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C-C motif chemokine 20 (Beta-chemokine exodus-1) (CC chemokine LARC) (CC chemokine ST38) (Liver and activation-regulated chemokine) (Macrophage inflammatory protein 3 alpha) (MIP-3-alpha) (Small-inducible cytokine A20)

 CCL20_RAT               Reviewed;          96 AA.
P97884;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
05-DEC-2018, entry version 124.
RecName: Full=C-C motif chemokine 20;
AltName: Full=Beta-chemokine exodus-1;
AltName: Full=CC chemokine LARC;
AltName: Full=CC chemokine ST38;
AltName: Full=Liver and activation-regulated chemokine;
AltName: Full=Macrophage inflammatory protein 3 alpha;
Short=MIP-3-alpha;
AltName: Full=Small-inducible cytokine A20;
Flags: Precursor;
Name=Ccl20; Synonyms=Scya20, St38;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
Kelner G.S., Maciejewski-Lenoir D., Lee E.D., Maki R.A.;
"Activated rat astrocytes produce the CC chemokine Exodus.";
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF N-TERMINUS.
STRAIN=Fischer 344; TISSUE=Brain;
PubMed=9916893; DOI=10.1016/S0165-5728(98)00204-5;
Utans-Schneitz U., Lorez H., Klinkert W.E.F., da Silva J.,
Lesslauer W.;
"A novel rat CC chemokine, identified by targeted differential
display, is upregulated in brain inflammation.";
J. Neuroimmunol. 92:179-190(1998).
-!- FUNCTION: Acts as a ligand for C-C chemokine receptor CCR6.
Signals through binding and activation of CCR6 and induces a
strong chemotactic response and mobilization of intracellular
calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible
for the chemotaxis of dendritic cells (DC), effector/memory T-
cells and B-cells and plays an important role at skin and mucosal
surfaces under homeostatic and inflammatory conditions, as well as
in pathology, including cancer and autoimmune diseases. CCL20 acts
as a chemotactic factor that attracts lymphocytes and, slightly,
neutrophils, but not monocytes. Involved in the recruitment of
both the proinflammatory IL17 producing helper T-cells (Th17) and
the regulatory T-cells (Treg) to sites of inflammation. Required
for optimal migration of thymic natural regulatory T cells
(nTregs) and DN1 early thymocyte progenitor cells. Positively
regulates sperm motility and chemotaxis via its binding to CCR6
which triggers Ca2+ mobilization in the sperm which is important
for its motility. May be involved in formation and function of the
mucosal lymphoid tissues by attracting lymphocytes and dendritic
cells towards epithelial cells. {ECO:0000250|UniProtKB:O89093,
ECO:0000250|UniProtKB:P78556}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P78556}.
-!- TISSUE SPECIFICITY: Low levels in thymus and lung.
-!- INDUCTION: By TNF in experimental allergic panencaphalomyelitis
(EAP) and by TNF and IL-1 in primary astrocytes.
-!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
{ECO:0000305}.
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EMBL; U90447; AAB61459.1; -; mRNA.
EMBL; AF053312; AAC78294.1; -; mRNA.
RefSeq; NP_062106.1; NM_019233.1.
UniGene; Rn.10722; -.
ProteinModelPortal; P97884; -.
SMR; P97884; -.
STRING; 10116.ENSRNOP00000021730; -.
PaxDb; P97884; -.
PRIDE; P97884; -.
Ensembl; ENSRNOT00000021730; ENSRNOP00000021730; ENSRNOG00000015992.
GeneID; 29538; -.
KEGG; rno:29538; -.
UCSC; RGD:3646; rat.
CTD; 6364; -.
RGD; 3646; Ccl20.
eggNOG; ENOG410J2BK; Eukaryota.
eggNOG; ENOG410ZGME; LUCA.
GeneTree; ENSGT00940000165529; -.
HOGENOM; HOG000036685; -.
HOVERGEN; HBG017871; -.
InParanoid; P97884; -.
KO; K14625; -.
OMA; CCLRYTE; -.
OrthoDB; EOG091G168B; -.
PhylomeDB; P97884; -.
TreeFam; TF334888; -.
Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
Reactome; R-RNO-418594; G alpha (i) signalling events.
PRO; PR:P97884; -.
Proteomes; UP000002494; Chromosome 9.
Bgee; ENSRNOG00000015992; Expressed in 6 organ(s), highest expression level in colon.
Genevisible; P97884; RN.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
GO; GO:0031731; F:CCR6 chemokine receptor binding; ISS:UniProtKB.
GO; GO:0008009; F:chemokine activity; IDA:RGD.
GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; ISS:UniProtKB.
GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
GO; GO:0071223; P:cellular response to lipoteichoic acid; IEP:RGD.
GO; GO:0071310; P:cellular response to organic substance; IEP:RGD.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0006935; P:chemotaxis; IDA:RGD.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
GO; GO:0050726; P:positive regulation of interleukin-1 alpha biosynthetic process; IDA:RGD.
GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IDA:RGD.
GO; GO:0072678; P:T cell migration; ISS:UniProtKB.
GO; GO:0072679; P:thymocyte migration; ISS:UniProtKB.
GO; GO:0042060; P:wound healing; IEP:RGD.
CDD; cd01119; Chemokine_CC_DCCL; 1.
InterPro; IPR039809; Chemokine_b/g/d.
InterPro; IPR034133; Chemokine_CC_DCCL.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR036048; Interleukin_8-like_sf.
PANTHER; PTHR12015; PTHR12015; 1.
Pfam; PF00048; IL8; 1.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
1: Evidence at protein level;
Chemotaxis; Complete proteome; Cytokine; Direct protein sequencing;
Disulfide bond; Inflammatory response; Reference proteome; Secreted;
Signal.
SIGNAL 1 26 {ECO:0000269|PubMed:9916893}.
CHAIN 27 96 C-C motif chemokine 20.
/FTId=PRO_0000005219.
DISULFID 31 58 {ECO:0000250}.
DISULFID 32 74 {ECO:0000250}.
SEQUENCE 96 AA; 10875 MW; 7B323410F2B2E6DF CRC64;
MACKHLPFLA LAGVLLAYLC SQSEAASNFD CCLTYTKNVY HHARNFVGFT TQMADEACDI
NAIIFHLKSK RSVCADPKQI WVKRILHLLS LRTKKM


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