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Brain-derived neurotrophic factor (BDNF)

 BDNF_CHICK              Reviewed;         246 AA.
P25429; Q45N27;
01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
01-DEC-1992, sequence version 2.
25-OCT-2017, entry version 117.
RecName: Full=Brain-derived neurotrophic factor;
Short=BDNF;
Flags: Precursor;
Name=BDNF;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Leghorn; TISSUE=Liver;
PubMed=1457809; DOI=10.3109/10425179209039695;
Maisonpierre P., Belluscio L., Conover J.C., Yancopoulos G.D.;
"Gene sequences of chicken BDNF and NT-3.";
DNA Seq. 3:49-54(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=16611805; DOI=10.1523/JNEUROSCI.0371-06.2006;
Katz A., Meiri N.;
"Brain-derived neurotrophic factor is critically involved in thermal-
experience-dependent developmental plasticity.";
J. Neurosci. 26:3899-3907(2006).
[3]
NUCLEOTIDE SEQUENCE OF 127-240.
PubMed=1906813; DOI=10.1016/0014-5793(91)80812-H;
Isackson P.J., Towner M.D., Huntsman M.M.;
"Comparison of mammalian, chicken and Xenopus brain-derived
neurotrophic factor coding sequences.";
FEBS Lett. 285:260-264(1991).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 184-226.
PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8;
Hallboeoek F., Ibanez C.F., Persson H.;
"Evolutionary studies of the nerve growth factor family reveal a novel
member abundantly expressed in Xenopus ovary.";
Neuron 6:845-858(1991).
-!- FUNCTION: Promotes the survival of neuronal populations that are
all located either in the central nervous system or directly
connected to it.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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EMBL; M83377; AAC42220.1; -; Genomic_DNA.
EMBL; DQ124361; AAZ31074.1; -; mRNA.
EMBL; X61476; CAA43704.1; -; mRNA.
PIR; I50606; I50606.
RefSeq; NP_001026787.1; NM_001031616.1.
RefSeq; XP_015141637.1; XM_015286151.1.
RefSeq; XP_015141638.1; XM_015286152.1.
RefSeq; XP_015141639.1; XM_015286153.1.
RefSeq; XP_015141640.1; XM_015286154.1.
UniGene; Gga.696; -.
ProteinModelPortal; P25429; -.
SMR; P25429; -.
STRING; 9031.ENSGALP00000019837; -.
PaxDb; P25429; -.
Ensembl; ENSGALT00000019864; ENSGALP00000019837; ENSGALG00000012163.
Ensembl; ENSGALT00000083974; ENSGALP00000063948; ENSGALG00000012163.
Ensembl; ENSGALT00000089246; ENSGALP00000063414; ENSGALG00000012163.
GeneID; 396186; -.
KEGG; gga:396186; -.
CTD; 627; -.
eggNOG; ENOG410IH7X; Eukaryota.
eggNOG; ENOG410XRPH; LUCA.
GeneTree; ENSGT00390000007725; -.
HOGENOM; HOG000231516; -.
HOVERGEN; HBG006494; -.
InParanoid; P25429; -.
KO; K04355; -.
OMA; RVGWRFI; -.
OrthoDB; EOG091G0GHL; -.
PhylomeDB; P25429; -.
TreeFam; TF106463; -.
PRO; PR:P25429; -.
Proteomes; UP000000539; Chromosome 5.
Bgee; ENSGALG00000012163; -.
ExpressionAtlas; P25429; baseline and differential.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
GO; GO:0005576; C:extracellular region; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IDA:AgBase.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
GO; GO:0005169; F:neurotrophin TRKB receptor binding; IBA:GO_Central.
GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
GO; GO:0009408; P:response to heat; IDA:AgBase.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR020430; Brain-der_neurotrophic_factor.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR020408; Nerve_growth_factor-like.
InterPro; IPR002072; Nerve_growth_factor-rel.
InterPro; IPR019846; Nerve_growth_factor_CS.
PANTHER; PTHR11589; PTHR11589; 1.
PANTHER; PTHR11589:SF3; PTHR11589:SF3; 1.
Pfam; PF00243; NGF; 1.
PIRSF; PIRSF001789; NGF; 1.
PRINTS; PR01912; BDNFACTOR.
PRINTS; PR00268; NGF.
ProDom; PD002052; Nerve_growth_factor-rel; 1.
SMART; SM00140; NGF; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00248; NGF_1; 1.
PROSITE; PS50270; NGF_2; 1.
2: Evidence at transcript level;
Cleavage on pair of basic residues; Complete proteome; Disulfide bond;
Glycoprotein; Growth factor; Reference proteome; Secreted; Signal.
SIGNAL 1 18 {ECO:0000255}.
PROPEP 19 127
/FTId=PRO_0000019649.
CHAIN 128 246 Brain-derived neurotrophic factor.
/FTId=PRO_0000019650.
SITE 57 58 Cleavage; by S1P. {ECO:0000250}.
CARBOHYD 120 120 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 140 207 {ECO:0000250}.
DISULFID 185 236 {ECO:0000250}.
DISULFID 195 238 {ECO:0000250}.
SEQUENCE 246 AA; 27715 MW; CE1D93E99FDD3BA0 CRC64;
MTILFLTMVI SYFSCMKAAP MKEASVRGHG SLAYPGLRTH GTLESLTGPN AGSRGLTSLA
DTFEHVIEEL LDEDQDIQPS EENKDADLYT SRVMLSSQVP LEPPLLFLLE EYKNYLDAAN
MSMRVRRHSD PARRGELSVC DSTSEWVTAA EKKTAVDMSG ATVTVLEKVP VPKGQLKQYF
YETKCNPKGY TKEGCRGIDK RHWNSQCRTT QSYVRALTMD NKKRVGWRFI RIDTSCVCTL
TIKRGR


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