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Bowman-Birk type proteinase inhibitor (EBI)

 IBB_ERYVA               Reviewed;          61 AA.
P81705;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 1.
12-SEP-2018, entry version 55.
RecName: Full=Bowman-Birk type proteinase inhibitor;
Short=EBI;
Erythrina variegata (Indian coral tree) (Erythrina indica).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae;
50 kb inversion clade; NPAAA clade; indigoferoid/millettioid clade;
Phaseoleae; Erythrina.
NCBI_TaxID=3845;
[1]
PROTEIN SEQUENCE, AND REACTIVE SITES.
STRAIN=Var. Orientalis; TISSUE=Seed;
PubMed=8056744;
Kimura M., Kouzuma Y., Abe K., Yamasaki N.;
"On a Bowman-Birk family proteinase inhibitor from Erythrina variegata
seeds.";
J. Biochem. 115:369-372(1994).
-!- FUNCTION: Strong inhibitor of trypsin with a 1:1 stoichiometry.
Weaker inhibitor of chymotrypsin.
-!- SIMILARITY: Belongs to the Bowman-Birk serine protease inhibitor
family. {ECO:0000305}.
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PIR; JX0309; JX0309.
ProteinModelPortal; P81705; -.
SMR; P81705; -.
MEROPS; I12.003; -.
GO; GO:0005576; C:extracellular region; IEA:InterPro.
GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
CDD; cd00023; BBI; 1.
InterPro; IPR035995; Bowman-Birk_prot_inh.
InterPro; IPR000877; Prot_inh_BBI.
Pfam; PF00228; Bowman-Birk_leg; 2.
SMART; SM00269; BowB; 1.
SUPFAM; SSF57247; SSF57247; 1.
1: Evidence at protein level;
Direct protein sequencing; Disulfide bond; Protease inhibitor;
Serine protease inhibitor.
CHAIN 1 61 Bowman-Birk type proteinase inhibitor.
/FTId=PRO_0000105838.
SITE 12 13 Reactive bond for trypsin.
SITE 38 39 Reactive bond for chymotrypsin.
DISULFID 4 57 {ECO:0000250|UniProtKB:P80321}.
DISULFID 5 20 {ECO:0000250|UniProtKB:P80321}.
DISULFID 8 53 {ECO:0000250|UniProtKB:P80321}.
DISULFID 10 18 {ECO:0000250|UniProtKB:P80321}.
DISULFID 27 34 {ECO:0000250|UniProtKB:P80321}.
DISULFID 31 46 {ECO:0000250|UniProtKB:P80321}.
DISULFID 36 44 {ECO:0000250|UniProtKB:P80321}.
SEQUENCE 61 AA; 6717 MW; 377EE4061D0AB0F2 CRC64;
TSACCDKCFC TKSNPPICQC RDVGETCHSA CKFCICALSY PAQCHCLDQN TFCYDKCDSD
S


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