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Brain-derived neurotrophic factor (BDNF) (Fragment)

 BDNF_ANISC              Reviewed;         191 AA.
Q1X700;
02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
02-MAY-2006, sequence version 1.
25-OCT-2017, entry version 31.
RecName: Full=Brain-derived neurotrophic factor;
Short=BDNF;
Flags: Precursor; Fragment;
Name=BDNF;
Anilius scytale (Red pipe snake) (Coral cylinder snake).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Henophidia; Aniliidae; Anilius.
NCBI_TaxID=51844;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=16624591; DOI=10.1016/j.ympev.2006.03.010;
Noonan B.P., Chippindale P.T.;
"Dispersal and vicariance: the complex evolutionary history of boid
snakes.";
Mol. Phylogenet. Evol. 40:347-358(2006).
-!- FUNCTION: Promotes the survival of neuronal populations that are
all located either in the central nervous system or directly
connected to it. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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EMBL; AY988038; AAY44245.1; -; Genomic_DNA.
HOVERGEN; HBG006494; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR020430; Brain-der_neurotrophic_factor.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR020408; Nerve_growth_factor-like.
InterPro; IPR002072; Nerve_growth_factor-rel.
InterPro; IPR019846; Nerve_growth_factor_CS.
PANTHER; PTHR11589; PTHR11589; 1.
PANTHER; PTHR11589:SF3; PTHR11589:SF3; 1.
Pfam; PF00243; NGF; 1.
PIRSF; PIRSF001789; NGF; 1.
PRINTS; PR01912; BDNFACTOR.
PRINTS; PR00268; NGF.
ProDom; PD002052; Nerve_growth_factor-rel; 1.
SMART; SM00140; NGF; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00248; NGF_1; 1.
PROSITE; PS50270; NGF_2; 1.
3: Inferred from homology;
Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
Growth factor; Secreted.
PROPEP <1 100 {ECO:0000250}.
/FTId=PRO_0000346656.
CHAIN 101 >191 Brain-derived neurotrophic factor.
/FTId=PRO_0000346657.
CARBOHYD 93 93 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 113 180 {ECO:0000250}.
NON_TER 1 1
NON_TER 191 191
SEQUENCE 191 AA; 21253 MW; 5048427A860922BA CRC64;
GQGSLAYPGL RTQGNLETLG GPNDATRGLT SLADTFEHVI EELLDEQQVI QPSKENKDAD
LYSSRVMLSS QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSTSEWV
TAAEKKTAVD MSGATVTVLE KVPVPKGQLK QXFYETKCSS KGYAKEGCRG IDKRYWNSQC
RTTQSYVRAL T


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