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C-8 sterol isomerase erg2 (EC 5.-.-.-) (Delta-8--delta-7 sterol isomerase erg2) (Ergosterol biosynthesis protein 2)

 ERG2_SCHPO              Reviewed;         219 AA.
P87113;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
25-OCT-2017, entry version 105.
RecName: Full=C-8 sterol isomerase erg2;
EC=5.-.-.-;
AltName: Full=Delta-8--delta-7 sterol isomerase erg2;
AltName: Full=Ergosterol biosynthesis protein 2;
Name=erg2; ORFNames=SPAC20G8.07c;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=16823372; DOI=10.1038/nbt1222;
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the
fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
[3]
FUNCTION.
PubMed=18310029; DOI=10.1099/mic.0.2007/011155-0;
Iwaki T., Iefuji H., Hiraga Y., Hosomi A., Morita T., Giga-Hama Y.,
Takegawa K.;
"Multiple functions of ergosterol in the fission yeast
Schizosaccharomyces pombe.";
Microbiology 154:830-841(2008).
-!- FUNCTION: Catalyzes the reaction which results in unsaturation at
C-7 in the B ring of sterols. Involved in the biosynthesis or
ergosterol which is important for plasma membrane structure and
function and for localization of plasma membrane proteins.
{ECO:0000269|PubMed:18310029}.
-!- PATHWAY: Steroid metabolism; ergosterol biosynthesis; ergosterol
from zymosterol: step 2/5.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000269|PubMed:16823372}; Single-pass membrane protein
{ECO:0000269|PubMed:16823372}.
-!- SIMILARITY: Belongs to the ERG2 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; CU329670; CAB08601.1; -; Genomic_DNA.
PIR; T38129; T38129.
RefSeq; NP_593324.1; NM_001018755.2.
SMR; P87113; -.
BioGrid; 278476; 1.
MINT; MINT-4692352; -.
STRING; 4896.SPAC20G8.07c.1; -.
MaxQB; P87113; -.
PRIDE; P87113; -.
EnsemblFungi; SPAC20G8.07c.1; SPAC20G8.07c.1:pep; SPAC20G8.07c.
GeneID; 2541992; -.
KEGG; spo:SPAC20G8.07c; -.
EuPathDB; FungiDB:SPAC20G8.07c; -.
PomBase; SPAC20G8.07c; erg2.
HOGENOM; HOG000211245; -.
InParanoid; P87113; -.
KO; K09829; -.
OMA; LFYTLRA; -.
OrthoDB; EOG092C47C3; -.
PhylomeDB; P87113; -.
UniPathway; UPA00768; UER00761.
PRO; PR:P87113; -.
Proteomes; UP000002485; Chromosome I.
GO; GO:0005783; C:endoplasmic reticulum; IDA:PomBase.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0000247; F:C-8 sterol isomerase activity; ISS:PomBase.
GO; GO:0006696; P:ergosterol biosynthetic process; IMP:PomBase.
InterPro; IPR006716; ERG2_sigma1_rcpt-like.
PANTHER; PTHR10868; PTHR10868; 1.
Pfam; PF04622; ERG2_Sigma1R; 1.
3: Inferred from homology;
Complete proteome; Endoplasmic reticulum; Isomerase;
Lipid biosynthesis; Lipid metabolism; Membrane; Reference proteome;
Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis;
Sterol metabolism; Transmembrane; Transmembrane helix.
CHAIN 1 219 C-8 sterol isomerase erg2.
/FTId=PRO_0000087019.
TRANSMEM 1 21 Helical. {ECO:0000255}.
SEQUENCE 219 AA; 24671 MW; 82C5EE63E28A8375 CRC64;
MKLTKFLTVF IPFIAGLIYY IQKYHLRSFY QFDPAKLQEL SKQSIALYAN DTKALLYDLS
DRLVAEYGDL ITPVNQDEWV HNNAGGAMGT MFILHASFSE YLIFFGTPIG TEGHSGVHMA
DDYFTILRGR QLAASANDLE ARVYLPGDQH VHPWGHTAQY SMPSGEPCFA LELAQGWIVS
MLPFGFMDGL FSTIDFGTLY KTVYFTAGRM LKSVLMGKF


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