Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)

 BCAR3_HUMAN             Reviewed;         825 AA.
O75815; D3DT43; Q5TEW3; Q6UW40; Q9BR50;
04-APR-2006, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
05-DEC-2018, entry version 156.
RecName: Full=Breast cancer anti-estrogen resistance protein 3;
AltName: Full=Novel SH2-containing protein 2;
AltName: Full=SH2 domain-containing protein 3B;
Name=BCAR3; Synonyms=NSP2, SH2D3B; ORFNames=UNQ271/PRO308;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
FUNCTION.
TISSUE=Testis;
PubMed=9582273; DOI=10.1093/emboj/17.10.2799;
van Agthoven T., van Agthoven T.L.A., Dekker A., van der Spek P.J.,
Vreede L., Dorssers L.C.J.;
"Identification of BCAR3 by a random search for genes involved in
antiestrogen resistance of human breast cancer cells.";
EMBO J. 17:2799-2808(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
TISSUE=Kidney;
PubMed=10187783; DOI=10.1074/jbc.274.15.10047;
Lu Y., Brush J., Stewart T.A.;
"NSP1 defines a novel family of adaptor proteins linking integrin and
tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-
activated protein kinase signaling pathway.";
J. Biol. Chem. 274:10047-10052(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
TISSUE=Heart;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND SER-375, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=16964243; DOI=10.1038/nbt1240;
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein
phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32; SER-83; SER-290;
SER-358; SER-363 AND SER-375, AND IDENTIFICATION BY MASS SPECTROMETRY
[LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
[11]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
Mann M.;
"Quantitative phosphoproteomics reveals widespread full
phosphorylation site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[12]
ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22814378; DOI=10.1073/pnas.1210303109;
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
Aldabe R.;
"N-terminal acetylome analyses and functional insights of the N-
terminal acetyltransferase NatB.";
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
[13]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78 AND SER-375, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[14]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[15]
METHYLATION [LARGE SCALE ANALYSIS] AT LYS-334 AND ARG-442, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Colon carcinoma;
PubMed=24129315; DOI=10.1074/mcp.O113.027870;
Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
Vemulapalli V., Bedford M.T., Comb M.J.;
"Immunoaffinity enrichment and mass spectrometry analysis of protein
methylation.";
Mol. Cell. Proteomics 13:372-387(2014).
-!- FUNCTION: May act as an adapter protein and couple activated
growth factor receptors to a signaling pathway that regulates the
proliferation in breast cancer cells. When overexpressed, it
confers anti-estrogen resistance in breast cancer cell lines. May
also be regulated by cellular adhesion to extracellular matrix
proteins. {ECO:0000269|PubMed:9582273}.
-!- SUBUNIT: Interacts with BCAR1, NEDD9, PTK2/FAK1 and PTPN1.
{ECO:0000250}.
-!- INTERACTION:
P56945:BCAR1; NbExp=3; IntAct=EBI-15953103, EBI-702093;
P04626:ERBB2; NbExp=2; IntAct=EBI-702336, EBI-641062;
P35568:IRS1; NbExp=3; IntAct=EBI-702336, EBI-517592;
P10721:KIT; NbExp=3; IntAct=EBI-702336, EBI-1379503;
Q14511:NEDD9; NbExp=3; IntAct=EBI-702336, EBI-2108053;
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=O75815-1; Sequence=Displayed;
Name=2;
IsoId=O75815-2; Sequence=VSP_017814;
Note=No experimental confirmation available.;
Name=3;
IsoId=O75815-3; Sequence=VSP_046716, VSP_046717;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Ubiquitously expressed. Found in several
cancer cell lines, but not in nonmalignant breast tissue.
{ECO:0000269|PubMed:10187783, ECO:0000269|PubMed:9582273}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; U92715; AAC39777.1; -; mRNA.
EMBL; AF124250; AAD28245.1; -; mRNA.
EMBL; AY358996; AAQ89355.1; -; mRNA.
EMBL; AL833121; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; AL049796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AL109613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AL359820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AL512488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471097; EAW73065.1; -; Genomic_DNA.
EMBL; CH471097; EAW73066.1; -; Genomic_DNA.
EMBL; CH471097; EAW73068.1; -; Genomic_DNA.
EMBL; BC039895; AAH39895.1; -; mRNA.
CCDS; CCDS58010.1; -. [O75815-3]
CCDS; CCDS745.1; -. [O75815-1]
CCDS; CCDS76181.1; -. [O75815-2]
RefSeq; NP_001248337.1; NM_001261408.1. [O75815-1]
RefSeq; NP_001248338.1; NM_001261409.1. [O75815-1]
RefSeq; NP_001248339.1; NM_001261410.1. [O75815-3]
RefSeq; NP_001295180.1; NM_001308251.1. [O75815-2]
RefSeq; NP_003558.1; NM_003567.3. [O75815-1]
RefSeq; XP_016857969.1; XM_017002480.1. [O75815-1]
UniGene; Hs.36958; -.
PDB; 3T6A; X-ray; 2.40 A; A/B/C/D=502-825.
PDBsum; 3T6A; -.
ProteinModelPortal; O75815; -.
SMR; O75815; -.
BioGrid; 114000; 38.
DIP; DIP-33857N; -.
IntAct; O75815; 38.
MINT; O75815; -.
STRING; 9606.ENSP00000260502; -.
iPTMnet; O75815; -.
PhosphoSitePlus; O75815; -.
BioMuta; BCAR3; -.
EPD; O75815; -.
MaxQB; O75815; -.
PaxDb; O75815; -.
PeptideAtlas; O75815; -.
PRIDE; O75815; -.
ProteomicsDB; 50205; -.
ProteomicsDB; 50206; -. [O75815-2]
DNASU; 8412; -.
Ensembl; ENST00000260502; ENSP00000260502; ENSG00000137936. [O75815-1]
Ensembl; ENST00000370243; ENSP00000359263; ENSG00000137936. [O75815-1]
Ensembl; ENST00000370244; ENSP00000359264; ENSG00000137936. [O75815-1]
Ensembl; ENST00000370247; ENSP00000359267; ENSG00000137936. [O75815-3]
Ensembl; ENST00000539242; ENSP00000441343; ENSG00000137936. [O75815-2]
GeneID; 8412; -.
KEGG; hsa:8412; -.
UCSC; uc001dpx.6; human. [O75815-1]
CTD; 8412; -.
DisGeNET; 8412; -.
EuPathDB; HostDB:ENSG00000137936.16; -.
GeneCards; BCAR3; -.
HGNC; HGNC:973; BCAR3.
HPA; HPA014858; -.
MIM; 604704; gene.
neXtProt; NX_O75815; -.
OpenTargets; ENSG00000137936; -.
PharmGKB; PA25283; -.
eggNOG; ENOG410IFQG; Eukaryota.
eggNOG; ENOG410XTJR; LUCA.
GeneTree; ENSGT00940000158309; -.
HOGENOM; HOG000231595; -.
HOVERGEN; HBG053174; -.
InParanoid; O75815; -.
OMA; MDCKVAR; -.
OrthoDB; EOG091G01KG; -.
PhylomeDB; O75815; -.
TreeFam; TF323756; -.
SignaLink; O75815; -.
ChiTaRS; BCAR3; human.
GeneWiki; BCAR3; -.
GenomeRNAi; 8412; -.
PRO; PR:O75815; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000137936; Expressed in 222 organ(s), highest expression level in chorionic villus.
CleanEx; HS_BCAR3; -.
Genevisible; O75815; HS.
GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO; GO:0002089; P:lens morphogenesis in camera-type eye; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
GO; GO:0042493; P:response to drug; TAS:ProtInc.
GO; GO:0007165; P:signal transduction; TAS:ProtInc.
GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
CDD; cd00155; RasGEF; 1.
Gene3D; 1.10.840.10; -; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR028849; BCAR3.
InterPro; IPR023578; Ras_GEF_dom_sf.
InterPro; IPR001895; RASGEF_cat_dom.
InterPro; IPR036964; RASGEF_cat_dom_sf.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
PANTHER; PTHR14247:SF10; PTHR14247:SF10; 1.
Pfam; PF00617; RasGEF; 1.
Pfam; PF00017; SH2; 1.
SMART; SM00147; RasGEF; 1.
SMART; SM00252; SH2; 1.
SUPFAM; SSF48366; SSF48366; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50009; RASGEF_CAT; 1.
PROSITE; PS50001; SH2; 1.
1: Evidence at protein level;
3D-structure; Acetylation; Alternative splicing; Complete proteome;
Guanine-nucleotide releasing factor; Methylation; Phosphoprotein;
Polymorphism; Reference proteome; SH2 domain.
INIT_MET 1 1 Removed. {ECO:0000244|PubMed:22814378}.
CHAIN 2 825 Breast cancer anti-estrogen resistance
protein 3.
/FTId=PRO_0000230284.
DOMAIN 154 253 SH2. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
DOMAIN 548 818 Ras-GEF. {ECO:0000255|PROSITE-
ProRule:PRU00168}.
COMPBIAS 479 482 Poly-Asp.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000244|PubMed:22814378}.
MOD_RES 32 32 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 78 78 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 83 83 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 182 182 Phosphoserine.
{ECO:0000244|PubMed:16964243}.
MOD_RES 290 290 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 334 334 N6-methyllysine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 358 358 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 363 363 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 375 375 Phosphoserine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 442 442 Omega-N-methylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 471 471 Phosphoserine.
{ECO:0000250|UniProtKB:Q9QZK2}.
VAR_SEQ 1 324 Missing (in isoform 2).
{ECO:0000303|PubMed:12975309}.
/FTId=VSP_017814.
VAR_SEQ 1 91 Missing (in isoform 3).
{ECO:0000303|PubMed:17974005}.
/FTId=VSP_046716.
VAR_SEQ 92 117 ESPWQDRHGETFTFRDPHLLDPTVEY -> MPKECSAFHAL
SAALCCFYHRKSFIG (in isoform 3).
{ECO:0000303|PubMed:17974005}.
/FTId=VSP_046717.
VARIANT 464 464 E -> G (in dbSNP:rs12062278).
/FTId=VAR_050689.
VARIANT 593 593 Q -> H (in dbSNP:rs17110107).
/FTId=VAR_050690.
CONFLICT 519 519 E -> G (in Ref. 4; AL833121).
{ECO:0000305}.
CONFLICT 543 543 L -> P (in Ref. 4; AL833121).
{ECO:0000305}.
HELIX 517 519 {ECO:0000244|PDB:3T6A}.
HELIX 534 546 {ECO:0000244|PDB:3T6A}.
HELIX 549 563 {ECO:0000244|PDB:3T6A}.
HELIX 571 577 {ECO:0000244|PDB:3T6A}.
STRAND 578 580 {ECO:0000244|PDB:3T6A}.
HELIX 582 585 {ECO:0000244|PDB:3T6A}.
HELIX 589 591 {ECO:0000244|PDB:3T6A}.
HELIX 592 614 {ECO:0000244|PDB:3T6A}.
HELIX 620 639 {ECO:0000244|PDB:3T6A}.
HELIX 644 655 {ECO:0000244|PDB:3T6A}.
HELIX 657 660 {ECO:0000244|PDB:3T6A}.
HELIX 663 672 {ECO:0000244|PDB:3T6A}.
HELIX 674 682 {ECO:0000244|PDB:3T6A}.
HELIX 684 692 {ECO:0000244|PDB:3T6A}.
HELIX 696 698 {ECO:0000244|PDB:3T6A}.
HELIX 711 717 {ECO:0000244|PDB:3T6A}.
HELIX 724 726 {ECO:0000244|PDB:3T6A}.
HELIX 732 734 {ECO:0000244|PDB:3T6A}.
HELIX 737 752 {ECO:0000244|PDB:3T6A}.
HELIX 754 764 {ECO:0000244|PDB:3T6A}.
TURN 765 767 {ECO:0000244|PDB:3T6A}.
HELIX 772 777 {ECO:0000244|PDB:3T6A}.
HELIX 780 792 {ECO:0000244|PDB:3T6A}.
HELIX 797 815 {ECO:0000244|PDB:3T6A}.
SEQUENCE 825 AA; 92566 MW; C55D61BB4AC7D0F2 CRC64;
MAAGKFASLP RNMPVNHQFP LASSMDLLSS RSPLAEHRPD AYQDVSIHGT LPRKKKGPPP
IRSCDDFSHM GTLPHSKSPR QNSPVTQDGI QESPWQDRHG ETFTFRDPHL LDPTVEYVKF
SKERHIMDRT PEKLKKELEE ELLLSSEDLR SHAWYHGRIP RQVSENLVQR DGDFLVRDSL
SSPGNFVLTC QWKNLAQHFK INRTVLRLSE AYSRVQYQFE MESFDSIPGL VRCYVGNRRP
ISQQSGAIIF QPINRTVPLR CLEEHYGTSP GQAREGSLTK GRPDVAKRLS LTMGGVQARE
QNLPRGNLLR NKEKSGSQPA CLDHMQDRRA LSLKAHQSES YLPIGCKLPP QSSGVDTSPC
PNSPVFRTGS EPALSPAVVR RVSSDARAGE ALRGSDSQLC PKPPPKPCKV PFLKVPSSPS
AWLNSEANYC ELNPAFATGC GRGAKLPSCA QGSHTELLTA KQNEAPGPRN SGVNYLILDD
DDRERPWEPA AAQMEKGQWD KGEFVTPLLE TVSSFRPNEF ESKFLPPENK PLETAMLKRA
KELFTNNDPK VIAQHVLSMD CRVARILGVS EEMRRNMGVS SGLELITLPH GHQLRLDIIE
RHNTMAIGIA VDILGCTGTL EDRAATLSKI IQVAVELKDS MGDLYSFSAL MKALEMPQIT
RLEKTWTALR HQYTQTAILY EKQLKPFSKL LHEGRESTCV PPNNVSVPLL MPLVTLMERQ
AVTFEGTDMW EKNDQSCEIM LNHLATARFM AEAADSYRMN AERILAGFQP DEEMNEICKT
EFQMRLLWGS KGAQVNQTER YEKFNQILTA LSRKLEPPPV KQAEL


Related products :

Catalog number Product name Quantity
20-783-74648 MOUSE ANTI HUMAN BREAST CANCER RESISTANCE PROTEIN - Placenta-specific ATP-binding cassette transporter; Breast cancer resistance protein; Mitoxantrone resistance-associated protein; CD338 antigen; CDw 1 ml
EM783 Breast cancer anti-estrogen resistance protein 3 Elisa Kit 96T
CSB-EL002593RA Rat Breast cancer anti-estrogen resistance protein 1(BCAR1) ELISA kit 96T
CSB-EL002594MO Mouse Breast cancer anti-estrogen resistance protein 3(BCAR3) ELISA kit 96T
CSB-EL002593MO Mouse Breast cancer anti-estrogen resistance protein 1(BCAR1) ELISA kit 96T
AE54595BO Bovine Breast cancer anti-estrogen resistance protein 3 (BCAR3) ELISA Kit 48T
CSB-EL002594BO Bovine Breast cancer anti-estrogen resistance protein 3(BCAR3) ELISA kit 96T
CSB-EL002593RA Rat Breast cancer anti-estrogen resistance protein 1(BCAR1) ELISA kit SpeciesRat 96T
CSB-EL002594HU Human Breast cancer anti-estrogen resistance protein 3(BCAR3) ELISA kit 96T
CSB-EL002593HU Human Breast cancer anti-estrogen resistance protein 1(BCAR1) ELISA kit 96T
CSB-EL002593MO Mouse Breast cancer anti-estrogen resistance protein 1(BCAR1) ELISA kit SpeciesMouse 96T
CSB-EL002594HU Human Breast cancer anti-estrogen resistance protein 3(BCAR3) ELISA kit SpeciesHuman 96T
CSB-EL002593HU Human Breast cancer anti-estrogen resistance protein 1(BCAR1) ELISA kit SpeciesHuman 96T
CSB-EL002594BO Bovine Breast cancer anti-estrogen resistance protein 3(BCAR3) ELISA kit SpeciesBovine 96T
CSB-EL002594MO Mouse Breast cancer anti-estrogen resistance protein 3(BCAR3) ELISA kit SpeciesMouse 96T
BCAR3_BOVIN ELISA Kit FOR Breast cancer anti-estrogen resistance protein 3; organism: Bovine; gene name: BCAR3 96T
BCAR1_HUMAN ELISA Kit FOR Breast cancer anti-estrogen resistance protein 1; organism: Human; gene name: BCAR1 96T
BCAR3_HUMAN ELISA Kit FOR Breast cancer anti-estrogen resistance protein 3; organism: Human; gene name: BCAR3 96T
FP-0006 Breast cancer ANTIESTROGEN resistance 3 protein ; SH2-Domain: BCAR3 10ug
U0960h CLIA ABCG2,ABCP,ATP-binding cassette sub-family G member 2,BCRP,BCRP1,Breast cancer resistance protein,CDw338,Homo sapiens,Human,Mitoxantrone resistance-associated protein,MXR,Placenta-specific ATP-bi 96T
E0960h ELISA kit ABCG2,ABCP,ATP-binding cassette sub-family G member 2,BCRP,BCRP1,Breast cancer resistance protein,CDw338,Homo sapiens,Human,Mitoxantrone resistance-associated protein,MXR,Placenta-specific 96T
E0960h ELISA ABCG2,ABCP,ATP-binding cassette sub-family G member 2,BCRP,BCRP1,Breast cancer resistance protein,CDw338,Homo sapiens,Human,Mitoxantrone resistance-associated protein,MXR,Placenta-specific ATP-b 96T
EIAAB43818 BCAR2,Breast cancer anti-estrogen resistance 2,Homo sapiens,Human,RAPA,Transcriptional-regulating factor 1,Transcriptional-regulating protein 132,TREP132,TRERF1,Zinc finger protein rapa,Zinc finger tr
bs-0662P Peptides: BCRP_ABCG2(breast cancer resistance protein) Protein Length:12-25 amino acids. 200ug lyophilized
E12857h Human Breast Cancer Anti Estrogen Resistance 1 ELI 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur