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C-C motif chemokine 2 (Immediate-early serum-responsive protein JE) (Monocyte chemoattractant protein 1) (Monocyte chemotactic protein 1) (MCP-1) (Small-inducible cytokine A2)

 CCL2_RAT                Reviewed;         148 AA.
P14844; Q549R5;
01-APR-1990, integrated into UniProtKB/Swiss-Prot.
01-APR-1990, sequence version 1.
27-SEP-2017, entry version 141.
RecName: Full=C-C motif chemokine 2;
AltName: Full=Immediate-early serum-responsive protein JE;
AltName: Full=Monocyte chemoattractant protein 1;
AltName: Full=Monocyte chemotactic protein 1;
Short=MCP-1;
AltName: Full=Small-inducible cytokine A2;
Flags: Precursor;
Name=Ccl2; Synonyms=Je, Mcp1, Scya2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=WAG/RIJ; TISSUE=Kidney;
PubMed=2106664; DOI=10.1093/nar/18.1.23;
Timmers H.T.M., Pronk G.J., Bos J.L., van der Eb A.J.;
"Analysis of the rat JE gene promoter identifies an AP-1 binding site
essential for basal expression but not for TPA induction.";
Nucleic Acids Res. 18:23-34(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1704226; DOI=10.1016/0006-291X(91)91445-I;
Yoshimura T., Takeya M., Takahashi K.;
"Molecular cloning of rat monocyte chemoattractant protein-1 (MCP-1)
and its expression in rat spleen cells and tumor cell lines.";
Biochem. Biophys. Res. Commun. 174:504-509(1991).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Aortic smooth muscle;
Poon M., Taubman M.B.;
"Cloning of the full-length rat JE/MCP-1 cDNA.";
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
[4]
SUBCELLULAR LOCATION, AND INDUCTION BY ENDOCANNABINOID ANANDAMIDE AND
IL1B.
PubMed=23955712; DOI=10.1038/nm.3265;
Jourdan T., Godlewski G., Cinar R., Bertola A., Szanda G., Liu J.,
Tam J., Han T., Mukhopadhyay B., Skarulis M.C., Ju C., Aouadi M.,
Czech M.P., Kunos G.;
"Activation of the Nlrp3 inflammasome in infiltrating macrophages by
endocannabinoids mediates beta cell loss in type 2 diabetes.";
Nat. Med. 19:1132-1140(2013).
-!- FUNCTION: Chemotactic factor that attracts monocytes, but not
neutrophils.
-!- SUBUNIT: Monomer or homodimer; in equilibrium. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23955712}.
-!- INDUCTION: In pancreatic islets, secretion is stimulated by IL1B.
In islets from Zucker diabetic fatty (ZDF) rats, but not lean
animals, secretion is also increased by endocannabinoid
anandamide/AEA. {ECO:0000269|PubMed:23955712}.
-!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X17053; CAA34901.1; -; Genomic_DNA.
EMBL; M57441; AAA63496.1; -; mRNA.
EMBL; AF058786; AAC15187.1; -; mRNA.
PIR; S07723; S07723.
RefSeq; NP_113718.1; NM_031530.1.
UniGene; Rn.4772; -.
ProteinModelPortal; P14844; -.
SMR; P14844; -.
STRING; 10116.ENSRNOP00000009448; -.
PhosphoSitePlus; P14844; -.
PaxDb; P14844; -.
PRIDE; P14844; -.
Ensembl; ENSRNOT00000009448; ENSRNOP00000009448; ENSRNOG00000007159.
GeneID; 24770; -.
KEGG; rno:24770; -.
CTD; 6347; -.
RGD; 3645; Ccl2.
eggNOG; ENOG410J1ST; Eukaryota.
eggNOG; ENOG410YXJU; LUCA.
GeneTree; ENSGT00860000133690; -.
HOGENOM; HOG000036686; -.
HOVERGEN; HBG017871; -.
InParanoid; P14844; -.
KO; K14624; -.
OMA; NAPLTCC; -.
OrthoDB; EOG091G14KV; -.
PhylomeDB; P14844; -.
TreeFam; TF339372; -.
PRO; PR:P14844; -.
Proteomes; UP000002494; Chromosome 10.
Bgee; ENSRNOG00000007159; -.
Genevisible; P14844; RN.
GO; GO:0043679; C:axon terminus; IDA:RGD.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:0030139; C:endocytic vesicle; IDA:RGD.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0043204; C:perikaryon; IDA:RGD.
GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
GO; GO:0005791; C:rough endoplasmic reticulum; IDA:RGD.
GO; GO:0045202; C:synapse; IDA:RGD.
GO; GO:0031727; F:CCR2 chemokine receptor binding; IMP:RGD.
GO; GO:0008009; F:chemokine activity; IDA:RGD.
GO; GO:0008201; F:heparin binding; IPI:RGD.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0031100; P:animal organ regeneration; IEP:RGD.
GO; GO:0043615; P:astrocyte cell migration; IEA:Ensembl.
GO; GO:0006874; P:cellular calcium ion homeostasis; IDA:RGD.
GO; GO:0071318; P:cellular response to ATP; IEP:RGD.
GO; GO:0071549; P:cellular response to dexamethasone stimulus; IEP:RGD.
GO; GO:0035690; P:cellular response to drug; IEP:RGD.
GO; GO:0071392; P:cellular response to estradiol stimulus; IEP:RGD.
GO; GO:0071398; P:cellular response to fatty acid; IEP:RGD.
GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO; GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
GO; GO:0071403; P:cellular response to high density lipoprotein particle stimulus; IEP:RGD.
GO; GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.
GO; GO:0071346; P:cellular response to interferon-gamma; IEP:RGD.
GO; GO:0071347; P:cellular response to interleukin-1; IEP:RGD.
GO; GO:0071354; P:cellular response to interleukin-6; IEP:RGD.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
GO; GO:0071402; P:cellular response to lipoprotein particle stimulus; IEP:RGD.
GO; GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; IEP:RGD.
GO; GO:0036120; P:cellular response to platelet-derived growth factor stimulus; IEP:RGD.
GO; GO:0071300; P:cellular response to retinoic acid; IEP:RGD.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IMP:RGD.
GO; GO:0042466; P:chemokinesis; TAS:RGD.
GO; GO:0002544; P:chronic inflammatory response; IEP:RGD.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IMP:RGD.
GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0008347; P:glial cell migration; IMP:RGD.
GO; GO:0035684; P:helper T cell extravasation; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEP:RGD.
GO; GO:0002523; P:leukocyte migration involved in inflammatory response; IMP:RGD.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
GO; GO:0048247; P:lymphocyte chemotaxis; IDA:RGD.
GO; GO:0048246; P:macrophage chemotaxis; IDA:RGD.
GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
GO; GO:0060135; P:maternal process involved in female pregnancy; IEP:RGD.
GO; GO:0060137; P:maternal process involved in parturition; IEP:RGD.
GO; GO:0002548; P:monocyte chemotaxis; IEA:Ensembl.
GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
GO; GO:0034351; P:negative regulation of glial cell apoptotic process; IEA:Ensembl.
GO; GO:2000502; P:negative regulation of natural killer cell chemotaxis; IEA:Ensembl.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; IMP:RGD.
GO; GO:2000427; P:positive regulation of apoptotic cell clearance; IEA:Ensembl.
GO; GO:0090280; P:positive regulation of calcium ion import; IEA:Ensembl.
GO; GO:0045785; P:positive regulation of cell adhesion; IDA:RGD.
GO; GO:0022409; P:positive regulation of cell-cell adhesion; IDA:RGD.
GO; GO:0002693; P:positive regulation of cellular extravasation; IDA:RGD.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IDA:RGD.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IMP:RGD.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
GO; GO:0090265; P:positive regulation of immune complex clearance by monocytes and macrophages; IEA:Ensembl.
GO; GO:0001912; P:positive regulation of leukocyte mediated cytotoxicity; IMP:RGD.
GO; GO:0002687; P:positive regulation of leukocyte migration; IDA:RGD.
GO; GO:0010759; P:positive regulation of macrophage chemotaxis; IDA:RGD.
GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:RGD.
GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IEA:Ensembl.
GO; GO:0090314; P:positive regulation of protein targeting to membrane; IDA:RGD.
GO; GO:0050806; P:positive regulation of synaptic transmission; IDA:RGD.
GO; GO:0050870; P:positive regulation of T cell activation; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IMP:RGD.
GO; GO:0090303; P:positive regulation of wound healing; IMP:RGD.
GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
GO; GO:0010574; P:regulation of vascular endothelial growth factor production; IEA:Ensembl.
GO; GO:0014823; P:response to activity; IEP:RGD.
GO; GO:0043200; P:response to amino acid; IEP:RGD.
GO; GO:0046677; P:response to antibiotic; IEP:RGD.
GO; GO:1905237; P:response to cyclosporin A; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0045471; P:response to ethanol; IEP:RGD.
GO; GO:0010332; P:response to gamma radiation; IEP:RGD.
GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
GO; GO:0009408; P:response to heat; IDA:RGD.
GO; GO:0001666; P:response to hypoxia; IEP:RGD.
GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
GO; GO:0009612; P:response to mechanical stimulus; IEP:RGD.
GO; GO:0032570; P:response to progesterone; IEP:RGD.
GO; GO:0034612; P:response to tumor necrosis factor; IEP:RGD.
GO; GO:0033552; P:response to vitamin B3; IEP:RGD.
GO; GO:0009611; P:response to wounding; IEA:Ensembl.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:RGD.
GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IMP:RGD.
InterPro; IPR000827; Chemokine_CC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
Pfam; PF00048; IL8; 1.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
2: Evidence at transcript level;
Chemotaxis; Complete proteome; Cytokine; Disulfide bond; Glycoprotein;
Inflammatory response; Pyrrolidone carboxylic acid;
Reference proteome; Secreted; Signal.
SIGNAL 1 23 {ECO:0000250}.
CHAIN 24 148 C-C motif chemokine 2.
/FTId=PRO_0000005151.
MOD_RES 24 24 Pyrrolidone carboxylic acid.
{ECO:0000250|UniProtKB:P13500}.
CARBOHYD 126 126 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 34 59 {ECO:0000250}.
DISULFID 35 75 {ECO:0000250}.
SEQUENCE 148 AA; 16460 MW; 62D4C42BF4B11C9D CRC64;
MQVSVTLLGL LFTVAACSIH VLSQPDAVNA PLTCCYSFTG KMIPMSRLEN YKRITSSRCP
KEAVVFVTKL KREICADPNK EWVQKYIRKL DQNQVRSETT VFYKIASTLR TSAPLNVNLT
HKSEANASTL FSTTTSSTSV EVTSMTEN


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