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C-C motif chemokine 12 (MCP-1-related chemokine) (Monocyte chemoattractant protein 5) (Monocyte chemotactic protein 5) (MCP-5) (Small-inducible cytokine A12)

 CCL12_MOUSE             Reviewed;         104 AA.
Q62401; Q9QYD6;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 1.
25-OCT-2017, entry version 141.
RecName: Full=C-C motif chemokine 12;
AltName: Full=MCP-1-related chemokine;
AltName: Full=Monocyte chemoattractant protein 5;
AltName: Full=Monocyte chemotactic protein 5;
Short=MCP-5;
AltName: Full=Small-inducible cytokine A12;
Flags: Precursor;
Name=Ccl12; Synonyms=Mcp5, Scya12;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8920881; DOI=10.1084/jem.184.5.1939;
Jia G.-Q., Gonzalo J.A., Lloyd C., Kremer L., Lu L., Martinez A.C.,
Wershil B.K., Gutierrez-Ramos J.-C.;
"Distinct expression and function of the novel mouse chemokine
monocyte chemotactic protein-5 in lung allergic inflammation.";
J. Exp. Med. 184:1939-1951(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8996246; DOI=10.1084/jem.185.1.99;
Sarafi M.N., Garcia-Zepeda E.A., MacLean J.A., Charo I.F.,
Luster A.D.;
"Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine
that is a structural and functional homologue of human MCP-1.";
J. Exp. Med. 185:99-109(1997).
[3]
NUCLEOTIDE SEQUENCE [MRNA], POLYMORPHISM, AND VARIANT 94-GLN--GLY-104
DELINS ARG-THR.
STRAIN=B10.S/J, BALB/cJ, DBA/2J, NOD/LtJ, and SJL/J; TISSUE=Spleen;
PubMed=10438970;
Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W.,
Blankenhorn E.P.;
"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2
(monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are
candidates for eae7, a locus controlling susceptibility to monophasic
remitting/nonrelapsing experimental allergic encephalomyelitis.";
J. Immunol. 163:2262-2266(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Chemotactic factor that attracts eosinophils, monocytes,
and lymphocytes but not neutrophils. Potent monocyte active
chemokine that signals through CCR2. Involved in allergic
inflammation and the host response to pathogens and may play a
pivotal role during early stages of allergic lung inflammation.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Predominantly expressed in the lymph nodes and
thymus. Also found in the salivary glands containing lymph nodes,
breast, heart, lung, brain, small intestine, kidney and colon.
-!- INDUCTION: By interferon gamma and lipopolysaccharides (LPS).
-!- POLYMORPHISM: The polymorphism in strain SJL/J may be associated
with severity of clinical symptoms of experimental allergic
encephalomyelitis, an animal model of multiple sclerosis, and
susceptibility to the monophasic remitting/nonrelapsing form of
the disease. {ECO:0000269|PubMed:10438970}.
-!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; U50712; AAB50053.1; -; mRNA.
EMBL; U66670; AAB49424.1; -; mRNA.
EMBL; AF065934; AAF15384.1; -; mRNA.
EMBL; AF065935; AAF15385.1; -; mRNA.
EMBL; AF065936; AAF15386.1; -; mRNA.
EMBL; AF065937; AAF15387.1; -; mRNA.
EMBL; AF065938; AAF15388.1; -; mRNA.
EMBL; BC027520; AAH27520.1; -; mRNA.
CCDS; CCDS36247.1; -.
RefSeq; NP_035461.2; NM_011331.2.
UniGene; Mm.867; -.
ProteinModelPortal; Q62401; -.
SMR; Q62401; -.
STRING; 10090.ENSMUSP00000000194; -.
PaxDb; Q62401; -.
PeptideAtlas; Q62401; -.
PRIDE; Q62401; -.
Ensembl; ENSMUST00000000194; ENSMUSP00000000194; ENSMUSG00000035352.
GeneID; 20293; -.
KEGG; mmu:20293; -.
UCSC; uc007kms.1; mouse.
CTD; 20293; -.
MGI; MGI:108224; Ccl12.
eggNOG; ENOG410J1ST; Eukaryota.
eggNOG; ENOG410YXJU; LUCA.
GeneTree; ENSGT00900000140949; -.
HOGENOM; HOG000036686; -.
HOVERGEN; HBG017871; -.
InParanoid; Q62401; -.
KO; K14624; -.
OMA; CCFSTIN; -.
OrthoDB; EOG091G14KV; -.
PhylomeDB; Q62401; -.
TreeFam; TF334888; -.
PRO; PR:Q62401; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000035352; -.
CleanEx; MM_CCL12; -.
ExpressionAtlas; Q62401; baseline and differential.
Genevisible; Q62401; MM.
GO; GO:0005576; C:extracellular region; ISO:MGI.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0031727; F:CCR2 chemokine receptor binding; IPI:BHF-UCL.
GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
GO; GO:0001525; P:angiogenesis; IDA:BHF-UCL.
GO; GO:0043615; P:astrocyte cell migration; ISO:MGI.
GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
GO; GO:0071407; P:cellular response to organic cyclic compound; ISO:MGI.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:MGI.
GO; GO:0007010; P:cytoskeleton organization; ISO:MGI.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IDA:BHF-UCL.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISO:MGI.
GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
GO; GO:0048246; P:macrophage chemotaxis; ISO:MGI.
GO; GO:0000165; P:MAPK cascade; ISO:MGI.
GO; GO:0002548; P:monocyte chemotaxis; IDA:BHF-UCL.
GO; GO:0034351; P:negative regulation of glial cell apoptotic process; ISO:MGI.
GO; GO:0070664; P:negative regulation of leukocyte proliferation; IEA:Ensembl.
GO; GO:2000502; P:negative regulation of natural killer cell chemotaxis; ISO:MGI.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:MGI.
GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0090280; P:positive regulation of calcium ion import; ISO:MGI.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
GO; GO:0002687; P:positive regulation of leukocyte migration; IEA:Ensembl.
GO; GO:0043491; P:protein kinase B signaling; ISO:MGI.
GO; GO:0008360; P:regulation of cell shape; ISO:MGI.
InterPro; IPR000827; Chemokine_CC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR036048; Interleukin_8-like_sf.
Pfam; PF00048; IL8; 1.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
2: Evidence at transcript level;
Chemotaxis; Complete proteome; Cytokine; Disulfide bond;
Inflammatory response; Polymorphism; Reference proteome; Secreted;
Signal.
SIGNAL 1 22 {ECO:0000250}.
CHAIN 23 104 C-C motif chemokine 12.
/FTId=PRO_0000005199.
DISULFID 33 58 {ECO:0000250}.
DISULFID 34 74 {ECO:0000250}.
VARIANT 94 104 QTFILEPSCLG -> RT (in strain: SJL/J).
{ECO:0000269|PubMed:10438970}.
SEQUENCE 104 AA; 11659 MW; 8D102F4FF4CC3DBF CRC64;
MKISTLLCLL LIATTISPQV LAGPDAVSTP VTCCYNVVKQ KIHVRKLKSY RRITSSQCPR
EAVIFRTILD KEICADPKEK WVKNSINHLD KTSQTFILEP SCLG


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