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C-myb v-myb myeloblastosis viral oncogene homologue (avian), exon 1 and joined CDS (V-myb myeloblastosis viral oncogene homolog (Avian), isoform CRA_k) (V-myb myeloblastosis viral oncogene homologue (Avian))

 Q708E8_HUMAN            Unreviewed;       350 AA.
Q708E8;
10-MAY-2005, integrated into UniProtKB/TrEMBL.
10-MAY-2005, sequence version 1.
23-MAY-2018, entry version 126.
SubName: Full=C-myb v-myb myeloblastosis viral oncogene homologue (avian), exon 1 and joined CDS {ECO:0000313|EMBL:CAF04478.1};
SubName: Full=V-myb myeloblastosis viral oncogene homolog (Avian), isoform CRA_k {ECO:0000313|EMBL:EAW47977.1};
SubName: Full=V-myb myeloblastosis viral oncogene homologue (Avian) {ECO:0000313|EMBL:CAE55168.1};
Name=MYB {ECO:0000313|EMBL:EAW47977.1};
Synonyms=c-myb {ECO:0000313|EMBL:CAE55168.1};
ORFNames=hCG_32380 {ECO:0000313|EMBL:EAW47977.1};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606 {ECO:0000313|EMBL:CAF04478.1};
[1] {ECO:0000313|EMBL:EAW47977.1}
NUCLEOTIDE SEQUENCE.
PubMed=11181995; DOI=10.1126/science.1058040;
Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
"The sequence of the human genome.";
Science 291:1304-1351(2001).
[2] {ECO:0000313|EMBL:CAF04478.1}
NUCLEOTIDE SEQUENCE.
Close J.P., Game L., Clark B., Berginoux J., Gerovassili A., Thein S.;
"Genome annotation and mutation analysis of a 1.5Mb region of 6q23
encompassing a Quantitative Trait Locus for foetal haemoglobin
expression.";
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:CAE55168.1}
NUCLEOTIDE SEQUENCE.
PubMed=15169551; DOI=10.1186/1471-2164-5-33;
Close J.P., Game L., Clark B., Bergounioux J., Gerovassili A.,
Thein S.L.;
"Genome annotation of a 1.5 Mb region of human chromosome 6q23
encompassing a quantitative trait locus for fetal hemoglobin
expression in adults.";
BMC Genomics 5:33-33(2004).
[4] {ECO:0000313|EMBL:EAW47977.1}
NUCLEOTIDE SEQUENCE.
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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EMBL; AJ606317; CAE55168.1; -; mRNA.
EMBL; AJ616791; CAF04478.1; -; mRNA.
EMBL; AJ616792; CAF04478.1; JOINED; mRNA.
EMBL; AJ616793; CAF04478.1; JOINED; mRNA.
EMBL; AJ616794; CAF04478.1; JOINED; mRNA.
EMBL; AJ616795; CAF04478.1; JOINED; mRNA.
EMBL; AJ616796; CAF04478.1; JOINED; mRNA.
EMBL; AJ616797; CAF04478.1; JOINED; mRNA.
EMBL; AJ616798; CAF04478.1; JOINED; mRNA.
EMBL; CH471051; EAW47977.1; -; Genomic_DNA.
UniGene; Hs.606320; -.
UniGene; Hs.626299; -.
SMR; Q708E8; -.
MaxQB; Q708E8; -.
UCSC; uc063rpn.1; human.
EuPathDB; HostDB:ENSG00000118513.18; -.
eggNOG; KOG0048; Eukaryota.
eggNOG; COG5147; LUCA.
HOGENOM; HOG000199899; -.
HOVERGEN; HBG007964; -.
ChiTaRS; MYB; human.
Bgee; ENSG00000118513; -.
ExpressionAtlas; Q708E8; baseline and differential.
GO; GO:0003677; F:DNA binding; IEA:InterPro.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
CDD; cd00167; SANT; 3.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017930; Myb_dom.
InterPro; IPR001005; SANT/Myb.
InterPro; IPR012642; Tscrpt_reg_Wos2-domain.
Pfam; PF07988; LMSTEN; 1.
Pfam; PF00249; Myb_DNA-binding; 3.
SMART; SM00717; SANT; 3.
SUPFAM; SSF46689; SSF46689; 2.
PROSITE; PS51294; HTH_MYB; 3.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils}.
DOMAIN 35 86 HTH myb-type.
{ECO:0000259|PROSITE:PS51294}.
DOMAIN 87 142 HTH myb-type.
{ECO:0000259|PROSITE:PS51294}.
DOMAIN 143 193 HTH myb-type.
{ECO:0000259|PROSITE:PS51294}.
COILED 295 315 {ECO:0000256|SAM:Coils}.
SEQUENCE 350 AA; 40620 MW; 60632631CFEE51FF CRC64;
MARRPRHSIY SSDEDDEDFE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK LKKLVEQNGT
DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED QRVIELVQKY GPKRWSVIAK
HLKGRIGKQC RERWHNHLNP EVKKTSWTEE EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA
IKNHWNSTMR RKVEQEGYLQ ESSKASQPAV ATSFQKNSHL MGFAQAPPTA QLPATGQPTV
NNDYSYYHIS EAQNVSSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL
LLMSTENELK GQQVLPLCGP LLNSDIFSDW AANWDGSLCF ATYIVNQQRQ


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