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C-C motif chemokine 5 (Small-inducible cytokine A5) (T-cell-specific protein RANTES)

 CCL5_HORSE              Reviewed;          91 AA.
Q8MKD0;
13-APR-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
30-AUG-2017, entry version 89.
RecName: Full=C-C motif chemokine 5;
AltName: Full=Small-inducible cytokine A5;
AltName: Full=T-cell-specific protein RANTES;
Flags: Precursor;
Name=CCL5; Synonyms=SCYA5;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Takafuji V.A., Sharova L.V., Crisman M.V., Howard R.D.;
"Equus caballus RANTES mRNA.";
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Chemoattractant for blood monocytes, memory T-helper
cells and eosinophils. Causes the release of histamine from
basophils and activates eosinophils. May activate several
chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also
be an agonist of the G protein-coupled receptor GPR75. Together
with GPR75, may play a role in neuron survival through activation
of a downstream signaling pathway involving the PI3, Akt and MAP
kinases. By activating GPR75 may also play a role in insulin
secretion by islet cells. {ECO:0000250|UniProtKB:P13501}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
{ECO:0000305}.
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EMBL; AF506970; AAM34212.1; -; mRNA.
RefSeq; NP_001075332.1; NM_001081863.2.
UniGene; Eca.1046; -.
ProteinModelPortal; Q8MKD0; -.
SMR; Q8MKD0; -.
STRING; 9796.ENSECAP00000022430; -.
PaxDb; Q8MKD0; -.
Ensembl; ENSECAT00000026840; ENSECAP00000022430; ENSECAG00000024888.
GeneID; 100033925; -.
KEGG; ecb:100033925; -.
CTD; 6352; -.
eggNOG; ENOG410J0XH; Eukaryota.
eggNOG; ENOG410ZUYI; LUCA.
GeneTree; ENSGT00860000133690; -.
HOGENOM; HOG000036685; -.
HOVERGEN; HBG017871; -.
InParanoid; Q8MKD0; -.
KO; K12499; -.
OMA; CCFAYLS; -.
OrthoDB; EOG091G14Y2; -.
TreeFam; TF334888; -.
Proteomes; UP000002281; Chromosome 11.
Bgee; ENSECAG00000024888; -.
ExpressionAtlas; Q8MKD0; baseline.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
GO; GO:0031726; F:CCR1 chemokine receptor binding; IEA:Ensembl.
GO; GO:0031729; F:CCR4 chemokine receptor binding; IEA:InterPro.
GO; GO:0031730; F:CCR5 chemokine receptor binding; IEA:Ensembl.
GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
GO; GO:0046817; F:chemokine receptor antagonist activity; IEA:Ensembl.
GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:Ensembl.
GO; GO:0016004; F:phospholipase activator activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
GO; GO:0043621; F:protein self-association; IEA:Ensembl.
GO; GO:0030298; F:receptor signaling protein tyrosine kinase activator activity; IEA:Ensembl.
GO; GO:0031584; P:activation of phospholipase D activity; IEA:Ensembl.
GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0043623; P:cellular protein complex assembly; IEA:Ensembl.
GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
GO; GO:0070098; P:chemokine-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0048245; P:eosinophil chemotaxis; IEA:Ensembl.
GO; GO:0006887; P:exocytosis; IEA:Ensembl.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:UniProtKB.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
GO; GO:0043922; P:negative regulation by host of viral transcription; IEA:Ensembl.
GO; GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; IEA:Ensembl.
GO; GO:2000110; P:negative regulation of macrophage apoptotic process; IEA:Ensembl.
GO; GO:0070233; P:negative regulation of T cell apoptotic process; IEA:Ensembl.
GO; GO:0045071; P:negative regulation of viral genome replication; IEA:Ensembl.
GO; GO:0042119; P:neutrophil activation; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl.
GO; GO:0033634; P:positive regulation of cell-cell adhesion mediated by integrin; IEA:Ensembl.
GO; GO:0031328; P:positive regulation of cellular biosynthetic process; IEA:Ensembl.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
GO; GO:0034112; P:positive regulation of homotypic cell-cell adhesion; IEA:Ensembl.
GO; GO:0010759; P:positive regulation of macrophage chemotaxis; IEA:Ensembl.
GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IEA:Ensembl.
GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0014911; P:positive regulation of smooth muscle cell migration; IEA:Ensembl.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0070234; P:positive regulation of T cell apoptotic process; IEA:Ensembl.
GO; GO:0010820; P:positive regulation of T cell chemotaxis; IBA:GO_Central.
GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
GO; GO:0051262; P:protein tetramerization; IEA:Ensembl.
GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
GO; GO:1901214; P:regulation of neuron death; ISS:UniProtKB.
GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO; GO:0009615; P:response to virus; IEA:InterPro.
InterPro; IPR030595; CCL5.
InterPro; IPR000827; Chemokine_CC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
PANTHER; PTHR12015:SF136; PTHR12015:SF136; 1.
Pfam; PF00048; IL8; 1.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
3: Inferred from homology;
Chemotaxis; Complete proteome; Cytokine; Disulfide bond;
Inflammatory response; Reference proteome; Secreted; Signal.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 91 C-C motif chemokine 5.
/FTId=PRO_0000005174.
DISULFID 33 57 {ECO:0000250}.
DISULFID 34 73 {ECO:0000250}.
SEQUENCE 91 AA; 10159 MW; AEB253E8CD4ED7FD CRC64;
MKVFAAALAV ILATATFCTP ASASPYASDT TPCCFAYISR PLPRAHIQEY FYTSSKCSIP
AVVFVTRKKR QVCANPEKKW VREYINTLEM S


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