
GO; GO:0048812; P:neuron projection morphogenesis; IMP:MGI.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IDA:MGI.
GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
GO; GO:0007389; P:pattern specification process; IMP:MGI.
GO; GO:0003344; P:pericardium morphogenesis; IGI:BHF-UCL.
GO; GO:0060037; P:pharyngeal system development; IGI:BHF-UCL.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:MGI.
GO; GO:0030501; P:positive regulation of bone mineralization; ISO:MGI.
GO; GO:1905312; P:positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; IGI:BHF-UCL.
GO; GO:0010942; P:positive regulation of cell death; IGI:UniProtKB.
GO; GO:0045597; P:positive regulation of cell differentiation; IDA:MGI.
GO; GO:1900006; P:positive regulation of dendrite development; ISO:MGI.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IGI:BHF-UCL.
GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; ISO:MGI.
GO; GO:1900106; P:positive regulation of hyaluranon cable assembly; ISO:MGI.
GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:MGI.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISO:MGI.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0034504; P:protein localization to nucleus; ISS:UniProtKB.
GO; GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IMP:MGI.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0060393; P:regulation of pathway-restricted SMAD protein phosphorylation; ISO:MGI.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
GO; GO:0033280; P:response to vitamin D; IEA:Ensembl.
GO; GO:0007435; P:salivary gland morphogenesis; IMP:MGI.
GO; GO:0060395; P:SMAD protein signal transduction; ISS:UniProtKB.
GO; GO:0043401; P:steroid hormone mediated signaling pathway; ISO:MGI.
GO; GO:0035239; P:tube morphogenesis; IDA:MGI.
GO; GO:0001657; P:ureteric bud development; IMP:UniProtKB.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
1: Evidence at protein level;
Chondrogenesis; Complete proteome; Cytokine; Developmental protein;
Differentiation; Disulfide bond; Glycoprotein; Growth factor;
Osteogenesis; Reference proteome; Secreted; Signal.
SIGNAL 1 29 {ECO:0000255}.
PROPEP 30 291 {ECO:0000250}.
/FTId=PRO_0000033878.
CHAIN 292 430 Bone morphogenetic protein 7.
/FTId=PRO_0000033879.
CARBOHYD 186 186 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 301 301 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 320 320 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 371 371 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 329 395 {ECO:0000250}.
DISULFID 358 427 {ECO:0000250}.
DISULFID 362 429 {ECO:0000250}.
DISULFID 394 394 Interchain. {ECO:0000250}.
CONFLICT 167 167 A -> R (in Ref. 1; CAA40222).
{ECO:0000305}.
SEQUENCE 430 AA; 49199 MW; 464F36D5D2E54041 CRC64;
MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS
ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEESGPDGQ GFSYPYKAVF STQGPPLASL
QDSHFLTDAD MVMSFVNLVE HDKEFFHPRY HHREFRFDLS KIPEGEAVTA AEFRIYKDYI
RERFDNETFQ ITVYQVLQEH SGRESDLFLL DSRTIWASEE GWLVFDITAT SNHWVVNPRH
NLGLQLSVET LDGQSINPKL AGLIGRHGPQ NKQPFMVAFF KATEVHLRSI RSTGGKQRSQ
NRSKTPKNQE ALRMASVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG
ECAFPLNSYM NATNHAIVQT LVHFINPDTV PKPCCAPTQL NAISVLYFDD SSNVILKKYR
NMVVRACGCH


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