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Brain-derived neurotrophic factor (BDNF)

 BDNF_XIPMA              Reviewed;         269 AA.
Q02193;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 1.
10-MAY-2017, entry version 68.
RecName: Full=Brain-derived neurotrophic factor;
Short=BDNF;
Flags: Precursor;
Name=bdnf;
Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
Poeciliinae; Xiphophorus.
NCBI_TaxID=8083;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1629719; DOI=10.1111/j.1471-4159.1992.tb09389.x;
Gotz R., Raulf F., Schartl M.;
"Brain-derived neurotrophic factor is more highly conserved in
structure and function than nerve growth factor during vertebrate
evolution.";
J. Neurochem. 59:432-442(1992).
-!- FUNCTION: BDNF promotes the survival of neuronal populations that
are all located either in the central nervous system or directly
connected to it.
-!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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EMBL; X59942; CAA42567.1; -; Genomic_DNA.
PIR; I51708; I51708.
ProteinModelPortal; Q02193; -.
SMR; Q02193; -.
STRING; 8083.ENSXMAP00000020028; -.
eggNOG; ENOG410IH7X; Eukaryota.
eggNOG; ENOG410XRPH; LUCA.
HOVERGEN; HBG006494; -.
InParanoid; Q02193; -.
Proteomes; UP000002852; Unassembled WGS sequence.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR020430; Brain-der_neurotrophic_factor.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR020408; Nerve_growth_factor-like.
InterPro; IPR002072; Nerve_growth_factor-rel.
InterPro; IPR019846; Nerve_growth_factor_CS.
PANTHER; PTHR11589; PTHR11589; 1.
PANTHER; PTHR11589:SF15; PTHR11589:SF15; 1.
Pfam; PF00243; NGF; 1.
PIRSF; PIRSF001789; NGF; 1.
PRINTS; PR01912; BDNFACTOR.
PRINTS; PR00268; NGF.
ProDom; PD002052; Nerve_growth_factor-rel; 1.
SMART; SM00140; NGF; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00248; NGF_1; 1.
PROSITE; PS50270; NGF_2; 1.
3: Inferred from homology;
Cleavage on pair of basic residues; Complete proteome; Disulfide bond;
Glycoprotein; Growth factor; Reference proteome; Signal.
SIGNAL 1 18 {ECO:0000255}.
PROPEP 19 150
/FTId=PRO_0000019653.
CHAIN 151 269 Brain-derived neurotrophic factor.
/FTId=PRO_0000019654.
CARBOHYD 143 143 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 163 230 {ECO:0000250}.
DISULFID 208 259 {ECO:0000250}.
DISULFID 218 261 {ECO:0000250}.
SEQUENCE 269 AA; 29709 MW; DAE774B79F2E5E52 CRC64;
MTILFLTMVI SYFSCMRAAP LRDAPGMRGH WTEGYLGAAA TAPRGHGTPQ SGGGPGQREE
LPSLTDTFEQ VIEELLEVEG EAAHVGQGAD KSQGGGGPSP VATAEANDVD LYNSRVMISN
QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPSRRGEL SVCDSISQWV TAVDKKTAID
MSGQTVTVME KVPVPNGQLK QYFYETKCNP MGYTKDGCRG IDKRHYTSQC RTTQSYVRAL
TMDSKKKIGW RFIRIDTSCV CTLTIKRGR


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