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C-X-C motif chemokine 5 (Cytokine LIX) (Small-inducible cytokine B5) [Cleaved into: GCP-2(1-78); GCP-2(9-78)]

 CXCL5_MOUSE             Reviewed;         132 AA.
P50228; Q8K3I3;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
03-OCT-2012, sequence version 2.
05-DEC-2018, entry version 139.
RecName: Full=C-X-C motif chemokine 5;
AltName: Full=Cytokine LIX;
AltName: Full=Small-inducible cytokine B5;
Contains:
RecName: Full=GCP-2(1-78);
Contains:
RecName: Full=GCP-2(9-78);
Flags: Precursor;
Name=Cxcl5; Synonyms=Scyb5;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7622488; DOI=10.1074/jbc.270.28.16756;
Smith J.B., Herschman H.R.;
"Glucocorticoid-attenuated response genes encode intercellular
mediators, including a new C-X-C chemokine.";
J. Biol. Chem. 270:16756-16765(1995).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=12439624; DOI=10.1007/s00251-002-0501-5;
Smith J.B., Wadleigh D.J., Xia Y.-R., Mar R.A., Herschman H.R.,
Lusis A.J.;
"Cloning and genomic localization of the murine LPS-induced CXC
chemokine (LIX) gene, Scyb5.";
Immunogenetics 54:599-603(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PROTEIN SEQUENCE OF 41-118, IDENTIFICATION OF GCP-2(1-78), AND
PROTEOLYTIC PROCESSING OF N-TERMINUS.
PubMed=8759763;
Wuyts A., Haelens A., Proost P., Lenaerts J.-P., Conings R.,
Opdenakker G., Van Damme J.;
"Identification of mouse granulocyte chemotactic protein-2 from
fibroblasts and epithelial cells. Functional comparison with natural
KC and macrophage inflammatory protein-2.";
J. Immunol. 157:1736-1743(1996).
[6]
PROTEIN SEQUENCE OF 49-55, IDENTIFICATION OF GCP-2(9-78) BY MASS
SPECTROMETRY, FUNCTION, AND PROTEOLYTIC PROCESSING OF N-TERMINUS AND
C-TERMINAL.
TISSUE=Fibroblast;
PubMed=10570306;
Wuyts A., D'Haese A., Cremers V., Menten P., Lenaerts J.-P.,
De Loof A., Heremans H., Proost P., Van Damme J.;
"NH2- and COOH-terminal truncations of murine granulocyte chemotactic
protein-2 augment the in vitro and in vivo neutrophil chemotactic
potency.";
J. Immunol. 163:6155-6163(1999).
-!- FUNCTION: May participate in the recruitment of inflammatory cells
by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-
2(9-78) attract neutrophils and are involved in neutrophil
activation. {ECO:0000269|PubMed:10570306}.
-!- SUBUNIT: Monomer. Homodimer. {ECO:0000250|UniProtKB:P42830}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- INDUCTION: By lipopolysaccharide (LPS).
-!- PTM: GCP-2(1-78) and GCP-2(9-78) are produced by proteolytic
cleavage after secretion from fibroblasts and epithelial cells.
GCP-2(9-78) is the most prominent form. A number of additional N-
terminal (processed between pos. 41 and 48) and C-terminal
(processed between pos. 118 and 132) processed forms have been
identified, probably also representing intermediate states.
{ECO:0000269|PubMed:10570306, ECO:0000269|PubMed:8759763}.
-!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
family. {ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; U27267; AAC52238.1; -; mRNA.
EMBL; AY100019; AAM48589.1; -; Genomic_DNA.
EMBL; AC105995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC024392; AAH24392.1; -; mRNA.
CCDS; CCDS19414.1; -.
PIR; A57325; A57325.
RefSeq; NP_033167.2; NM_009141.3.
UniGene; Mm.4660; -.
ProteinModelPortal; P50228; -.
SMR; P50228; -.
STRING; 10090.ENSMUSP00000031318; -.
iPTMnet; P50228; -.
PhosphoSitePlus; P50228; -.
PaxDb; P50228; -.
PRIDE; P50228; -.
Ensembl; ENSMUST00000031318; ENSMUSP00000031318; ENSMUSG00000029371.
GeneID; 20311; -.
KEGG; mmu:20311; -.
UCSC; uc008ybg.2; mouse.
CTD; 6374; -.
MGI; MGI:1096868; Cxcl5.
eggNOG; ENOG410J4TR; Eukaryota.
eggNOG; ENOG41117DC; LUCA.
GeneTree; ENSGT00940000162749; -.
HOGENOM; HOG000220915; -.
HOVERGEN; HBG107789; -.
InParanoid; P50228; -.
KO; K05506; -.
OMA; TELRCTC; -.
OrthoDB; EOG091G132U; -.
TreeFam; TF333433; -.
Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
Reactome; R-MMU-418594; G alpha (i) signalling events.
PMAP-CutDB; P50228; -.
PRO; PR:P50228; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000029371; Expressed in 76 organ(s), highest expression level in fibroblast.
CleanEx; MM_CXCL5; -.
Genevisible; P50228; MM.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0008009; F:chemokine activity; ISO:MGI.
GO; GO:0031100; P:animal organ regeneration; ISO:MGI.
GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:MGI.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0001816; P:cytokine production; ISO:MGI.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; ISO:MGI.
GO; GO:0030595; P:leukocyte chemotaxis; IBA:GO_Central.
GO; GO:0001776; P:leukocyte homeostasis; IMP:MGI.
GO; GO:0042119; P:neutrophil activation; ISO:MGI.
GO; GO:0030593; P:neutrophil chemotaxis; ISO:MGI.
GO; GO:0046427; P:positive regulation of JAK-STAT cascade; ISO:MGI.
GO; GO:0010976; P:positive regulation of neuron projection development; ISO:MGI.
GO; GO:0032642; P:regulation of chemokine production; IMP:MGI.
GO; GO:0070951; P:regulation of neutrophil mediated killing of gram-negative bacterium; IMP:MGI.
GO; GO:0032496; P:response to lipopolysaccharide; IMP:MGI.
CDD; cd00273; Chemokine_CXC; 1.
InterPro; IPR001089; Chemokine_CXC.
InterPro; IPR018048; Chemokine_CXC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR033899; CXC_Chemokine_domain.
InterPro; IPR036048; Interleukin_8-like_sf.
PANTHER; PTHR10179; PTHR10179; 1.
Pfam; PF00048; IL8; 1.
PRINTS; PR00437; SMALLCYTKCXC.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
1: Evidence at protein level;
Chemotaxis; Complete proteome; Cytokine; Direct protein sequencing;
Disulfide bond; Inflammatory response; Reference proteome; Secreted;
Signal.
SIGNAL 1 40 {ECO:0000269|PubMed:8759763}.
CHAIN 41 132 C-X-C motif chemokine 5.
/FTId=PRO_0000005078.
CHAIN 41 118 GCP-2(1-78).
/FTId=PRO_0000005079.
CHAIN 49 118 GCP-2(9-78).
/FTId=PRO_0000005080.
DISULFID 53 79 {ECO:0000250|UniProtKB:P42830}.
DISULFID 55 95 {ECO:0000250|UniProtKB:P42830}.
CONFLICT 10 10 R -> H (in Ref. 1; AAC52238 and 4;
AAH24392). {ECO:0000305}.
CONFLICT 16 16 I -> S (in Ref. 1; AAC52238 and 4;
AAH24392). {ECO:0000305}.
CONFLICT 81 82 TV -> N (in Ref. 5; AA sequence).
{ECO:0000305}.
SEQUENCE 132 AA; 14235 MW; B7E9C4E6094DE365 CRC64;
MSLQLRSSAR IPSGSISPFM RMAPLAFLLL FTLPQHLAEA APSSVIAATE LRCVCLTVTP
KINPKLIANL EVIPAGPQCP TVEVIAKLKN QKEVCLDPEA PVIKKIIQKI LGSDKKKAKR
NALAVERTAS VQ


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