Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

C-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine)

 CCL17_HUMAN             Reviewed;          94 AA.
Q92583; A0N0Q9; Q2M287;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
23-MAY-2018, entry version 156.
RecName: Full=C-C motif chemokine 17;
AltName: Full=CC chemokine TARC;
AltName: Full=Small-inducible cytokine A17;
AltName: Full=Thymus and activation-regulated chemokine;
Flags: Precursor;
Name=CCL17; Synonyms=SCYA17, TARC;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 24-32.
TISSUE=Peripheral blood monocyte;
PubMed=8702936; DOI=10.1074/jbc.271.35.21514;
Imai T., Yoshida T., Baba M., Nishimura M., Kakizaki M., Yoshie O.;
"Molecular cloning of a novel T cell-directed CC chemokine expressed
in thymus by signal sequence trap using Epstein-Barr virus vector.";
J. Biol. Chem. 271:21514-21521(1996).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B.,
Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O.,
Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I.,
Nickerson D.A.;
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=10493829; DOI=10.1006/geno.1999.5927;
Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R.,
Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L.,
Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E.,
Harris P.C., Venter J.C., Adams M.D.;
"Genome duplications and other features in 12 Mb of DNA sequence from
human chromosome 16p and 16q.";
Genomics 60:295-308(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
RECEPTOR INTERACTION.
PubMed=9521068;
DOI=10.1002/(SICI)1521-4141(199802)28:02<582::AID-IMMU582>3.0.CO;2-A;
Bernardini G., Hedrick J., Sozzani S., Luini W., Spinetti G.,
Weiss M., Menon S., Zlotnik A., Mantovani A., Santoni A.,
Napolitano M.;
"Identification of the CC chemokines TARC and macrophage inflammatory
protein-1 beta as novel functional ligands for the CCR8 receptor.";
Eur. J. Immunol. 28:582-588(1998).
[7]
FUNCTION.
PubMed=10540332;
DOI=10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W;
Garlisi C.G., Xiao H., Tian F., Hedrick J.A., Billah M.M., Egan R.W.,
Umland S.P.;
"The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1
beta are not ligands for human CC-chemokine receptor 8.";
Eur. J. Immunol. 29:3210-3215(1999).
[8]
X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 24-94, AND DISULFIDE BONDS.
PubMed=12832759; DOI=10.1107/S0907444903009454;
Asojo O.A., Boulegue C., Hoover D.M., Lu W., Lubkowski J.;
"Structures of thymus and activation-regulated chemokine (TARC).";
Acta Crystallogr. D 59:1165-1173(2003).
-!- FUNCTION: Chemotactic factor for T-lymphocytes but not monocytes
or granulocytes. May play a role in T-cell development in thymus
and in trafficking and activation of mature T-cells. Binds to
CCR4. {ECO:0000269|PubMed:10540332}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed at high levels in thymus and at low
levels in the lung, colon and small intestine.
-!- INDUCTION: By phytohemagglutinin (PHA) in the peripheral blood
mononuclear cells and by cytokines in monocytes.
-!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
{ECO:0000305}.
-!- CAUTION: Was originally thought to be a ligand for CCR8.
{ECO:0000305|PubMed:9521068}.
-!- WEB RESOURCE: Name=Wikipedia; Note=CCL17 entry;
URL="https://en.wikipedia.org/wiki/CCL17";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; D43767; BAA07824.1; -; mRNA.
EMBL; EF064767; ABK41950.1; -; Genomic_DNA.
EMBL; AC004382; AAC24308.1; -; Genomic_DNA.
EMBL; CH471092; EAW82921.1; -; Genomic_DNA.
EMBL; BC069107; AAH69107.1; -; mRNA.
EMBL; BC112066; AAI12067.1; -; mRNA.
EMBL; BC112068; AAI12069.1; -; mRNA.
CCDS; CCDS10780.1; -.
RefSeq; NP_002978.1; NM_002987.2.
UniGene; Hs.546294; -.
PDB; 1NR2; X-ray; 2.18 A; A/B=24-94.
PDB; 1NR4; X-ray; 1.72 A; A/B/C/D/E/F/G/H=24-94.
PDB; 5WK3; X-ray; 1.90 A; A/B/C/D=24-94.
PDBsum; 1NR2; -.
PDBsum; 1NR4; -.
PDBsum; 5WK3; -.
ProteinModelPortal; Q92583; -.
SMR; Q92583; -.
BioGrid; 112264; 6.
DIP; DIP-5842N; -.
STRING; 9606.ENSP00000219244; -.
iPTMnet; Q92583; -.
PhosphoSitePlus; Q92583; -.
BioMuta; CCL17; -.
DMDM; 3024711; -.
PaxDb; Q92583; -.
PeptideAtlas; Q92583; -.
PRIDE; Q92583; -.
Ensembl; ENST00000219244; ENSP00000219244; ENSG00000102970.
Ensembl; ENST00000616880; ENSP00000480147; ENSG00000102970.
GeneID; 6361; -.
KEGG; hsa:6361; -.
UCSC; uc002elj.1; human.
CTD; 6361; -.
DisGeNET; 6361; -.
EuPathDB; HostDB:ENSG00000102970.10; -.
GeneCards; CCL17; -.
HGNC; HGNC:10615; CCL17.
HPA; CAB002583; -.
MIM; 601520; gene.
neXtProt; NX_Q92583; -.
OpenTargets; ENSG00000102970; -.
PharmGKB; PA35548; -.
eggNOG; ENOG410J0QF; Eukaryota.
eggNOG; ENOG41113EM; LUCA.
GeneTree; ENSGT00530000064258; -.
HOGENOM; HOG000036685; -.
HOVERGEN; HBG098492; -.
InParanoid; Q92583; -.
KO; K21083; -.
OMA; CSDPKDT; -.
OrthoDB; EOG091G11AP; -.
PhylomeDB; Q92583; -.
TreeFam; TF334888; -.
ChiTaRS; CCL17; human.
EvolutionaryTrace; Q92583; -.
GeneWiki; CCL17; -.
GenomeRNAi; 6361; -.
PRO; PR:Q92583; -.
Proteomes; UP000005640; Chromosome 16.
Bgee; ENSG00000102970; -.
CleanEx; HS_CCL17; -.
Genevisible; Q92583; HS.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc.
GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB.
GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0006935; P:chemotaxis; TAS:ProtInc.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0031640; P:killing of cells of other organism; IDA:UniProtKB.
GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
GO; GO:0007275; P:multicellular organism development; TAS:ProtInc.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
InterPro; IPR000827; Chemokine_CC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR036048; Interleukin_8-like_sf.
Pfam; PF00048; IL8; 1.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
1: Evidence at protein level;
3D-structure; Chemotaxis; Complete proteome; Cytokine;
Direct protein sequencing; Disulfide bond; Inflammatory response;
Polymorphism; Reference proteome; Secreted; Signal.
SIGNAL 1 23 {ECO:0000269|PubMed:8702936}.
CHAIN 24 94 C-C motif chemokine 17.
/FTId=PRO_0000005211.
DISULFID 33 57 {ECO:0000269|PubMed:12832759}.
DISULFID 34 73 {ECO:0000269|PubMed:12832759}.
VARIANT 5 5 K -> N (in dbSNP:rs34693308).
/FTId=VAR_048708.
VARIANT 67 67 V -> M (in dbSNP:rs34379253).
/FTId=VAR_048709.
STRAND 27 29 {ECO:0000244|PDB:1NR4}.
STRAND 32 36 {ECO:0000244|PDB:1NR4}.
HELIX 44 46 {ECO:0000244|PDB:1NR4}.
STRAND 47 52 {ECO:0000244|PDB:1NR4}.
STRAND 57 59 {ECO:0000244|PDB:1NR4}.
STRAND 62 66 {ECO:0000244|PDB:1NR4}.
STRAND 71 74 {ECO:0000244|PDB:1NR4}.
HELIX 79 90 {ECO:0000244|PDB:1NR4}.
SEQUENCE 94 AA; 10507 MW; 7959C56BA8FDAF08 CRC64;
MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW YQTSEDCSRD
AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS


Related products :

Catalog number Product name Quantity
U1571h CLIA CC chemokine TARC,C-C motif chemokine 17,CCL17,Homo sapiens,Human,SCYA17,Small-inducible cytokine A17,TARC,Thymus and activation-regulated chemokine 96T
E1571h ELISA kit CC chemokine TARC,C-C motif chemokine 17,CCL17,Homo sapiens,Human,SCYA17,Small-inducible cytokine A17,TARC,Thymus and activation-regulated chemokine 96T
E1571h ELISA CC chemokine TARC,C-C motif chemokine 17,CCL17,Homo sapiens,Human,SCYA17,Small-inducible cytokine A17,TARC,Thymus and activation-regulated chemokine 96T
E1571c ELISA kit Canis familiaris,Canis lupus familiaris,CC chemokine TARC,C-C motif chemokine 17,CCL17,Dog,Small-inducible cytokine A17,TARC,Thymus and activation-regulated chemokine 96T
E1571c ELISA Canis familiaris,Canis lupus familiaris,CC chemokine TARC,C-C motif chemokine 17,CCL17,Dog,Small-inducible cytokine A17,TARC,Thymus and activation-regulated chemokine 96T
U1571c CLIA Canis familiaris,Canis lupus familiaris,CC chemokine TARC,C-C motif chemokine 17,CCL17,Dog,Small-inducible cytokine A17,TARC,Thymus and activation-regulated chemokine 96T
15-288-21085 Small inducible cytokine A17 - CCL17; Thymus and activation-regulated chemokine; CC chemokine TARC Polyclonal 0.1 mg
15-288-21085 Small inducible cytokine A17 - CCL17; Thymus and activation-regulated chemokine; CC chemokine TARC Polyclonal 0.05 mg
E1248m ELISA kit C-C motif chemokine 25,Ccl25,Chemokine TECK,Mouse,Mus musculus,Scya25,Small-inducible cytokine A25,Teck,Thymus-expressed chemokine 96T
E1248m ELISA C-C motif chemokine 25,Ccl25,Chemokine TECK,Mouse,Mus musculus,Scya25,Small-inducible cytokine A25,Teck,Thymus-expressed chemokine 96T
U1248m CLIA C-C motif chemokine 25,Ccl25,Chemokine TECK,Mouse,Mus musculus,Scya25,Small-inducible cytokine A25,Teck,Thymus-expressed chemokine 96T
E1248h ELISA C-C motif chemokine 25,CCL25,Chemokine TECK,Homo sapiens,Human,SCYA25,Small-inducible cytokine A25,TECK,Thymus-expressed chemokine 96T
E1248h ELISA kit C-C motif chemokine 25,CCL25,Chemokine TECK,Homo sapiens,Human,SCYA25,Small-inducible cytokine A25,TECK,Thymus-expressed chemokine 96T
U1248h CLIA C-C motif chemokine 25,CCL25,Chemokine TECK,Homo sapiens,Human,SCYA25,Small-inducible cytokine A25,TECK,Thymus-expressed chemokine 96T
U1607m CLIA B-cell and monocyte-activating chemokine,Bmac,Chemokine BRAK,C-X-C motif chemokine 14,Cxcl14,Kec,Kidney-expressed chemokine CXC,Ks1,Mip2g,MIP-2G,Mouse,Mus musculus,Scyb14,Small-inducible cytokine 96T
18-783-75647 RABBIT ANTI HUMAN MIP-3 ALPHA - CCL20; Small-inducible cytokine A20; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Liver and activation-regulated chemokine; CC chemokine LARC; Beta chemokine e 0.1 mg
U1651h CLIA CC chemokine ILC,C-C motif chemokine 27,CCL27,CTACK,Cutaneous T-cell-attracting chemokine,ESkine,Homo sapiens,Human,IL-11 R-alpha-locus chemokine,ILC,SCYA27,Skinkine,Small-inducible cytokine A27 96T
E1651h ELISA CC chemokine ILC,C-C motif chemokine 27,CCL27,CTACK,Cutaneous T-cell-attracting chemokine,ESkine,Homo sapiens,Human,IL-11 R-alpha-locus chemokine,ILC,SCYA27,Skinkine,Small-inducible cytokine A27 96T
18-003-42916 Small inducible cytokine A18 - CCL18; Macrophage inflammatory protein 4; MIP-4; Pulmonary and activation-regulated chemokine; CC chemokine PARC; Alternative macrophage activation-associated CC chemoki 0.05 mg Aff Pur
EIAAB05843 6Ckine,Beta-chemokine exodus-2,C-C motif chemokine 21c,Ccl21c,Mouse,Mus musculus,Scya21c,Small-inducible cytokine A21c,TCA4,Thymus-derived chemotactic agent 4
EIAAB05842 6Ckine,Beta-chemokine exodus-2,C-C motif chemokine 21b,Ccl21b,Mouse,Mus musculus,Scya21,Scya21b,Small-inducible cytokine A21b,TCA4,Thymus-derived chemotactic agent 4
15-288-21084 Small inducible cytokine A16 - CCL16; IL-10-inducible chemokine; Chemokine LEC; Liver-expressed chemokine; Monotactin-1; MTN-1; Chemokine CC-4; HCC-4; NCC-4; Lymphocyte and monocyte chemoattractant; L 0.05 mg
15-288-21084 Small inducible cytokine A16 - CCL16; IL-10-inducible chemokine; Chemokine LEC; Liver-expressed chemokine; Monotactin-1; MTN-1; Chemokine CC-4; HCC-4; NCC-4; Lymphocyte and monocyte chemoattractant; L 0.1 mg
E1575m ELISA kit 6Ckine,Beta-chemokine exodus-2,C-C motif chemokine 21a,Ccl21a,Mouse,Mus musculus,Scya21,Scya21a,Small-inducible cytokine A21a,TCA4,Thymus-derived chemotactic agent 4 96T
U1575m CLIA 6Ckine,Beta-chemokine exodus-2,C-C motif chemokine 21a,Ccl21a,Mouse,Mus musculus,Scya21,Scya21a,Small-inducible cytokine A21a,TCA4,Thymus-derived chemotactic agent 4 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur