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C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (Chemokine receptor-like 3) (CKR-L3) (DRY6) (G-protein coupled receptor 29) (GPR-CY4) (GPRCY4) (LARC receptor) (CD antigen CD196)

 CCR6_HUMAN              Reviewed;         374 AA.
P51684; E1P5C6; P78553; Q92846;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
15-JUL-1998, sequence version 2.
05-DEC-2018, entry version 182.
RecName: Full=C-C chemokine receptor type 6;
Short=C-C CKR-6;
Short=CC-CKR-6;
Short=CCR-6;
AltName: Full=Chemokine receptor-like 3;
Short=CKR-L3;
AltName: Full=DRY6;
AltName: Full=G-protein coupled receptor 29;
AltName: Full=GPR-CY4;
Short=GPRCY4;
AltName: Full=LARC receptor;
AltName: CD_antigen=CD196;
Name=CCR6; Synonyms=CKRL3, CMKBR6, GPR29, STRL22;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
PubMed=9169459; DOI=10.1074/jbc.272.23.14893;
Baba M., Imai T., Nishimura M., Kakizaki M., Takagi S., Hieshima K.,
Nomiyama H., Yoshie O.;
"Identification of CCR6, the specific receptor for a novel lymphocyte-
directed CC chemokine LARC.";
J. Biol. Chem. 272:14893-14898(1997).
[2]
NUCLEOTIDE SEQUENCE.
Lautens L.L., Modi W., Bonner T.I.;
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
PubMed=8886020; DOI=10.1006/bbrc.1996.1595;
Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G.;
"Molecular cloning and RNA expression of two new human chemokine
receptor-like genes.";
Biochem. Biophys. Res. Commun. 227:846-853(1996).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
McCoy R., Perlmutter D.H.;
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9070937; DOI=10.1006/geno.1996.4544;
Liao F., Lee H.-H., Farber J.M.;
"Cloning of STRL22, a new human gene encoding a G-protein-coupled
receptor related to chemokine receptors and located on chromosome
6q27.";
Genomics 40:175-180(1997).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Warren C.N., Aronstam R.S., Sharma S.V.;
"cDNA clones of human proteins involved in signal transduction
sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=14574404; DOI=10.1038/nature02055;
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[10]
DISULFIDE BOND, MUTAGENESIS OF CYS-36; CYS-57; CYS-118; CYS-131;
CYS-138; CYS-168; CYS-197; CYS-233; CYS-266; CYS-288; CYS-309;
CYS-310; CYS-336 AND CYS-348, AND SUBCELLULAR LOCATION.
PubMed=12081481; DOI=10.1021/bi025855y;
Ai L.S., Liao F.;
"Mutating the four extracellular cysteines in the chemokine receptor
CCR6 reveals their differing roles in receptor trafficking, ligand
binding, and signaling.";
Biochemistry 41:8332-8341(2002).
[11]
FUNCTION, AND BINDING TO CCL20; DEFB4 AND DEFB4A.
PubMed=20068036; DOI=10.1074/jbc.M109.091090;
Roehrl J., Yang D., Oppenheim J.J., Hehlgans T.;
"Specific binding and chemotactic activity of mBD4 and its functional
orthologue hBD2 to CCR6-expressing cells.";
J. Biol. Chem. 285:7028-7034(2010).
[12]
REVIEW, AND FUNCTION.
PubMed=21376174; DOI=10.1016/j.yexcr.2010.12.018;
Ito T., Carson W.F. IV, Cavassani K.A., Connett J.M., Kunkel S.L.;
"CCR6 as a mediator of immunity in the lung and gut.";
Exp. Cell Res. 317:613-619(2011).
[13]
FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=23765988; DOI=10.1002/jcp.24418;
Caballero-Campo P., Buffone M.G., Benencia F., Conejo-Garcia J.R.,
Rinaudo P.F., Gerton G.L.;
"A role for the chemokine receptor CCR6 in mammalian sperm motility
and chemotaxis.";
J. Cell. Physiol. 229:68-78(2014).
[14]
FUNCTION, TISSUE SPECIFICITY, AND BINDING TO DEFB1.
PubMed=25122636; DOI=10.1126/scitranslmed.3009071;
Diao R., Fok K.L., Chen H., Yu M.K., Duan Y., Chung C.M., Li Z.,
Wu H., Li Z., Zhang H., Ji Z., Zhen W., Ng C.F., Gui Y., Cai Z.,
Chan H.C.;
"Deficient human beta-defensin 1 underlies male infertility associated
with poor sperm motility and genital tract infection.";
Sci. Transl. Med. 6:249RA108-249RA108(2014).
[15]
REVIEW, AND FUNCTION.
PubMed=25585877; DOI=10.1016/j.cyto.2014.11.029;
Lee A.Y., Phan T.K., Hulett M.D., Koerner H.;
"The relationship between CCR6 and its binding partners: does the
CCR6-CCL20 axis have to be extended?";
Cytokine 72:97-101(2015).
-!- FUNCTION: Receptor for the C-C type chemokine CCL20
(PubMed:9169459). Binds to CCL20 and subsequently transduces a
signal by increasing the intracellular calcium ion levels
(PubMed:20068036). Although CCL20 is its major ligand it can also
act as a receptor for non-chemokine ligands such as beta-defensins
(PubMed:25585877). Binds to defensin DEFB1 leading to increase in
intracellular calcium ions and cAMP levels. Its binding to DEFB1
is essential for the function of DEFB1 in regulating sperm
motility and bactericidal activity (PubMed:25122636). Binds to
defensins DEFB4 and DEFB4A/B and mediates their chemotactic
effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is
responsible for the chemotaxis of dendritic cells (DC), effector/
memory T-cells and B-cells and plays an important role at skin and
mucosal surfaces under homeostatic and inflammatory conditions, as
well as in pathology, including cancer and various autoimmune
diseases. CCR6-mediated signals are essential for immune responses
to microbes in the intestinal mucosa and in the modulation of
inflammatory responses initiated by tissue insult and trauma
(PubMed:21376174). CCR6 is essential for the recruitment of both
the proinflammatory IL17 producing helper T-cells (Th17) and the
regulatory T-cells (Treg) to sites of inflammation. Required for
the normal migration of Th17 cells in Peyers-patches and other
related tissue sites of the intestine and plays a role in
regulating effector T-cell balance and distribution in inflamed
intestine. Plays an important role in the coordination of early
thymocyte precursor migration events important for normal
subsequent thymocyte precursor development, but is not required
for the formation of normal thymic natural regulatory T-cells
(nTregs). Required for optimal differentiation of DN2 and DN3
thymocyte precursors. Essential for B-cell localization in the
subepithelial dome of Peyers-patches and for efficient B-cell
isotype switching to IgA in the Peyers-patches. Essential for
appropriate anatomical distribution of memory B-cells in the
spleen and for the secondary recall response of memory B-cells (By
similarity). Positively regulates sperm motility and chemotaxis
via its binding to CCL20 (PubMed:23765988).
{ECO:0000250|UniProtKB:O54689, ECO:0000269|PubMed:20068036,
ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:25122636,
ECO:0000269|PubMed:9169459, ECO:0000303|PubMed:21376174,
ECO:0000303|PubMed:25585877}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23765988};
Multi-pass membrane protein {ECO:0000255}. Cell surface
{ECO:0000269|PubMed:12081481}.
-!- TISSUE SPECIFICITY: Sperm. Mainly localized in the tail and in the
postacrosomal region but is also found in the midpiece and basal
region in a small percentage of sperm cells. Reduced levels found
in the sperms of asthenozoospermia and leukocytospermia patients
(at protein level). Spleen, lymph nodes, appendix, and fetal
liver. Expressed in lymphocytes, T-cells and B-cells but not in
natural killer cells, monocytes or granulocytes.
{ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:25122636,
ECO:0000269|PubMed:8886020}.
-!- INDUCTION: By IL2/interleukin-2.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAB02144.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=Wikipedia; Note=CC chemokine receptors entry;
URL="https://en.wikipedia.org/wiki/CC_chemokine_receptors";
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EMBL; U45984; AAB62714.1; -; Genomic_DNA.
EMBL; Z79784; CAB02144.1; ALT_INIT; Genomic_DNA.
EMBL; U60000; AAB06949.1; -; mRNA.
EMBL; U68030; AAC51124.1; -; mRNA.
EMBL; U68032; AAC51125.1; -; Genomic_DNA.
EMBL; AY242126; AAO92293.1; -; mRNA.
EMBL; AL121935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471051; EAW47506.1; -; Genomic_DNA.
EMBL; CH471051; EAW47507.1; -; Genomic_DNA.
EMBL; BC037960; AAH37960.1; -; mRNA.
CCDS; CCDS5298.1; -.
PIR; JC5068; JC5068.
RefSeq; NP_004358.2; NM_004367.5.
RefSeq; NP_113597.2; NM_031409.3.
UniGene; Hs.46468; -.
ProteinModelPortal; P51684; -.
BioGrid; 107640; 70.
DIP; DIP-5865N; -.
STRING; 9606.ENSP00000339393; -.
BindingDB; P51684; -.
ChEMBL; CHEMBL4423; -.
GuidetoPHARMACOLOGY; 63; -.
iPTMnet; P51684; -.
PhosphoSitePlus; P51684; -.
BioMuta; CCR6; -.
DMDM; 2851567; -.
PaxDb; P51684; -.
PeptideAtlas; P51684; -.
PRIDE; P51684; -.
ProteomicsDB; 56368; -.
DNASU; 1235; -.
Ensembl; ENST00000341935; ENSP00000343952; ENSG00000112486.
Ensembl; ENST00000349984; ENSP00000339393; ENSG00000112486.
Ensembl; ENST00000400926; ENSP00000383715; ENSG00000112486.
Ensembl; ENST00000643861; ENSP00000493637; ENSG00000112486.
GeneID; 1235; -.
KEGG; hsa:1235; -.
UCSC; uc003qvm.5; human.
CTD; 1235; -.
DisGeNET; 1235; -.
EuPathDB; HostDB:ENSG00000112486.14; -.
GeneCards; CCR6; -.
HGNC; HGNC:1607; CCR6.
HPA; CAB006820; -.
HPA; HPA014488; -.
MalaCards; CCR6; -.
MIM; 601835; gene.
neXtProt; NX_P51684; -.
OpenTargets; ENSG00000112486; -.
Orphanet; 220393; Diffuse cutaneous systemic sclerosis.
Orphanet; 220402; Limited cutaneous systemic sclerosis.
PharmGKB; PA26171; -.
eggNOG; ENOG410IKPR; Eukaryota.
eggNOG; ENOG410XSP7; LUCA.
GeneTree; ENSGT00940000153132; -.
HOGENOM; HOG000234122; -.
HOVERGEN; HBG106917; -.
InParanoid; P51684; -.
KO; K04181; -.
OMA; IMKDLWC; -.
OrthoDB; EOG091G08B0; -.
PhylomeDB; P51684; -.
TreeFam; TF330966; -.
Reactome; R-HSA-1461957; Beta defensins.
Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
Reactome; R-HSA-418594; G alpha (i) signalling events.
ChiTaRS; CCR6; human.
GeneWiki; C-C_chemokine_receptor_type_6; -.
GenomeRNAi; 1235; -.
PRO; PR:P51684; -.
Proteomes; UP000005640; Chromosome 6.
Bgee; ENSG00000112486; Expressed in 57 organ(s), highest expression level in leukocyte.
CleanEx; HS_CCR6; -.
Genevisible; P51684; HS.
GO; GO:0009986; C:cell surface; IDA:UniProtKB.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0036126; C:sperm flagellum; IDA:UniProtKB.
GO; GO:0097225; C:sperm midpiece; IDA:UniProtKB.
GO; GO:0097524; C:sperm plasma membrane; IDA:UniProtKB.
GO; GO:0097228; C:sperm principal piece; IDA:UniProtKB.
GO; GO:0019957; F:C-C chemokine binding; IDA:UniProtKB.
GO; GO:0016493; F:C-C chemokine receptor activity; IDA:UniProtKB.
GO; GO:0019956; F:chemokine binding; IBA:GO_Central.
GO; GO:0004950; F:chemokine receptor activity; TAS:ProtInc.
GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc.
GO; GO:0019722; P:calcium-mediated signaling; IMP:UniProtKB.
GO; GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO; GO:0006968; P:cellular defense response; TAS:ProtInc.
GO; GO:0006935; P:chemotaxis; IDA:UniProtKB.
GO; GO:0002407; P:dendritic cell chemotaxis; TAS:BHF-UCL.
GO; GO:1904155; P:DN2 thymocyte differentiation; ISS:UniProtKB.
GO; GO:1904156; P:DN3 thymocyte differentiation; ISS:UniProtKB.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0006959; P:humoral immune response; TAS:ProtInc.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0048290; P:isotype switching to IgA isotypes; ISS:UniProtKB.
GO; GO:0002523; P:leukocyte migration involved in inflammatory response; ISS:UniProtKB.
GO; GO:0072676; P:lymphocyte migration; ISS:UniProtKB.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
GO; GO:2000510; P:positive regulation of dendritic cell chemotaxis; IBA:GO_Central.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:0060474; P:positive regulation of flagellated sperm motility involved in capacitation; IDA:UniProtKB.
GO; GO:2000404; P:regulation of T cell migration; ISS:UniProtKB.
GO; GO:0007165; P:signal transduction; TAS:ProtInc.
GO; GO:0072678; P:T cell migration; ISS:UniProtKB.
GO; GO:0072679; P:thymocyte migration; ISS:UniProtKB.
CDD; cd15172; 7tmA_CCR6; 1.
InterPro; IPR004067; Chemokine_CCR6.
InterPro; IPR000355; Chemokine_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
PANTHER; PTHR10489:SF611; PTHR10489:SF611; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00657; CCCHEMOKINER.
PRINTS; PR01529; CHEMOKINER6.
PRINTS; PR00237; GPCRRHODOPSN.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
Reference proteome; Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 374 C-C chemokine receptor type 6.
/FTId=PRO_0000069286.
TOPO_DOM 1 47 Extracellular. {ECO:0000255}.
TRANSMEM 48 74 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 75 83 Cytoplasmic. {ECO:0000255}.
TRANSMEM 84 104 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 105 119 Extracellular. {ECO:0000255}.
TRANSMEM 120 141 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 142 159 Cytoplasmic. {ECO:0000255}.
TRANSMEM 160 180 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 181 211 Extracellular. {ECO:0000255}.
TRANSMEM 212 238 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 239 254 Cytoplasmic. {ECO:0000255}.
TRANSMEM 255 279 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 280 303 Extracellular. {ECO:0000255}.
TRANSMEM 304 321 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 322 374 Cytoplasmic. {ECO:0000255}.
CARBOHYD 7 7 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 23 23 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 118 197 {ECO:0000269|PubMed:12081481}.
MUTAGEN 36 36 C->A: No loss of calcium flux but loss of
chemotaxis in response to CCL20
stimulation. No effect on cell surface
expression.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 36 36 C->D,G: Loss of calcium flux and
chemotaxis in response to CCL20
stimulation. No effect on cell surface
expression.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 36 36 C->S: No loss of calcium flux but loss of
chemotaxis in response to CCL20
stimulation, impaired CCL20-binding and
no effect on cell surface expression;
when associated with or without S-288.
Loss of calcium flux in response to CCL20
stimulation and significant reduction in
cell surface expression; when associated
with S-118; S-197 and S-288.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 57 57 C->S: No effect on calcium flux and
chemotaxis in response to CCL20
stimulation. No effect on cell surface
expression.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 118 118 C->S: Loss of calcium flux and chemotaxis
in response to CCL20 stimulation,
impaired CCL20-binding and significant
reduction in cell surface expression;
when associated with or without S-197.
Loss of calcium flux in response to CCL20
stimulation and significant reduction in
cell surface expression; when associated
with S-36; S-197 and S-288.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 131 131 C->S: No effect on calcium flux and
chemotaxis in response to CCL20
stimulation. No effect on cell surface
expression.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 138 138 C->S: No effect on calcium flux and
chemotaxis in response to CCL20
stimulation. No effect on cell surface
expression.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 168 168 C->S: No effect on calcium flux and
chemotaxis in response to CCL20
stimulation. No effect on cell surface
expression.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 197 197 C->S: Loss of calcium flux and chemotaxis
in response to CCL20 stimulation,
impaired CCL20-binding and significant
reduction in cell surface expression;
when associated with or without S-118.
Loss of calcium flux in response to CCL20
stimulation and significant reduction in
cell surface expression; when associated
with S-36; S-118 and S-288.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 233 233 C->S: No effect on calcium flux and
chemotaxis in response to CCL20
stimulation. No effect on cell surface
expression.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 266 266 C->S: No effect on calcium flux and
chemotaxis in response to CCL20
stimulation. No effect on cell surface
expression.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 288 288 C->A,G,R: No loss of calcium flux but
loss of chemotaxis in response to CCL20
stimulation. No effect on cell surface
expression.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 288 288 C->S: No loss of calcium flux but loss of
chemotaxis in response to CCL20
stimulation, impaired CCL20-binding and
no effect on cell surface expression;
when associated with or without S-36.
Loss of calcium flux in response to CCL20
stimulation and significant reduction in
cell surface expression; when associated
with S-36; S-118 and S-197.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 309 309 C->S: No effect on calcium flux and
chemotaxis in response to CCL20
stimulation. No effect on cell surface
expression.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 310 310 C->S: No effect on calcium flux and
chemotaxis in response to CCL20
stimulation. No effect on cell surface
expression.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 336 336 C->S: Reduced calcium flux and chemotaxis
in response to CCL20 stimulation, and
reduced CCL20-binding. No effect on cell
surface expression.
{ECO:0000269|PubMed:12081481}.
MUTAGEN 348 348 C->S: No effect on calcium flux and
chemotaxis in response to CCL20
stimulation. No effect on CCL20-binding
and cell surface expression.
{ECO:0000269|PubMed:12081481}.
CONFLICT 60 60 G -> A (in Ref. 4; AAB06949).
{ECO:0000305}.
CONFLICT 74 74 Y -> N (in Ref. 4; AAB06949).
{ECO:0000305}.
CONFLICT 86 86 L -> V (in Ref. 4; AAB06949).
{ECO:0000305}.
CONFLICT 164 164 S -> T (in Ref. 5; AAC51124/AAC51125).
{ECO:0000305}.
CONFLICT 182 182 T -> S (in Ref. 4; AAB06949).
{ECO:0000305}.
CONFLICT 192 192 Q -> L (in Ref. 4; AAB06949).
{ECO:0000305}.
CONFLICT 206 206 E -> V (in Ref. 4; AAB06949).
{ECO:0000305}.
CONFLICT 225 225 I -> F (in Ref. 4; AAB06949).
{ECO:0000305}.
CONFLICT 370 374 SSFTM -> VVLHYVIES (in Ref. 4; AAB06949).
{ECO:0000305}.
SEQUENCE 374 AA; 42494 MW; D7F963534E990BC4 CRC64;
MSGESMNFSD VFDSSEDYFV SVNTSYYSVD SEMLLCSLQE VRQFSRLFVP IAYSLICVFG
LLGNILVVIT FAFYKKARSM TDVYLLNMAI ADILFVLTLP FWAVSHATGA WVFSNATCKL
LKGIYAINFN CGMLLLTCIS MDRYIAIVQA TKSFRLRSRT LPRSKIICLV VWGLSVIISS
STFVFNQKYN TQGSDVCEPK YQTVSEPIRW KLLMLGLELL FGFFIPLMFM IFCYTFIVKT
LVQAQNSKRH KAIRVIIAVV LVFLACQIPH NMVLLVTAAN LGKMNRSCQS EKLIGYTKTV
TEVLAFLHCC LNPVLYAFIG QKFRNYFLKI LKDLWCVRRK YKSSGFSCAG RYSENISRQT
SETADNDNAS SFTM


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