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Brain-derived neurotrophic factor (BDNF)

 BDNF_URSAR              Reviewed;         247 AA.
O18752;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
25-OCT-2017, entry version 64.
RecName: Full=Brain-derived neurotrophic factor;
Short=BDNF;
Flags: Precursor;
Name=BDNF;
Ursus arctos (Brown bear) (Grizzly bear).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
Ursus.
NCBI_TaxID=9644;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Lin F.;
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: During development, promotes the survival and
differentiation of selected neuronal populations of the peripheral
and central nervous systems. Participates in axonal growth,
pathfinding and in the modulation of dendritic growth and
morphology. Major regulator of synaptic transmission and
plasticity at adult synapses in many regions of the CNS (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: Converted into mature BDNF by plasmin (PLG). {ECO:0000250}.
-!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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EMBL; AF002239; AAB71652.1; -; Genomic_DNA.
ProteinModelPortal; O18752; -.
SMR; O18752; -.
HOVERGEN; HBG006494; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR020430; Brain-der_neurotrophic_factor.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR020408; Nerve_growth_factor-like.
InterPro; IPR002072; Nerve_growth_factor-rel.
InterPro; IPR019846; Nerve_growth_factor_CS.
PANTHER; PTHR11589; PTHR11589; 1.
PANTHER; PTHR11589:SF3; PTHR11589:SF3; 1.
Pfam; PF00243; NGF; 1.
PIRSF; PIRSF001789; NGF; 1.
PRINTS; PR01912; BDNFACTOR.
PRINTS; PR00268; NGF.
ProDom; PD002052; Nerve_growth_factor-rel; 1.
SMART; SM00140; NGF; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00248; NGF_1; 1.
PROSITE; PS50270; NGF_2; 1.
3: Inferred from homology;
Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
Growth factor; Secreted; Signal.
SIGNAL 1 18 {ECO:0000255}.
PROPEP 19 128 {ECO:0000250}.
/FTId=PRO_0000019645.
CHAIN 129 247 Brain-derived neurotrophic factor.
/FTId=PRO_0000019646.
SITE 57 58 Cleavage; by S1P. {ECO:0000250}.
CARBOHYD 121 121 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 141 208 {ECO:0000250}.
DISULFID 186 237 {ECO:0000250}.
DISULFID 196 239 {ECO:0000250}.
SEQUENCE 247 AA; 27837 MW; EF1B3256F704D883 CRC64;
MTILFLTMVI SYFGCMKAAP MKEANVRGQG SLAYPGVRTH GTLESVNGPK AGSRGLTSLA
DTFEHVIEEL LDEDQKVRPS EENNKDADLY TSRVMLSSQV PLEPPLLFLL EEYKNYLDAA
NMSMRVRRHS DPTRRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY
FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT
LTIKRGR


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