Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

C-X-C motif chemokine 2 (Cytokine-induced neutrophil chemoattractant 3) (CINC-3) (Macrophage inflammatory protein 2) (MIP2)

 CXCL2_RAT               Reviewed;         100 AA.
P30348; Q5WA60;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
23-MAY-2018, entry version 128.
RecName: Full=C-X-C motif chemokine 2;
AltName: Full=Cytokine-induced neutrophil chemoattractant 3;
Short=CINC-3;
AltName: Full=Macrophage inflammatory protein 2;
Short=MIP2;
Flags: Precursor;
Name=Cxcl2; Synonyms=Cinc3, Mip-2, Mip2, Scyb2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Fischer 344; TISSUE=Lung;
PubMed=7665992;
Driscoll K.E., Hassenbein D.G., Howard B.W., Isfort R.J., Cody D.,
Tindal M.H., Suchanek M., Carter J.M.;
"Cloning, expression, and functional characterization of rat MIP-2: a
neutrophil chemoattractant and epithelial cell mitogen.";
J. Leukoc. Biol. 58:359-364(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Fischer;
PubMed=7883948; DOI=10.1172/JCI117745;
Feng L., Xia Y., Yoshimura T., Wilson C.B.;
"Modulation of neutrophil influx in glomerulonephritis in the rat with
anti-macrophage inflammatory protein-2 (MIP-2) antibody.";
J. Clin. Invest. 95:1009-1017(1995).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=CD Charles River; TISSUE=Lung;
Farone A., Farone M., Shi M.M., Kobzik L., Paulauskis J.D.;
"Molecular cloning and mRNA expression of rat macrophage inflammatory
protein-2.";
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
PubMed=14624457; DOI=10.1002/jcb.10710;
Numahata K., Komagata T., Hirasawa N., Someya K., Xiao Y.Q.,
Ohuchi K.;
"Analysis of the mechanism regulating the stability of rat macrophage
inflammatory protein-2 mRNA in RBL-2H3 cells.";
J. Cell. Biochem. 90:976-986(2003).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 39-91.
TISSUE=Lung;
PubMed=1415488;
Huang S., Paulauskis J.D., Godleski J.J., Kobzik L.;
"Expression of macrophage inflammatory protein-2 and KC mRNA in
pulmonary inflammation.";
Am. J. Pathol. 141:981-988(1992).
[6]
PROTEIN SEQUENCE OF 32-100.
STRAIN=Wistar;
PubMed=8043001; DOI=10.1042/bj3010545;
Nakagawa H., Komorita N., Shibata F., Ikesue A., Konishi K.,
Fujioka M., Kato H.;
"Identification of cytokine-induced neutrophil chemoattractants
(CINC), rat GRO/CINC-2 alpha and CINC-2 beta, produced by granulation
tissue in culture: purification, complete amino acid sequences and
characterization.";
Biochem. J. 301:545-550(1994).
[7]
PROTEIN SEQUENCE OF 32-59.
STRAIN=Wistar;
PubMed=8607872; DOI=10.1006/bbrc.1996.0511;
Nakagawa H., Shiota S., Takano K., Shibata F., Kato H.;
"Cytokine-induced neutrophil chemoattractant (CINC)-2 alpha, a novel
member of rat GRO/CINCs, is a predominant chemokine produced by
lipopolysaccharide-stimulated rat macrophages in culture.";
Biochem. Biophys. Res. Commun. 220:945-948(1996).
[8]
PROTEIN SEQUENCE OF 32-45.
PubMed=8471066; DOI=10.1016/0006-2952(93)90041-T;
Nakagawa H., Ikesue A., Hatakeyama S., Kato H., Gotoda T.,
Komorita N., Watanabe K., Miyai H.;
"Production of an interleukin-8-like chemokine by cytokine-stimulated
rat NRK-49F fibroblasts and its suppression by anti-inflammatory
steroids.";
Biochem. Pharmacol. 45:1425-1430(1993).
-!- FUNCTION: Chemotactic for human polymorphonuclear leukocytes but
does not induce chemokinesis or an oxidative burst. Contributes to
neutrophil activation during inflammation.
-!- SUBUNIT: Homotetramer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: At least expressed in the lung and trachea.
-!- INDUCTION: By lipopolysaccharide (LPS) and inflammation; in lung.
-!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; X65647; CAA46599.1; -; mRNA.
EMBL; S77604; AAB33749.1; -; mRNA.
EMBL; U45965; AAA92438.1; -; mRNA.
EMBL; AB060092; BAB41105.1; -; mRNA.
EMBL; S45855; -; NOT_ANNOTATED_CDS; mRNA.
PIR; S21467; S21467.
RefSeq; NP_446099.1; NM_053647.1.
UniGene; Rn.10230; -.
ProteinModelPortal; P30348; -.
SMR; P30348; -.
BioGrid; 250284; 1.
STRING; 10116.ENSRNOP00000003745; -.
PaxDb; P30348; -.
PRIDE; P30348; -.
Ensembl; ENSRNOT00000003745; ENSRNOP00000003745; ENSRNOG00000002792.
GeneID; 114105; -.
KEGG; rno:114105; -.
UCSC; RGD:70069; rat.
CTD; 2920; -.
RGD; 70069; Cxcl2.
eggNOG; ENOG410J3WE; Eukaryota.
eggNOG; ENOG410ZT1C; LUCA.
GeneTree; ENSGT00530000062901; -.
HOGENOM; HOG000220915; -.
HOVERGEN; HBG107789; -.
InParanoid; P30348; -.
KO; K05505; -.
OMA; NGKKACL; -.
OrthoDB; EOG091G14TE; -.
PhylomeDB; P30348; -.
TreeFam; TF333433; -.
Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
Reactome; R-RNO-418594; G alpha (i) signalling events.
Reactome; R-RNO-6798695; Neutrophil degranulation.
PRO; PR:P30348; -.
Proteomes; UP000002494; Chromosome 14.
Bgee; ENSRNOG00000002792; -.
Genevisible; P30348; RN.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0008009; F:chemokine activity; IDA:RGD.
GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
GO; GO:0071347; P:cellular response to interleukin-1; IEP:RGD.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0030595; P:leukocyte chemotaxis; IMP:RGD.
GO; GO:0070997; P:neuron death; IDA:RGD.
GO; GO:0030593; P:neutrophil chemotaxis; IMP:RGD.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:RGD.
GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:0001975; P:response to amphetamine; IEP:RGD.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
GO; GO:0010332; P:response to gamma radiation; IEP:RGD.
GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
GO; GO:0009408; P:response to heat; IEP:RGD.
GO; GO:0042060; P:wound healing; IEP:RGD.
CDD; cd00273; Chemokine_CXC; 1.
InterPro; IPR001089; Chemokine_CXC.
InterPro; IPR018048; Chemokine_CXC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR033899; CXC_Chemokine_domain.
InterPro; IPR036048; Interleukin_8-like_sf.
PANTHER; PTHR10179; PTHR10179; 1.
Pfam; PF00048; IL8; 1.
PRINTS; PR00437; SMALLCYTKCXC.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
1: Evidence at protein level;
Chemotaxis; Complete proteome; Cytokine; Direct protein sequencing;
Disulfide bond; Inflammatory response; Reference proteome; Secreted;
Signal.
SIGNAL 1 31 {ECO:0000269|PubMed:8043001,
ECO:0000269|PubMed:8471066,
ECO:0000269|PubMed:8607872}.
CHAIN 32 100 C-X-C motif chemokine 2.
/FTId=PRO_0000005062.
DISULFID 36 62 {ECO:0000250}.
DISULFID 38 78 {ECO:0000250}.
SEQUENCE 100 AA; 10783 MW; 4299DFE68FF37A9B CRC64;
MAPPTRQLLN AVLVLLLLLA TNHQGTGVVV ASELRCQCLT TLPRVDFKNI QSLTVTPPGP
HCAQTEVIAT LKDGHEVCLN PEAPLVQRIV QKILNKGKAN


Related products :

Catalog number Product name Quantity
U0094r CLIA Cinc3,CINC-3,C-X-C motif chemokine 2,Cxcl2,Cytokine-induced neutrophil chemoattractant 3,Macrophage inflammatory protein 2,MIP2,Mip2,Mip-2,Rat,Rattus norvegicus,Scyb2 96T
E0094r ELISA kit Cinc3,CINC-3,C-X-C motif chemokine 2,Cxcl2,Cytokine-induced neutrophil chemoattractant 3,Macrophage inflammatory protein 2,MIP2,Mip2,Mip-2,Rat,Rattus norvegicus,Scyb2 96T
E0094r ELISA Cinc3,CINC-3,C-X-C motif chemokine 2,Cxcl2,Cytokine-induced neutrophil chemoattractant 3,Macrophage inflammatory protein 2,MIP2,Mip2,Mip-2,Rat,Rattus norvegicus,Scyb2 96T
E0369r ELISA kit Cinc2,CINC-2,C-X-C motif chemokine 3,Cxcl3,Cytokine-induced neutrophil chemoattractant 2,Macrophage inflammatory protein 2-alpha_beta,MIP2-alpha_beta,Rat,Rattus norvegicus 96T
U0369r CLIA Cinc2,CINC-2,C-X-C motif chemokine 3,Cxcl3,Cytokine-induced neutrophil chemoattractant 2,Macrophage inflammatory protein 2-alpha_beta,MIP2-alpha_beta,Rat,Rattus norvegicus 96T
E0369r ELISA Cinc2,CINC-2,C-X-C motif chemokine 3,Cxcl3,Cytokine-induced neutrophil chemoattractant 2,Macrophage inflammatory protein 2-alpha_beta,MIP2-alpha_beta,Rat,Rattus norvegicus 96T
E1210r ELISA kit Cinc1,CINC-1,C-X-C motif chemokine 1,Cxcl1,Cytokine-induced neutrophil chemoattractant 1,Gro,Growth-regulated alpha protein,Platelet-derived growth factor-inducible protein KC,Rat,Rattus no 96T
U1210r CLIA Cinc1,CINC-1,C-X-C motif chemokine 1,Cxcl1,Cytokine-induced neutrophil chemoattractant 1,Gro,Growth-regulated alpha protein,Platelet-derived growth factor-inducible protein KC,Rat,Rattus norvegic 96T
E1210r ELISA Cinc1,CINC-1,C-X-C motif chemokine 1,Cxcl1,Cytokine-induced neutrophil chemoattractant 1,Gro,Growth-regulated alpha protein,Platelet-derived growth factor-inducible protein KC,Rat,Rattus norvegi 96T
E0094m ELISA C-X-C motif chemokine 2,Cxcl2,Macrophage inflammatory protein 2,MIP2,Mip2,Mip-2,Mouse,Mus musculus,Scyb2 96T
U0094m CLIA C-X-C motif chemokine 2,Cxcl2,Macrophage inflammatory protein 2,MIP2,Mip2,Mip-2,Mouse,Mus musculus,Scyb2 96T
E0094m ELISA kit C-X-C motif chemokine 2,Cxcl2,Macrophage inflammatory protein 2,MIP2,Mip2,Mip-2,Mouse,Mus musculus,Scyb2 96T
AE61036RA Rat Cytokine-Induced Neutrophil Chemoattractant-3 (CINC-3) ELISA Kit 96T
CSB-E13667r Rat cytokine-induced neutrophil chemoattractant(CINC) ELISA Kit, Species Rat, Sample Type serum, plasma 96T
EIAAB06112 CC chemokine IMAC,C-C motif chemokine 26,CCL26,Eotaxin-3,Homo sapiens,Human,Macrophage inflammatory protein 4-alpha,MIP-4-alpha,SCYA26,Small-inducible cytokine A26,Thymic stroma chemokine-1,TSC-1,UNQ2
U0272h CLIA C-C motif chemokine 15,CCL15,Chemokine CC-2,HCC-2,Homo sapiens,Human,Leukotactin-1,LKN-1,Macrophage inflammatory protein 5,MIP-1 delta,MIP5,MIP-5,Mrp-2b,NCC3,NCC-3,SCYA15,Small-inducible cytokine 96T
U0094h CLIA C-X-C motif chemokine 2,CXCL2,GRO2,GROB,Gro-beta,Growth-regulated protein beta,Homo sapiens,Human,Macrophage inflammatory protein 2-alpha,MIP2A,MIP2-alpha,SCYB2 96T
E0094h ELISA kit C-X-C motif chemokine 2,CXCL2,GRO2,GROB,Gro-beta,Growth-regulated protein beta,Homo sapiens,Human,Macrophage inflammatory protein 2-alpha,MIP2A,MIP2-alpha,SCYB2 96T
E0094h ELISA C-X-C motif chemokine 2,CXCL2,GRO2,GROB,Gro-beta,Growth-regulated protein beta,Homo sapiens,Human,Macrophage inflammatory protein 2-alpha,MIP2A,MIP2-alpha,SCYB2 96T
E0096h ELISA Beta-chemokine exodus-3,C-C motif chemokine 19,CCL19,CK beta-11,EBI1 ligand chemokine,ELC,ELC,Epstein-Barr virus-induced molecule 1 ligand chemokine,Homo sapiens,Human,Macrophage inflammatory pr 96T
U0096h CLIA Beta-chemokine exodus-3,C-C motif chemokine 19,CCL19,CK beta-11,EBI1 ligand chemokine,ELC,ELC,Epstein-Barr virus-induced molecule 1 ligand chemokine,Homo sapiens,Human,Macrophage inflammatory pro 96T
U0369h CLIA C-X-C motif chemokine 3,CXCL3,GRO3,GROG,GRO-gamma,GRO-gamma(1-73),Growth-regulated protein gamma,Homo sapiens,Human,Macrophage inflammatory protein 2-beta,MIP2-beta,SCYB3 96T
E0369h ELISA kit C-X-C motif chemokine 3,CXCL3,GRO3,GROG,GRO-gamma,GRO-gamma(1-73),Growth-regulated protein gamma,Homo sapiens,Human,Macrophage inflammatory protein 2-beta,MIP2-beta,SCYB3 96T
E0369h ELISA C-X-C motif chemokine 3,CXCL3,GRO3,GROG,GRO-gamma,GRO-gamma(1-73),Growth-regulated protein gamma,Homo sapiens,Human,Macrophage inflammatory protein 2-beta,MIP2-beta,SCYB3 96T
18-783-75649 RABBIT ANTI HUMAN MIP-4 - CCL18; Small-inducible cytokine A18; Macrophage inflammatory protein 4; MIP-4; Pulmonary and activation-regulated chemokine; CC chemokine PARC; Alternative macrophage activat 0.1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur