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C-X-C motif chemokine 14 (B-cell and monocyte-activating chemokine) (Chemokine BRAK) (Kidney-expressed chemokine CXC) (MIP-2G) (Small-inducible cytokine B14)

 CXL14_MOUSE             Reviewed;          99 AA.
Q9WUQ5; Q548T5; Q91V02; Q9JHH7;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
23-MAR-2010, sequence version 2.
20-DEC-2017, entry version 124.
RecName: Full=C-X-C motif chemokine 14;
AltName: Full=B-cell and monocyte-activating chemokine;
AltName: Full=Chemokine BRAK;
AltName: Full=Kidney-expressed chemokine CXC;
AltName: Full=MIP-2G;
AltName: Full=Small-inducible cytokine B14;
Flags: Precursor;
Name=Cxcl14; Synonyms=Bmac, Kec, Ks1, Mip2g, Scyb14;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10049774; DOI=10.1006/bbrc.1999.0257;
Hromas R., Broxmeyer H.E., Kim C., Nakshatri H., Christopherson K. II,
Azam M., Hou Y.-H.;
"Cloning of BRAK, a novel divergent CXC chemokine preferentially
expressed in normal versus malignant cells.";
Biochem. Biophys. Res. Commun. 255:703-706(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
STRAIN=BALB/cByJ; TISSUE=Keratinocyte;
PubMed=10784614; DOI=10.1093/intimm/12.5.677;
Sleeman M.A., Fraser J.K., Murison J.G., Kelly S.L., Prestidge R.L.,
Palmer D.J., Watson J.D., Kumble K.D.;
"B cell- and monocyte-activating chemokine (BMAC), a novel non-ELR
alpha-chemokine.";
Int. Immunol. 12:677-689(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Kidney;
PubMed=10946286; DOI=10.4049/jimmunol.165.5.2588;
Cao X., Zhang W., Wan T., He L., Chen T., Yuan Z., Ma S., Yu Y.,
Chen G.;
"Molecular cloning and characterization of a novel CXC chemokine
macrophage inflammatory protein-2 gamma chemoattractant for human
neutrophils and dendritic cells.";
J. Immunol. 165:2588-2595(2000).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C3H/HeJ;
Wang L., Deng L., Raikwar N., Sahota A., Tischfield J.A.;
"Identification of a kidney-expressed chemokine (KEC), a member of the
CXC family, that is selectively elevated in aprt knockout mice.";
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S.,
Hashimoto K.;
"Isolation of full-length cDNA clones from mouse brain cDNA library
made by oligo-capping method.";
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and NOD;
TISSUE=Dendritic cell, Embryo, Embryonic head, and Lung;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
NUCLEOTIDE SEQUENCE [MRNA] OF 5-99.
STRAIN=C57BL/6J; TISSUE=Fetus, and Placenta;
Schilderink N., Geerts D.;
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Chemotactic for CESS B-cells and THP-1 monocytes, but
not T-cells. {ECO:0000269|PubMed:10784614}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
-!- TISSUE SPECIFICITY: Highly expressed in brain, lung, ovary, muscle
and in kidney and liver parenchyma, and at lower levels in bone
marrow. {ECO:0000269|PubMed:10784614,
ECO:0000269|PubMed:10946286}.
-!- DOMAIN: The destruction box (D-box) acts as a recognition signal
for degradation via the ubiquitin-proteasome pathway.
{ECO:0000250}.
-!- PTM: Ubiquitinated, followed by degradation by the proteasome.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF152377; AAD34157.1; -; mRNA.
EMBL; AF144754; AAF66694.1; -; mRNA.
EMBL; AF252873; AAF65570.1; -; mRNA.
EMBL; AF192557; AAF03753.1; -; mRNA.
EMBL; AB041614; BAA95097.1; -; mRNA.
EMBL; AK004615; BAB23411.1; -; mRNA.
EMBL; AK014351; BAB29292.1; -; mRNA.
EMBL; AK076112; BAC36192.1; -; mRNA.
EMBL; AK155356; BAE33213.1; -; mRNA.
EMBL; CH466546; EDL41235.1; -; Genomic_DNA.
EMBL; BC147274; AAI47275.1; -; mRNA.
EMBL; BC147275; AAI47276.1; -; mRNA.
EMBL; AF352784; AAK52902.1; -; mRNA.
EMBL; AF352785; AAK52903.1; -; mRNA.
CCDS; CCDS36679.1; -.
RefSeq; NP_062514.2; NM_019568.2.
RefSeq; XP_006517371.1; XM_006517308.3.
UniGene; Mm.30211; -.
ProteinModelPortal; Q9WUQ5; -.
SMR; Q9WUQ5; -.
STRING; 10090.ENSMUSP00000021970; -.
PhosphoSitePlus; Q9WUQ5; -.
MaxQB; Q9WUQ5; -.
PaxDb; Q9WUQ5; -.
PRIDE; Q9WUQ5; -.
Ensembl; ENSMUST00000021970; ENSMUSP00000021970; ENSMUSG00000021508.
GeneID; 57266; -.
KEGG; mmu:57266; -.
UCSC; uc007qsm.2; mouse.
CTD; 9547; -.
MGI; MGI:1888514; Cxcl14.
eggNOG; ENOG410J0K5; Eukaryota.
eggNOG; ENOG4111XWS; LUCA.
GeneTree; ENSGT00390000000618; -.
HOGENOM; HOG000065700; -.
HOVERGEN; HBG054250; -.
InParanoid; Q9WUQ5; -.
KO; K10033; -.
OMA; CQEKMIF; -.
OrthoDB; EOG091G10GY; -.
PhylomeDB; Q9WUQ5; -.
TreeFam; TF332769; -.
PRO; PR:Q9WUQ5; -.
Proteomes; UP000000589; Chromosome 13.
Bgee; ENSMUSG00000021508; -.
CleanEx; MM_CXCL14; -.
ExpressionAtlas; Q9WUQ5; baseline and differential.
Genevisible; Q9WUQ5; MM.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
GO; GO:0008009; F:chemokine activity; IEA:InterPro.
GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB.
GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0048839; P:inner ear development; IDA:MGI.
GO; GO:0031640; P:killing of cells of other organism; IDA:UniProtKB.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IMP:MGI.
GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; IMP:MGI.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR036048; Interleukin_8-like_sf.
Pfam; PF00048; IL8; 1.
SUPFAM; SSF54117; SSF54117; 1.
2: Evidence at transcript level;
Complete proteome; Cytokine; Disulfide bond; Reference proteome;
Secreted; Signal; Ubl conjugation.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 99 C-X-C motif chemokine 14.
/FTId=PRO_0000005116.
MOTIF 55 69 D-box.
DISULFID 25 51 {ECO:0000250}.
DISULFID 27 72 {ECO:0000250}.
CONFLICT 17 20 ASRV -> VRAL (in Ref. 1; AAD34157, 3;
AAF65570 and 4; AAF03753). {ECO:0000305}.
CONFLICT 64 64 S -> F (in Ref. 1; AAD34157 and 3;
AAF65570). {ECO:0000305}.
SEQUENCE 99 AA; 11716 MW; 97352E91FF7F46D6 CRC64;
MRLLAAALLL LLLALCASRV DGSKCKCSRK GPKIRYSDVK KLEMKPKYPH CEEKMVIVTT
KSMSRYRGQE HCLHPKLQST KRFIKWYNAW NEKRRVYEE


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