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Brain-derived neurotrophic factor (BDNF)

 BDNF_RAT                Reviewed;         249 AA.
P23363; Q53YL8;
01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
01-NOV-1991, sequence version 1.
10-MAY-2017, entry version 138.
RecName: Full=Brain-derived neurotrophic factor;
Short=BDNF;
Flags: Precursor;
Name=Bdnf;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=1889806; DOI=10.1016/0888-7543(91)90436-I;
Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y.,
Belluscio L., de la Monte S.M., Squinto S., Furth M.E.,
Yancopoulos G.D.;
"Human and rat brain-derived neurotrophic factor and neurotrophin-3:
gene structures, distributions, and chromosomal localizations.";
Genomics 10:558-568(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1446835; DOI=10.1016/0378-1119(92)90148-I;
Ohara O., Gahara Y., Teraoka H., Kitamura T.;
"A rat brain-derived neurotrophic factor-encoding gene generates
multiple transcripts through alternative use of 5' exons and
polyadenylation sites.";
Gene 121:383-386(1992).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1966766;
Yancopoulos G.D., Maisonpierre P.C., Ip N.Y., Aldrich T.H.,
Belluscio L., Boulton T.G., Cobb M.H., Squinto S.P., Furth M.E.;
"Neurotrophic factors, their receptors, and the signal transduction
pathways they activate.";
Cold Spring Harb. Symp. Quant. Biol. 55:371-379(1990).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
PubMed=16376315; DOI=10.1016/j.brainres.2005.10.004;
Liu Q.-R., Lu L., Zhu X.-G., Gong J.-P., Shaham Y., Uhl G.R.;
"Rodent BDNF genes, novel promoters, novel splice variants, and
regulation by cocaine.";
Brain Res. 1067:1-12(2006).
[5]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
PubMed=17149751; DOI=10.1002/jnr.21139;
Aid T., Kazantseva A., Piirsoo M., Palm K., Timmusk T.;
"Mouse and rat BDNF gene structure and expression revisited.";
J. Neurosci. Res. 85:525-535(2007).
[6]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Brain;
Zhao L.X., Zhang J., Wang D.M., Yu X.J., Yue W., Pei X.T., Xu X.H.;
"Reconstituting BDNF gene to bone marrow mesenchymal stem cells:
serving as portals in the therapy of Parkinson's disease.";
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
NUCLEOTIDE SEQUENCE [MRNA] OF 8-249.
PubMed=8461137; DOI=10.1016/0896-6273(93)90335-O;
Timmusk T., Palm K., Metsis M., Reintam T., Palme V., Saarma M.,
Persson H.;
"Multiple promoters direct tissue-specific expression of the rat BDNF
gene.";
Neuron 10:475-489(1993).
[9]
NUCLEOTIDE SEQUENCE OF 187-229.
STRAIN=Sprague-Dawley; TISSUE=Liver;
PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8;
Hallboeoek F., Ibanez C.F., Persson H.;
"Evolutionary studies of the nerve growth factor family reveal a novel
member abundantly expressed in Xenopus ovary.";
Neuron 6:845-858(1991).
-!- FUNCTION: During development, promotes the survival and
differentiation of selected neuronal populations of the peripheral
and central nervous systems. Participates in axonal growth,
pathfinding and in the modulation of dendritic growth and
morphology. Major regulator of synaptic transmission and
plasticity at adult synapses in many regions of the CNS (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: Converted into mature BDNF by plasmin (PLG). {ECO:0000250}.
-!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M61175; AAA16841.1; -; mRNA.
EMBL; M61178; AAA63483.1; -; Genomic_DNA.
EMBL; D10938; BAA01732.1; -; Genomic_DNA.
EMBL; AY559248; AAS67380.1; -; mRNA.
EMBL; AY559249; AAS67381.1; -; mRNA.
EMBL; AY559250; AAS67382.1; -; mRNA.
EMBL; EF125675; ABM30161.1; -; mRNA.
EMBL; EF125676; ABM30162.1; -; mRNA.
EMBL; EF125677; ABM30163.1; -; mRNA.
EMBL; EF125678; ABM30164.1; -; mRNA.
EMBL; EF125679; ABM30165.1; -; mRNA.
EMBL; EF125680; ABM30166.1; -; mRNA.
EMBL; EF125686; ABM30172.1; -; mRNA.
EMBL; EF125687; ABM30173.1; -; mRNA.
EMBL; EF125688; ABM30174.1; -; mRNA.
EMBL; EF125689; ABM30175.1; -; mRNA.
EMBL; EF125690; ABM30176.1; -; mRNA.
EMBL; AY176065; AAO17828.1; -; mRNA.
EMBL; BC087634; AAH87634.1; -; mRNA.
EMBL; X67108; CAA47481.1; -; mRNA.
PIR; B60536; B40304.
RefSeq; NP_001257559.1; NM_001270630.1.
RefSeq; NP_001257560.1; NM_001270631.1.
RefSeq; NP_001257561.1; NM_001270632.1.
RefSeq; NP_001257562.1; NM_001270633.1.
RefSeq; NP_001257563.1; NM_001270634.1.
RefSeq; NP_001257564.1; NM_001270635.1.
RefSeq; NP_001257565.1; NM_001270636.1.
RefSeq; NP_001257566.1; NM_001270637.1.
RefSeq; NP_001257567.1; NM_001270638.1.
RefSeq; NP_036645.2; NM_012513.4.
UniGene; Rn.11266; -.
ProteinModelPortal; P23363; -.
SMR; P23363; -.
IntAct; P23363; 3.
MINT; MINT-234599; -.
STRING; 10116.ENSRNOP00000064356; -.
PaxDb; P23363; -.
PRIDE; P23363; -.
Ensembl; ENSRNOT00000077703; ENSRNOP00000072849; ENSRNOG00000047466.
Ensembl; ENSRNOT00000078543; ENSRNOP00000072315; ENSRNOG00000047466.
Ensembl; ENSRNOT00000080190; ENSRNOP00000073265; ENSRNOG00000047466.
Ensembl; ENSRNOT00000083289; ENSRNOP00000074338; ENSRNOG00000047466.
Ensembl; ENSRNOT00000089233; ENSRNOP00000075479; ENSRNOG00000047466.
Ensembl; ENSRNOT00000090445; ENSRNOP00000073685; ENSRNOG00000047466.
GeneID; 24225; -.
KEGG; rno:24225; -.
CTD; 627; -.
RGD; 2202; Bdnf.
eggNOG; ENOG410IH7X; Eukaryota.
eggNOG; ENOG410XRPH; LUCA.
GeneTree; ENSGT00390000007725; -.
HOVERGEN; HBG006494; -.
InParanoid; P23363; -.
KO; K04355; -.
OrthoDB; EOG091G0GHL; -.
PhylomeDB; P23363; -.
Reactome; R-RNO-167021; PLC-gamma1 signalling.
Reactome; R-RNO-167044; Signalling to RAS.
Reactome; R-RNO-170968; Frs2-mediated activation.
Reactome; R-RNO-170984; ARMS-mediated activation.
Reactome; R-RNO-177504; Retrograde neurotrophin signalling.
Reactome; R-RNO-187042; TRKA activation by NGF.
Reactome; R-RNO-187706; Signalling to p38 via RIT and RIN.
Reactome; R-RNO-193648; NRAGE signals death through JNK.
Reactome; R-RNO-198745; Signalling to STAT3.
PMAP-CutDB; P23363; -.
PRO; PR:P23363; -.
Proteomes; UP000002494; Chromosome 3.
Bgee; ENSRNOG00000047466; -.
ExpressionAtlas; P23363; baseline and differential.
Genevisible; P23363; RN.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0030061; C:mitochondrial crista; IDA:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0043204; C:perikaryon; IDA:RGD.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO; GO:0098794; C:postsynapse; IEA:GOC.
GO; GO:0008021; C:synaptic vesicle; IDA:RGD.
GO; GO:0043195; C:terminal bouton; IDA:RGD.
GO; GO:0008083; F:growth factor activity; TAS:RGD.
GO; GO:0005169; F:neurotrophin TRKB receptor binding; IDA:RGD.
GO; GO:0000186; P:activation of MAPKK activity; TAS:Reactome.
GO; GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.
GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IEP:RGD.
GO; GO:0071874; P:cellular response to norepinephrine stimulus; IEP:RGD.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
GO; GO:0002544; P:chronic inflammatory response; IEP:RGD.
GO; GO:0050890; P:cognition; IEP:RGD.
GO; GO:0060079; P:excitatory postsynaptic potential; IMP:RGD.
GO; GO:0007612; P:learning; IMP:RGD.
GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IMP:RGD.
GO; GO:0010832; P:negative regulation of myotube differentiation; IMP:BHF-UCL.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
GO; GO:1901215; P:negative regulation of neuron death; IMP:RGD.
GO; GO:0045843; P:negative regulation of striated muscle tissue development; IMP:RGD.
GO; GO:0007399; P:nervous system development; IDA:RGD.
GO; GO:0030182; P:neuron differentiation; TAS:RGD.
GO; GO:1990138; P:neuron projection extension; IDA:RGD.
GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
GO; GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO; GO:2000324; P:positive regulation of glucocorticoid receptor signaling pathway; IDA:MGI.
GO; GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity; IMP:RGD.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IGI:MGI.
GO; GO:1900122; P:positive regulation of receptor binding; IDA:ParkinsonsUK-UCL.
GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:MGI.
GO; GO:0007265; P:Ras protein signal transduction; TAS:Reactome.
GO; GO:0031099; P:regeneration; IDA:RGD.
GO; GO:0030516; P:regulation of axon extension; IMP:RGD.
GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IDA:RGD.
GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IDA:RGD.
GO; GO:0014823; P:response to activity; IEP:RGD.
GO; GO:0072347; P:response to anesthetic; IEP:RGD.
GO; GO:0010996; P:response to auditory stimulus; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0051602; P:response to electrical stimulus; IEP:RGD.
GO; GO:0032094; P:response to food; IEP:RGD.
GO; GO:0009725; P:response to hormone; IEP:RGD.
GO; GO:0055093; P:response to hyperoxia; IEP:RGD.
GO; GO:0001666; P:response to hypoxia; IEP:RGD.
GO; GO:1902065; P:response to L-glutamate; IEP:RGD.
GO; GO:0009642; P:response to light intensity; IEP:RGD.
GO; GO:0009416; P:response to light stimulus; IEP:RGD.
GO; GO:1990089; P:response to nerve growth factor; IEP:RGD.
GO; GO:0031667; P:response to nutrient levels; IEP:RGD.
GO; GO:0035864; P:response to potassium ion; IEP:RGD.
GO; GO:0034612; P:response to tumor necrosis factor; IEP:RGD.
GO; GO:0033189; P:response to vitamin A; IEP:RGD.
GO; GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR020430; Brain-der_neurotrophic_factor.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR020408; Nerve_growth_factor-like.
InterPro; IPR002072; Nerve_growth_factor-rel.
InterPro; IPR019846; Nerve_growth_factor_CS.
PANTHER; PTHR11589; PTHR11589; 1.
PANTHER; PTHR11589:SF15; PTHR11589:SF15; 1.
Pfam; PF00243; NGF; 1.
PIRSF; PIRSF001789; NGF; 1.
PRINTS; PR01912; BDNFACTOR.
PRINTS; PR00268; NGF.
ProDom; PD002052; Nerve_growth_factor-rel; 1.
SMART; SM00140; NGF; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00248; NGF_1; 1.
PROSITE; PS50270; NGF_2; 1.
2: Evidence at transcript level;
Cleavage on pair of basic residues; Complete proteome; Disulfide bond;
Glycoprotein; Growth factor; Reference proteome; Secreted; Signal.
SIGNAL 1 18 {ECO:0000255}.
PROPEP 19 130
/FTId=PRO_0000019643.
CHAIN 131 249 Brain-derived neurotrophic factor.
/FTId=PRO_0000019644.
SITE 57 58 Cleavage; by S1P. {ECO:0000250}.
CARBOHYD 123 123 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 143 210 {ECO:0000250}.
DISULFID 188 239 {ECO:0000250}.
DISULFID 198 241 {ECO:0000250}.
SEQUENCE 249 AA; 28109 MW; F9CAAA5DEF9A78B7 CRC64;
MTILFLTMVI SYFGCMKAAP MKEANVHGQG NLAYPAVRTH GTLESVNGPR AGSRGLTTTS
LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS QVPLEPPLLF LLEEYKNYLD
AANMSMRVRR HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK
QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV
CTLTIKRGR


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