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Bradykinin-releasing enzyme KR-E-1 (Snake venom serine protease) (SVSP) (Thrombin-like enzyme defibrase) (EC 3.4.21.-)

 VSPD_GLOUS              Reviewed;         234 AA.
Q7SZE2; P86171;
24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
01-OCT-2003, sequence version 1.
10-MAY-2017, entry version 54.
RecName: Full=Bradykinin-releasing enzyme KR-E-1;
AltName: Full=Snake venom serine protease;
Short=SVSP;
AltName: Full=Thrombin-like enzyme defibrase;
EC=3.4.21.-;
Gloydius ussuriensis (Ussuri mamushi) (Gloydius blomhoffii
ussuriensis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Gloydius.
NCBI_TaxID=35671;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Venom gland;
Sun D.-J., Yang T.-S.;
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
[2]
PROTEIN SEQUENCE.
TISSUE=Venom;
PubMed=18723043; DOI=10.1016/j.toxicon.2008.07.014;
Oyama E., Fukuda T., Takahashi H.;
"Amino acid sequence of a kinin-releasing enzyme, KR-E-1, from the
venom of Agkistrodon caliginosus (Kankoku-mamushi).";
Toxicon 52:651-654(2008).
[3]
FUNCTION.
TISSUE=Venom;
PubMed=3201479; DOI=10.1016/0041-0101(88)90254-1;
Ohtani Y., Yabuki Y., Mimura M., Takahashi H.;
"Purification of a kininogenase from the venom of Agkistrodon
caliginosus (Kankoku-Mamushi).";
Toxicon 26:891-901(1988).
-!- FUNCTION: Bradykinin-releasing enzyme. Releases bradykinin from
bovine HMW kininogen. Has anticoagulant activity. Increases
permeability of capillaries by intradermal injection into rabbits.
{ECO:0000269|PubMed:3201479}.
-!- SUBUNIT: Monomer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- MISCELLANEOUS: Does not show a thrombin-like activity.
{ECO:0000305|PubMed:18723043}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
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EMBL; AY204242; AAP20637.1; -; mRNA.
ProteinModelPortal; Q7SZE2; -.
SMR; Q7SZE2; -.
MEROPS; S01.023; -.
HOVERGEN; HBG013304; -.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO; GO:0008236; F:serine-type peptidase activity; IDA:UniProtKB.
GO; GO:0009405; P:pathogenesis; IDA:UniProtKB.
GO; GO:0002353; P:plasma kallikrein-kinin cascade; IDA:UniProtKB.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
1: Evidence at protein level;
Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase;
Protease; Secreted; Serine protease; Toxin.
CHAIN 1 234 Bradykinin-releasing enzyme KR-E-1.
/FTId=PRO_0000295820.
DOMAIN 1 225 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
ACT_SITE 41 41 Charge relay system. {ECO:0000250}.
ACT_SITE 86 86 Charge relay system. {ECO:0000250}.
ACT_SITE 180 180 Charge relay system. {ECO:0000250}.
CARBOHYD 20 20 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 7 139 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 26 42 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 74 232 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 118 186 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 150 165 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 176 201 {ECO:0000255|PROSITE-ProRule:PRU00274}.
CONFLICT 2 2 I -> V (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 98 98 N -> T (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 141 141 N -> Y (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 204 204 S -> G (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 229 234 DASCPP -> AATCSSF (in Ref. 2; AA
sequence). {ECO:0000305}.
SEQUENCE 234 AA; 25352 MW; 0124C1485525F560 CRC64;
VIGGDECNIN EHRSLVAFFN STGFFCSGTL VNEEWVLSAA HCDSTNFQMK LGVHSKKVLN
EDEQTRNPKE KFICPNKKND EVLDKDIMLI KLDSRVSNSE HIAPLSLPSS PPSVGSVCHI
MGWGSITPIK ETYPDVPYCA NINLLDDEVC QAGYPELLAE YRTLCAGILE GGKDTCGGDS
GGPLICNGQF QGIVSYGAHP CGQSLKPGIY TKVFDYSDWI QSIIAGNTDA SCPP


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